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Women may experience different PCOS or PCOD symptoms depending on where they live

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Women with polycystic ovary syndrome (PCOS) in Alabama may be more likely to have excessive hair growth and insulin resistance, whereas women with PCOS in California may be more likely to have higher testosterone levels, according to new research published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

PCOS affects 7–10% of women of childbearing age and is the most common cause of infertility. In the United States, an estimated 5 to 6 million women have PCOS, but the disorder is still underdiagnosed. Women are diagnosed with PCOS if they have two of the following criteria: androgen excess (excess male sex hormones such as testosterone), ovulatory dysfunction and polycystic ovaries.

“Our study found geographical differences in PCOS in black and white women, suggesting there are both genetic and environmental influences on how this disease manifests,” said Margareta D. Pisarska, M.D., of Cedars-Sinai Medical Center in Los Angeles, Calif. “Ongoing research is needed to identify modifiable risk factors for PCOS that may be race and ethnicity-specific to bring precision medicine to the management of this disease.”

PCOS/en.wikipedia.org

The researchers compared data from 1,620 back and white women with PCOS in Alabama and California. They found regional differences in the way these women met criteria for the diagnosis of PCOS and in symptoms associated with PCOS, with some variations among black and white women.

Overall, there were many similarities among the races. Women with PCOS in Alabama were more likely to have excessive hair growth and insulin resistance, whereas women with PCOS in California were more likely to have higher levels of testosterone.

When comparing black women with PCOS in Alabama and California, the average body mass index (BMI) did not differ between the locations, whereas in white women with PCOS, the average BMI was higher in Alabama than California.

“Since we have now identified that there are geo-epidemiologic differences, we intend to do follow up studies comparing black and white women with PCOS, controlling for geo-epidemiologic differences,” Pisarska said. “Furthermore, we are trying to look at factors that are contributing to these differences in order to tailor treatments based on specific needs for improvements in care for all women with PCOS.”

Also Read:

Study in mice may reveal insights into causes of miscarriages for some women

Some cancer immunotherapy treatments may damage fertility, women’s hormonal health

Mind your language when diagnosing women with polycystic ovary syndrome

Evidence that babies react to taste, smell in the womb; Carrot for “laughter-face” response, kale for “cry-face” response: Study

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A study led by Durham University’s Fetal and Neonatal Research Lab, UK, took 4D ultrasound scans of 100 pregnant women to see how their unborn babies responded after being exposed to flavours from foods eaten by their mothers.

Researchers looked at how the fetuses reacted to either carrot or kale flavours just a short time after the flavours had been ingested by the mothers.

Fetuses exposed to carrot showed more “laughter-face” responses while those exposed to kale showed more “cry-face” responses.

Their findings could further our understanding of the development of human taste and smell receptors.

The researchers also believe that what pregnant women eat might influence babies’ taste preferences after birth and potentially have implications for establishing healthy eating habits.

The study is published in the journal Psychological Science.

pregnant lady/Commons.wikimedia.org

Humans experience flavour through a combination of taste and smell. In fetuses it is thought that this might happen through inhaling and swallowing the amniotic fluid in the womb.

Lead researcher Beyza Ustun, a postgraduate researcher in the Fetal and Neonatal Research Lab, Department of Psychology, Durham University, said: “A number of studies have suggested that babies can taste and smell in the womb, but they are based on post-birth outcomes while our study is the first to see these reactions prior to birth.

“As a result, we think that this repeated exposure to flavours before birth could help to establish food preferences post-birth, which could be important when thinking about messaging around healthy eating and the potential for avoiding ‘food-fussiness’ when weaning.

“It was really amazing to see unborn babies’ reaction to kale or carrot flavours during the scans and share those moments with their parents.”

The research team, which also included scientists from Aston University, Birmingham, UK, and the National Centre for Scientific Research-University of Burgundy, France, scanned the mothers, aged 18 to 40, at both 32 weeks and 36 weeks of pregnancy to see fetal facial reactions to the kale and carrot flavours.

Mothers were given a single capsule containing approximately 400mg of carrot or 400mg kale powder around 20 minutes before each scan. They were asked not to consume any food or flavoured drinks one hour before their scans.

A 4D scan image of a fetus showing a neutral face/CREDIT: FETAP (Fetal Taste Preferences) Study, Fetal and Neonatal Research Lab, Durham University.

The mothers also did not eat or drink anything containing carrot or kale on the day of their scans to control for factors that could affect fetal reactions.

Facial reactions seen in both flavour groups, compared with fetuses in a control group who were not exposed to either flavour, showed that exposure to just a small amount of carrot or kale flavour was enough to stimulate a reaction.

Co-author Professor Nadja Reissland, head of the Fetal and Neonatal Research Lab, Department of Psychology, Durham University, supervised Beyza Ustun’s research. She said: “Previous research conducted in my lab has suggested that 4D ultrasound scans are a way of monitoring fetal reactions to understand how they respond to maternal health behaviours such as smoking, and their mental health including stress, depression, and anxiety.

“This latest study could have important implications for understanding the earliest evidence for fetal abilities to sense and discriminate different flavours and smells from the foods ingested by their mothers.”

Co-author Professor Benoist Schaal, of the National Centre for Scientific Research-University of Burgundy, France, said: “Looking at fetuses’ facial reactions we can assume that a range of chemical stimuli pass through maternal diet into the fetal environment.

“This could have important implications for our understanding of the development of our taste and smell receptors, and related perception and memory.”

The researchers say their findings might also help with information given to mothers about the importance of taste and healthy diets during pregnancy.

They have now begun a follow-up study with the same babies post-birth to see if the influence of flavours they experienced in the womb affects their acceptance of different foods.

Research co-author Professor Jackie Blissett, of Aston University, said: “It could be argued that repeated prenatal flavour exposures may lead to preferences for those flavours experienced postnatally. In other words, exposing the fetus to less ‘liked’ flavours, such as kale, might mean they get used to those flavours in utero.

“The next step is to examine whether fetuses show less ‘negative’ responses to these flavours over time, resulting in greater acceptance of those flavours when babies first taste them outside of the womb.”

Related: http://dx.doi.org/10.1177/09567976221105460

 

New hope for ‘bubble baby disease’

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Babies born with Severe Combined Immune Deficiency (SCID) syndrome are defenceless against bacterial and viral infections that would be virtually harmless to most healthy people. If untreated, SCID is often fatal within a baby’s first year of life.

Research led by the University of Hong Kong has resulted in a new testing regime that could speed up the diagnosis of SCID, allowing more infants to receive life-saving treatment within a critical timeframe.

For the best chance of survival, infants with SCID should be treated as soon after birth as possible, and preferably within three-and-a-half months. However, poor recognition of SCID by front-line doctors is leading to delays in diagnosis, later treatments and poorer outcomes.

The authors of a recent study, published in open-access journal Frontiers in Immunology, have developed a “checklist” of potential SCID markers: a family history of early infant death, persistent candidiasis (often presenting as persistent thrush), Bacillus Calmette-Guérin (BCG) infections, and low absolute lymphocyte counts. “Flagging” an infant showing any one of these four factors would allow potential SCID patients to be fast-tracked for further tests and treatment.

Many countries – including much of Asia and the UK – do not test for SCID in their newborn health-screening programmes, with front-line doctors often left to diagnose the fatal condition. By using this checklist, the authors believe that identification, and hence treatment, of SCID patients will be possible much sooner.

Without a working immune system, newborns with SCID are highly vulnerable, and many will repeatedly visit doctors with serious and recurring infections before being diagnosed.

“The recognition of SCID by doctors is poor in Asia, resulting in delayed diagnoses that jeopoardize the chance of treatment success,” explains lead author Professor Yu Lung Lau, who focused his research on Asian and North African patients. “We wanted to see if we could identify any clinical features that would help doctors to diagnose SCID earlier.”

The study of 147 patients looked at how long it took for doctors to diagnose SCID, relative to the age the babies were first brought to their doctors, and what symptoms they had.

They found that it took an average of two months for babies to be diagnosed, and that the average age at diagnosis was four months old – beyond the critical age for treatment (which is usually stem cell transplants or gene therapy) to begin.

As the researchers examined the data, four SCID “markers” emerged. Taken in isolation, none helped reduce the time taken for a diagnosis. However, 94% of the patients studied showed at least one of the four factors.

“Family history of early infant death due to infection was useful to aid earlier diagnosis, but it was not due to doctors realizing the importance of the family history, but rather due to the family taking the child to see the doctors earlier,” says Lau. “This demonstrates the failure of our medical training and systems in using family history to aid earlier SCID diagnosis.”

Candidiasis emerged as one of the most common infections. Unfortunately, as thrush is relatively common in all infants, its presence actually slowed down the time to diagnosis.

Complications from the BCG vaccination also appeared frequently, and over 88% of the patients in the study had a very low absolute lymphocyte counts (ALC).

“Our main recommendation is to perform lymphocyte subsets for any infant with one or more of the following clinical features: family history, persistent candidiasis, BCG infections and ALC less than 3×10^9/L”, explains Lau. “This would confirm the diagnosis of SCID, if present”.

For the time being, newborn screening remains out of reach in much of Asia, so education of front-line doctors and parents is key.

“Our recommendations may help earlier diagnosis of SCID, and need to be communicated to doctors as well as to ordinary citizens, who can then urge the doctors along our recommendation,” concludes Lau.