Children are ‘skin and bones’ as Sudan marks a grim milestone

It is a grim milestone for Sudan, the world’s worst humanitarian crisis. But with insufficient funding, lack of access to key regions and intensifying violence, milestones like this have become the grim norm.  

This is not hypothetical. It is a looming catastrophe,” said Sheldon Yett, the UN Children’s Fund (UNICEF) representative in Sudan.

And it is a catastrophe that is unduly affecting women and children, many of whom have been displaced multiple times and lack access to even the most basic of services such as clean water, food and protection.  

“Every day the conflict continues in Sudan, innocent lives are lost, communities are torn apart and trauma continues to haunt generations,” said Radhouane Nouicer, the UN’s designated expert on human rights in Sudan.  

Emotional scar tissue 

Children in Sudan are among those most affected by the crisis – 3.2 million  children under five are projected to suffer from acute malnutrition in the next year.

On a recent trip Jebel Aulia, a locality in Khartoum state which is at extreme risk of famine, Mr. Yett was horrified by what he saw.  

Many of the children are reduced to just skin and bones,” Mr. Yett said.

However, these children are not only contending with malnutrition – some of them have also been displaced four or five times, and over three-quarters of Sudanese children are out of school.  

“The emotional scar tissue is massive – children don’t know where they are going next … often feeling like aliens in their own land,” Mr. Yett said.  

He spoke with one mother in Jebel Aulia whose daughter may be forever changed by the violence.  

Since the war started, my daughter has fallen into a state of silence, and I can feel her heart racing with fear,” one mother said.  

A gendered crisis

Around Sudan, as the food insecurity crisis spirals, women and girls are the “hungriest face of the crisis,” according to Salvator Nkurunziza, the UN Women representative in Sudan.

“With conditions now at near famine thresholds in several regions in the country, it is not just a food crisis but a gender emergency caused by a failure of gender-responsive action,” said Mr. Nkurunziza at a Tuesday press briefing in Geneva.  

A recent report further drove home the gendered nature of the crisis, revealing that women-led households in Sudan are three times more likely to experience severe insecurity than households led by men.  

This is especially concerning as the death, displacement or forced disappearance of men has left more and more women the sole bread winners. In total 75 per cent of women-led households cannot meet basic food needs.

The data is unequivocal: female-headed households are slipping deeper into starvation, with fewer coping mechanisms, less access to income, and even more systemic barriers than last year,” the report said.  

Nevertheless, Mr. Nkurunziza reminded the international community that women are not just victims but also agents of change in crisis settings.  

Women-led organizations are on the frontlines, providing food through soup kitchens and supporting displaced families. And yet, they remain excluded from many of the decision-making processes and exposed to undue risks.  

An unchanged human rights landscape

Food security and displacement are not the only challenges that the Sudanese face. Rather, the human rights situation is also deteriorating, according to Mr. Nouicer who visited Sudan to meet key government officials in July.  

“I remain gravely concerned that civilians in Sudan continue to suffer widespread violations and abuses, including extrajudicial killings, sexual violence, forced displacement and arbitrary detention,” he said.  

He specifically highlighted the unique challenges that women, children and people with disabilities face when confronting displacement and violence.  

“The ongoing war has devastated civilian lives and turned daily survival into a constant struggle.”  

‘Irreversible damage’

Mr Yett said that in his most recent trip, he saw the best and worst of humanity – the devastating impact of violence and inaction coupled with the hopeful possibilities that peace and action could provide.  

We are on the verge of irreversible damage to an entire generation of children, not because we lack the knowledge or the tools to save them but because we are collectively failing to act with the urgency and at the scale this crisis demands,” he said.  

The first step is ensuring access to regions of Sudan like Zamzam which have been cut off from aid. With the rainy season approaching – and some roads already impassable – this is only becoming more difficult.  

Mr. Nouicer highlighted that even if a ceasefire between the warring rival militaries happened, the level of devastation and abuse is so extreme that the future will require more than just peace.  

“The path forward demands more than ceasefires and peace talks. It requires a sustained commitment to justice, accountability, and inclusive governance.” 

Source link

Scent, sweat from human skin attract disease-spreading mosquitoes

Mosquitoes that spread Zika, dengue and yellow fever are guided toward their victims by a scent from human skin. The exact composition of that scent has not been identified until now.

A UC Riverside-led team discovered that the combination of carbon dioxide plus two chemicals, 2-ketoglutaric and lactic acids, elicits a scent that causes a mosquito to locate and land on its victim. This chemical cocktail also encourages probing, the use of piercing mouthparts to find blood.

This chemical mixture appears to specifically attract female Aedes aegypti mosquitoes, vectors of Zika as well as chikungunya, dengue, and yellow fever viruses. This mosquito originated in Africa, but has spread to tropical and subtropical regions worldwide, including the U.S.

Mosquitoes use a variety of cues to locate their victims, including carbon dioxide, sight, temperature, and humidity. However, Cardé’s recent research shows skin odors are even more important for pinpointing a biting site.

Aedes aegyptii mosquito biting a person./CREDIT CDC

“We demonstrated that mosquitoes land on visually indistinct targets imbued with these two odors, and these targets aren’t associated with heat or moisture,” Cardé said. “That leaves skin odor as the key guiding factor.”

Given the significance of odor in helping mosquitoes successfully feed on humans, Cardé wanted to discover the exact chemicals that make our scent so potent for the insects. Part of the equation, lactic acid, was identified as one chemical element in the odor cocktail as long ago as 1968.

Since then, several studies have identified that carbon dioxide combined with ammonia, and other chemicals produced by humans also attract these mosquitoes. However, Cardé, who has studied mosquitoes for 26 years, felt these other chemicals were not strong attractants.

Methods that chemists typically use to identify these chemicals would not have worked for 2-ketoglutaric acid, Cardé said. Gas chromatography, which separates chemicals by their molecular weight and polarity, would have missed this acid.

“I think that these chemicals may not have been found before because of the complexity of the human odor profile and the minute amounts of these compounds present in sweat,” said chemist Jan Bello, formerly of UCR and now with insect pest control company Provivi.

Searching for mosquito attractors, Cardé turned to Bello, who extracted compounds from the sweat in his own feet. He filled his socks with glass beads and walked around with the beads in his socks for four hours per odor collection.

Credit: MINDY TAKAMIYA/KYOTO UNIVERSITY ICEMS

“Wearing the beads felt almost like a massage, like squeezing stress balls full of sand, but with your feet,” said Bello. ‘The most frustrating part of doing it for a long time is that they would get stuck in between your toes, so it would be uncomfortable after a while.”

The inconvenience was worth the investment. Bello isolated chemicals from the sweat deposited on the sock beads and observed the mosquitoes’ response to those chemicals. In this way, the most active combination emerged.

Future studies are planned to determine whether the same compound is effective for any other mosquitoes, and why there is such variation in how individuals are apt to be bitten. “Some are more attractive than others to these mosquitoes, but no one’s yet established why this is so,” Cardé said.

Though this discovery may not lead to insights for the development of new repellants, the research team is hopeful their discovery can be used to attract, trap, and potentially kill disease-spreading mosquitoes.

Non-invasive ‘FAST device’ measures the changing size of tumors below the skin

Engineers at the Georgia Institute of Technology and Stanford University have created a small, autonomous device with a stretchable/flexible sensor that can be adhered to the skin to measure the changing size of tumors below. The non-invasive, battery-operated device is sensitive to one-hundredth of a millimeter (10 micrometers) and can beam results to a smartphone app wirelessly in real-time with the press of a button.

In practical terms, the researchers say, their device—dubbed FAST for “Flexible Autonomous Sensor measuring Tumors”—represents a wholly new, fast, inexpensive, hands-free, and accurate way to test the efficacy of cancer drugs. On a grander scale, it could lead to promising new directions in cancer treatment.

Each year researchers test thousands of potential cancer drugs on mice with subcutaneous tumors. Few make it to human patients, and the process for finding new therapies is slow because technologies for measuring tumor regression from drug treatment take weeks to read out a response. The inherent biological variation of tumors, the shortcomings of existing measuring approaches, and the relatively small sample sizes make drug screenings difficult and labor-intensive.

“FAST” sensor/Photo:Stanford University

“In some cases, the tumors under observation must be measured by hand with calipers,” says Alex Abramson, first author of the study and a recent post-doc in the lab of Zhenan Bao at the Stanford School of Engineering and now an assistant professor at Georgia Tech. The use of metal pincer-like calipers to measure soft tissues is not ideal, and radiological approaches cannot deliver the sort of continuous data needed for real-time assessment. FAST can detect changes in tumor volume on the minute-timescale, while caliper and bioluminescence measurements often require weeks-long observation periods to read out changes in tumor size.

FAST’s sensor is composed of a flexible and stretchable skin-like polymer that includes an embedded layer of gold circuitry. This sensor is connected to a small electronic backpack designed by former post-docs and co-authors Yasser Khan and Naoji Matsuhisa. The device measures the strain on the membrane—how much it stretches or shrinks—and transmits that data to a smartphone. Using the FAST backpack, potential therapies that are linked to tumor size regression can quickly and confidently be excluded as ineffective or fast-tracked for further study.

The researchers say that the new device offers few significant advances.

  1. It provides continuous monitoring, as the sensor is physically connected to the mouse/human patients and remains in place over the entire experimental period.
  2. FAST can detect changes in tumor volume on the minute-timescale, while caliper and bioluminescence measurements often require weeks-long observation periods to read out changes in tumor size.
  3. FAST is both autonomous and non-invasive. It is connected to the skin, not unlike a band-aid, battery operated and connected wirelessly. The mouse/human patients are free to move unencumbered by the device or wires, and scientists do not need to actively handle the mice following sensor placement.
  4. FAST packs are also reusable, cost just $60 or so to assemble and can be attached to the mouse/human patients in minutes.
  5. FAST could significantly expedite, automate and lower the cost of the process of screening cancer therapies.

FAST’s sensor is composed of a flexible and stretchable skin-like polymer that includes an embedded layer of gold circuitry.\/Photo:Alex Abramson, Bao Group, Stanford University

The breakthrough is in FAST’s flexible electronic material. Coated on top of the skin-like polymer is a layer of gold, which, when stretched, develops small cracks that change the electrical conductivity of the material. Stretch the material and number of cracks increases, causing the electronic resistance in the sensor to increase as well. When the material contracts, the cracks come back into contact and conductivity improves.

Both Abramson and co-author Naoji Matsuhisa, an associate professor at the University of Tokyo, characterized how these crack propagation and exponential changes in conductivity can be mathematically equated with changes in dimension and volume.

One hurdle the researchers had to overcome was the concern that the sensor itself might compromise measurements by applying undue pressure to the tumor, effectively squeezing it. To circumvent that risk, they carefully matched the mechanical properties of the flexible material to skin itself to make the sensor as pliant and as supple as real skin.

“It is a deceptively simple design,” Abramson says, “But these inherent advantages should be very interesting to the pharmaceutical and oncological communities. FAST could significantly expedite, automate and lower the cost of the process of screening cancer therapies.”