Tag Archives: COPD

Mobile phone app accurately detects COVID-19 infection in people’s voices

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Artificial intelligence (AI) can be used to detect COVID-19 infection in people’s voices by means of a mobile phone app, according to research to be presented on Monday at the European Respiratory Society International Congress in Barcelona, Spain [1].

The AI model used in this research is more accurate than lateral flow/rapid antigen tests and is cheap, quick and easy to use, which means it can be used in low-income countries where PCR tests are expensive and/or difficult to distribute.

Ms Wafaa Aljbawi, a researcher at the Institute of Data Science, Maastricht University, The Netherlands, told the congress that the AI model was accurate 89% of the time, whereas the accuracy of lateral flow tests varied widely depending on the brand. Also, lateral flow tests were considerably less accurate at detecting COVID infection in people who showed no symptoms.

COVID-19 infection usually affects the upper respiratory track and vocal cords, leading to changes in a person’s voice.

Covid/commons.wikimedia.org

“These promising results suggest that simple voice recordings and fine-tuned AI algorithms can potentially achieve high precision in determining which patients have COVID-19 infection,” she said.Moreover, they enable remote, virtual testing and have a turnaround time of less than a minute. They could be used, for example, at the entry points for large gatherings, enabling rapid screening of the population.”

The app is installed on the user’s mobile phone, the participants report some basic information about demographics, medical history and smoking status, and then are asked to record some respiratory sounds. These include coughing three times, breathing deeply through their mouth three to five times, and reading a short sentence on the screen three times.

The researchers used a voice analysis technique called Mel-spectrogram analysis, which identifies different voice features such as loudness, power and variation over time.

“In this way we can decompose the many properties of the participants’ voices,” said Ms Aljbawi. “In order to distinguish the voice of COVID-19 patients from those who did not have the disease, we built different artificial intelligence models and evaluated which one worked best at classifying the COVID-19 cases.”

Its overall accuracy was 89%, its ability to correctly detect positive cases (the true positive rate or “sensitivity”) was 89%, and its ability to correctly identify negative cases (the true negative rate or “specificity”) was 83%.

“These results show a significant improvement in the accuracy of diagnosing COVID-19 compared to state-of-the-art tests such as the lateral flow test,” said Ms Aljbawi.

The patients were “high engagers”, who had been using the app weekly over months or even years to record their symptoms and other health information, record medication, set reminders, and have access to up-to-date health and lifestyle information. Doctors can assess the data via a clinician dashboard, enabling them to provide oversight, co-management and remote monitoring.

Air pollution is more dangerous for women than men: Study

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The impact of breathing diesel exhaust fumes may be more severe for females than males, according to new research that will be presented at the European Respiratory Society International Congress in Barcelona, Spain [1].

Researchers looked for changes in people’s blood brought about by exposure to diesel exhaust. In both females and males, they found changes in components of the blood related to inflammation, infection and cardiovascular disease, but they found more changes in females than males.

The research was presented by Dr Hemshekhar Mahadevappa, from the University of Manitoba, Winnipeg, Canada and was a collaboration between two research groups led by Professor Neeloffer Mookherjee at the University of Manitoba and Professor Chris Carlsten at the University of British Columbia, Vancouver, Canada. Dr Mahadevappa told the Congress: “We already know that there are sex differences in lung diseases such as asthma and respiratory infections.

Air pollution/Photo:en.wikipedia.org

Research showed that breathing diesel exhaust creates inflammation in the lungs and has an impact on how the body deals with respiratory infections. In this study, we wanted to look for any effects in the blood and how these differ in females and males.”

The study involved ten volunteers, five female and five male, who were all healthy non-smokers. Each volunteer spent four hours breathing filtered air and four hours breathing air containing diesel exhaust fumes at three different concentrations – 20, 50 and 150 micrograms of fine particulate matter (PM2.5) per cubic metre – with a four-week break in between each exposure.

Volunteers donated blood samples 24 hours after each exposure and the researchers made detailed examinations of the volunteers’ blood plasma. Plasma is the liquid component of the blood that carries blood cells as well as hundreds of proteins and other molecules around the body. Using a well-established analysis technology called liquid chromatography–mass spectrometry, the researchers looked for changes in the levels of different proteins following exposure to diesel exhaust and compared the changes in females and males.

Airpollution/Photo:en.wikipedia.org

Comparing the plasma samples, the researchers found levels of 90 proteins that were distinctly different between female and male volunteers following exposure to diesel exhaust. Among the proteins that differed between females and males, were some that are known to play a role in inflammation, damage repair, blood clotting, cardiovascular disease and the immune system. Some of these differences became clearer when volunteers were exposed to the higher levels of diesel exhaust.

Professor Mookherjee explained: “These are preliminary findings, however they show that exposure to diesel exhaust has different effects in female bodies compared to male and that could indicate that air pollution is more dangerous for females than males.

“This is important as respiratory diseases such as asthma are known to effect females and males differently, with females more likely to suffer severe asthma that does not respond to treatments. Therefore, we need to know a lot more about how females and males respond to air pollution and what this means for preventing, diagnosing and treating their respiratory disease.”

Air pollution/photo:en.wikipedia.org

Professor Zorana Andersen from the University of Copenhagen, Denmark, is Chair of the European Respiratory Society Environment and Health Committee and was not involved in the research. She said: “We know that exposure to air pollution, especially diesel exhaust, is a major risk factor in diseases such as asthma and chronic obstructive pulmonary disease. There is very little we can do as individuals to avoid beathing polluted air, so we need governments to set and enforce limits on air pollutants.