SARS-CoV-2, the virus that causes COVID-19, is an airborne disease transmitted via aerosols, which are spread from the oral and nasal cavities—the mouth and the nose. In addition to the well-known division and spread of the virus in the cells of the respiratory tract, SARS-CoV-2 is also known to infect the cells of the lining of the mouth and the salivary glands.
A team of researchers led by Professor Kyoko Hida at Hokkaido University have shown that low concentrations of the chemical cetylpyridinium chloride, a component of some mouthwashes, has an antiviral effect on SARS-CoV-2. Their findings were published in the journal Scientific Reports.
Commercially available mouthwashes contain a number of antibiotic and antiviral components that act against microorganisms in the mouth. One of these, cetylpyridinium chloride (CPC), has been shown to reduce the viral load of SARS-CoV-2 in the mouth, primarily by disrupting the lipid membrane surrounding the virus. While there are other chemicals with similar effects, CPC has the advantage of being tasteless and odorless.
Cetylpyridinium chloride (CPC), the chemical tested in the study (Photo: Ryo Takeda)/CREDIT:Ryo Takeda
The researchers were interested in studying the effects of CPC in Japanese mouthwashes. Mouthwashes in Japan typically contain a fraction of the CPC compared to previously tested mouthwashes. They tested the effects of CPC on cell cultures that express trans-membrane protease serine 2 (TMPRSS2), which is required for SARS-CoV-2 entry into the cell.
They found that, within 10 minutes of application, 30–50 µg/mL of CPC inhibited the infectivity and capability for cell entry of SARS-CoV-2. Interestingly, commercially available mouthwashes that contain CPC performed better than CPC alone. They also showed that saliva did not alter the effects of CPC. Most significantly, they tested four variants of SARS-CoV-2—the original, alpha, beta and gamma variants—and showed that the effects of CPC were similar across all strains.
Covid/commons.wikimedia.org
This study shows that low concentrations of CPC in commercial mouthwash suppress the infectivity of four variants of SARS-CoV-2. The authors have already begun assessing the effect on CPC-containing mouthwashes on viral loads in saliva of COVID-19 patients. Future work will also focus on fully understanding the mechanism of effect, as lower concentrations of CPC do not disrupt lipid membranes.
For billions of years, the Milky Way’s largest satellite galaxies – the Large and Small Magellanic Clouds – have followed a perilous journey. Orbiting one another as they are pulled in toward our home galaxy, they have begun to unravel, leaving behind trails of gaseous debris. And yet – to the puzzlement of astronomers – these dwarf galaxies remain intact, with ongoing vigorous star formation.
“A lot of people were struggling to explain how these streams of material could be there,” said Dhanesh Krishnarao, assistant professor at Colorado College. “If this gas was removed from these galaxies, how are they still forming stars?”
With the help of data from NASA’s Hubble Space Telescope and a retired satellite called the Far Ultraviolet Spectroscopic Explorer (FUSE), a team of astronomers led by Krishnarao has finally found the answer: the Magellanic system is surrounded by a corona, a protective shield of hot supercharged gas. This cocoons the two galaxies, preventing their gas supplies from being siphoned off by the Milky Way, and therefore allowing them to continue forming new stars.
Description of the above image:
Researchers have used spectroscopic observations of ultraviolet light from quasars to detect and map out the Magellanic Corona, a diffuse halo of hot, supercharged gas surrounding the Small and Large Magellanic Clouds. Shown here in purple, the corona stretches more than 100,000 light-years from the main mass of stars, gas, and dust that make up the Magellanic Clouds, intermingling with the hotter and more extensive corona that surrounds the Milky Way. The Magellanic Clouds, dwarf galaxies roughly 160,000 light-years from Earth, are the largest of the Milky Way’s satellites and are thought to be on their first in-falling passage around the Milky Way. This journey has begun to unravel what were once barred spirals with multiple arms into more irregular-shaped galaxies with long tails of debris. The corona is thought to act as a buffer protecting the dwarf galaxies’ vital star-forming gas from the gravitational pull of the much larger Milky Way. The detection of the Magellanic Corona was made by analyzing patterns in ultraviolet light from 28 distant background quasars. As the quasar light passes through the corona, certain wavelengths (colors) of ultraviolet light are absorbed. The quasar spectra become imprinted with the distinct signatures of carbon, oxygen, and silicon ions that make up the corona gas. Because each quasar probes a different part of the corona, the research team was also able to show that the amount of gas decreases with distance from the center of the Large Magellanic Cloud. This study used archival observations of quasars from Hubble’s Cosmic Origins Spectrograph (COS) and the Far Ultraviolet Spectroscopic Explorer (FUSE). Quasars have also been used to probe the Magellanic Stream, outflows from the Milky Way , and the halo surrounding the Andromeda Galaxy./Illustration Credits: STScI, Leah Hustak
This discovery, which was just published in Nature, addresses a novel aspect of galaxy evolution. “Galaxies envelope themselves in gaseous cocoons, which act as defensive shields against other galaxies,” said co-investigator Andrew Fox of the Space Telescope Science Institute in Baltimore, Maryland.
Astronomers predicted the corona’s existence several years ago. “We discovered that if we included a corona in the simulations of the Magellanic Clouds falling onto the Milky Way, we could explain the mass of extracted gas for the first time,” explained Elena D’Onghia, a co-investigator at the University of Wisconsin–Madison. “We knew that the Large Magellanic Cloud should be massive enough to have a corona.”
But although the corona stretches more than 100,000 light-years from the Magellanic clouds and covers a huge portion of the southern sky, it is effectively invisible. Mapping it out required scouring through 30 years of archived data for suitable measurements.
Researchers think that a galaxy’s corona is a remnant of the primordial cloud of gas that collapsed to form the galaxy billions of years ago. Although coronas have been seen around more distant dwarf galaxies, astronomers had never before been able to probe one in as much detail as this.
There’re lots of predictions from computer simulations about what they should look like, how they should interact over billions of years, but observationally we can’t really test most of them because dwarf galaxies are typically just too hard to detect,” said Krishnarao. Because they are right on our doorstep, the Magellanic Clouds provide an ideal opportunity to study how dwarf galaxies interact and evolve.
In search of direct evidence of the Magellanic Corona, the team combed through the Hubble and FUSE archives for ultraviolet observations of quasars located billions of light-years behind it. Quasars are the extremely bright cores of galaxies harboring massive active black holes. The team reasoned that although the corona would be too dim to see on its own, it should be visible as a sort of fog obscuring and absorbing distinct patterns of bright light from quasars in the background. Hubble observations of quasars were used in the past to map the corona surrounding the Andromeda galaxy.
By analyzing patterns in ultraviolet light from 28 quasars, the team was able to detect and characterize the material surrounding the Large Magellanic Cloud and confirm that the corona exists. As predicted, the quasar spectra are imprinted with the distinct signatures of carbon, oxygen, and silicon that make up the halo of hot plasma that surrounds the galaxy.
The ability to detect the corona required extremely detailed ultraviolet spectra. “The resolution of Hubble and FUSE were crucial for this study,” explained Krishnarao. “The corona gas is so diffuse, it’s barely even there.” In addition, it is mixed with other gases, including the streams pulled from the Magellanic Clouds and material originating in the Milky Way.
By mapping the results, the team also discovered that the amount of gas decreases with distance from the center of the Large Magellanic Cloud. “It’s a perfect telltale signature that this corona is really there,” said Krishnarao. “It really is cocooning the galaxy and protecting it.”
How can such a thin shroud of gas protect a galaxy from destruction?
“Anything that tries to pass into the galaxy has to pass through this material first, so it can absorb some of that impact,” explained Krishnarao. “In addition, the corona is the first material that can be extracted. While giving up a little bit of the corona, you’re protecting the gas that’s inside of the galaxy itself and able to form new stars.”
New UMBC-led research in Frontiers in Microbiology suggests that viruses are using information from their environment to “decide” when to sit tight inside their hosts and when to multiply and burst out, killing the host cell. The work has implications for antiviral drug development.
A virus’s ability to sense its environment, including elements produced by its host, adds “another layer of complexity to the viral-host interaction,” says Ivan Erill, professor of biological sciences and senior author on the new paper. Right now, viruses are exploiting that ability to their benefit. But in the future, he says, “we could exploit it to their detriment.”
Not a coincidence
The new study focused on bacteriophages—viruses that infect bacteria, often referred to simply as “phages.” The phages in the study can only infect their hosts when the bacterial cells have special appendages, called pili and flagella, that help the bacteria move and mate. The bacteria produce a protein called CtrA that controls when they generate these appendages. The new paper shows that many appendage-dependent phages have patterns in their DNA where the CtrA protein can attach, called binding sites. A phage having a binding site for a protein produced by its host is unusual, Erill says.
Even more surprising, Erill and the paper’s first author Elia Mascolo, a Ph.D. student in Erill’s lab, found through detailed genomic analysis that these binding sites were not unique to a single phage, or even a single group of phages. Many different types of phages had CtrA binding sites—but they all required their hosts to have pili and/or flagella to infect them. It couldn’t be a coincidence, they decided.
The ability to monitor CtrA levels “has been invented multiple times throughout evolution by different phages that infect different bacteria,” Erill says. When distantly related species demonstrate a similar trait, it’s called convergent evolution—and it indicates that the trait is definitely useful.
A delta bacteriophage, the first identified in a new study in Frontiers in Microbiology to have binding sites for CtrA, a protein produced by the bacteriophage’s host that regulates the production of pili and flagella. The presence of these binding sites only in phages that require their host cells to have pili/flagella in order to infect them suggests that the phage is monitoring the presence of this protein in order to “decide” whether to stay put or replicate and emerge from its host cell./CREDIT:Tagide deCarvalho/UMBC
Timing is everything
Another wrinkle in the story: The first phage in which the research team identified CtrA binding sites infects a particular group of bacteria called Caulobacterales. Caulobacterales are an especially well-studied group of bacteria, because they exist in two forms: a “swarmer” form that swims around freely, and a “stalked” form that attaches to a surface. The swarmers have pili/flagella, and the stalks do not. In these bacteria, CtrA also regulates the cell cycle, determining whether a cell will divide evenly into two more of the same cell type, or divide asymmetrically to produce one swarmer and one stalk cell.
Because the phages can only infect swarmer cells, it’s in their best interest only to burst out of their host when there are many swarmer cells available to infect. Generally, Caulobacterales live in nutrient-poor environments, and they are very spread out. “But when they find a good pocket of microhabitat, they become stalked cells and proliferate,” Erill says, eventually producing large quantities of swarmer cells.
So, “We hypothesize the phages are monitoring CtrA levels, which go up and down during the life cycle of the cells, to figure out when the swarmer cell is becoming a stalk cell and becoming a factory of swarmers,” Erill says, “and at that point, they burst the cell, because there are going to be many swarmers nearby to infect.”
Listening in
“Everything that we know about phages, every single evolutionary strategy they have developed, has been shown to translate to viruses that infect plants and animals,” he says. “It’s almost a given. So if phages are listening in on their hosts, the viruses that affect humans are bound to be doing the same.”
There are a few other documented examples of phages monitoring their environment in interesting ways, but none include so many different phages employing the same strategy against so many bacterial hosts.
This new research is the “first broad scope demonstration that phages are listening in on what’s going on in the cell, in this case, in terms of cell development,” Erill says. But more examples are on the way, he predicts. Already, members of his lab have started looking for receptors for other bacterial regulatory molecules in phages, he says—and they’re finding them.
New therapeutic avenues
The key takeaway from this research is that “the virus is using cellular intel to make decisions,” Erill says, “and if it’s happening in bacteria, it’s almost certainly happening in plants and animals, because if it’s an evolutionary strategy that makes sense, evolution will discover it and exploit it.”
For example, to optimize its strategy for survival and replication, an animal virus might want to know what kind of tissue it is in, or how robust the host’s immune response is to its infection. While it might be unsettling to think about all the information viruses could gather and possibly use to make us sicker, these discoveries also open up avenues for new therapies.
“If you are developing an antiviral drug, and you know the virus is listening in on a particular signal, then maybe you can fool the virus,” Erill says. That’s several steps away, however. For now, “We are just starting to realize how actively viruses have eyes on us—how they are monitoring what’s going on around them and making decisions based on that,” Erill says. “It’s fascinating.”
Mosquitoes that spread Zika, dengue and yellow fever are guided toward their victims by a scent from human skin. The exact composition of that scent has not been identified until now.
A UC Riverside-led team discovered that the combination of carbon dioxide plus two chemicals, 2-ketoglutaric and lactic acids, elicits a scent that causes a mosquito to locate and land on its victim. This chemical cocktail also encourages probing, the use of piercing mouthparts to find blood.
This chemical mixture appears to specifically attract female Aedes aegypti mosquitoes, vectors of Zika as well as chikungunya, dengue, and yellow fever viruses. This mosquito originated in Africa, but has spread to tropical and subtropical regions worldwide, including the U.S.
Mosquitoes use a variety of cues to locate their victims, including carbon dioxide, sight, temperature, and humidity. However, Cardé’s recent research shows skin odors are even more important for pinpointing a biting site.
Aedes aegyptii mosquito biting a person./CREDIT CDC
“We demonstrated that mosquitoes land on visually indistinct targets imbued with these two odors, and these targets aren’t associated with heat or moisture,” Cardé said. “That leaves skin odor as the key guiding factor.”
Given the significance of odor in helping mosquitoes successfully feed on humans, Cardé wanted to discover the exact chemicals that make our scent so potent for the insects. Part of the equation, lactic acid, was identified as one chemical element in the odor cocktail as long ago as 1968.
Since then, several studies have identified that carbon dioxide combined with ammonia, and other chemicals produced by humans also attract these mosquitoes. However, Cardé, who has studied mosquitoes for 26 years, felt these other chemicals were not strong attractants.
Methods that chemists typically use to identify these chemicals would not have worked for 2-ketoglutaric acid, Cardé said. Gas chromatography, which separates chemicals by their molecular weight and polarity, would have missed this acid.
“I think that these chemicals may not have been found before because of the complexity of the human odor profile and the minute amounts of these compounds present in sweat,” said chemist Jan Bello, formerly of UCR and now with insect pest control company Provivi.
Searching for mosquito attractors, Cardé turned to Bello, who extracted compounds from the sweat in his own feet. He filled his socks with glass beads and walked around with the beads in his socks for four hours per odor collection.
Credit: MINDY TAKAMIYA/KYOTO UNIVERSITY ICEMS
“Wearing the beads felt almost like a massage, like squeezing stress balls full of sand, but with your feet,” said Bello. ‘The most frustrating part of doing it for a long time is that they would get stuck in between your toes, so it would be uncomfortable after a while.”
The inconvenience was worth the investment. Bello isolated chemicals from the sweat deposited on the sock beads and observed the mosquitoes’ response to those chemicals. In this way, the most active combination emerged.
Future studies are planned to determine whether the same compound is effective for any other mosquitoes, and why there is such variation in how individuals are apt to be bitten. “Some are more attractive than others to these mosquitoes, but no one’s yet established why this is so,” Cardé said.
Though this discovery may not lead to insights for the development of new repellants, the research team is hopeful their discovery can be used to attract, trap, and potentially kill disease-spreading mosquitoes.
Scientists have created a face mask that can detect common respiratory viruses, including influenza and the coronavirus, in the air in droplets or aerosols. The highly sensitive mask, presented September 19 in the journal Matter, can alert the wearers via their mobile devices within 10 minutes if targeted pathogens are present in the surrounding air.
“Previous research has shown face mask wearing can reduce the risk of spreading and contracting the disease. So, we wanted to create a mask that can detect the presence of virus in the air and alert the wearer,” says Yin Fang, the study’s corresponding author and a material scientist at Shanghai Tongji University.
Respiratory pathogens that cause COVID-19 and H1N1 influenza spread through small droplets and aerosols released by infected people when they talk, cough, and sneeze. These virus-containing molecules, especially tiny aerosols, can remain suspended in the air for a long time.
Fang and his colleagues tested the mask in an enclosed chamber by spraying the viral surface protein containing trace-level liquid and aerosols on the mask. The sensor responded to as little as 0.3 microliters of liquid containing viral proteins, about 70 to 560 times less than the volume of liquid produced in one sneeze and much less than the volume produced by coughing or talking, Fang says.
Facemask
The team designed a small sensor with aptamers, which are a type of synthetic molecule that can identify unique proteins of pathogens like antibodies. In their proof-of-concept design, the team modified the multi-channel sensor with three types of aptamers, which can simultaneously recognize surface proteins on SARS-CoV-2, H5N1, and H1N1.
Once the aptamers bind to the target proteins in the air, the ion-gated transistor connected will amplify the signal and alert the wearers via their phones. An ion-gated transistor is a novel type of device that is highly sensitive, and thus the mask can detect even trace levels of pathogens in the air within 10 minutes.
“Our mask would work really well in spaces with poor ventilation, such as elevators or enclosed rooms, where the risk of getting infected is high,” Fang says. In the future, if a new respiratory virus emerges, they can easily update the sensor’s design for detecting the novel pathogens, he adds.
coronavirus
Next, the team hopes to shorten the detection time and further increase the sensitivity of the sensor by optimizing the design of the polymers and transistors. They are also working on wearable devices for a variety of health conditions including cancers and cardiovascular diseases.
“Currently, doctors have been relying heavily on their experiences in diagnosing and treating diseases. But with richer data collected by wearable devices, disease diagnosis and treatment can become more precise,” Fang says.
Sep 19 (IANS) In the last 24 hours, India logged 4,858 new Covid-19 cases and 18 deaths, the Union Health Ministry said on Monday.
The new fatalities have pushed the nationwide death toll to 5,28,355.
The active caseload rose to 48,027, accounting for 0.11 per cent of the country’s total positive cases.
The recovery of 4,735 patients in the last 24 hours took the cumulative tally to 4,39,62,664. Consequently, India’s recovery rate stands at 98.71 per cent.
Meanwhile, the daily and weekly positivity rates stood at 2.76 per cent and 1.78 per cent, respectively.
Covid cases/Ians
Also in the same period, a total of 1,75,935 tests were conducted across the country, increasing the overall tally to over 89.17 crore.
As of Monday morning, India’s Covid-19 vaccination coverage exceeded 216.70 crore.
Over 4.08 crore adolescents have been administered with a first dose of Covid-19 jab since the beginning of vaccination drive for this age bracket.
Sep 18 (IANS) India on Sunday reported 5,664 fresh Covid cases in the last 24 hrs, against 5,747 Covid cases reported on previous day, said the Union Health Ministry.
In the same period, the country has recorded 35 more Covid related deaths, taking the national fatalities tally to 5,28,337 as per the report.
Meanwhile, the active caseload of the country has marginally risen to 47,922 cases, accounting for 0.11 per cent of the country’s total positive cases.
The recovery of 4,555 patients in the last 24 hours took the cumulative tally to 4,39,57,929. Consequently, India’s recovery rate stands at 98.71 per cent.
Vaccine
Meanwhile, India’s Daily Positivity Rate has been reported to be 1.96 per cent, while the Weekly Positivity Rate in the country currently also stands at 1.79 per cent.
Also in the same period, a total of 2,89,228 tests were conducted across the country, increasing the overall tally to over 89.15 crore.
As of Sunday morning, India’s Covid-19 vaccination coverage exceeded 216.56 crore.
Over 4.08 crore adolescents have been administered the first dose of Covid-19 jab since the beginning of vaccination drive for this age bracket.
Starting twice daily flushing of the mucus-lined nasal cavity with a mild saline solution soon after testing positive for COVID-19 can significantly reduce hospitalization and death, investigators report.
They say the technique that can be used at home by mixing a half teaspoon each of salt and baking soda in a cup of boiled or distilled water then putting it into a sinus rinse bottle is a safe, effective and inexpensive way to reduce the risk of severe illness and death from coronavirus infection that could have a vital public health impact.
“What we say in the emergency room and surgery is the solution to pollution is dilution,” says Dr. Amy Baxter, emergency medicine physician at the Medical College of Georgia at Augusta University
“By giving extra hydration to your sinuses, it makes them function better.
If you have a contaminant, the more you flush it out, the better you are able to get rid of dirt, viruses and anything else,” says Baxter.
“We found an 8.5-fold reduction in hospitalizations and no fatalities compared to our controls,” says senior author Dr. Richard Schwartz, chair of the MCG Department of Emergency Medicine. “Both of those are pretty significant endpoints.”
Drs. Richard Schwartz and Amy Baxter/Photo:Medical College of Georgia
The study appears to be the largest, prospective clinical trial of its kind and the older, high-risk population they studied — many of whom had preexisting conditions like obesity and hypertension — may benefit most from the easy, inexpensive practice, the investigators say.
They found that less than 1.3% of the 79 study subjects age 55 and older who enrolled within 24-hours of testing positive for COVID-19 between Sept. 24 and Dec. 21, 2020, experienced hospitalization. No one died.
Among the participants, who were treated at MCG and the AU Health System and followed for 28 days, one participant was admitted to the hospital and another went to the emergency room but was not admitted.
Schwartz says Baxter brought him the idea early in the pandemic and he liked that it was inexpensive, easy to use and could potentially impact millions at a time where, like other health care facilities, the Emergency Department of the AU Health System was starting to see a lot of SARS-CoV-2-positive patients.
They knew that the more virus that was present in your body, the worse the impact, Baxter says. “One of our thoughts was: If we can rinse out some of the virus within 24 hours of them testing positive, then maybe we can lower the severity of that whole trajectory,” she says, including reducing the likelihood the virus could get into the lungs, where it was doing permanent, often lethal damage to many.
Covid/commons.wikimedia.org
Additionally, the now-infamous spiky SARS-CoV-2 is known to attach to the ACE2 receptor, which is pervasive throughout the body and in abundance in locations like the nasal cavity, mouth and lungs. Drugs that interfere with the virus’ ability to attach to ACE2 have been pursued, and Baxter says the nasal irrigation with saline helps decrease the usual robust attachment. Saline appears to inhibit the virus’ ability to essentially make two cuts in itself, called furin cleavage, so it can better fit into an ACE2 receptor once it spots one.
Participants self-administered nasal irrigation using either povidone-iodine, that brown antiseptic that gets painted on your body before surgery, or sodium bicarbonate, or baking soda, which is often used as a cleanser, mixed with water that had the same salt concentration normally found in the body.
But their experience indicates the saline solution alone sufficed. “It’s really just the rinsing and the quantity that matter,” Baxter says.
The investigators also wanted to know any impact on symptom severity, like chills and loss of taste and smell. Twenty-three of the 29 participants who consistently irrigated twice daily had zero or one symptom at the end of two weeks compared to 14 of the 33 who were less diligent.
Those who completed nasal irrigation twice daily reported quicker resolution of symptoms regardless of which of two common antiseptics they were adding to the saline water.
Others have shown the nasal irrigation, also called lavage, can also be effective in reducing duration and severity of infection by a family of viruses that include the coronaviruses, which are also known to cause the common cold, as well as the influenza viruses, the investigators write. “SARS-CoV-2 infection was another perfect situation for it,” Baxter says.
In fact, nasal irrigation is something that has been done for millennia in Southeast Asia, and Baxter had noted lower death rates from COVID-19 in countries like Laos, Vietnam and Thailand. “Those were places that I knew from having been there where they use nasal irrigation as a normal part of hygiene just like brushing their teeth,” she says. A 2019 pre-COVID study provided evidence that regular nasal irrigation in Thailand can improve nasal congestion, decrease postnasal drip, improve sinus pain or headache, improve taste and smell and improve sleep quality.
Saline water
Schwartz said the simplicity and safety of the treatment had him recommending nasal irrigation to positive patients early on and the published results make him even more confident in recommending nasal irrigation to essentially anyone who tests positive.
“Many of the people who have been using this now for months have told me their seasonal allergies have gone away, that it really makes a huge difference in any of the things that go through the nose that are annoying.”
A study released in September 2020 indicated that gargling with a saline-based solution can reduce viral load in COVID-19, and another released in 2021 suggested that saline works multiple ways to reduce cold symptoms related to infection with other coronaviruses and might work as well as a first-line intervention for COVID-19.
Despite the two nostrils, the nasal sinus is just one cavity, so the water is pushed into one side and comes out the other, Baxter notes.
Tourism in Hungary has bounced back to the pre-pandemic level, with 16.4 million guest nights registered this summer, the Hungarian Tourism Agency (MTU) said.
This is the same level as the summer of 2019, Xinhua news agency quoted the MTU as saying.
MTU welcomed the fact that domestic tourism has maintained its momentum in recent years.
“About 10.5 million of the guest nights were spent by domestic visitors in accommodation facilities, which is 12 per cent more than the data for the summer of 2019,” it said.
Hungary was able to welcome 2.5 times more international visitors this summer than in the summer of 2021, MTU added.
Hungary: People wearing face masks are seen on the elevator of a subway station in Budapest
In 2021, the proportion of foreign visitors was 20 per cent in the three summer months (June, July and August).
Meanwhile, this year it rose to 36 per cent, accounting for nearly 6 million international guest nights.
The famous Lake Balaton retained its title as the number one destination, with more than 5.4 million guests staying there, accounting for 41 per cent of total rural accommodation turnover.
The largest proportion of guests in the countryside were Hungarian (75 per cent of total guests), while in Budapest, 83 per cent of total guests this summer were foreign tourists.
Covid/commons.wikimedia.org
The largest numbers of tourists visiting Budapest came from the UK, Germany, the US, Israel, Italy and the Netherlands.
MTU also said that the general hotel-room occupancy rate stood at 60 per cent nationally during the three summer months.
The Union Government is committed to accelerating the pace and expanding the scope of COVID-19 vaccination throughout the country. The nationwide COVID 19 vaccination started on 16th January 2021. The new phase of universalization of COVID-19 vaccination commenced from 21st June 2021. The vaccination drive has been ramped up through availability of more vaccines, advance visibility of vaccine availability to States and UTs for enabling better planning by them, and streamlining the vaccine supply chain.
As part of the nationwide vaccination drive, Government of India has been supporting the States and UTs by providing them COVID Vaccines free of cost. In the new phase of the universalization of the COVID19 vaccination drive, the Union Government will procure and supply (free of cost) 75% of the vaccines being produced by the vaccine manufacturers in the country to States and UTs.
covid vaccines doses
More than 201.88 crore (2,01,88,89,325) vaccine doses have been provided to States/UTs so far through Govt. of India (free of cost channel) and through direct state procurement category.
More than5.58Cr (5,58,87,590) balance and unutilized COVID Vaccine doses are still available with the States/UTs to be administered.
COVID mRNA vaccines are associated with a decreased risk of death in patients with heart failure,according to research presented at ESC Congress 2022.1 The study also found that the vaccines were not associated with an increased risk of worsening heart failure, venous thromboembolism or myocarditis in heart failure patients.
“Our results indicate that heart failure patients should be prioritised for COVID-19 vaccinations and boosters,” said study author Dr. Caroline Sindet-Pedersen of Herlev and Gentofe Hospital, Hellerup, Denmark. “COVID-19 vaccines will continue to be important for preventing morbidity and mortality in vulnerable patient populations. Thus, studies emphasising the safety of these vaccines are essential to reassure those who might be hesitant and ensure continued uptake of vaccinations.”
Patients with heart failure are at increased risk of hospitalisation, need for mechanical ventilation, and death due to COVID-19.2 Vaccination reduces the risk of serious illness from COVID-19. However, “Due to perceptions about possible cardiovascular side effects from mRNA vaccines in heart failure patients, this study examined the risk of cardiovascular complications and death associated with mRNA vaccines in a nationwide cohort of patients with heart failure,” said Dr. Sindet-Pedersen.
The study included 50,893 unvaccinated patients with heart failure in 2019 and 50,893 patients with heart failure in 2021 who were vaccinated with either of the two mRNA vaccines (BNT162B2 or mRNA-1273).3 The two groups were matched for age, sex, and duration of heart failure. The median age of participants was 74 years and 35% were women. The median duration of heart failure was 4.1 years. Participants were followed for 90 days for all-cause mortality, worsening heart failure, venous thromboembolism, and myocarditis, starting from the date of the second vaccination for the 2021 group and the same date in 2019 for the unvaccinated group.
The researchers compared the risk of adverse outcomes in the two groups, after standardising for age, sex, heart failure duration, use of heart failure medications, ischaemic heart disease, cancer, diabetes, atrial fibrillation, and admission with heart failure less than 90 days before the first date of follow up. Dr. Sindet-Pedersen explained: “Standardisation imitates a randomised trial and is a way to obtain a better causal interpretation of the results from observational studies.”
Among 101,786 heart failure patients, the researchers found that receiving an mRNA vaccine was not associated with an increased risk of worsening heart failure, myocarditis or venous thromboembolism but was associated with a decreased risk of all-cause mortality. The standardised risk of all-cause mortality within 90 days was 2.2% in the 2021 cohort (vaccinated) and 2.6% in the 2019 cohort (not vaccinated), showing a significantly lower risk for all-cause mortality in 2021 versus 2019. The standardised risk of worsening heart failure within 90 days was 1.1% in both cohorts. Similarly, no significant differences were found between groups for venous thromboembolism or myocarditis.
Dr. Sindet-Pedersen concluded: “The study suggests that there should be no concern about cardiovascular side effects from mRNA vaccines in heart failure patients. In addition, the results point to a beneficial effect of vaccination on mortality.”
Congress leader Priyanka Gandhi’s offer to ply 1,000 buses to transport stranded labourers and migrants in Delhi to their homes in Uttar Pradesh has been accepted by the UP government after dragging ts feet for over two days. The state Additional Chief Secretary Awanish Awasthi replied to Priyanka Gandhi’s private secretary accepting the offer and requesting more details including a list of the drivers and conductors.
प्रवासी मजदूरों की भारी संख्या घर जाने के लिए गाजियाबाद के रामलीला मैदान में जुटी है। यूपी सरकार से कोई व्यवस्था ढंग से नहीं हो पाती। यदि एक महीने पहले इसी व्यवस्था को सुचारू रूप से किया जाता तो श्रमिकों को इतनी परेशानी नहीं झेलनी पड़ती।
— Priyanka Gandhi Vadra (@priyankagandhi) May 18, 2020
In her May 16 letter soon after the tragic road accident when 25 migrants had died near Aurraiya, Congress general secretary Priyanka Gandhi wrote to CM Yogi Adityanath offering to bear the cost of 1,000 buses to transport migrants to UP. She said thousands of migrants from various parts of the country were walking down to their homes and 65 of them died on the road that was more than the COVID-19 tally in the state.
.@myogiadityanath जी महामारी के समय इंसान की जिंदगी को बचाना, गरीबों की रक्षा करना, उनकी गरिमा की हिफाजत करना हमारा नैतिक दायित्व और अधिकार है।
कांग्रेस इस कठिन समय में अपनी पूरी क्षमता और सेवाव्रत के साथ अपने कर्तव्यों का पालन कर रही है।
ये बसें हमारी सेवा का विस्तार हैं। 1/3
— Priyanka Gandhi Vadra (@priyankagandhi) May 18, 2020
Priyanka Gandhi offered to provide 1,000 buses to transport migrants and bear the cost by the Congress Party and said 500 buses were being parked at Ghazipur border in Ghaziabad and another 500 buses at Noida. Amid adverse media reports, the UP Government has finally decided to give permission.
Earlier, Priyanka had deplored the poor mismanagement at Ghaziabad’s Ram Lila ground where a large uncontrollable crowd of migrants had gathered and were seen pushing each other, ignoring social distancing norms in the wake of coronavirus pandemic, to register to return home.
“If this exercise had started a month ago the migrants would not have had to undergo such hardship. I had offered 1,000 buses and had parked them at the UP border but the UP Government kept playing politics and did not give permission. The UP Government is not helping those hit by this pandemic and is neither allowing others to do it,” Priyanka had said in her earlier tweet.
After the approval of her request, she said, “The nation-building workers cannot be left like this to fend for themselves. The Congress party is committed to help them,” and thanked the state government for accepting the offer.
