Pandemics to pollution: WHO Assembly delivers landmark health decisions

In addition, the Assembly endorsed a wide range of measures to promote health equity, reduce air pollution, and strengthen protections for vulnerable populations.

The words ‘historic’ and ‘landmark’ are overused, but they are perfectly apt to describe this year’s World Health Assembly,” WHO Director-General Tedros Adhanom Ghebreyesus said at the Assembly’s closing, ending nine days of intense debate and decisions.

The centrepiece of the Assembly’s outcomes was the WHO Pandemic Agreement, adopted on 20 May after more than three years of negotiations.

The agreement, seen as a once-in-a-generation opportunity to improve global preparedness and response to future pandemics, aims to strengthen international coordination, enhance equity in access to medical tools and ensure that no country is left behind in future health crises.

A key next step will be consultations on access to pathogen and benefit-sharing, which seeks to guarantee equitable sharing of medical countermeasures derived from pathogens.

Boost for WHO budget

Another major outcome was the approval of a 20 per cent increase in assessed contributions – the core, mandatory funding from Member States that underpins WHO’s work.

By 2030-2031, these contributions will cover 50 per cent of the agency’s core budget, a crucial step toward financial sustainability.

Health leaders also pledged at least $210 million to WHO’s ongoing Investment Round, adding to the $1.7 billion already raised and expanding the agency’s donor base.

A healthier world

The Assembly also delivered a sweeping slate of resolutions addressing a wide range of health challenges.

For the first time, nations adopted global resolutions on lung and kidney health, aligning with the growing recognition of noncommunicable diseases as a global priority.

Countries also set an ambitious new target to halve the health impacts of air pollution by 2040 and in an innovative move, adopted a resolution on social connection, acknowledging mounting evidence linking social isolation to poor health outcomes.

They also endorsed measures to combat the digital marketing of formula milk and baby foods, and addressed rare diseases, a lead-free future and the eradication of Guinea worm disease.

Delegates meeting in a committee at the 78th World Health Assembly.

History is made

In conclusion, Director-General Tedros urged countries to continue the momentum beyond the Assembly, highlighting the spirit of cooperation and commitment to health for all.

You, the nations of the world, made history,” he said.

“Yes, there is conflict in our world, but you have shown that there is also cooperation. Yes, there is inequity, but you have shown a commitment to equity. Yes, there is disease, but you have shown a commitment to health – health for all.”

Sudan conflict triggers regional health crisis, warns WHO

“The ongoing conflict and displacement, in addition to fragile health infrastructure and limited access to affected populations, pose a risk of mass disease transmission,” the UN health agency said in a report issued Tuesday, urging immediate support to sustain surveillance, bolster outbreak response and preserve lifesaving health services.

Since civil war erupted in April 2023, 14.5 million people have been displaced – 10.5 million internally and four million to neighbouring countries such as Egypt, South Sudan, Chad, Ethiopia, Libya and the Central African Republic – making this the world’s largest displacement crisis.

Inside Sudan, conflict has devastated infrastructure and triggered the breakdown of essential services and infrastructure, fuelling the spread of cholera, measles and other communicable diseases.

At Tuesday’s press briefing in New York, UN Spokesperson Stéphane Dujarric reported that with fighting and shelling intensify across the country “the cholera outbreak in Khartoum state is worsening at an alarming rate,” with cases rising by 80 per cent over the past two weeks.

Mr. Dujarric called for “increased, flexible and timely funding to scale-up the humanitarian response, as well as unimpeded access via all necessary routes, so that aid workers can reach people in need wherever they may be.”

Disease and displacement

The impact extends well beyond Sudan’s borders. As of 7 May, Egypt has received 1.5 million Sudanese refugees during the two years of fighting. 

The country has expanded healthcare coverage, but Sudanese face higher costs under the Universal Health Insurance system. WHO Egypt is working with national authorities to strengthen health services and reach the most vulnerable.

However, as Sudanese refugees arrive at overcrowded refugee camps across the region, the situation is far grimmer.

Chad. Rapid Influx of Sudanese refugees leaves thousands in desperate need

In Chad, where over 726,000 have arrived in four crisis-affected eastern provinces already overwhelmed with other refugees, health needs are urgent.

Refugees face outbreaks of malaria, measles, hepatitis E and severe acute malnutrition. There have been 657,135 cases of malaria alone and 314 deaths across the country this year.

South Sudan has received over 1.5 million people, including 352,000 Sudanese. But conflict and attacks on health facilities in the host country have severely hindered response efforts and exacerbated disease.

Hunger and cholera are especially concerning, with 7.7 million people facing severe food insecurity, and more than 54,800 cholera cases and 1,000 deaths since late September.

Ongoing WHO support

Despite the growing funding crisis and severe operational challenges, WHO and its partners continue providing support.

These include support for 136 nutrition stabilisation centres, delivery of medical supplies and consultations, cholera treatment sites, and efforts to rebuild damaged health infrastructure.

The agency has called for sustained support to prevent the worsening of what is already one of the gravest humanitarian and public health emergencies in the world today.

Public health champions honoured for work ‘beyond the call of normal duty’

But this is not universal. Many people worldwide struggle – unable to walk into clinics or explain their symptoms: “[These patients] do not line up on waiting lists. They wait, unknowingly, for inside understanding and the courage to seek care,” said Dr. Merete Nordentoft of Denmark, describing the patients with whom she has worked most closely.

Dr. Nordentoft was one of six public health champions to receive an award on Friday for “outstanding, innovative work in health development”, at the 78th World Health Assembly.

Each was honoured for their contributions to treating underserved communities and advancing the goal of healthcare for all.

“We celebrate the lifelong commitment and the relentless work accomplished by our very own health professionals across member states from every region of the world with one common goal – health for all,” President Teodoro Herbosa who presided over the awards ceremony.

Reaching vulnerable communities

Dr. Nordentoft received the Sasakawa Health Prize for her work on suicide prevention and with young patients undergoing their first psychotic episode. She was the first to receive this prize for mental health work, and emphasized the importance of early interventions which prioritize community-based care.

“With the right support, early enough, recovery is not only possible – it is likely,” Dr. Nordentoft said of her patients.

Many of the other award recipients have also spent their careers focused on healthcare policies and treatments which foreground integrated, community-based care. 

The principles for which Nelson Mandela fought urge us to pursue a policy of cooperation and partnership in sharing knowledge, science and resources – Dr. Majed Zemni

Professor Huali Wang of China and the Geriatric Healthcare Directorate of Kuwait were both awarded the Sheikh Al-Sabah Prize which honours research and policy done to support and advance healthy ageing.

Professor Wang was recognised in part for her work to integrate professional and family support networks for older adults with dementia. She dedicated her award to these families and everyone living with the complex illness.

The Kuwaiti Directorate was also honoured for the way in which they promoted high-quality, integrated care for older adults which “[preserves] the dignity, the rights and [recognises] the invaluable experiences of older persons.”

Dr. Jožica Maučec Zakotnik from Slovenia, who received the United Arab Emirates Foundation Prize, has also worked tirelessly to increase healthcare access and co-developed a new type of free-of-charge health care promotion centre scheme.

“Growing up in a less developed region in Slovenia, I set myself a task that the most disadvantaged communities would be given greater attention,” she said.

‘Force quit button’

Some of the awardees acknowledged that they were receiving these highly coveted awards during a time when global health is facing unprecedented challenges, specifically financial.

The proposed budget before the 78th World Health Assembly has been reduced by over $1.1 billion due to currently projected funding cuts.

“The global health world has just been hit with a ‘force quit’ button and we have been pushed to stop some of the things we really want to do,” said Dr. Helen Rees of South Africa, recipient of the Dr. LEE Jong-wook Memorial Prize for her work in HIV prevention and community-based health services. 

Dr. Majed Zemni of Tunisia received the Nelson Mandela Award for his patient-centred work in forensic medicine and in promoting the integration of medical ethics into policy. In his remarks, he noted the global civil rights icon’s legacy in also fighting for health policies.

“The principles for which Nelson Mandela fought urge us to pursue a policy of cooperation and partnership in sharing knowledge, science and resources,” Dr. Zemni said. 

Continuing the work 

Dr. Rees also emphasized the importance of seizing this moment to reimage global public health and uphold its sustainability.

“What we need now is action. We need good science and evidence-based policies so we can address the needs of all people, including the most vulnerable,” she said.

Dr. Tedros Adhanom Ghebreyesus, World Health Organization (WHO) Director General, also urged all of the recipients to continue their work towards a healthier and fairer world.

“At a time when the world faces many challenges, each of you is an inspiration and a reminder of the progress that can be made to improve health and well-being for all.”

Source link

World Health Assembly opens amid high-stakes pandemic treaty vote, global funding crisis

Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization, urged Member States to remain focused on shared goals even amid global instability.

We are here to serve not our own interests, but the eight billion people of our world,” he said in his keynote address at the Palais des Nations. “To leave a heritage for those who come after us; for our children and our grandchildren; and to work together for a healthier, more peaceful and more equitable world. It’s possible.”

The Assembly, WHO’s highest decision-making body, runs through 27 May and brings together delegations from 194 Member States under the theme One World for Health.

This year’s agenda includes a vote on the intensely negotiated Pandemic Agreement, a  reduced budget proposal, and discussions on climate, conflict, antimicrobial resistance, and digital health.

Pandemic prevention focus

A central item on the Assembly’s agenda is the proposed WHO pandemic accord, a global compact aimed at preventing the kind of fragmented response that marked the early stages of COVID-19.

The treaty is the result of three years of negotiations between all WHO Member States.

“This is truly a historic moment,” Dr Tedros said. “Even in the middle of crisis, and in the face of significant opposition, you worked tirelessly, you never gave up, and you reached your goal.”

A final vote on the agreement is expected on Tuesday.

If adopted, it would mark only the second time countries have come together to approve a legally binding global health treaty under WHO’s founding rules. The first was the Framework Convention on Tobacco Control, adopted in 2003 to curb the global tobacco epidemic.

2024 health check

In his address, Tedros presented highlights from WHO’s 2024 Results Report, noting both progress and persistent global health gaps.

On tobacco control, he cited a global one-third reduction in smoking prevalence since the WHO Framework Convention entered into force two decades ago.

He praised countries including Côte d’Ivoire, Oman, and Viet Nam for introducing stronger regulations last year, including plain packaging and restrictions on e-cigarettes.

On nutrition, he pointed to new WHO guidelines on wasting and the expansion of the Tobacco-Free Farms Initiative in Africa, which has supported thousands of farmers in transitioning to food crops.

He also emphasised WHO’s growing work on air pollution and climate-resilient health systems, including partnerships with Gavi and UNICEF to install solar energy in health facilities across multiple countries.

On maternal and child health, Tedros noted stalled progress and outlined new national acceleration plans to reduce newborn mortality. Immunisation coverage now reaches 83 per cent of children globally, compared to less than 5 per cent when the Expanded Programme on Immunisation was launched in 1974.

We are living in a golden age of disease elimination,” he said, citing the certification of Cabo Verde, Egypt, and Georgia as malaria-free; progress in neglected tropical diseases; and Botswana’s recognition as the first country to reach gold-tier status in eliminating mother-to-child transmission of HIV.

WHO has been supporting Universal Health Coverage in Rwanda.

WHO budget strain

Turning to WHO’s internal operations, Tedros offered a stark assessment of the organisation’s finances.

We are facing a salary gap for the next biennium of more than US$ 500 million,” he said. “A reduced workforce means a reduced scope of work.”

This week, Member States will vote on a proposed 20 per cent increase in assessed contributions, as well as a reduced Programme Budget of $ 4.2 billion for 2026–2027, down from an earlier proposal of $ 5.3 billion. The cuts reflect an effort to align WHO’s work with current funding levels while preserving core functions.

Tedros acknowledged that WHO’s long-standing reliance on voluntary earmarked funding from a small group of donors had left it vulnerable. He urged Member States to see the budget shortfall not only as a crisis but also as a potential turning point.

“Either we must lower our ambitions for what WHO is and does, or we must raise the money,” he said. “I know which I will choose.”

He drew a sharp contrast between WHO’s budget and global spending priorities: “US$ 2.1 billion is the equivalent of global military expenditure every eight hours; US$ 2.1 billion is the price of one stealth bomber – to kill people; US$ 2.1 billion is one-quarter of what the tobacco industry spends on advertising and promotion every single year. And again, a product that kills people.”

It seems somebody switched the price tags on what is truly valuable in our world,” he said.

Emergencies and appeals

The Director-General also detailed WHO’s emergency operations in 2024, which spanned 89 countries. These included responses to outbreaks of cholera, Ebola, mpox, and polio, as well as humanitarian interventions in conflict zones such as Sudan, Ukraine, and Gaza.

In Gaza, he said, WHO had supported more than 7,300 medical evacuations since late 2023, but over 10,000 patients remained in urgent need of care.

Looking ahead: a transformed WHO?

The WHO chief closed with a look at the agency’s future direction, shaped by lessons from the COVID-19 pandemic. He highlighted new initiatives in pandemic intelligence, vaccine development, and digital health, including expanded work on artificial intelligence and support for mRNA technology transfer to 15 countries.

WHO has also restructured its headquarters, reducing management layers and streamlining departments.

Our current crisis is an opportunity,” Dr Tedros concluded. “Together, we will do it.”

‘The world is failing its health checkup,’ says WHO

“Behind every data point is a person – a child who didn’t reach their fifth birthday, a mother lost in childbirth, a life cut short by a preventable disease,” said WHO chief Tedros Adhanom Ghebreyesus, as the organization’s latest statistics report revealed the pandemic’s deeper health impacts.

Warning that overall progress is under threat today, WHO on Thursday called on governments “to act, with urgency, commitment, and accountability to the people they serve.” Tedros bemoaned the “avoidable tragedies” behind the statistics.

Chronic diseases

The 2025 report shows an estimated 1.4 billion more people were living healthier lives by the end of 2024, surpassing WHO’s one billion target. This was driven by reduced tobacco use, better overall air quality and access to water, hygiene and sanitation, said WHO.

But underinvestment in primary health care, shortages of skilled health workers, and gaps in service like immunisation and safe childbirth are now holding countries back.

Driven by population growth and aging, premature deaths from noncommunicable diseases, such as cancer and diabetes, are rising. Worldwide, such diseases now account for the leading causes of deaths among people under 70.

Additionally, “air pollution continues to harm population health around the world,” said WHO’s Haidong Wang. 

Maternal deaths

The rate of maternal deaths fell by over 40 per cent and deaths of children under five were cut by half between 2000 and 2023.

However, progress has been either stalling or reversing in many countries, and maternal and child deaths are not falling “fast enough” – putting millions of lives at risk.

Millions more lives on the line

Essential health service coverage and protection from emergencies have lagged, the UN health agency data shows.

Without urgent course correction, WHO estimates that the world risks losing the chance to prevent an additional 700.000 maternal deaths and eight million deaths of children under five years old,” between 2024 and 2030.

More than 30-year difference in life expectancy highlights health inequities

The study by the World Health Organization (WHO) reveals that they can be responsible for a dramatic reduction in life expectancy in both rich and poor countries alike.

For example, people living in the country with the highest life expectancy will on average live 33 years longer than those born in the country with the lowest life expectancy.

An unequal world

“Our world is an unequal one. Where we are born, grow, live, work and age significantly influences our health and well-being,” said WHO Director-General Tedros Adhanom Ghebreyesus.

Inequities in health are closely linked to degrees of social disadvantage and levels of discrimination.

Health follows a social gradient whereby the more deprived the area in which people live, the lower their incomes are,” WHO said.

Inequities are especially exacerbated in populations that face discrimination and marginalization, such as Indigenous Peoples, who have lower life expectancies than their non-Indigenous counterparts.  

This is the case in both high and low-income countries.

Key targets at risk

The study is the first to be published since 2008 when the WHO Commission on Social Determinants of Health released its final report laying out targets for 2040 for reducing gaps between and within countries in life expectancy, childhood and maternal mortality. 

It shows that these targets are likely to be missed, and despite a scarcity of data there is sufficient evidence to show that health inequities are often widening.

For example, children born in poorer countries are 13 times more likely to die before their fifth birthday than in wealthier countries. 

Moreover, modelling shows that the lives of nearly two million children annually could be saved by closing the gap and enhancing equity between the poorest and wealthiest sectors of the population within low- and-middle-income countries.

Additionally, although maternal mortality declined by 40 per cent between the years 2000 and 2023, the majority of deaths, 94 per cent, still occur in low and lower-middle-income countries.

Appeal for action

WHO is calling for collective action to address economic inequality and invest in social infrastructure and universal public services.

The agency also recommends other steps, including overcoming structural discrimination and the determinants and impacts of conflicts, emergencies and forced migration. 

WHO chief laments most disruptive cuts to global health funding ‘in living memory’

We are living through the greatest disruption to global health financing in memory,” said WHO Director-General Dr Tedros Adhanom Ghebreyesus.

He cautioned that abrupt withdrawals of funding are jeopardising hard-won medical progress, including efforts to combat tropical diseases, which are now re-emerging in some regions.

This is just the tip of the iceberg,” he told journalists at WHO headquarters in Geneva.

Outbreaks intensify

Since January, Angola has been facing its worst cholera outbreaks in 20 years, with over 17,000 cases and more than 550 deaths recorded so far. 

Inadequate access to safe water, hygiene and sanitation is fuelling the outbreak. 

As WHO and partners carry out a large-scale vaccination campaign on the ground, one of their priorities is to bring the death rate down, said Tedros. 

Amid funding cuts, advances in tackling neglected tropical diseases affecting over one billion people, are disproportionately impacting the poorest and most marginalized communities.

Reduced access

In many countries where insecurity is rife and hospitals are being targeted, access to healthcare has been severely reduced, Tedros continued. 

On April 22, one of Haiti’s largest public hospitals, Hôpital Universitaire de Mirebalais, was forced to shut down due to violence. In the capital Port-au-Prince, more than 40 per cent of health facilities remain closed, he said.  

Needless deaths

Turning to the Gaza blockade, he said the situation there was “catastrophically bad,” with the violence “driving an influx of casualties to a health system that is already on its knees.” 

While essential medicines, and trauma and medical supplies, are running out, “people are dying from preventable diseases while medicines wait at the border,” said Tedros. 

Reiterating the UN’s call for a ceasefire, Tedros added that “peace is the best medicine.” 

Source link

One in four female genital mutilation cases now carried out by health workers

While the health sector worldwide plays a key role in stopping the abusive practice of FGM and supporting survivors, in several regions, evidence suggests otherwise.

As of 2020, an estimated 52 million girls and women were subjected to FGM at the hands of health workers – that’s around one in four cases.

Health workers must be agents for change rather than perpetrators of this harmful practice,” said Dr Pascale Allotey, WHO’s Director for Sexual and Reproductive Health and Research.

She insisted that cutting is a “severe violation of girls’ rights” which critically endangers their health.

Evidence has shown that FGM causes harm, regardless of who performs it – but  it can be more dangerous when performed by health workers, as a “medicalised” procedure can result in more severe wounds, WHO warned in a statement on Monday.  

As part of ongoing efforts to halt the practice altogether, the UN agency issued new guidelines urging greater action from doctors, governments, and local communities.

FGM in retreat

Cutting – which encompasses any procedure that removes or injures parts of the female genitalia for non-medical reasons – also requires high-quality medical care for those suffering its effects, WHO says.

Since 1990, the likelihood of a girl undergoing genital mutilation has dropped threefold, but 30 countries still practise it, putting four million girls each year at risk.

FGM can lead to short and long-term health issues, from mental health conditions to obstetric risks and sometimes the need for surgical repairs.

The newly published guidelines from WHO also suggest ways to improve care for survivors at different stages in their lives.

‘Opinion leaders’

Putting an end to the practice is within the realm of the possible – and some countries are heading in that direction, the UN health agency said.

Research shows that health workers can be influential opinion leaders in changing attitudes on FGM, and play a crucial role in its prevention,” said Christina Pallitto, a senior author of the study at Scientist at WHO and the Human Reproduction Programme (HRP).

“Engaging doctors, nurses and midwives should be a key element in FGM prevention and response, as countries seek to end the practice and protect the health of women and girls,” she said.

Unrelenting efforts to stop FGM have led countries including Burkina Faso to reduce rates among 15 to 19-year-olds by 50 per cent in the past three decades.

Likewise, prevalence fell by 35 per cent in Sierra Leone and 30 per cent in Ethiopia – thanks to action and political will to enforce bans and accelerate prevention.

WHO in 2022 published a prevention training package for primary care health workers, to highlight the risks of the practice and equip them to engage sensitively with communities, while factoring in local culture and perspectives.

“Because of this training, I am now able to raise women’s awareness [of FGM] and persuade them about the… disadvantages,” said one health worker during the launch. 

Health, education, opportunity at stake, amid stubborn digital gender divide

Closing this gap is not optional. There were189 million fewer women than men online in 2024.  

The disparity is about more than access, it reflects deeper systemic barriers, according to ​Doreen Bogdan-Martin who heads the UN telecommunications agency, ITU.

That’s too many missed opportunities to learn, to earn and to shape our shared digital future,” she said in a message for Thursday’s International Girls in ICT Day.

She underscored that connectivity alone is not enough to ensure true digital transformation.

“It must be meaningful – being able to afford digital devices and services, having the skills to use technology and feeling safe in online spaces. Everyone deserves the chance to thrive in an increasingly digital world.”

ITU Secretary-General Doreen Bogdan-Martin’s video message.

2025 Theme

Celebrated annually on the fourth Thursday of April, Girls in ICT Day encourages girls to pursue careers in science, technology, engineering and mathematics (STEM).

Since its launch in 2011, more than 417,000 girls and young women have participated in over 11,500 celebrations across 175 countries.

This year’s theme is Girls in ICT for inclusive digital transformation. The ITU is calling for more investment in girls’ digital education and expansion of access to technology.  

More young women need to become creators – not just consumers in the digital world, the agency argues.

“Whether you are an entrepreneur, launching an AI startup, a teacher incorporating digital skills into your classroom or a policymaker shaping our shared digital future, you can help ensure every woman and girl has the chance to connect, create and lead in digital spaces,” Ms. Bogdan-Martin emphasised.

A participant at a UN-supported training on STEM for girls and young women.

Global observance

The 2025 global observance will be co-hosted this year by the Commonwealth of Independent States (CIS) in Eurasia together with States from the Arab region, featuring a live-streamed hybrid event linking Bishkek, Kyrgyzstan and Nouakchott, Mauritania.

The programme includes an intergenerational dialogue bringing together girls, women leaders, and ICT experts to discuss practical strategies for closing the gender gap.

Events are also being organized worldwide, including Girls in ICT in Solomon Islands in the Pacific, the Melon Girls Club in North Macedonia and STEM Supergirls in Croatia.

Source link

What are Forever Chemicals? Study Reveals They’re Linked to Sleep Disruptions

A groundbreaking study led by the University of South California (USC) has unveiled a concerning link between high levels of per- and polyfluoroalkyl substances (PFAS), also known as ‘forever chemicals’, and sleep disruptions.

This research, published in the journal Environmental Advances, has shed light on the potential health risks associated with these pervasive chemicals. PFAS are a group of man-made chemicals that have been used in a variety of industries around the globe since the 1940s. They are found in a wide range of consumer products that people use daily such as cookware, pizza boxes, and stain repellants.

Due to their chemical structure, PFAS are resistant to heat, water, and oil, earning them the moniker forever chemicals. They do not break down easily and can persist in the environment and the human body for extended periods. The USC study examined the blood samples and sleep patterns of 144 participants aged between 19 and 24.

The researchers found that higher levels of four specific types of PFAS – PFDA, PFHxS, PFOA, and PFOS – were significantly associated with less sleep or worse quality of sleep.

The Impact of PFAS on Sleep and Health

Young adults with higher levels of these toxic chemicals in their blood had 80 fewer minutes of sleep at night. They also had trouble falling asleep, staying asleep, waking up, or feeling tired during waking hours. Sleep is a fundamental pillar of health.

A person must sleep 7-8 hours daily. Prolonged poor sleep may raise chronic health issues, including diabetes and Alzheimer’s disease. The study’s findings are particularly concerning given the widespread presence of PFAS in our environment and daily lives.

Previous studies have shown that PFAS have contaminated water, food, and people through products such as Teflon pans, waterproof clothing, stain-resistant carpets and fabrics, and food packaging. They have also been linked to cancers of the breast, ovary, skin, and uterus in women, among other diseases.

The USC study also examined the overlap between genes affected by the four forever chemicals and genes related to sleep disorders. Out of 600-plus candidate genes, seven activated by PFAS seemed to influence sleep.

Historical Parallels and Reducing Exposure

This included HSD11B1, which helps produce the hormone cortisol that plays an important role in regulating the rhythm of sleep and wakefulness. Another gene was cathepsin B, related to cognitive function and memory. Disruption in this gene was linked to Alzheimer’s.

The study’s findings echo historical events where chemicals once deemed safe were later found to have harmful effects on human health. For instance, lead was widely used in paint, gasoline, and plumbing until research revealed its toxic effects, particularly in children. Similarly, asbestos was a popular building material until its fibers were found to cause lung diseases.

The USC study adds to the growing body of evidence suggesting that PFAS could be the next major public health concern.

To reduce exposure to PFAS, individuals can avoid using products that are stain-resistant, waterproof, or nonstick, as these often contain PFAS. They can also choose natural fiber clothing, use glass, stainless steel, or ceramic cookware instead of Teflon or other nonstick pans, and be cautious with food packaging, especially for microwave meals.

Filtering drinking water with a system designed to remove PFAS, if necessary, and being mindful of personal care products, checking labels for PFAS ingredients, can also help. As we continue to learn more about these forever chemicals, it is crucial that we take steps to minimize our exposure and protect our health.

Snoring Linked to High Blood Pressure, Australian Study Finds

A new Australian study has revealed that regular snoring may lead to higher blood pressure. Researchers from Flinders University in South Australia found that people who snore often are more likely to suffer from elevated blood pressure and uncontrolled hypertension.

The study monitored 12,287 participants over six months, using home-based sleep tracking technology. It showed that 15% of the participants snored for more than 20% of the night. Those who snored heavily had a 3.8 mmHg higher systolic blood pressure and 4.5 mmHg higher diastolic pressure compared to non-snorers.

Hypertension, commonly known as high blood pressure, occurs when blood vessels have consistently high pressure. This condition can cause heart attacks, strokes, heart failure, and other serious heart diseases.

“For the first time, we can say there’s a strong link between frequent snoring at night and high blood pressure,” said Bastien Lechat, lead author of the research from the College of Medicine and Public Health at Flinders University in Australia. He stressed the importance of addressing snoring in managing hypertension.

The World Health Organization estimates that 1.28 billion adults globally have hypertension, with nearly half of them unaware of their condition.

London Underground polluted with metallic particles small enough to enter human bloodstream

The London Underground is polluted with ultrafine metallic particles small enough to end up in the human bloodstream, according to University of Cambridge researchers. These particles are so small that they are likely being underestimated in surveys of pollution in the world’s oldest metro system.

The researchers carried out a new type of pollution analysis, using magnetism to study dust samples from Underground ticket halls, platforms and operator cabins.

The team found that the samples contained high levels of a type of iron oxide called maghemite. Since it takes time for iron to oxidise into maghemite, the results suggest that pollution particles are suspended for long periods, due to poor ventilation throughout the Underground, particularly on station platforms.

Some of the particles are as small as five nanometres in diameter: small enough to be inhaled and end up in the bloodstream, but too small to be captured by typical methods of pollution monitoring. However, it is not clear whether these particles pose a health risk.

Other studies have looked at overall pollution levels on the Underground and the associated health risks, but this is the first time that the size and type of particles has been analysed in detail. The researchers suggest that periodic removal of dust from Underground tunnels, as well as magnetic monitoring of pollution levels, could improve air quality throughout the network. Their results are reported in the journal Scientific Reports.

The London Underground carries five million passengers per day. Multiple studies have shown that air pollution levels on the Underground are higher than those in London more broadly, and beyond the World Health Organization’s (WHO) defined limits. Earlier studies have also suggested that most of the particulate matter on the Underground is generated as the wheels, tracks and brakes grind against one another, throwing up tiny, iron-rich particles.

“Since most of these air pollution particles are metallic, the Underground is an ideal place to test whether magnetism can be an effective way to monitor pollution,” said Professor Richard Harrison from Cambridge’s Department of Earth Sciences, the paper’s senior author. “Normally, we study magnetism as it relates to planets, but we decided to explore how those techniques could be applied to different areas, including air pollution.”

Pollution levels are normally monitored using standard air filters, but these cannot capture ultrafine particles, and they do not detect what kinds of particles are contained within the particulate matter.

“I started studying environmental magnetism as part of my PhD, looking at whether low-cost monitoring techniques could be used to characterise pollution levels and sources,” said lead author Hassan Sheikh from Cambridge’s Department of Earth Sciences. “The Underground is a well-defined micro-environment, so it’s an ideal place to do this type of study.”

Working with colleagues from Cambridge’s Department of Materials Science and Metallurgy, Sheikh and Harrison analysed 39 dust samples from the London Underground, provided by Transport for London (TfL). The samples were collected in 2019 and 2021 from platforms, ticket halls, and train operator cabins on the Piccadilly, Northern, Central, Bakerloo, Victoria, Northern, District and Jubilee lines. The sampling included major stations such as King’s Cross St Pancras, Paddington, and Oxford Circus.

The researchers used magnetic fingerprinting, 3D imaging and nanoscale microscopy to characterise the structure, size, shape, composition and magnetic properties of particles contained in the samples. Earlier studies have shown that 50% of the pollution particles in the Underground are iron-rich, but the Cambridge team were able to look in much closer detail. They found a high abundance of maghemite particles, ranging in diameter from five to 500 nanometres, and with an average diameter of 10 nanometres. Some particles formed larger clusters with diameters between 100 and 2,000 nanometres.

“The abundance of these very fine particles was surprising,” said Sheikh. “The magnetic properties of iron oxides fundamentally change as the particle size changes. In addition, the size range where those changes happen is the same as where air pollution becomes a health risk.”

While the researchers did not look at whether these maghemite particles pose a direct health risk, they say that their characterisation methods could be useful in future studies.

“If you’re going to answer the question of whether these particles are bad for your health, you first need to know what the particles are made of and what their properties are,” said Sheikh.

“Our techniques give a much more refined picture of pollution in the Underground,” said Harrison. “We can measure particles that are small enough to be inhaled and enter the bloodstream. Typical pollution monitoring doesn’t give you a good picture of the very small stuff.”

The researchers say that due to poor ventilation in the Underground, iron-rich dust can be resuspended in the air when trains arrive at platforms, making the air quality on platforms worse than in ticket halls or in operator cabins.

Given the magnetic nature of the resuspended dust, the researchers suggest that an efficient removal system might be magnetic filters in ventilation, cleaning of the tracks and tunnel walls, or placing screen doors between platforms and trains.

Also Read:

Nasal irrigation twice a day reduces COVID-related illness, death

Exposure to air pollution in infancy alters gut microorganisms, may boost disease risk [Preventive Steps]

Soon new material to replace rogue plastic; It biodegrades in ocean water within 4 weeks

“Walnuts” the new brain food for stressed university students

Stressed university students might want to add walnuts to their daily diet in the weeks leading up to their next exam.

A new  clinical trial of undergraduate students during their university studies has shown positive effects of walnut consumption on self-reported measures of mental health and biomarkers of general health.

The University of South Australia study, published in the journal Nutrients, also suggests that walnuts may counteract the effects of academic stress on the gut microbiota during periods of stress, especially in females.

Lead researchers, PhD student Mauritz Herselman and Associate Professor Larisa Bobrovskaya, say the results add to the growing body of evidence linking walnuts with improved brain and gut health.

Walnuts may counteract the effects of academic stress on the gut microbiota during periods of stress, especially in women./CREDIT:Open Verse

“Students experience academic stress throughout their studies, which has a negative effect on their mental health, and they are particularly vulnerable during exam periods,” Herselman says.

Eighty undergraduate students split into treatment and control groups were clinically assessed in three intervals, at the beginning of a 13-week university semester, during the examination period and two weeks after the examination period. Those in the treatment group were given walnuts to consume daily for 16 weeks over these three intervals.

“We found that those who consumed about half a cup of walnuts every day showed improvements in self-reported mental health indicators.  Walnut consumers also showed improved metabolic biomarkers and overall sleep quality in the longer term.”

Students in the control group reported increased stress and depression levels in the leadup to exams but those in the treatment group did not. The walnut consumers also reported a significant drop in feelings associated with depression between the first and final visits, compared to the controls.

Previous research has shown that walnuts are full of omega-3 fatty acids, antioxidants, as well as melatonin (sleep inducing hormone), polyphenols, folate and vitamin E, all of which promote a healthy brain and gut.

“The World Health Organization has recently stated that at least 75 per cent of mental health disorders affect people under the age of 24 years, making undergraduate students particularly vulnerable to mental health problems,” Herselman says.

Assoc Prof Larisa Bobrovskaya says mental health disorders are common in university students and can adversely affect students’ academic performance and long-term physical health.

“We have shown that consuming walnuts during stressful periods can improve mental health and general wellbeing in university students, as well as being a healthy and delicious snack and a versatile ingredient in many recipes, to fight some negative effects of academic stress,” Assoc Prof Bobrovskaya says.

“Due to fewer numbers of males in the study, more research is needed to establish sex-dependent effects of walnuts and academic stress in university students. It’s also possible that a placebo effect might have come into play as this was not a blind study.”

Also Read:

b-type procyanidin-rich foods consumed in right amounts have multiple health benefits

Subcutaneous fat emerges as a protector of Womans’ brains

Health: Which grains you eat can impact your risk of getting heart disease earlier

Researchers uncover factors linked to optimal aging

What are the keys to “successful” or optimal aging? A new study followed more than 7000 middle aged and older Canadians for approximately three years to identify the factors linked to well-being as we age.

They found that those who were female, married, physically active and not obese and those who had never smoked, had higher incomes, and who did not have insomnia, heart disease or arthritis, were more likely to maintain excellent health across the study period and less likely to develop disabling cognitive, physical, or emotional problems.

As a baseline, the researchers selected participants who were in excellent health at the start of the approximately three-year period of study. This included the absence of memory problems or chronic disabling pain, freedom from any serious mental illness and absence of physical disabilities that limit daily activities — as well as the presence of adequate social support and high levels of happiness and life satisfaction.

Japan’s oldest woman Misao Owasa receiving Huinness Record for longest living person (http://www.guinnessworldrecords.com)

“We were surprised and delighted to learn that more than 70% of our sample maintained their excellent state of health across the study period,” says the first author, Mabel Ho, a doctoral candidate at the University of Toronto’s Factor-Inwentash Faculty of Social Work (FIFSW) and the Institute of Life Course and Aging. “Our findings underline the importance of a strength-based rather than a deficit-based focus on aging and older adults. The media and research tend to ignore the positive and just focus on the problems.”

There was considerable variation in the prevalence of successful aging based on the respondents’ age at the beginning of the study. Three quarters of the respondents who were aged 55 to 64 at the start of the study period maintained excellent health throughout the study. Among those aged 80 and older, approximately half remained in excellent health.

“It is remarkable that half of those aged 80 and older maintained this extremely high bar of cognitive, physical, and emotional well-being across the three years of the study. This is wonderful news for older adults and their families who may anticipate that precipitous decline is inevitable for those aged 80 and older.”  says Mabel Ho. “By understanding factors associated with successful aging, we can work with older adults, families, practitioners, policymakers, and researchers to create an environment that supports a vibrant and healthy later life.”

Sleep/en.wikipedia.org

Older adults who were obese were less likely to maintain good health in later life. Compared to older adults who were obese, those who had a normal weight were 24% more likely to age optimally.

“Our findings are in keeping with other studies which have found that obesity was related to a range of physical symptoms and cognitive problems and that physical activity also plays a key role in optimal aging,” says co-author David Burnes, Associate Professor at the University of Toronto’s FIFSW and a Canada Research Chair in Older Adult Mistreatment Prevention. “These findings highlight the importance of maintaining an appropriate weight and engaging in an active lifestyle throughout the life course”.

Income was also as an important factor. Only about half of those below the poverty line aged optimally compared to three-quarters of those living above the poverty line.

“Although our study does not provide information on why low income is important, it is possible that inadequate income causes stress and also restricts healthy choices such as optimal nutrition. Future research is needed to further explore this relationship,” says senior author Esme Fuller-Thomson, Director of the Institute for Life Course & Aging and Professor at the University of Toronto’s Factor-Inwentash Faculty of Social Work.

 

Lifestyle factors are associated with optimal health in later life. Older adults who never smoked were 46% more likely to maintain an excellent state of health compared to current smokers. Previous studies showed that quitting smoking in later life could improve survival statistics, pulmonary function, and quality of life; lower rates of coronary events, and reduce respiratory symptoms. The study found that former smokers did as well as those who had never smoked, underscoring that it is never too late to quit.

The study also found that engaging in physical activity was important in maintaining good health in later life. Older adults who engaged in moderate to strenuous physical activity were 35% to 45% more likely to age well, respectively.

The findings indicated that respondents who never or rarely experienced sleep problems at baseline were 29% more likely to maintain excellent health across the study.

“Clearly, good sleep is an important factor as we age. Sleep problems undermine cognitive, mental, and physical health. There is strong evidence that an intervention called cognitive-behavioral therapy for insomnia (CBT-I) is very helpful for people living with insomnia,” says Esme Fuller-Thomson.

Also Read:

New Algorithm Can Read Your Mind, Shows Study Using Brain Imaging Technology

VMC is biomarker of ageing for nematode; what is its role in Humans?

b-type procyanidin-rich foods consumed in right amounts have multiple health benefits

No more blood tests, now life-saving light beam to detect malaria

A fast, needle-free malaria detection tool developed by a University of Queensland-led team could help save hundreds of thousands of lives annually.

Malaria is usually detected by a blood test, but scientists have devised a method using a device that shines a beam of harmless infrared light on a person’s ear or finger for five-to-10 seconds, it collects an infrared signature that is processed by a computer algorithm.

International team leader, Dr Maggy Lord from UQ’s School of Biological Sciences, said the technology would revolutionise how malaria is fought globally.

The malaria detection tool collects an infrared signature for a mobile phone to process./CREDIT:The University of Queensland

“Currently it’s incredibly challenging to test large groups of people, such as the population of a village or town – you have to take blood from everyone and mix it with a reagent to get a result,” Dr Lord said.

“But with this tool we can find out very quickly whether a whole village or town is suffering from, or carrying, malaria.

“The technique is chemical-free, needle-free and detects malaria through the skin using infrared-light – it’s literally just a flash on a person’s skin and it’s done.

“The device is smart-phone operated, so results are acquired in real time.”

The researchers believe the technology is the first step to eliminating malaria.

Tiger Mosquito of Asia is adaing to survive the state of Illinois’s harsh winters / CREDIT: JAMES GATHANY/CDC

“According to the World Health Organisation malaria report, in 2020 there were an estimated 241 million cases worldwide and more than 600,000 died from malaria,” Dr Lord said.

“Most of the cases are in sub-Saharan Africa, where 90 per cent of deaths are children under five years old.

“The biggest challenge in eliminating the disease is the presence of asymptomatic people in a population who act as a reservoir for transmission by mosquitos.

“The World Health Organisation has proposed large-scale surveillance in endemic areas and this non-invasive, affordable and rapid tool offers a way to achieve that.”

The technology could also help tackle other diseases.

“We’ve successfully used this technology on mosquitoes to non-invasively detect infections such as malaria, Zika and dengue,” Dr Lord said.

“In our post-COVID world, it could be used to better tackle diseases as people move around the globe.

“We hope the tool could be used at ports of entry to screen travellers, minimising the re-introduction of diseases and reducing global outbreaks.

“It’s still early days, but this proof-of-concept is exciting.”

UQ collaborated with the Instituto Oswaldo Cruz, Brazil, led by Dr Rafael Maciel de Freitas, who applied the tool to detect malaria in patients in the Amazon region.

The work was funded by Fiocruz INOVA Ideias Inovadoras, Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico, Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro and by Advance Queensland Industry Research Fellowship and the National Health and Medical Research Council.

Also Read:

New ecology tools predict disease transmission among wildlife, humans

Japan, India scientists develop new approach to lessen severity of malaria

Scent, sweat from human skin attract disease-spreading mosquitoes

Detecting Alzheimer’s disease in the blood using Digital ICA

Researchers from Hokkaido University and Toppan have developed a method to detect build-up of amyloid β in the brain, a characteristic of Alzheimer’s disease, from biomarkers in blood samples.

Alzheimer’s disease is a neurodegenerative disease, characterised by a gradual loss of neurons and synapses in the brain. One of the primary causes of Alzheimer’s disease is the accumulation of amyloid β (Aβ) in the brain, where it forms plaques. Alzheimer’s disease is mostly seen in individuals over 65 years of age, and cannot currently be stopped or reversed. Thus, Alzheimer’s disease is a major concern for nations with ageing populations, such as Japan.

A team of scientists from Hokkaido University and Toppan, led by Specially Appointed Associate Professor Kohei Yuyama at the Faculty of Advanced Life Science, Hokkaido University, have developed a biosensing technology that can detect Aβ-binding exosomes in the blood of mice, which increase as Aβ accumulates in the brain. Their research was published in the journal Alzheimer’s Research & Therapy.

Alzheimer’s disease model mice (Photo: Kohei Yuyama)./CREDIT:Kohei Yuyama

When tested on mice models, the Aβ-binding exosome Digital ICATM (idICA) showed that the concentration of Aβ-binding exosomes increased with the increase in age of the mice. This is significant as the mice used were Alzheimer’s disease model mice, where Aβ builds up in the brain with age.

In addition to the lack of effective treatments of Alzheimer’s, there are few methods to diagnose Alzheimer’s. Alzheimer’s can only be definitively diagnosed by direct examination of the brain—which can only be done after death. Aβ accumulation in the brain can be measured by cerebrospinal fluid testing or by positron emission tomography; however, the former is an extremely invasive test that cannot be repeated, and the latter is quite expensive. Thus, there is a need for a diagnostic test that is economical, accurate and widely available.

Previous work by Yuyama’s group has shown that Aβ build-up in the brain is associated with Aβ-binding exosomes secreted from neurons, which degrade and transport Aβ to the microglial cells of the brain. Exosomes are membrane-enclosed sacs secreted by cells that possess cell markers on their surface. The team adapted Toppan’s proprietary Digital Invasive Cleavage Assay (Digital ICATM) to quantify the concentration of Aβ-binding exosomes in as little as 100 µL of blood. The device they developed traps molecules and particles in a sample one-by-one in a million micrometer-sized microscopic wells on a measurement chip and detects the presence or absence of fluorescent signals emitted by the cleaving of the Aβ-binding exosomes.

Clinical trials of the technology are currently underway in humans. This highly sensitive idICA technology is the first application of ICA that enables highly sensitive detection of exosomes that retain specific surface molecules from a small amount of blood without the need to learn special techniques; as it is applicable to exosome biomarkers in general, it can also be adapted for use in the diagnosis of other diseases.

Noninvasive eye scan could detect key signs of Alzheimer’s years before patients show symptoms

‘Love hormone’ revealed to have heart healing properties in Humans like EpiPCs regenerate organs in zebrafish

The neurohormone oxytocin is well-known for promoting social bonds including trust, empathy, positive memories, processing of bonding cues, and positive communication and generating pleasurable feelings, for example from art, exercise, or intimacy.

Now, researchers from Michigan State University show that in zebrafish and human cell cultures, oxytocin has yet another, unsuspected, function: it stimulates stem cells derived from the heart’s outer layer (epicardium) to migrate into its middle layer (myocardium) and there develop into cardiomyocytes, muscle cells that generate heart contractions. This discovery could one day be used to promote the regeneration of the human heart after a heart attack.

“Here we show that oxytocin, a neuropeptide also known as the love hormone, is capable of activating heart repair mechanisms in injured hearts in zebrafish and human cell cultures, opening the door to potential new therapies for heart regeneration in humans,” said Dr Aitor Aguirre, an assistant professor at the Department of Biomedical Engineering of Michigan State University, and the study’s senior author.

Stem-like cells can replenish cardiomyocytes

Cardiomyocetes typically die off in great numbers after a heart attack. Because they are highly specialized cells, they can’t replenish themselves. But previous studies have shown that a subset of cells in the epicardium can undergo reprogramming to become stem-like cells, called Epicardium-derived Progenitor Cells (EpiPCs), which can regenerate not only cardiomyocytes, but also other types of heart cells.

“Think of the EpiPCs as the stonemasons that repaired cathedrals in Europe in the Middle Ages,” explained Aguirre.

Unfortunately for us, the production of EpiPCs is inefficient for heart regeneration in humans under natural conditions.

Zebrafish could teach us how to regenerate hearts more efficiently

Enter the zebrafish: famous for their extraordinary capacity for regenerating organs, including the brain, retina, internal organs, bone, and skin. They don’t suffer heart attacks, but its many predators are happy to take a bite out of any organ, including the heart – so zebrafish can regrow their heart when as much as a quarter of it has been lost. This is done partly by proliferation of cardiomyocytes, but also by EpiPCs. But how do the EpiPCs of zebrafish repair the heart so efficiently? And can we find a ‘magic bullet’ in zebrafish that could artificially boost the production of EpiPCs in humans?

Yes, and this ‘magic bullet’ appears to be oxytocin, argue the authors.

To reach this conclusion, the authors found that in zebrafish, within three days after cryoinjury – injury due to freezing – to the heart, the expression of the messenger RNA for oxytocin increases up to 20-fold in the brain. They further showed that this oxytocin then travels to the zebrafish epicardium and binds to the oxytocin receptor, triggering a molecular cascade that stimulates local cells to expand and develop into EpiPCs. These new EpiPCs then migrate to the zebrafish myocardium to develop into cardiomyocytes, blood vessels, and other important heart cells, to replace those which had been lost.

zebrafish/wikipedia

Similar effect on human tissue cultures

Crucially, the authors showed that oxytocin has a similar effect on human tissue in vitro. Oxytocin – but none of 14 other neurohormones tested here – stimulates cultures of human Induced Pluripotent Stem Cells (hIPSCs) to become EpiPCs, at up to twice the basal rate: a much stronger effect than other molecules previously shown to stimulate EpiPC production in mice. Conversely, genetic knock-down of the oxytocin receptor prevented the the regenerative activation of human EpiPCs in culture. The authors also showed that the link between oxytocin and the stimulation of EpiPCs is the important ‘TGF-β signaling pathway’, known to regulate the growth, differentiation, and migration of cells.

Aguirre said: “These results show that it is likely that the stimulation by oxytocin of EpiPC production is evolutionary conserved in humans to a significant extent. Oxytocin is widely used in the clinic for other reasons, so repurposing for patients after heart damage is not a long stretch of the imagination. Even if heart regeneration is only partial, the benefits for patients could be enormous.”

Also Read:

Meal timing may influence mood vulnerability; Daytime eating benefits mental health

 

Mind your language when diagnosing women with polycystic ovary syndrome

 

 

Frozen embryo transfers linked with high blood pressure risks in pregnancy; What is sibling comparison?

In vitro fertilization (IVF) using frozen embryos may be associated with a 74% higher risk of hypertensive disorders in pregnancy, according to new research published today in Hypertension, an American Heart Association journal.

In comparison, the study found that pregnancies from fresh embryo transfers – transferring the fertilized egg immediately after in vitro fertilization (IVF) instead of a frozen, fertilized egg – and pregnancy from natural conception shared a similar risk of developing a hypertensive disorder.

High blood pressure during pregnancy often signals preeclampsia, a pregnancy complication including persistent high blood pressure that can endanger the health and life of the mother and fetus. Approximately 1 out of every 25 pregnancies in the United States results in preeclampsia, according to the American Heart Association.

One IVF treatment process available utilizes frozen embryos: after an egg is fertilized by sperm in the lab, it is frozen using a cryopreservation process before being thawed and transferred to the uterus at a later date. The procedure is becoming more common because of the significantly improved freezing technology or cryopreservation methods that started in the late 2000s and because more patients are choosing to freeze embryos, according to the study authors. Yet, frozen embryo transfer is known to be associated with a higher risk of hypertensive disorders in pregnancy than both natural conception and fresh embryo transfer. However, prior to this study, it was unknown whether this was due to the freezing process or a risk factor from the parents.

“Frozen embryo transfers are now increasingly common all over the world, and in the last few years, some doctors have begun skipping fresh embryo transfer to routinely freeze all embryos in their clinical practice, the so-called ‘freeze-all’ approach,” said Sindre H. Petersen, M.D., the study’s lead author and a Ph.D. fellow at the Norwegian University of Science and Technology in Trondheim, Norway.

Researchers examined national data from medical birth registries from Denmark, Norway and Sweden of nearly 2.4 million women who were ages 20 to 44 years old who had single deliveries and gave birth during the study period – from 1988 through 2015. These data were the basis of a population-based study that also included a comparison of women who had both an IVF pregnancy and a naturally conceived pregnancy, called sibling comparison. This approach was used to isolate if the potential reason for the hypertensive disorders was attributable to parental factors or to the IVF treatment.

pregnant lady/Commons.wikimedia.org

The study included more than 4.5 million pregnancies, of which 4.4 million were naturally conceived; more than 78,000 pregnancies were fresh embryo transfers; and more than 18,000 pregnancies were frozen embryo transfers. Among all of the pregnancies, more than 33,000 were grouped for sibling comparison – mothers who conceived via more than one of these methods. The study is the largest to-date using sibling comparison. The odds of developing hypertensive disorders in pregnancy after fresh vs. frozen embryo transfers compared to natural conception were adjusted for variables such as birth year and the mother’s age.

“In summary, although most IVF pregnancies are healthy and uncomplicated,” Petersen said. “This analysis found that the risk of high blood pressure in pregnancy was substantially higher after frozen embryo transfer compared to pregnancies from fresh embryo transfer or natural conception.”

Specifically, the study found:

  • In the population analysis, women whose pregnancy was the result of a frozen embryo transfer were 74% more likely to develop hypertensive disorders in pregnancy compared to those who conceived naturally.
  • Among women who had both a natural conception and an frozen embryo transfer IVF conception (the sibling comparison), the risk of hypertensive disorders in pregnancy after frozen embryo transfer was twice as high compared to pregnancies from natural conception.
  • Pregnancies from fresh embryo transfer did not have a higher risk of developing hypertensive disorders compared to natural conception, neither in population level analysis nor in sibling comparisons.

“Our sibling comparisons indicate that the higher risk is not caused by factors related to the parents, rather, however, that some IVF treatment factors may be involved,” Petersen said. “Future research should investigate which parts of the frozen embryo transfer process may impact risk of hypertension during pregnancy.”

Among other findings, women in the study who gave birth after IVF pregnancies were average age 34 years for frozen embryo transfer, 33 years for fresh embryo transfer and 29 years for those who conceived naturally. About 7% of babies conceived from frozen embryo transfer were born preterm (before 40 weeks gestation) and 8% of babies after fresh embryo transfer were born preterm, compared to 5% of babies after natural conception.

In addition to preeclampsia, the researchers defined hypertensive disorders in pregnancy as a combined outcome, including gestational hypertension, eclampsia (the onset of seizures in those with preeclampsia) and chronic hypertension with superimposed preeclampsia.

One limitation of the study was the lack of data on the kind of frozen embryo cycle, so they were not able to pinpoint what part of the frozen cycle or frozen transfer may contribute to the higher risk of hypertensive disorders. Another limitation is that data from Scandinavian countries may limit generalizing the findings to people in other countries.

“Our results highlight that careful consideration of all benefits and potential risks is needed before freezing all embryos as a routine in clinical practice.  A comprehensive, individualized conversation between physicians and patients about the benefits and risks of a fresh vs. frozen embryo transfer is key,” said Petersen.

 

 

Immune targets for chemotherapy-resistant breast cancers identified

Scientists have identified immune cell types that could be targeted to develop specific immunotherapies in chemotherapy-resistant breast cancers.

Researchers from King’s College London and The Institute of Cancer Research, London, with support from Breast Cancer Now, have performed a deep dive into the different immune markers within tumour tissues and blood samples of early breast cancer patients whose cancer failed to respond to chemotherapy given to them prior to surgery.

The research, published today in Clinical Cancer Research, a journal of the American Association for Cancer Research, gives insight into the function of immune cells in patients with chemotherapy-resistant breast cancers. While chemotherapy may not kill cancer cells in these high-risk patients, immunotherapy, a type of treatment that helps the immune system to attack cancer cells, may provide a benefit.

To investigate the immune environment that surrounds these chemotherapy resistant tumours, researchers employed multiple and novel complementary technologies looking at proteins and genes on both pre-treatment and post-treatment breast cancer tissue. They also measured how 1,330 cancer and immune-related genes within cancer tissues were affected by chemotherapy.

Flax seeds help women combat menstrual complications and fight post-menopausal risk of breast cancer, say studies

They found that chemotherapy resistant cancer cells had very few immune cells around them, but chemotherapy did induce changes in several immune cell types. Specifically, they found increases in the number of “innate” (first responder) cells such as neutrophils and natural killer (NK) cells. NK cells help the body to fight infection and cancer. But analysis found the increased NK cells in patients with chemotherapy resistant disease lacked cytotoxic activity – the ‘killing instinct’.

Researchers also found immune-related genes associated with NK cells were those associated with cell inhibition or exhaustion, which meant NK cells were unable to fight cancer cells. This new insight into the behaviour of NK cells could be used to develop specific immunotherapies for these high-risk patients. This would need to be investigated in future clinical trials.

These findings also show that blood monitoring during chemotherapy may help predict chemotherapy response early, potentially allow for tailoring of treatment prior to surgery.

Lead author Dr Sheeba Irshad, Cancer Research UK Clinician Scientist at King’s College London said: “Chemotherapy resistance in aggressive early breast cancers is a major reason why cancer regrows after treatment, contributing significantly to people not surviving their disease. In order to find the right targets for drug developments, it’s important to have a deep understanding of the complex mechanisms that allow some cancer cells to resist treatment, then hide from our immune system to only re-emerge later when they’re harder to eradicate.

“Our work has identified several cell types that would be worth investigating further to understand how they are interacting with the resistant cancer cell and how we can tweak that for our benefit. I am excited to continue to investigate these findings further.”

chemotherapy

Professor Andrew Tutt, Director of the Breast Cancer Now Toby Robins Research Centre at The Institute of Cancer Research, London, and of the Breast Cancer Now Research Unit at King’s College London, said: “Great strides have been made in harnessing immunotherapies to treat several types of cancer, but we need to do better to realise their potential for patients with breast cancer.

“This exciting work advances our understanding of the interaction between cancer cells and the immune system during treatment, and why existing treatments work well for some patients, but not others. I hope this research will help us to enhance the anti-cancer immune response in breast cancer, particularly for patients whose cancer has not responded well to chemotherapy.”

Dr Kotryna Temcinaite, Senior Research Communications Manager at Breast Cancer Now, said: “With an estimated 35,000 people living with incurable secondary (metastatic) breast cancer in the UK, it’s vital we develop smarter, more effective treatments to ensure fewer people hear the devastating news the disease has returned and spread to other parts of the body. This exciting early-stage research, which has been part-funded by Breast Cancer Now, helps to lay the groundwork for discovering a way to target breast cancer cells that resist chemotherapy treatment. We hope by building on these findings, scientists will ultimately be able to develop immunotherapy treatments that may help more people survive breast cancer.

India wins UN awards for Initiative against Hypertension

In a significant achievement and recognition to country’s efforts against hypertension, India has won an UN award for its “India Hypertension Control Initiative (IHCI)”, a large-scale hypertension intervention under National Health Mission. IHCI has been recognized for its exceptional work within India’s existing primary healthcare system.

Complimenting the healthcare initiative, Dr. Mansukh Mandaviya, Union Minister of Health & Family Welfare stated in a tweet: “IHCI has strengthened PM @NarendraModi  Ji’s mission to ensure health & wellness for all”. We are committed to building a healthy & fit India, he further noted.

A collaborative initiative of Ministry of Health and Family Welfare, Indian Council of Medical Research (ICMR), State Governments and World Health Organization-India, IHCI has won the ‘2022 UN Interagency Task Force, and WHO Special Programme on Primary Health Care Award’ at the UN General Assembly side event held on 21st September 2022 at New York, USA. The award recognizes outstanding commitment and action of India to: (i) prevent and control Non-Communicable Diseases (NCDs) and (ii) deliver integrated people-centric primary care. The UN Task Force has identified organisation which has multisectoral approach in prevention and control of NCDs and multisectoral action with demonstrated results at primary care for prevention and control of NCDs and related Sustainable Development Goals (SDGs).

Significance of the initiative can be adjudged from the fact that one in four adults in India has high blood pressure. The control of hypertension at primary care system level will contribute  to reducing deaths due to heart attacks, stroke and kidney failures.

IHCI has been able to leverage and strengthen the existing healthcare delivery system, hypertension control interventions under National Health Mission and improve the linkages between populations-based screening initiative with health care.  The initiative was launched in 2017 and expanded in a phased manner to cover more than 130 districts across 23 states. Under the initiative, more than 34 lakh people with hypertension are taking treatment in government health facilities, including Ayushman Bharat Health Wellness Centres (HWCs).  The project strategies are easily scalable within the health system. The strategies include a simple drug-dose-specific standard treatment protocol, ensuring adequate quantity of protocol medications, decentralization of care with follow-up and refills of medicines at Health Wellness Centres, task sharing involving all health staff and a powerful real-time information system which can track every patient for follow-up and blood pressure control. Under IHCI, nearly half of those who were treated had blood pressure under control.

The IHCI complements the National Programme for Prevention and Control of Diabetes, Cardiovascular Disease and Stroke (NPCDCS) of the Ministry of Health & Family Welfare, Government of India. IHCI accelerates the achievement of targets of the Government of India by ensuring a continuum of care and giving a boost to the ongoing “Ayushman Bharat” programme.