Tag Archives: health

London Underground polluted with metallic particles small enough to enter human bloodstream

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The London Underground is polluted with ultrafine metallic particles small enough to end up in the human bloodstream, according to University of Cambridge researchers. These particles are so small that they are likely being underestimated in surveys of pollution in the world’s oldest metro system.

The researchers carried out a new type of pollution analysis, using magnetism to study dust samples from Underground ticket halls, platforms and operator cabins.

The team found that the samples contained high levels of a type of iron oxide called maghemite. Since it takes time for iron to oxidise into maghemite, the results suggest that pollution particles are suspended for long periods, due to poor ventilation throughout the Underground, particularly on station platforms.

Some of the particles are as small as five nanometres in diameter: small enough to be inhaled and end up in the bloodstream, but too small to be captured by typical methods of pollution monitoring. However, it is not clear whether these particles pose a health risk.

Other studies have looked at overall pollution levels on the Underground and the associated health risks, but this is the first time that the size and type of particles has been analysed in detail. The researchers suggest that periodic removal of dust from Underground tunnels, as well as magnetic monitoring of pollution levels, could improve air quality throughout the network. Their results are reported in the journal Scientific Reports.

The London Underground carries five million passengers per day. Multiple studies have shown that air pollution levels on the Underground are higher than those in London more broadly, and beyond the World Health Organization’s (WHO) defined limits. Earlier studies have also suggested that most of the particulate matter on the Underground is generated as the wheels, tracks and brakes grind against one another, throwing up tiny, iron-rich particles.

“Since most of these air pollution particles are metallic, the Underground is an ideal place to test whether magnetism can be an effective way to monitor pollution,” said Professor Richard Harrison from Cambridge’s Department of Earth Sciences, the paper’s senior author. “Normally, we study magnetism as it relates to planets, but we decided to explore how those techniques could be applied to different areas, including air pollution.”

Pollution levels are normally monitored using standard air filters, but these cannot capture ultrafine particles, and they do not detect what kinds of particles are contained within the particulate matter.

“I started studying environmental magnetism as part of my PhD, looking at whether low-cost monitoring techniques could be used to characterise pollution levels and sources,” said lead author Hassan Sheikh from Cambridge’s Department of Earth Sciences. “The Underground is a well-defined micro-environment, so it’s an ideal place to do this type of study.”

Working with colleagues from Cambridge’s Department of Materials Science and Metallurgy, Sheikh and Harrison analysed 39 dust samples from the London Underground, provided by Transport for London (TfL). The samples were collected in 2019 and 2021 from platforms, ticket halls, and train operator cabins on the Piccadilly, Northern, Central, Bakerloo, Victoria, Northern, District and Jubilee lines. The sampling included major stations such as King’s Cross St Pancras, Paddington, and Oxford Circus.

The researchers used magnetic fingerprinting, 3D imaging and nanoscale microscopy to characterise the structure, size, shape, composition and magnetic properties of particles contained in the samples. Earlier studies have shown that 50% of the pollution particles in the Underground are iron-rich, but the Cambridge team were able to look in much closer detail. They found a high abundance of maghemite particles, ranging in diameter from five to 500 nanometres, and with an average diameter of 10 nanometres. Some particles formed larger clusters with diameters between 100 and 2,000 nanometres.

“The abundance of these very fine particles was surprising,” said Sheikh. “The magnetic properties of iron oxides fundamentally change as the particle size changes. In addition, the size range where those changes happen is the same as where air pollution becomes a health risk.”

While the researchers did not look at whether these maghemite particles pose a direct health risk, they say that their characterisation methods could be useful in future studies.

“If you’re going to answer the question of whether these particles are bad for your health, you first need to know what the particles are made of and what their properties are,” said Sheikh.

“Our techniques give a much more refined picture of pollution in the Underground,” said Harrison. “We can measure particles that are small enough to be inhaled and enter the bloodstream. Typical pollution monitoring doesn’t give you a good picture of the very small stuff.”

The researchers say that due to poor ventilation in the Underground, iron-rich dust can be resuspended in the air when trains arrive at platforms, making the air quality on platforms worse than in ticket halls or in operator cabins.

Given the magnetic nature of the resuspended dust, the researchers suggest that an efficient removal system might be magnetic filters in ventilation, cleaning of the tracks and tunnel walls, or placing screen doors between platforms and trains.

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“Walnuts” the new brain food for stressed university students

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Stressed university students might want to add walnuts to their daily diet in the weeks leading up to their next exam.

A new  clinical trial of undergraduate students during their university studies has shown positive effects of walnut consumption on self-reported measures of mental health and biomarkers of general health.

The University of South Australia study, published in the journal Nutrients, also suggests that walnuts may counteract the effects of academic stress on the gut microbiota during periods of stress, especially in females.

Lead researchers, PhD student Mauritz Herselman and Associate Professor Larisa Bobrovskaya, say the results add to the growing body of evidence linking walnuts with improved brain and gut health.

Walnuts may counteract the effects of academic stress on the gut microbiota during periods of stress, especially in women./CREDIT:Open Verse

“Students experience academic stress throughout their studies, which has a negative effect on their mental health, and they are particularly vulnerable during exam periods,” Herselman says.

Eighty undergraduate students split into treatment and control groups were clinically assessed in three intervals, at the beginning of a 13-week university semester, during the examination period and two weeks after the examination period. Those in the treatment group were given walnuts to consume daily for 16 weeks over these three intervals.

“We found that those who consumed about half a cup of walnuts every day showed improvements in self-reported mental health indicators.  Walnut consumers also showed improved metabolic biomarkers and overall sleep quality in the longer term.”

Students in the control group reported increased stress and depression levels in the leadup to exams but those in the treatment group did not. The walnut consumers also reported a significant drop in feelings associated with depression between the first and final visits, compared to the controls.

Previous research has shown that walnuts are full of omega-3 fatty acids, antioxidants, as well as melatonin (sleep inducing hormone), polyphenols, folate and vitamin E, all of which promote a healthy brain and gut.

“The World Health Organization has recently stated that at least 75 per cent of mental health disorders affect people under the age of 24 years, making undergraduate students particularly vulnerable to mental health problems,” Herselman says.

Assoc Prof Larisa Bobrovskaya says mental health disorders are common in university students and can adversely affect students’ academic performance and long-term physical health.

“We have shown that consuming walnuts during stressful periods can improve mental health and general wellbeing in university students, as well as being a healthy and delicious snack and a versatile ingredient in many recipes, to fight some negative effects of academic stress,” Assoc Prof Bobrovskaya says.

“Due to fewer numbers of males in the study, more research is needed to establish sex-dependent effects of walnuts and academic stress in university students. It’s also possible that a placebo effect might have come into play as this was not a blind study.”

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Researchers uncover factors linked to optimal aging

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What are the keys to “successful” or optimal aging? A new study followed more than 7000 middle aged and older Canadians for approximately three years to identify the factors linked to well-being as we age.

They found that those who were female, married, physically active and not obese and those who had never smoked, had higher incomes, and who did not have insomnia, heart disease or arthritis, were more likely to maintain excellent health across the study period and less likely to develop disabling cognitive, physical, or emotional problems.

As a baseline, the researchers selected participants who were in excellent health at the start of the approximately three-year period of study. This included the absence of memory problems or chronic disabling pain, freedom from any serious mental illness and absence of physical disabilities that limit daily activities — as well as the presence of adequate social support and high levels of happiness and life satisfaction.

Japan’s oldest woman Misao Owasa receiving Huinness Record for longest living person (http://www.guinnessworldrecords.com)

“We were surprised and delighted to learn that more than 70% of our sample maintained their excellent state of health across the study period,” says the first author, Mabel Ho, a doctoral candidate at the University of Toronto’s Factor-Inwentash Faculty of Social Work (FIFSW) and the Institute of Life Course and Aging. “Our findings underline the importance of a strength-based rather than a deficit-based focus on aging and older adults. The media and research tend to ignore the positive and just focus on the problems.”

There was considerable variation in the prevalence of successful aging based on the respondents’ age at the beginning of the study. Three quarters of the respondents who were aged 55 to 64 at the start of the study period maintained excellent health throughout the study. Among those aged 80 and older, approximately half remained in excellent health.

“It is remarkable that half of those aged 80 and older maintained this extremely high bar of cognitive, physical, and emotional well-being across the three years of the study. This is wonderful news for older adults and their families who may anticipate that precipitous decline is inevitable for those aged 80 and older.”  says Mabel Ho. “By understanding factors associated with successful aging, we can work with older adults, families, practitioners, policymakers, and researchers to create an environment that supports a vibrant and healthy later life.”

Sleep/en.wikipedia.org

Older adults who were obese were less likely to maintain good health in later life. Compared to older adults who were obese, those who had a normal weight were 24% more likely to age optimally.

“Our findings are in keeping with other studies which have found that obesity was related to a range of physical symptoms and cognitive problems and that physical activity also plays a key role in optimal aging,” says co-author David Burnes, Associate Professor at the University of Toronto’s FIFSW and a Canada Research Chair in Older Adult Mistreatment Prevention. “These findings highlight the importance of maintaining an appropriate weight and engaging in an active lifestyle throughout the life course”.

Income was also as an important factor. Only about half of those below the poverty line aged optimally compared to three-quarters of those living above the poverty line.

“Although our study does not provide information on why low income is important, it is possible that inadequate income causes stress and also restricts healthy choices such as optimal nutrition. Future research is needed to further explore this relationship,” says senior author Esme Fuller-Thomson, Director of the Institute for Life Course & Aging and Professor at the University of Toronto’s Factor-Inwentash Faculty of Social Work.

 

Lifestyle factors are associated with optimal health in later life. Older adults who never smoked were 46% more likely to maintain an excellent state of health compared to current smokers. Previous studies showed that quitting smoking in later life could improve survival statistics, pulmonary function, and quality of life; lower rates of coronary events, and reduce respiratory symptoms. The study found that former smokers did as well as those who had never smoked, underscoring that it is never too late to quit.

The study also found that engaging in physical activity was important in maintaining good health in later life. Older adults who engaged in moderate to strenuous physical activity were 35% to 45% more likely to age well, respectively.

The findings indicated that respondents who never or rarely experienced sleep problems at baseline were 29% more likely to maintain excellent health across the study.

“Clearly, good sleep is an important factor as we age. Sleep problems undermine cognitive, mental, and physical health. There is strong evidence that an intervention called cognitive-behavioral therapy for insomnia (CBT-I) is very helpful for people living with insomnia,” says Esme Fuller-Thomson.

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No more blood tests, now life-saving light beam to detect malaria

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A fast, needle-free malaria detection tool developed by a University of Queensland-led team could help save hundreds of thousands of lives annually.

Malaria is usually detected by a blood test, but scientists have devised a method using a device that shines a beam of harmless infrared light on a person’s ear or finger for five-to-10 seconds, it collects an infrared signature that is processed by a computer algorithm.

International team leader, Dr Maggy Lord from UQ’s School of Biological Sciences, said the technology would revolutionise how malaria is fought globally.

The malaria detection tool collects an infrared signature for a mobile phone to process./CREDIT:The University of Queensland

“Currently it’s incredibly challenging to test large groups of people, such as the population of a village or town – you have to take blood from everyone and mix it with a reagent to get a result,” Dr Lord said.

“But with this tool we can find out very quickly whether a whole village or town is suffering from, or carrying, malaria.

“The technique is chemical-free, needle-free and detects malaria through the skin using infrared-light – it’s literally just a flash on a person’s skin and it’s done.

“The device is smart-phone operated, so results are acquired in real time.”

The researchers believe the technology is the first step to eliminating malaria.

Tiger Mosquito of Asia is adaing to survive the state of Illinois’s harsh winters / CREDIT: JAMES GATHANY/CDC

“According to the World Health Organisation malaria report, in 2020 there were an estimated 241 million cases worldwide and more than 600,000 died from malaria,” Dr Lord said.

“Most of the cases are in sub-Saharan Africa, where 90 per cent of deaths are children under five years old.

“The biggest challenge in eliminating the disease is the presence of asymptomatic people in a population who act as a reservoir for transmission by mosquitos.

“The World Health Organisation has proposed large-scale surveillance in endemic areas and this non-invasive, affordable and rapid tool offers a way to achieve that.”

The technology could also help tackle other diseases.

“We’ve successfully used this technology on mosquitoes to non-invasively detect infections such as malaria, Zika and dengue,” Dr Lord said.

“In our post-COVID world, it could be used to better tackle diseases as people move around the globe.

“We hope the tool could be used at ports of entry to screen travellers, minimising the re-introduction of diseases and reducing global outbreaks.

“It’s still early days, but this proof-of-concept is exciting.”

UQ collaborated with the Instituto Oswaldo Cruz, Brazil, led by Dr Rafael Maciel de Freitas, who applied the tool to detect malaria in patients in the Amazon region.

The work was funded by Fiocruz INOVA Ideias Inovadoras, Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico, Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro and by Advance Queensland Industry Research Fellowship and the National Health and Medical Research Council.

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Detecting Alzheimer’s disease in the blood using Digital ICA

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Researchers from Hokkaido University and Toppan have developed a method to detect build-up of amyloid β in the brain, a characteristic of Alzheimer’s disease, from biomarkers in blood samples.

Alzheimer’s disease is a neurodegenerative disease, characterised by a gradual loss of neurons and synapses in the brain. One of the primary causes of Alzheimer’s disease is the accumulation of amyloid β (Aβ) in the brain, where it forms plaques. Alzheimer’s disease is mostly seen in individuals over 65 years of age, and cannot currently be stopped or reversed. Thus, Alzheimer’s disease is a major concern for nations with ageing populations, such as Japan.

A team of scientists from Hokkaido University and Toppan, led by Specially Appointed Associate Professor Kohei Yuyama at the Faculty of Advanced Life Science, Hokkaido University, have developed a biosensing technology that can detect Aβ-binding exosomes in the blood of mice, which increase as Aβ accumulates in the brain. Their research was published in the journal Alzheimer’s Research & Therapy.

Alzheimer’s disease model mice (Photo: Kohei Yuyama)./CREDIT:Kohei Yuyama

When tested on mice models, the Aβ-binding exosome Digital ICATM (idICA) showed that the concentration of Aβ-binding exosomes increased with the increase in age of the mice. This is significant as the mice used were Alzheimer’s disease model mice, where Aβ builds up in the brain with age.

In addition to the lack of effective treatments of Alzheimer’s, there are few methods to diagnose Alzheimer’s. Alzheimer’s can only be definitively diagnosed by direct examination of the brain—which can only be done after death. Aβ accumulation in the brain can be measured by cerebrospinal fluid testing or by positron emission tomography; however, the former is an extremely invasive test that cannot be repeated, and the latter is quite expensive. Thus, there is a need for a diagnostic test that is economical, accurate and widely available.

Previous work by Yuyama’s group has shown that Aβ build-up in the brain is associated with Aβ-binding exosomes secreted from neurons, which degrade and transport Aβ to the microglial cells of the brain. Exosomes are membrane-enclosed sacs secreted by cells that possess cell markers on their surface. The team adapted Toppan’s proprietary Digital Invasive Cleavage Assay (Digital ICATM) to quantify the concentration of Aβ-binding exosomes in as little as 100 µL of blood. The device they developed traps molecules and particles in a sample one-by-one in a million micrometer-sized microscopic wells on a measurement chip and detects the presence or absence of fluorescent signals emitted by the cleaving of the Aβ-binding exosomes.

Clinical trials of the technology are currently underway in humans. This highly sensitive idICA technology is the first application of ICA that enables highly sensitive detection of exosomes that retain specific surface molecules from a small amount of blood without the need to learn special techniques; as it is applicable to exosome biomarkers in general, it can also be adapted for use in the diagnosis of other diseases.

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‘Love hormone’ revealed to have heart healing properties in Humans like EpiPCs regenerate organs in zebrafish

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The neurohormone oxytocin is well-known for promoting social bonds including trust, empathy, positive memories, processing of bonding cues, and positive communication and generating pleasurable feelings, for example from art, exercise, or intimacy.

Now, researchers from Michigan State University show that in zebrafish and human cell cultures, oxytocin has yet another, unsuspected, function: it stimulates stem cells derived from the heart’s outer layer (epicardium) to migrate into its middle layer (myocardium) and there develop into cardiomyocytes, muscle cells that generate heart contractions. This discovery could one day be used to promote the regeneration of the human heart after a heart attack.

“Here we show that oxytocin, a neuropeptide also known as the love hormone, is capable of activating heart repair mechanisms in injured hearts in zebrafish and human cell cultures, opening the door to potential new therapies for heart regeneration in humans,” said Dr Aitor Aguirre, an assistant professor at the Department of Biomedical Engineering of Michigan State University, and the study’s senior author.

Stem-like cells can replenish cardiomyocytes

Cardiomyocetes typically die off in great numbers after a heart attack. Because they are highly specialized cells, they can’t replenish themselves. But previous studies have shown that a subset of cells in the epicardium can undergo reprogramming to become stem-like cells, called Epicardium-derived Progenitor Cells (EpiPCs), which can regenerate not only cardiomyocytes, but also other types of heart cells.

“Think of the EpiPCs as the stonemasons that repaired cathedrals in Europe in the Middle Ages,” explained Aguirre.

Unfortunately for us, the production of EpiPCs is inefficient for heart regeneration in humans under natural conditions.

Zebrafish could teach us how to regenerate hearts more efficiently

Enter the zebrafish: famous for their extraordinary capacity for regenerating organs, including the brain, retina, internal organs, bone, and skin. They don’t suffer heart attacks, but its many predators are happy to take a bite out of any organ, including the heart – so zebrafish can regrow their heart when as much as a quarter of it has been lost. This is done partly by proliferation of cardiomyocytes, but also by EpiPCs. But how do the EpiPCs of zebrafish repair the heart so efficiently? And can we find a ‘magic bullet’ in zebrafish that could artificially boost the production of EpiPCs in humans?

Yes, and this ‘magic bullet’ appears to be oxytocin, argue the authors.

To reach this conclusion, the authors found that in zebrafish, within three days after cryoinjury – injury due to freezing – to the heart, the expression of the messenger RNA for oxytocin increases up to 20-fold in the brain. They further showed that this oxytocin then travels to the zebrafish epicardium and binds to the oxytocin receptor, triggering a molecular cascade that stimulates local cells to expand and develop into EpiPCs. These new EpiPCs then migrate to the zebrafish myocardium to develop into cardiomyocytes, blood vessels, and other important heart cells, to replace those which had been lost.

zebrafish/wikipedia

Similar effect on human tissue cultures

Crucially, the authors showed that oxytocin has a similar effect on human tissue in vitro. Oxytocin – but none of 14 other neurohormones tested here – stimulates cultures of human Induced Pluripotent Stem Cells (hIPSCs) to become EpiPCs, at up to twice the basal rate: a much stronger effect than other molecules previously shown to stimulate EpiPC production in mice. Conversely, genetic knock-down of the oxytocin receptor prevented the the regenerative activation of human EpiPCs in culture. The authors also showed that the link between oxytocin and the stimulation of EpiPCs is the important ‘TGF-β signaling pathway’, known to regulate the growth, differentiation, and migration of cells.

Aguirre said: “These results show that it is likely that the stimulation by oxytocin of EpiPC production is evolutionary conserved in humans to a significant extent. Oxytocin is widely used in the clinic for other reasons, so repurposing for patients after heart damage is not a long stretch of the imagination. Even if heart regeneration is only partial, the benefits for patients could be enormous.”

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Frozen embryo transfers linked with high blood pressure risks in pregnancy; What is sibling comparison?

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In vitro fertilization (IVF) using frozen embryos may be associated with a 74% higher risk of hypertensive disorders in pregnancy, according to new research published today in Hypertension, an American Heart Association journal.

In comparison, the study found that pregnancies from fresh embryo transfers – transferring the fertilized egg immediately after in vitro fertilization (IVF) instead of a frozen, fertilized egg – and pregnancy from natural conception shared a similar risk of developing a hypertensive disorder.

High blood pressure during pregnancy often signals preeclampsia, a pregnancy complication including persistent high blood pressure that can endanger the health and life of the mother and fetus. Approximately 1 out of every 25 pregnancies in the United States results in preeclampsia, according to the American Heart Association.

One IVF treatment process available utilizes frozen embryos: after an egg is fertilized by sperm in the lab, it is frozen using a cryopreservation process before being thawed and transferred to the uterus at a later date. The procedure is becoming more common because of the significantly improved freezing technology or cryopreservation methods that started in the late 2000s and because more patients are choosing to freeze embryos, according to the study authors. Yet, frozen embryo transfer is known to be associated with a higher risk of hypertensive disorders in pregnancy than both natural conception and fresh embryo transfer. However, prior to this study, it was unknown whether this was due to the freezing process or a risk factor from the parents.

“Frozen embryo transfers are now increasingly common all over the world, and in the last few years, some doctors have begun skipping fresh embryo transfer to routinely freeze all embryos in their clinical practice, the so-called ‘freeze-all’ approach,” said Sindre H. Petersen, M.D., the study’s lead author and a Ph.D. fellow at the Norwegian University of Science and Technology in Trondheim, Norway.

Researchers examined national data from medical birth registries from Denmark, Norway and Sweden of nearly 2.4 million women who were ages 20 to 44 years old who had single deliveries and gave birth during the study period – from 1988 through 2015. These data were the basis of a population-based study that also included a comparison of women who had both an IVF pregnancy and a naturally conceived pregnancy, called sibling comparison. This approach was used to isolate if the potential reason for the hypertensive disorders was attributable to parental factors or to the IVF treatment.

pregnant lady/Commons.wikimedia.org

The study included more than 4.5 million pregnancies, of which 4.4 million were naturally conceived; more than 78,000 pregnancies were fresh embryo transfers; and more than 18,000 pregnancies were frozen embryo transfers. Among all of the pregnancies, more than 33,000 were grouped for sibling comparison – mothers who conceived via more than one of these methods. The study is the largest to-date using sibling comparison. The odds of developing hypertensive disorders in pregnancy after fresh vs. frozen embryo transfers compared to natural conception were adjusted for variables such as birth year and the mother’s age.

“In summary, although most IVF pregnancies are healthy and uncomplicated,” Petersen said. “This analysis found that the risk of high blood pressure in pregnancy was substantially higher after frozen embryo transfer compared to pregnancies from fresh embryo transfer or natural conception.”

Specifically, the study found:

  • In the population analysis, women whose pregnancy was the result of a frozen embryo transfer were 74% more likely to develop hypertensive disorders in pregnancy compared to those who conceived naturally.
  • Among women who had both a natural conception and an frozen embryo transfer IVF conception (the sibling comparison), the risk of hypertensive disorders in pregnancy after frozen embryo transfer was twice as high compared to pregnancies from natural conception.
  • Pregnancies from fresh embryo transfer did not have a higher risk of developing hypertensive disorders compared to natural conception, neither in population level analysis nor in sibling comparisons.

“Our sibling comparisons indicate that the higher risk is not caused by factors related to the parents, rather, however, that some IVF treatment factors may be involved,” Petersen said. “Future research should investigate which parts of the frozen embryo transfer process may impact risk of hypertension during pregnancy.”

Among other findings, women in the study who gave birth after IVF pregnancies were average age 34 years for frozen embryo transfer, 33 years for fresh embryo transfer and 29 years for those who conceived naturally. About 7% of babies conceived from frozen embryo transfer were born preterm (before 40 weeks gestation) and 8% of babies after fresh embryo transfer were born preterm, compared to 5% of babies after natural conception.

In addition to preeclampsia, the researchers defined hypertensive disorders in pregnancy as a combined outcome, including gestational hypertension, eclampsia (the onset of seizures in those with preeclampsia) and chronic hypertension with superimposed preeclampsia.

One limitation of the study was the lack of data on the kind of frozen embryo cycle, so they were not able to pinpoint what part of the frozen cycle or frozen transfer may contribute to the higher risk of hypertensive disorders. Another limitation is that data from Scandinavian countries may limit generalizing the findings to people in other countries.

“Our results highlight that careful consideration of all benefits and potential risks is needed before freezing all embryos as a routine in clinical practice.  A comprehensive, individualized conversation between physicians and patients about the benefits and risks of a fresh vs. frozen embryo transfer is key,” said Petersen.

 

 

Immune targets for chemotherapy-resistant breast cancers identified

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Scientists have identified immune cell types that could be targeted to develop specific immunotherapies in chemotherapy-resistant breast cancers.

Researchers from King’s College London and The Institute of Cancer Research, London, with support from Breast Cancer Now, have performed a deep dive into the different immune markers within tumour tissues and blood samples of early breast cancer patients whose cancer failed to respond to chemotherapy given to them prior to surgery.

The research, published today in Clinical Cancer Research, a journal of the American Association for Cancer Research, gives insight into the function of immune cells in patients with chemotherapy-resistant breast cancers. While chemotherapy may not kill cancer cells in these high-risk patients, immunotherapy, a type of treatment that helps the immune system to attack cancer cells, may provide a benefit.

To investigate the immune environment that surrounds these chemotherapy resistant tumours, researchers employed multiple and novel complementary technologies looking at proteins and genes on both pre-treatment and post-treatment breast cancer tissue. They also measured how 1,330 cancer and immune-related genes within cancer tissues were affected by chemotherapy.

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They found that chemotherapy resistant cancer cells had very few immune cells around them, but chemotherapy did induce changes in several immune cell types. Specifically, they found increases in the number of “innate” (first responder) cells such as neutrophils and natural killer (NK) cells. NK cells help the body to fight infection and cancer. But analysis found the increased NK cells in patients with chemotherapy resistant disease lacked cytotoxic activity – the ‘killing instinct’.

Researchers also found immune-related genes associated with NK cells were those associated with cell inhibition or exhaustion, which meant NK cells were unable to fight cancer cells. This new insight into the behaviour of NK cells could be used to develop specific immunotherapies for these high-risk patients. This would need to be investigated in future clinical trials.

These findings also show that blood monitoring during chemotherapy may help predict chemotherapy response early, potentially allow for tailoring of treatment prior to surgery.

Lead author Dr Sheeba Irshad, Cancer Research UK Clinician Scientist at King’s College London said: “Chemotherapy resistance in aggressive early breast cancers is a major reason why cancer regrows after treatment, contributing significantly to people not surviving their disease. In order to find the right targets for drug developments, it’s important to have a deep understanding of the complex mechanisms that allow some cancer cells to resist treatment, then hide from our immune system to only re-emerge later when they’re harder to eradicate.

“Our work has identified several cell types that would be worth investigating further to understand how they are interacting with the resistant cancer cell and how we can tweak that for our benefit. I am excited to continue to investigate these findings further.”

chemotherapy

Professor Andrew Tutt, Director of the Breast Cancer Now Toby Robins Research Centre at The Institute of Cancer Research, London, and of the Breast Cancer Now Research Unit at King’s College London, said: “Great strides have been made in harnessing immunotherapies to treat several types of cancer, but we need to do better to realise their potential for patients with breast cancer.

“This exciting work advances our understanding of the interaction between cancer cells and the immune system during treatment, and why existing treatments work well for some patients, but not others. I hope this research will help us to enhance the anti-cancer immune response in breast cancer, particularly for patients whose cancer has not responded well to chemotherapy.”

Dr Kotryna Temcinaite, Senior Research Communications Manager at Breast Cancer Now, said: “With an estimated 35,000 people living with incurable secondary (metastatic) breast cancer in the UK, it’s vital we develop smarter, more effective treatments to ensure fewer people hear the devastating news the disease has returned and spread to other parts of the body. This exciting early-stage research, which has been part-funded by Breast Cancer Now, helps to lay the groundwork for discovering a way to target breast cancer cells that resist chemotherapy treatment. We hope by building on these findings, scientists will ultimately be able to develop immunotherapy treatments that may help more people survive breast cancer.”

India wins UN awards for Initiative against Hypertension

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In a significant achievement and recognition to country’s efforts against hypertension, India has won an UN award for its “India Hypertension Control Initiative (IHCI)”, a large-scale hypertension intervention under National Health Mission. IHCI has been recognized for its exceptional work within India’s existing primary healthcare system.

Complimenting the healthcare initiative, Dr. Mansukh Mandaviya, Union Minister of Health & Family Welfare stated in a tweet: “IHCI has strengthened PM @NarendraModi  Ji’s mission to ensure health & wellness for all”. We are committed to building a healthy & fit India, he further noted.

A collaborative initiative of Ministry of Health and Family Welfare, Indian Council of Medical Research (ICMR), State Governments and World Health Organization-India, IHCI has won the ‘2022 UN Interagency Task Force, and WHO Special Programme on Primary Health Care Award’ at the UN General Assembly side event held on 21st September 2022 at New York, USA. The award recognizes outstanding commitment and action of India to: (i) prevent and control Non-Communicable Diseases (NCDs) and (ii) deliver integrated people-centric primary care. The UN Task Force has identified organisation which has multisectoral approach in prevention and control of NCDs and multisectoral action with demonstrated results at primary care for prevention and control of NCDs and related Sustainable Development Goals (SDGs).

Significance of the initiative can be adjudged from the fact that one in four adults in India has high blood pressure. The control of hypertension at primary care system level will contribute  to reducing deaths due to heart attacks, stroke and kidney failures.

IHCI has been able to leverage and strengthen the existing healthcare delivery system, hypertension control interventions under National Health Mission and improve the linkages between populations-based screening initiative with health care.  The initiative was launched in 2017 and expanded in a phased manner to cover more than 130 districts across 23 states. Under the initiative, more than 34 lakh people with hypertension are taking treatment in government health facilities, including Ayushman Bharat Health Wellness Centres (HWCs).  The project strategies are easily scalable within the health system. The strategies include a simple drug-dose-specific standard treatment protocol, ensuring adequate quantity of protocol medications, decentralization of care with follow-up and refills of medicines at Health Wellness Centres, task sharing involving all health staff and a powerful real-time information system which can track every patient for follow-up and blood pressure control. Under IHCI, nearly half of those who were treated had blood pressure under control.

The IHCI complements the National Programme for Prevention and Control of Diabetes, Cardiovascular Disease and Stroke (NPCDCS) of the Ministry of Health & Family Welfare, Government of India. IHCI accelerates the achievement of targets of the Government of India by ensuring a continuum of care and giving a boost to the ongoing “Ayushman Bharat” programme.

Take a deep breath, your smartphone could help measure blood oxygen levels at home [Details]

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First, pause and take a deep breath.

When we breathe in, our lungs fill with oxygen, which is distributed to our red blood cells for transportation throughout our bodies. Our bodies need a lot of oxygen to function, and healthy people have at least 95% oxygen saturation all the time.

Conditions like asthma or COVID-19 make it harder for bodies to absorb oxygen from the lungs. This leads to oxygen saturation percentages that drop to 90% or below, an indication that medical attention is needed.

In a clinic, doctors monitor oxygen saturation using pulse oximeters — those clips you put over your fingertip or ear. But monitoring oxygen saturation at home multiple times a day could help patients keep an eye on COVID symptoms, for example.

In a proof-of-principle study, University of Washington and University of California San Diego researchers have shown that smartphones are capable of detecting blood oxygen saturation levels down to 70%. This is the lowest value that pulse oximeters should be able to measure, as recommended by the U.S. Food and Drug Administration.

The technique involves participants placing their finger over the camera and flash of a smartphone, which uses a deep-learning algorithm to decipher the blood oxygen levels. When the team delivered a controlled mixture of nitrogen and oxygen to six subjects to artificially bring their blood oxygen levels down, the smartphone correctly predicted whether the subject had low blood oxygen levels 80% of the time.

In a proof-of-principle study, University of Washington and University of California San Diego researchers have shown that smartphones are capable of detecting blood oxygen saturation levels down to 70%. The technique involves having participants place their finger over the camera and flash of a smartphone, which uses a deep-learning algorithm to decipher the blood oxygen levels from the blood flow patterns in the resulting video./Photo:Dennis Wise/University of Washington

“Other smartphone apps that do this were developed by asking people to hold their breath. But people get very uncomfortable and have to breathe after a minute or so, and that’s before their blood-oxygen levels have gone down far enough to represent the full range of clinically relevant data,” said co-lead author Jason Hoffman, a UW doctoral student in the Paul G. Allen School of Computer Science & Engineering. “With our test, we’re able to gather 15 minutes of data from each subject. Our data shows that smartphones could work well right in the critical threshold range.”

Another benefit of measuring blood oxygen levels on a smartphone is that almost everyone has one.

“This way you could have multiple measurements with your own device at either no cost or low cost,” said co-author Dr. Matthew Thompson, professor of family medicine in the UW School of Medicine. “In an ideal world, this information could be seamlessly transmitted to a doctor’s office. This would be really beneficial for telemedicine appointments or for triage nurses to be able to quickly determine whether patients need to go to the emergency department or if they can continue to rest at home and make an appointment with their primary care provider later.”

The team recruited six participants ranging in age from 20 to 34. Three identified as female, three identified as male. One participant identified as being African American, while the rest identified as being Caucasian.

To gather data to train and test the algorithm, the researchers had each participant wear a standard pulse oximeter on one finger and then place another finger on the same hand over a smartphone’s camera and flash. Each participant had this same set up on both hands simultaneously.

“The camera records how much that blood absorbs the light from the flash in each of the three color channels it measures: red, green and blue,” said Wang, who also directs the UC San Diego DigiHealth Lab. “Then we can feed those intensity measurements into our deep-learning model.”

Each participant breathed in a controlled mixture of oxygen and nitrogen to slowly reduce oxygen levels. The process took about 15 minutes. For all six participants, the team acquired more than 10,000 blood oxygen level readings between 61% and 100%.

“Smartphone light can get scattered by all these other components in your finger, which means there’s a lot of noise in the data that we’re looking at,” said co-lead author Varun Viswanath, a UW alumnus who is now a doctoral student advised by Wang at UC San Diego. “Deep learning is a really helpful technique here because it can see these really complex and nuanced features and helps you find patterns that you wouldn’t otherwise be able to see.”

 

Covid update: India logs 4,858 new Covid-19 cases, 18 deaths

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Sep 19 (IANS) In the last 24 hours, India logged 4,858 new Covid-19 cases and 18 deaths, the Union Health Ministry said on Monday.

The new fatalities have pushed the nationwide death toll to 5,28,355.

The active caseload rose to 48,027, accounting for 0.11 per cent of the country’s total positive cases.

The recovery of 4,735 patients in the last 24 hours took the cumulative tally to 4,39,62,664. Consequently, India’s recovery rate stands at 98.71 per cent.

Meanwhile, the daily and weekly positivity rates stood at 2.76 per cent and 1.78 per cent, respectively.

Covid cases/Ians

Also in the same period, a total of 1,75,935 tests were conducted across the country, increasing the overall tally to over 89.17 crore.

As of Monday morning, India’s Covid-19 vaccination coverage exceeded 216.70 crore.

Over 4.08 crore adolescents have been administered with a first dose of Covid-19 jab since the beginning of vaccination drive for this age bracket.

Infants, young children finally get relief from eczema’s terrible itch, scratching

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· More than half of children treated had at least a 75% reduction in signs of eczema and itch
· Kids sleep through night for first time instead of scratching
· Parents see children’s personalities change as they are able to lead a normal life.

Eczema, also known as atopic dermatitis, is a chronic inflammatory skin disorder characterized by red, dry, often oozing skin and itch that can profoundly affect the lives of affected patients and their families.

An estimated 19% or more of all children under 6 years of age have eczema and 85 to 90% of individuals affected overall with eczema have the onset of disease during the first five years of life.

The children’s debilitating itch leads to sleep disturbance, poor neurocognitive development and, on average, a full night of sleep lost per week.

CHICAGO — The first study to treat moderate-to-severe eczema in infants and children 6 months to 5 years old with a biologic drug (monoclonal antibody) rather than immune-suppressing medications shows the drug was highly effective in reducing the signs and symptoms of moderate-to-severe eczema, report researchers involved in a new multi-site international phase III study led by Northwestern Medicine.

A 16-week course of dupilumab, a medication that targets a key immune pathway in allergies, resulted in more than half the children having at least a 75% reduction in signs of eczema and highly significant reductions in itch with improved sleep.

This is the first large-scale, randomized, placebo-controlled trial of a monoclonal antibody in any skin disease, including eczema, in children as young as 6 months. The study, which included 31 sites in Europe and North America, will be published Sept. 15 in The Lancet.

“Preschoolers who are constantly scratching, awake multiple times a night with their parents, irritable and markedly curtailed in their ability to do what other children their ages can do improved to the extent that they sleep through the night, change their personalities and have a normal life — as babies and children should,” said lead study author Dr. Amy Paller, chair of dermatology at Northwestern University Feinberg School of Medicine and an attending physician at Ann & Robert H. Lurie Children’s Hospital of Chicago.

“The ability to take this drug will significantly improve the quality of life for infants and young children who suffer tremendously with this disease,” Paller said. “Atopic dermatitis or eczema is so much more than just itchy skin. It is a devastating disease. The quality of life of severe eczema — not only for the child but also parents — is equivalent to many life-threatening diseases.”

As a result of this study, this medication is now available to infants and preschoolers as young as 6 months of age. It has “an outstanding safety profile” and does not even require any laboratory tests before starting the medication, Paller said.

Although one-half to two-thirds of young children with eczema have mild symptoms, which can be handled with steroid ointment and moisturizers, the other one-third or more have moderate-to-severe disease and require more aggressive management.

“Up to now, all we have had to treat more severe eczema is immune-suppressing medications, such as oral steroids, which we try to avoid in children, because they are associated with so many side effects and thus are not a preferred treatment for a chronic skin disease,” Paller said. “The potential long-term impact on the development of the immune system in young children is also of concern with these immunosuppressants.”

During the past few years, a new medication has become available called dupilumab, which is the first “biologic” drug to treat eczema in a targeted manner, meaning a narrow attack on just what scientists have found is causing the manifestations of the disease in skin. This medication was found to be effective and safe in studies with adults, then adolescents, then other school-aged children. 

“But the group in whom we worry the most about safety — those under 5 — had not been tested and were unable to get this medication,” Paller said.

The parent or a health care provider gives the child a monthly shot to administer the medication.

“The effect for most of these younger children is dramatic and at least as good as we’ve seen with the risky immunosuppressant medications,” Paller said.

Potential added benefit by treating associated allergies

This medication has also been shown to be effective for treating asthma, gastrointestinal manifestations of allergy and other allergy-mediated problems but is not yet approved for these indications in infants and young children.

In fact, 66% of children in this trial had developed their eczema during the first six months of life and, by the time of initiating the dupilumab, more than 80% had already developed at least one allergic disorder, such as asthma or food allergy.

“By treating more aggressively to calm the immune system activation in these young children with early, severe eczema, we may also reduce the risk of their developing a range of allergic problems, changing their life beyond improving eczema,” Paller said. “These associated allergic issues most often begin after the eczema starts.”

Children were randomized to receive either a placebo injection or the dupilumab (weight-based dosing) every four weeks for 16 weeks. Only children who were not responding adequately to topical medications were allowed to enroll, and they had to be of a high severity, even with the topical medications.

As a result of the study, Paller said, scientists and physicians can start to better understand the relationships between eczema and a variety of allergic disorders and can consider the possibility of using this medication for other disorders that affect these very young children.

The trial was sponsored by Regeneron Pharmaceuticals, Inc. and Sanofi, who jointly developed dupilumab.

PM Narendra Modi to visit Madhya Pradesh on 17th September to release wild Cheetahs

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Prime Minister Narendra Modi will visit Madhya Pradesh on 17th September. At around 10:45 AM, Prime Minister will release Cheetahs in Kuno National Park. After that, at around 12 Noon, he will participate in SHG Sammelan with women SHG members/community resource persons at Karahal, Sheopur.

  • PM to release wild Cheetahs – which had become extinct from India – in Kuno National Park.
  • Cheetahs – brought from Namibia – are being introduced in India under Project Cheetah, which is world’s first inter-continental large wild carnivore translocation project.
  • Bringing Cheetahs back to India will help in the restoration of open forest and grassland ecosystems and also lead to enhanced livelihood opportunities for the local community.
  • In line with the Prime Minister’s commitment towards environment protection and wildlife conservation.
  • Prime Minister to participate in SHG Sammelan at Karahal, Sheopur.
  • Thousands of women SHG members/community resource persons to attend the Sammelan.
  • PM to also inaugurate four Particularly Vulnerable Tribal Groups skilling centres under PM Kaushal Vikas Yojana.

PM at Kuno National Park

The release of wild Cheetahs by the Prime Minister in Kuno National Park is part of his efforts to revitalise and diversify India’s wildlife and its habitat. Cheetah was declared extinct from India in 1952. The Cheetahs that would be released are from Namibia and have been brought under an MoU signed earlier this year. The introduction of Cheetah in India is being done under Project Cheetah, which is world’s first inter-continental large wild carnivore translocation project.

Cheetah

Cheetahs will help in the restoration of open forest and grassland ecosystems in India. This will help conserve biodiversity and enhance the ecosystem services like water security, carbon sequestration and soil moisture conservation, benefiting the society at large. This effort, in line with the Prime Minister’s commitment towards environment protection and wildlife conservation, will also lead to enhanced livelihood opportunities for the local community through eco-development and ecotourism activities.

Kuno national park

PM at SHG Sammelan

Prime Minister will participate in the SHG Sammelan being organised at Karahal, Sheopur. The Sammelan will witness the attendance of thousands of women Self Help Group (SHG) members/community resource persons that are being promoted under the Deendayal Antyodaya Yojana-National Rural Livelihoods Mission (DAY-NRLM).

During the programme, Prime Minister will also be inaugurating four Particularly Vulnerable Tribal Groups (PVTG) skilling centres under PM Kaushal Vikas Yojana.

DAY-NRLM aims at mobilising rural poor households into SHGs in a phased manner and provide them long-term support to diversify their livelihoods, improve their incomes and quality of life. The Mission is also working towards empowering the women SHG members through awareness generation and behaviour change communication on issues like domestic violence, women’s education and other gender related concerns, nutrition, sanitation, health etc.

Indian, US, Spain surgeons win global robotic surgery innovation awards

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Robotic surgeons from the US, India and Spain were named the top three winners in the KS International Robotic Surgery Innovation competition, as robotic surgery slowly becomes mainstream.

The winners were selected by an international jury form Oxford and Stanford Universities, and New-Delhi based AIIMS, from the fields of urology, gynaecology, general surgery, hepato-biliary-pancreatic surgery, colorectal, head and neck, paediatric and joint replacement surgeries.

The winning entry of Dr Jihad Kaouk, department of urology, Cleveland Clinic in Ohio was titled Single Port Robot-Assisted Kidney Transplantation Extraperitoneal Approach’ in the unique competition organised by Michigan-based robotic surgery evangelist Vattikuti Foundation.

Dr Kaouk and his team modified the technique of robotic kidney transplant developed at the Vattikuti Urology Institute and Medanta Medicity.

Kaouk used a da Vinci single port robot for truly minimally invasive surgery.

Indian, US surgeons win global robotic surgery innovation award

“The early results of patients who had undergone robotic kidney transplant through this technique could go home in only 2 days,” the foundation said in a statement.

For Robotic Infraclavicular Approach for Minimally Invasive Neck Dissection,’ the second award went to Dr Sandeep Nayak, Director, Surgical Oncology, Fortis Cancer Institute, Bengaluru.

Dr Nayak innovated a robotic technique to perform very major cancer surgery of the head neck to clear the lymph nodes in the neck with quick patient recovery and minimal discomfort.

cancer cells/photo:en.wikipedia.org

The third award went to a team of Dr Alberto Piana, Dr Paolo Verri, and Dr Alberto Breda of Oncology Urology and Kidney Transplant Surgery, Fundacio Puigvert, Barcelona, Spain for their entry of 3D Augmented Reality Guided Robotic Assisted Kidney Transplantation’.

The KS National Robotic Surgery Video’ competition is being organised in India since 2015 by Vattikuti Foundation. This year, it went international for the first time.

“As surgeons continue to innovate newer procedures in robotic surgery, the Vattikuti Foundation will continue to invest and make it accessible to other surgeons,” said Raj Vattikuti, president of Vattikuti Foundation.

Meal timing may influence mood vulnerability; Daytime eating benefits mental health

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Beating the blues with food? A new study adds evidence that meal timing may affect mental health, including levels of depression- and anxiety-related mood. Investigators from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, designed a study that simulated night work and then tested the effects of daytime and nighttime eating versus daytime eating only. The team found that, among participants in the daytime and nighttime eating group, depression-like mood levels increased by 26 percent and anxiety-like mood levels by 16 percent. Participants in the daytime-only eating group did not experience this increase, suggesting that meal timing may influence mood vulnerability. Results are published in the Proceedings of the National Academy of Sciences.

“Our findings provide evidence for the timing of food intake as a novel strategy to potentially minimize mood vulnerability in individuals experiencing circadian misalignment, such as people engaged in shift work, experiencing jet lag, or suffering from circadian rhythm disorders,” said co-corresponding author Frank A. J. L. Scheer, PhD, Director of the Medical Chronobiology Program in the Brigham’s Division of Sleep and Circadian Disorders. “Future studies in shift workers and clinical populations are required to firmly establish if changes in meal timing can prevent their increased mood vulnerability. Until then, our study brings a new ‘player’ to the table: the timing of food intake matters for our mood.”

Shift workers account for up to 20 percent of the workforce in industrial societies and are directly responsible for many hospital services, factory work, and other essential services. Shift workers often experience a misalignment between their central circadian clock in the brain and daily behaviors, such as sleep/wake and fasting/eating cycles. Importantly, they also have a 25 to 40 percent higher risk of depression and anxiety.

Eating/Photo:en.wikipedia.org

“Shift workers — as well as individuals experiencing circadian disruption, including jet lag — may benefit from our meal timing intervention,” said co-corresponding author Sarah L. Chellappa, MD, PhD, who completed work on this project while at the Brigham.“Our findings open the door for a novel sleep/circadian behavioral strategy that might also benefit individuals experiencing mental health disorders. Our study adds to a growing body of evidence finding that strategies that optimize sleep and circadian rhythms may help promote mental health.”

To conduct the study, Scheer, Chellappa, and colleagues enrolled 19 participants (12 men and 7 women) for a randomized controlled study. Participants underwent a Forced Desynchrony protocol in dim light for four 28-hour “days,” such that by the fourth “day” their behavioral cycles were inverted by 12 hours, simulating night work and causing circadian misalignment. Participants were randomly assigned to one of two meal timing groups: the Daytime and Nighttime Meal Control Group, which had meals according to a 28-hour cycle (resulting in eating both during the night and day, which is typical among night workers), and the Daytime-Only Meal Intervention Group, which had meals on a 24-hour cycle (resulting in eating only during the day). The team assessed depression- and anxiety-like mood levels every hour.

food

The team found that meal timing significantly affected the participants’ mood levels. During the simulated night shift (day 4), those in the Daytime and Nighttime Meal Control Group had increased depression-like mood levels and anxiety-like mood levels, compared to baseline (day 1). In contrast, there were no changes in mood in the Daytime Meal Intervention Group during the simulated night shift. Participants with a greater degree of circadian misalignment experienced more depression– and anxiety-like mood.

“Meal timing is emerging as an important aspect of nutrition that may influence physical health,” said Chellappa. “But the causal role of the timing of food intake on mental health remains to be tested. Future studies are required to establish if changes in meal timing can help individuals experiencing depressive and anxiety/anxiety-related disorders.”

Obesity drug may decrease type 2 diabetes risk: Study reveals

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New York, Sep 12 (IANS) The risk of type 2 diabetes is more than halved by weekly injections of the new obesity drug semaglutide, which was recently approved in the US and has been provisionally approved in England, says a new study.

The researchers of the study, to be presented at the annual meeting of the European Association for the Study of Diabetes (EASD), said semaglutide reduces the future risk of diabetes by over 60 per cent in patients with obesity.

“Semaglutide appears to be the most effective medication to date for treating obesity and is beginning to close the gap with the amount of weight loss following bariatric surgery,” said researcher W. Timothy Garvey from the University of Alabama at Birmingham in the US.

diabetes

Obesity is known to increase the risk of type 2 diabetes at least six-fold and the team was interested in understanding whether semaglutide could reduce this risk. To learn more, they conducted a new analysis of the data from two trials of semaglutide.

In STEP 1, 1,961 overweight or obese participants received an injection of 2.4 mg of semaglutide or a placebo weekly, for 68 weeks.

STEP 4 involved 803 participants with overweight or obesity. All received weekly injections of 2.4 mg semaglutide for 20 weeks. They then either remained on semaglutide or were switched to placebo for the next 48 weeks.

In STEP 1 participants receiving semaglutide, 10-year risk scores for type 2 diabetes decreased by 61 per cent (from 18.2 per cent at week 0 to 7.1 per cent at week 68). This compares to a 13 per cent reduction in risk score for those given the placebo (17.8 per cent at week +0 to 15.6 per cent at week 68).

In the STEP 4 participants, the largest decreases in risk scores were seen in the first 20 weeks (from 20.6 per cent at week 0 to 11.4 per cent at week 20). In those who continued receiving semaglutide, the risk score decreased further to 7.7 per cent but in those who were switched to placebo, it rose to 15.4 per cent.

Ovarian cancer detection takes a step forward with liquid biopsy

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Ovarian cancer is most often found in people of middle-age or older as the Wilmot study showed that the mean age of participants was 56.

Of the 183 participants, 42 were found to have ovarian cancer, which is 23 percent. The technology also discovered that 20 other participants had non-ovarian cancers.

Ovarian cancer symptoms can be vague, such as gas and bloating, but there are some that should not be ignored, Moore said: pelvic pain or pressure, feeling full quickly after eating, vaginal discharge or abnormal bleeding, urgency to urinate frequently, fatigue, upset stomach, pain during sex, constipation, or menstrual changes.

Because ovarian cancer is most often diagnosed in later stages.

A new type of technology can capture stray ovarian cancer cells from a simple blood test and successfully predict cancer in people who have a lesion or cyst in the pelvic region, according to a new study by a Wilmot Cancer Institute physician/scientist.

Nearly 200 local people participated in the study.

One of those local participants, Toni Masci, 51, of Fairport, took part in Moore’s study by providing blood samples for analysis. She had an ovarian cyst that burst — only to find out that a large tumor was also in her abdomen. She was treated with surgery and six rounds of chemotherapy in 2017 for stage 1 ovarian cancer, and just celebrated the milestone of five years in remission.

“I feel lucky to be part of this,” Masci said. “As most people know, ovarian cancer usually doesn’t get detected early. If Dr. Moore hadn’t been doing this research, we might not have had this advance and I might not be here.”

Currently, there is no routine ovarian cancer screening method available for people who do not have symptoms or a known lesion. And yet, the new technology, called a “liquid biopsy,” developed by United Kingdom-based ANGLE PLC, and the URMC team at Wilmot, advances the field in a couple of important ways, according to the study:

  • It confirmed for physicians quickly and accurately that cancer was present in patients who were scheduled for surgery or other procedures. The detection enabled physicians to classify which patients needed immediate care from a specially trained gynecological oncologist to improve survival.
  • The study analyzed gene expression from captured cells in blood and evaluated 72 different gene transcripts and seven blood biomarkers related to ovarian cancer (including CA125). From this collection, the study identified nine gene transcripts and four biomarkers that were useful for detecting cancers. They were used to develop an algorithm known as MAGIC (Malignancy Assessment using Gene Identification in Captured Cells). The algorithm achieved a sensitivity of 95 percent and an accuracy of 83 percent for detecting ovarian cancer.
  • In the clinical trial, MAGIC also was able to detect ovarian cancer in early and late stages. Early-stage detection is critical for survival and difficult to achieve. And, the test picked up other types of cancer that had spread to the pelvic region or originated there.

“This is an important step forward for the detection of ovarian cancer in patients with a pelvic mass,” Moore said. “The fact that we can capture circulating tumor cells and analyze them from a simple blood draw is extremely exciting.”

Being able to find circulating tumor cells is the key, Moore said. These are rare, living cells that break off from the original tumor. They have an estimated ratio in the blood of one in 100 million to one in one billion. The technology captures the rare cells and allows for genetic analysis in a single tool within a couple of hours.

 

 

Currently, if a person has a suspicious lesion, surgery is necessary to diagnose ovarian cancer, and annually, more than 200,000 people in the U.S. are in this situation. A non-invasive test that predicts malignancy beforehand would enable people with the highest risk to have surgery done by an oncology specialist with greater experience and surgical volume for these types of cases, Moore said.

Masci, a U.S. Navy veteran and esthetician at a local salon, was 46 years old in January 2017 when her cancer was diagnosed.

“I was in such shock,” she said. “Looking back, I did have some symptoms: bloating, my back hurt, weight loss, and when I would sit down to eat I would feel full right away.”

She enrolled in the study a month later, and Moore performed her ovarian cancer surgery.

“I had wonderful care from everyone at Wilmot,” Masci added, “but I can’t say enough good things about Dr. Moore. He needs to clone himself a million times.”

ANGLE Europe Limited funded the study. Moore has worked extensively with the company to test its detection system. Earlier this summer, the FDA gave approval for the same tool to be used to track breast cancer cells that have spread. Moore’s lab was the sole location nationally to test the reproducibility of the breast cancer tests, and local residents were also involved in that clinical trial.

 

Hidden black diamond: Delicious, aromatic, rare ‘Appalachian truffle’

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A hallmark of a truly luxurious meal is a sprinkling of truffle shavings — the fungal kind, not the chocolate. Nicknamed “diamonds” of the culinary world, these fanciful fungi are prized for their unique flavor and scent. But newer truffle species are fighting to achieve that same gourmet status. Now, researchers reporting in ACS Omega have performed the first full aroma characterization of the Appalachian truffle, unlocking the potential for a new North American “black diamond.”

The gourmet delicacies known as truffles are subterranean fungi of the Tuber species that require several years and very particular conditions to grow. Figuring out how to cultivate the fungi efficiently has been very difficult, so most people forage for them in the wild using trained animals, such as pigs or dogs, that can uncover these hidden gems. Because truffles are so rare and challenging to obtain, they are very expensive.

These Appalachian truffles might one day be just as prized as those from Europe/ Photo:David Fortier

For example, a large 3.3-pound behemoth from Italy cost $330,000 at auction several years ago. Commercial truffles most often originate from Europe, Australia and the western U.S., but different species exist all over the world. Unlike the fancy white or black truffles grown in Italy or France, however, many unearthed in North America have not been well studied. So, Normand Voyer and colleagues wanted to thoroughly analyze the aromatic profile of one of these North American varieties, known as Tuber canaliculatum, or Appalachian truffle.

To accomplish this, the researchers investigated three T. canaliculatum samples using headspace solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC/MS). With these techniques, the team identified the species’ “volatilome,” or the chemical fingerprint responsible for its aroma.

A total of 30 different compounds, including six that had never been reported in other truffle species, were identified. Some, such as 2,4-dithiapentane, are found in many truffle species and give truffle oil its unique smell. The most prevalent compounds were described as having strong odors of garlic, fungus and even a cabbage-like, rotten smell that was found in higher concentrations in older samples. The researchers say that this work could spur future studies of T. canaliculatum, which might one day place it at the same high status as its European cousins.

Manuka Honey emerges miracle drug for lung infection if combined with widely used ‘amikacin’

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A potential new treatment combining natural manuka honey with a widely used drug has been developed by scientists at Aston University to treat a potentially lethal lung infection and greatly reduce side effects of one of the current drugs used for its treatment.

Manuka honey can also be used to help treat wounds, injuries, improve oral health, soothe a sore throat and treat ulcers. The findings are published in the journal Microbiology.

The scientists in the Mycobacterial Research Group in the College of Health and Life Sciences at Aston University were able to combine manuka honey and the drug amikacin in a lab-based nebulisation formulation to treat the harmful bacterial lung infection Mycobacterium abscessus, said lead author and PhD researcher Victoria Nolan.

Manuka honey is long known to have wide ranging medicinal properties, but more recently has been identified for its broad spectrum antimicrobial activity. Now scientists have found that manuka honey has the potential to kill a number of drug resistant bacterial infections such as Mycobacterium abscessus – which usually affects patients with cystic fibrosis (CF) or bronchiectasis.

Manuka honey could help to clear deadly drug-resistant lung infection – research/Photo:Microbiology Society

According to the Cystic Fibrosis Trust, CF is a genetic condition affecting around 10,800 people – one in every 2,500 babies born in the UK – and there are more than 100,000 people with the condition worldwide. The NHS defines bronchiectasis  as a long-term condition where the airways of the lungs become widened, leading to a build-up of excess mucus that can make the lungs more vulnerable to infection..

In the study, the researchers used samples of the bacteria Mycobacterium abscessus taken from 16 infected CF patients. They then tested the antibiotic amikacin, combined with manuka honey, to discover what dosage was required to kill the bacteria.

Dr Jonathan Cox, senior lecturer in microbiology, Aston University said: “By combining a totally natural ingredient such as manuka honey with amikacin, one of the most important yet toxic drugs used for treating Mycobacterium abscessus, we have found a way to potentially kill off these bacteria with eight times less drug than before.”

As part of the study the team used a lab-based lung model and nebuliser – a device that produces a fine spray of liquid often used for inhaling a medicinal drug. By nebulising manuka honey and amikacin together, it was found they could improve bacterial clearance, even when using lower doses of amikacin, which would result in less life-changing side-effects to the patient.

In the UK, of the 10,800 people living with CF, Mycobacterium abscessus infects 13% of all patients with the condition. This new approach is advantageous not only because it has the potential to kill off a highly drug resistant infection, but because of the reduced side effects, benefitting quality of life and greatly improving survival chances for infected CF patients.

Mycobacterium abscessus is a bacterial pathogen from the same family that causes tuberculosis, but this bug differs by causing serious lung infections in people (particularly children) with pre-existing lung conditions, such as CF and bronchiectasis, as well as causing skin and soft tissue infections. The bacteria is also highly drug resistant.

Currently, patients are given a cocktail of antibiotics, consisting of 12 months or more of antimicrobial chemotherapy and often doesn’t result in a cure. The dosage of amikacin usually used on a patient to kill the infection is 16 micrograms per millilitre. But the researchers found that the new combination using manuka honey, required a dosage of just 2 micrograms per millitre of amikacin – resulting in a one eighth reduction in the dosage of the drug.

Until now Mycobacterium abscessus has been virtually impossible to eradicate in people with cystic fibrosis. It can also be deadly if the patient requires a lung transplant because they are not eligible for surgery if the infection is present.

 

 

 

 

President to launch TB Mukt Bharat initiative, target 2025

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President Droupadi Murmu will virtually launch the TB Mukt Bharat Abhiyaan on Friday to reinvigorate the mission of TB elimination from the country by 2025.

Following the government’s initiative to end Tuberculosis or TB in the country five years ahead of Sustainable Development Goals (SDG) target of 2030 by the United Nations, the Abhiyaan will be launched in presence of Mansukh Mandaviya, Union Minister of Health and Family Welfare and other officials.

The virtual event will be attended by representatives from State and district health administration, corporates, industries, civil society and NGOs as the country reiterates the commitment towards TB elimination by 2025.

The TB Mukt Bharat Abhiyaan has been envisioned to bring together all community stakeholders to support those on TB treatment and accelerate the country’s progress towards TB elimination.

The President will also launch the Ni-kshay Mitra initiative which forms a vital component of the Abhiyaan. The Ni-kshay Mitra  portal provides a platform for donors to provide various forms of support to those undergoing TB treatment. The three pronged support includes nutritional, additional diagnostic, and vocational support.

The launch event aims to highlight the need for a societal approach that brings together people from all backgrounds to achieve the ambitious target of eliminating TB from the country by 2025, ahead of the SDG targets set by the UN.

SDG target to eliminate TB

Tuberculosis is an infectious bacterial disease caused by Mycobacterium tuberculosis, which most commonly affects the lungs. In June 2022, WHO’s Director-General Dr Tedros Adhanom Ghebreyesus held a dialogue with WHO’s Civil Society Task Force on Tuberculosis (CSTF-TB) sought to support the rapid adoption of WHO guidelines at country level.

It has called upon nations to increase access to the best evidence-based interventions for people and communities affected by TB, including prevention, detection and treatment of people with TB and related comorbidities, with the involvement of civil society and affected communities.