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Women may experience different PCOS or PCOD symptoms depending on where they live

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Women with polycystic ovary syndrome (PCOS) in Alabama may be more likely to have excessive hair growth and insulin resistance, whereas women with PCOS in California may be more likely to have higher testosterone levels, according to new research published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

PCOS affects 7–10% of women of childbearing age and is the most common cause of infertility. In the United States, an estimated 5 to 6 million women have PCOS, but the disorder is still underdiagnosed. Women are diagnosed with PCOS if they have two of the following criteria: androgen excess (excess male sex hormones such as testosterone), ovulatory dysfunction and polycystic ovaries.

“Our study found geographical differences in PCOS in black and white women, suggesting there are both genetic and environmental influences on how this disease manifests,” said Margareta D. Pisarska, M.D., of Cedars-Sinai Medical Center in Los Angeles, Calif. “Ongoing research is needed to identify modifiable risk factors for PCOS that may be race and ethnicity-specific to bring precision medicine to the management of this disease.”

PCOS/en.wikipedia.org

The researchers compared data from 1,620 back and white women with PCOS in Alabama and California. They found regional differences in the way these women met criteria for the diagnosis of PCOS and in symptoms associated with PCOS, with some variations among black and white women.

Overall, there were many similarities among the races. Women with PCOS in Alabama were more likely to have excessive hair growth and insulin resistance, whereas women with PCOS in California were more likely to have higher levels of testosterone.

When comparing black women with PCOS in Alabama and California, the average body mass index (BMI) did not differ between the locations, whereas in white women with PCOS, the average BMI was higher in Alabama than California.

“Since we have now identified that there are geo-epidemiologic differences, we intend to do follow up studies comparing black and white women with PCOS, controlling for geo-epidemiologic differences,” Pisarska said. “Furthermore, we are trying to look at factors that are contributing to these differences in order to tailor treatments based on specific needs for improvements in care for all women with PCOS.”

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Study in mice may reveal insights into causes of miscarriages for some women

Some cancer immunotherapy treatments may damage fertility, women’s hormonal health

Mind your language when diagnosing women with polycystic ovary syndrome

How the mother’s mood influences her baby’s ability to speak

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Up to 70 percent of mothers develop postnatal depressive mood, also known as baby blues, after their baby is born. Analyses show that this can also affect the development of the children themselves and their speech. Until now, however, it was unclear exactly how this impairment manifests itself in early language development in infants.

In a study, scientists at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig have now investigated how well babies can distinguish speech sounds from one another depending on their mother’s mood. This ability is considered an important prerequisite for the further steps towards a well-developed language. If sounds can be distinguished from one another, individual words can also be distinguished from one another. It became clear that if mothers indicate a more negative mood two months after birth, their children show on average a less mature processing of speech sounds at the age of six months.

The infants found it particularly difficult to distinguish between syllable-pitches. Specifically, they showed that the development of their so-called Mismatch Response was delayed than in those whose mothers were in a more positive mood. This Mismatch Response in turn serves as a measure of how well someone can separate sounds from one another. If this development towards a pronounced mismatch reaction is delayed, this is considered an indication of an increased risk of suffering from a speech disorder later in life.

“We suspect that the affected mothers use less infant-directed-speech,” explains Gesa Schaadt, postdoc at MPI CBS, professor of development in childhood and adolescence at FU Berlin and first author of the study, which has now appeared in the journal JAMA Network Open. “They probably use less pitch variation when directing speech to their infants.” This also leads to a more limited perception of different pitches in the children, she said. This perception, in turn, is considered a prerequisite for further language development.

The results show how important it is that parents use infant-directed speech for the further language development of their children. Infant-directed speech that varies greatly in pitch, emphasizes certain parts of words more clearly – and thus focuses the little ones’ attention on what is being said – is considered appropriate for children. Mothers, in turn, who suffer from depressive mood, often use more monotonous, less infant-directed speech. “To ensure the proper development of young children, appropriate support is also needed for mothers who suffer from mild upsets that often do not yet require treatment,” Schaadt says. That doesn’t necessarily have to be organized intervention measures. “Sometimes it just takes the fathers to be more involved.”

The researchers investigated these relationships with the help of 46 mothers who reported different moods after giving birth. Their moods were measured using a standardized questionnaire typically used to diagnose postnatal upset. They also used electroencephalography (EEG), which helps to measure how well babies can distinguish speech sounds from one another. The so-called Mismatch Response is used for this purpose, in which a specific EEG signal shows how well the brain processes and distinguishes between different speech sounds. The researchers recorded this reaction in the babies at the ages of two and six months while they were presented with various syllables such as “ba,” “ga” and “bu.

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Evidence that babies react to taste, smell in the womb; Carrot for “laughter-face” response, kale for “cry-face” response: Study

Fish oil, vitamin D supplements during pregnancy lower risk of croup in babies

A scientific recipe that helps babies stop crying, calm down and sleep in bed

Evidence that babies react to taste, smell in the womb; Carrot for “laughter-face” response, kale for “cry-face” response: Study

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A study led by Durham University’s Fetal and Neonatal Research Lab, UK, took 4D ultrasound scans of 100 pregnant women to see how their unborn babies responded after being exposed to flavours from foods eaten by their mothers.

Researchers looked at how the fetuses reacted to either carrot or kale flavours just a short time after the flavours had been ingested by the mothers.

Fetuses exposed to carrot showed more “laughter-face” responses while those exposed to kale showed more “cry-face” responses.

Their findings could further our understanding of the development of human taste and smell receptors.

The researchers also believe that what pregnant women eat might influence babies’ taste preferences after birth and potentially have implications for establishing healthy eating habits.

The study is published in the journal Psychological Science.

pregnant lady/Commons.wikimedia.org

Humans experience flavour through a combination of taste and smell. In fetuses it is thought that this might happen through inhaling and swallowing the amniotic fluid in the womb.

Lead researcher Beyza Ustun, a postgraduate researcher in the Fetal and Neonatal Research Lab, Department of Psychology, Durham University, said: “A number of studies have suggested that babies can taste and smell in the womb, but they are based on post-birth outcomes while our study is the first to see these reactions prior to birth.

“As a result, we think that this repeated exposure to flavours before birth could help to establish food preferences post-birth, which could be important when thinking about messaging around healthy eating and the potential for avoiding ‘food-fussiness’ when weaning.

“It was really amazing to see unborn babies’ reaction to kale or carrot flavours during the scans and share those moments with their parents.”

The research team, which also included scientists from Aston University, Birmingham, UK, and the National Centre for Scientific Research-University of Burgundy, France, scanned the mothers, aged 18 to 40, at both 32 weeks and 36 weeks of pregnancy to see fetal facial reactions to the kale and carrot flavours.

Mothers were given a single capsule containing approximately 400mg of carrot or 400mg kale powder around 20 minutes before each scan. They were asked not to consume any food or flavoured drinks one hour before their scans.

A 4D scan image of a fetus showing a neutral face/CREDIT: FETAP (Fetal Taste Preferences) Study, Fetal and Neonatal Research Lab, Durham University.

The mothers also did not eat or drink anything containing carrot or kale on the day of their scans to control for factors that could affect fetal reactions.

Facial reactions seen in both flavour groups, compared with fetuses in a control group who were not exposed to either flavour, showed that exposure to just a small amount of carrot or kale flavour was enough to stimulate a reaction.

Co-author Professor Nadja Reissland, head of the Fetal and Neonatal Research Lab, Department of Psychology, Durham University, supervised Beyza Ustun’s research. She said: “Previous research conducted in my lab has suggested that 4D ultrasound scans are a way of monitoring fetal reactions to understand how they respond to maternal health behaviours such as smoking, and their mental health including stress, depression, and anxiety.

“This latest study could have important implications for understanding the earliest evidence for fetal abilities to sense and discriminate different flavours and smells from the foods ingested by their mothers.”

Co-author Professor Benoist Schaal, of the National Centre for Scientific Research-University of Burgundy, France, said: “Looking at fetuses’ facial reactions we can assume that a range of chemical stimuli pass through maternal diet into the fetal environment.

“This could have important implications for our understanding of the development of our taste and smell receptors, and related perception and memory.”

The researchers say their findings might also help with information given to mothers about the importance of taste and healthy diets during pregnancy.

They have now begun a follow-up study with the same babies post-birth to see if the influence of flavours they experienced in the womb affects their acceptance of different foods.

Research co-author Professor Jackie Blissett, of Aston University, said: “It could be argued that repeated prenatal flavour exposures may lead to preferences for those flavours experienced postnatally. In other words, exposing the fetus to less ‘liked’ flavours, such as kale, might mean they get used to those flavours in utero.

“The next step is to examine whether fetuses show less ‘negative’ responses to these flavours over time, resulting in greater acceptance of those flavours when babies first taste them outside of the womb.”

Related: http://dx.doi.org/10.1177/09567976221105460

 

A scientific recipe that helps babies stop crying, calm down and sleep in bed

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New research published in Current Biology on September 13 demonstrates the importance of carrying crying infants rather than simply holding them. Led by Kumi Kuroda at the RIKEN Center for Brain Science (CBS) in Japan, the study details how crying babies are physiologically affected by being held, carried, and laid down. The data yield a simple but cost-free and effective technique that increases the chance of getting a crying infant to calm down and sleep in bed.

Most parents know the occasional frustration and discomfort of dealing with a crying baby. For some, it’s a regular occurrence that affects the baby’s ability to sleep and stresses out the parents. What can you do in this situation? Kuroda and her team found a “Transport Response” in distressed mouse pups and human babies in which infants calm down when carried by their mothers. The response is a complex series of parallel biological processes that result in reduced crying and lower heart rates, which helps parents to transport the infants.

Based on the ‘Transport response’ in which distressed animals calm down when carried, the behavioral and physiological data in this study showed that when babies are crying a lot, walking for about 5 minutes, following by sitting for about 8 minutes should help calm them down and put them to sleep. Note, sitting and holding a crying baby never calmed them down and heart rates rose. Putting babies to sleep immediately after walking often led to higher heart rates and woke babies up./photo:RIKEN

 

The new study used a baby ECG machine and video cameras to systematically compare changes in heart-rate and behavior as mothers acted out activities that are commonly used to calm infants, including carrying, being pushed in a stroller, and holding while sitting. Data during these activities were recorded from babies that were crying, awake and calm, or sleeping. At each heartbeat, behavior was assessed as asleep, alert, or crying, and scored accordingly. This way the researchers could track changes in both behavior and physiology with sub-second precision.

The experiment led to a few important findings. First, as Kuroda explains, “walking for five minutes promoted sleep, but only for crying infants. Surprisingly, this effect was absent when babies were already calm beforehand.” Among the babies studied, all had stopped crying by the end of the five-minute walk and had reduced heart rates, and about half were asleep. Second, sitting and holding crying babies was not calming; heart rates tended to go up and crying persisted.

The heartbeat measure allowed the researchers to dissect the effect of each micro-activity as infants were handled. The researchers found that the babies were extremely sensitive to all movements by their mothers. For example, heartrates went up when mothers turned or when they stopped walking. The most significant event that disturbed the sleeping infants happened just when they became separated from their mothers.

infant-small child

Every mother has experienced the disappointment of having a finally sleeping baby wake up again after being put down. The researchers pinpointed the problem using the heartbeat data. “Although we did not predict it,” says Kuroda, “the key parameter for successful laydown of sleeping infants was the latency from sleep onset.” Babies often woke up if they were put down before they got about 8 minutes of sleep. Thus, based on the data, Kuroda recommends that when babies are crying too much and can’t sleep, mothers should carry them steadily for about 5 minutes with few abrupt movements, followed by about 8 minutes of sitting before laying them down for sleep.

Although this procedure does not address why some babies cry excessively and cannot sleep, it offers an immediate solution that can help parents of newborns. Additionally, the researchers recognize the usefulness of heartrate data in this age of wearable fitness devices. “We are developing a “baby-tech” wearable device with which parents can see the physiological states of their babies on their smartphoness in real-time,” says Kuroda. “Like science-based fitness training, we can do science-based parenting with these advances, and hopefully help babies to sleep and reduce parental stress caused by excessive infant crying.”

Exposure to air pollution in infancy alters gut microorganisms, may boost disease risk [Preventive Steps]

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Exposure to air pollution in the first six months of life impacts a child’s inner world of gut bacteria, or microbiome, in ways that could increase risk of allergies, obesity and diabetes, and even influence brain development, suggests new CU Boulder research.

“This study adds to the growing body of literature showing that air pollution exposure, even during infancy, may alter the gut microbiome, with important implications for growth and development,” said senior author Tanya Alderete, assistant professor of Integrative Physiology at CU Boulder.

At birth, an infant hosts little resident bacteria. Over the first two to three years of life, exposure to mother’s milk, solid food, antibiotics and other environmental influences shape which microorganisms take hold. Those microbes, and the metabolites, or byproducts, they produce when they break down food or chemicals in the gut, influence a host of bodily systems that shape appetite, insulin sensitivity, immunity, mood and cognition. While many are beneficial, some microbiome compositions have been associated with Chrohn’s disease, asthma, type 2 diabetes, and other chronic illnesses.

Air pollution/photo:en.wikipedia.org

“The microbiome plays a role in nearly every physiological process in the body, and the environment that develops in those first few years of life sticks with you,” said first author Maximilian Bailey, who graduated in May with a master’s in Integrative Physiology and is now a medical student at Stanford University.

Boosting inflammation

For the study, the researchers obtained fecal samples from 103 healthy, primarily breast-fed Latino infants enrolled in the Southern California Mother’s Milk Study and used genetic sequencing to analyze them.

Using their street addresses and data from the U.S. Environmental Protection Agency’s Air Quality System, which records hourly data from monitoring systems, they estimated exposure to PM2.5 and PM10 (fine inhalable particles from things like factories, wildfires and construction sites) and Nitrogen Dioxide (NO2), a gas largely emitted from cars.

“Overall, we saw that ambient air pollution exposure was associated with a more inflammatory gut-microbial profile, which may contribute to a whole host of future adverse health outcomes,” said Alderete.

For instance, infants with the highest exposure to PM2.5 had 60% less Phascolarctobacterium, a beneficial bacterium known to decrease inflammation, support gastrointestinal health and aid in neurodevelopment. Those with the highest exposure to PM10 had 85% more of the microorganism Dialister, which is associated with inflammation.

infant-small child/photo:en.wikipedia.org

Infants are particularly vulnerable to the health hazards of air pollution because they breathe faster and their gut microbiome is just taking shape.

“This makes early life a critical window where exposure to air pollution may have disproportionately deleterious health effects,” they write.

Meantime, Alderete advises everyone to take these steps to reduce their exposure to both indoor and outdoor pollutants:

  • Avoid walking outdoors in high-traffic zones
  • Consider a low-cost air-filtration system, particularly for rooms children spend a lot of time in
  • If you are cooking, open the windows
  • And for new moms, breastfeed for as long as possible

“Breast milk is a fantastic way to develop a healthy microbiome and may help offset some of the adverse effects from environmental exposures,” Alderete said.

Bilingual babies listen to language

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Are two languages at a time too much for the mind? Caregivers and teachers should know that infants growing up bilingual have the learning capacities to make sense of the complexities of two languages just by listening. In a new study, an international team of researchers, including those from Princeton University, report that bilingual infants as young as 20 months of age efficiently and accurately process two languages.

The study, published Aug. 7 in the journal Proceedings of the National Academy of Sciences, found that infants can differentiate between words in different languages. “By 20 months, bilingual babies already know something about the differences between words in their two languages,” said Casey Lew-Williams, an assistant professor of psychology and co-director of the Princeton Baby Lab, where researchers study how babies and young children learn to see, talk and understand the world. He is also the co-author of the paper.

“They do not think that ‘dog’ and ‘chien’ [French] are just two versions of the same thing,” Lew-Williams said. “They implicitly know that these words belong to different languages.”

To determine infants’ ability to monitor and control language, the researchers showed 24 French-English bilingual infants and 24 adults in Montreal pairs of photographs of familiar objects. Participants heard simple sentences in either a single language (“Look! Find the dog!”) or a mix of two languages (“Look! Find the chien!”). In another experiment, they heard a language switch that crossed sentences (“That one looks fun! Le chien!”). These types of language switches, called code switches, are regularly heard by children in bilingual communities.

The researchers then used eye-tracking measures, such as how long an infant’s or an adult’s eyes remained fixed to a photograph after hearing a sentence, and pupil dilation. Pupil diameter is an involuntary response to how hard the brain is “working,” and is used as an indirect measure of cognitive effort.

The researchers tested bilingual adults as a control group and used the same photographs and eye-tracking procedure as tested on bilingual infants to examine whether these language-control mechanisms were the same across a bilingual speaker’s life.

They found that bilingual infants and adults incurred a processing “cost” when hearing switched-language sentences and, at the moment of the language switch, their pupils dilated. However, this switch cost was reduced or eliminated when the switch was from the non-dominant to the dominant language, and when the language switch crossed sentences.

“We identified convergent behavioral and physiological markers of there being a ‘cost’ associated with language switching,” Lew-Williams said. Rather than indicating barriers to comprehension, the study “shows an efficient processing strategy where there is an activation and prioritization of the currently heard language,” Lew-Williams said.

The similar results in both the infant and adult subjects also imply that “bilinguals across the lifespan have important similarities in how they process their languages,” Lew-Williams said.

“We have known for a long time that the language currently being spoken between two bilingual interlocutors — the base language — is more active than the language not being spoken, even when mixed speech is possible,” said François Grosjean, professor emeritus of psycholinguistics at Neuchâtel University in Switzerland, who is familiar with the research but was not involved with the study.

“This creates a preference for the base language when listening, and hence processing a code-switch can take a bit more time, but momentarily,” added Grosjean. “When language switches occur frequently, or are situated at [sentence] boundaries, or listeners expect them, then no extra processing time is needed. The current study shows that many of these aspects are true in young bilingual infants, and this is quite remarkable.”

“These findings advance our understanding of bilingual language use in exciting ways — both in toddlers in the initial stages of acquisition and in the proficient bilingual adult,” said Janet Werker, a professor of psychology at the University of British Columbia, who was not involved with the research. She noted that the findings may have implications for optimal teaching in bilingual settings. “One of the most obvious implications of these results is that we needn’t be concerned that children growing up bilingual will confuse their two languages. Indeed, rather than being confused as to which language to expect, the results indicate that even toddlers naturally activate the vocabulary of the language that is being used in any particular setting.”

A bilingual advantage?

Lew-Williams suggests that this study not only confirms that bilingual infants monitor and control their languages while listening to the simplest of sentences, but also provides a likely explanation of why bilinguals show cognitive advantages across the lifespan. Children and adults who have dual-language proficiency have been observed to perform better in “tasks that require switching or the inhibiting of a previously learned response,” Lew-Williams said.

“Researchers used to think this ‘bilingual advantage’ was from bilinguals’ practice dealing with their two languages while speaking,” Lew-Williams said. “We believe that everyday listening experience in infancy — this back-and-forth processing of two languages — is likely to give rise to the cognitive advantages that have been documented in both bilingual children and adults.”

Early term babies are at greater risk for diabetes and obesity-related diseases

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Early term deliveries impact babies’ long-term health with increased risk of diabetes and obesity-related illnesses as well as a shortened life span, according to a new study by Ben-Gurion University of the Negev (BGU) researchers.

“Early term” is defined as delivery between 37 and 39 weeks. Pregnancy is considered at full term when gestation has lasted between 37 and 42 weeks. Babies born between 39 and 41 weeks of gestation have better outcomes than those born either before or afterward.

In the study, published in the American Journal of Obstetrics and Gynecology, the researchers investigated hospitalizations of children up to age 18 to determine the impact that early-term versus full-term gestation had on pediatric health and hospitalizations. A population-based cohort analysis was conducted of 54,073 early-term deliveries and 171,000 full-term deliveries.

“We found that hospitalizations up to the age of 18 involving endocrine and metabolic morbidity were found to be more common in the early-term group as compared with the full-term group, especially at ages five and older,” says Prof. Eyal Sheiner, M.D., Ph.D., a vice dean of the BGU Faculty of Health Sciences (FOHS) and head of the Department of Obstetrics and Gynecology at Soroka University Medical Center. What’s more, “Obesity was significantly more frequent among the early term.”

The researchers also discovered that children older than five exhibited significantly higher rates of type I diabetes mellitus when born early term.

“Pregnancies ending at early term were more likely to be complicated by hypertensive disorders and maternal diabetes (both gestational and pre-gestational). Deliveries were more often cesarean, and mean birthweight was significantly smaller,” Dr. Sheiner says. “Babies delivered at early term were also more likely to be low birthweight — less than 5.5 pounds (2.5 kilograms).”

These diseases may increase the likelihood of other associated maladies with a detrimental long-term impact on one’s health and well-being, increased lifetime healthcare expenditures and a shorter life span, the researchers conclude.

Infants know what we like best, WashU study finds

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Behind the chubby cheeks and bright eyes of babies as young as 8 months lies the smoothly whirring mind of a social statistician, logging our every move and making odds on what a person is most likely to do next, suggests new research in the journal Infancy.

“Even before they can talk, babies are keeping close track of what’s going on in front of them and looking for patterns of activity that may suggest preferences,” said study co-author Lori Markson, associate professor of psychological & brain sciences and director of the Cognition & Development Lab at Washington University in St. Louis. “Make the same choice three or four times in a row, and babies as young as 8 months come to view that consistent behavior as a preference.”

The findings demonstrated that infants look for consistent patterns of behavior and make judgements about people’s preferences based on simple probabilities calculated from observed events and actions.

Co-led by Yuyan Luo, an associate professor of psychological sciences at the University of Missouri-Columbia, the study may shed light on how infants and young children learn about people’s preferences for a certain kind of food, toy or activity. It might also explain why kids always seem to want the toy that someone else is playing with.

“Consistency seems to be an important factor for infants in helping them sort out what’s happening in the world around them,” Markson said. “Our findings suggest that, if a person does something different even a single time, it undoes the notion of someone having a clear preference and changes an infant’s expectations for that individual’s behavior. In other words, if you break the routine, all bets are off in terms of what they expect from you.”

The findings confirmed that infants as young as 8 months are already developing the ability to see the world through someone else’s eyes, to sense what another person may or may not know, think or believe about a situation.

Because babies can’t tell us what they’re thinking, researchers had previously speculated that the ability to see life from someone else’s perspective did not develop until about 4 years of age. But more recent research over the past decade gets around this spoken-language barrier by relying on a proven premise — that babies spend much more time looking at events they consider to be new and unusual.

In this study, Markson and Luo conducted a series of experiments to track how infant “looking times” changed when an actor made an unexpected choice between one of two stuffed-animal toys displayed before the infant on a small puppet stage.

They corroborated these findings using a similar experiment that tracked whether infants, when asked to give a toy to the actor, would reach more often for the toy consistently chosen by the actor in previous trials, thus implying that the infant understood the actor’s preference.

The experiments were conducted on a sample of 60 healthy, full-term infants with an even split of males and females ranging in age from 7 to 9 months and an average age of 8 1/2 months.

Seated on a parent’s lap, the infants watched as a young woman reached out and grabbed one of two stuffed animals on the stage, either a white-and-brown dog or a yellow duck with orange beak and a purple bonnet.

During the “familiarization” phase of these experiments, the toy selection process was repeated four times under three separate conditions.

In the “consistent” condition, a woman in a blue or black shirt picked up the yellow duck four times in a row. In the “inconsistent” condition, the same woman picked up the duck three times and the dog once. And, in the “two actor” condition, the woman in the blue shirt selected the duck three times, while another woman in a white shirt selected the dog once.

After each four-trial familiarization phase, the researcher observed the babies’ reactions as the women reappeared on the stage and made a fifth selection, either going back to the previously targeted duck or making a new selection of the dog.

Two trained observers watched the babies’ reactions through concealed peepholes and independently coded the babies’ “looking time” responses based on seconds spent watching each toy-selection event. Video cameras captured both the babies’ reactions and the toy-selection process so that response time coding could be further analyzed and confirmed.

Findings confirmed that the babies spent about 50 percent more time looking at selections that represented a break from consistent patterns made in the familiarization trials.

“Infants who saw someone make the same choice three or four times in a row showed clear signs of being surprised when that person did not follow the same pattern in the future,” Markson said. “They obviously paid more attention to actions that did not fit their assumptions about what toys the women appeared to prefer most.”

In a second phase of the study, researchers reaffirmed their findings using a variation on the experiment in which the women who had chosen the stuffed animals during the trial phase asked the infant to choose between two toys by saying: “Can you give it to me? Can you give me the toy?”

In this variation, the infants also seemed to have made assumptions about the women’s toy preferences, reaching for the stuffed animal that had been consistently chosen by the woman during the trial phase.

“Our study is the first one to show how inconsistent choices affect infants’ understanding about others’ preferences,” Markson said. “Based on these findings, we hope to further explore how ratios of consistent/inconsistent choices matter to infants and eventually compare infants’ understanding to adults’ knowledge about others’ choices.”