What are Zombie cells? Mayo Clinic researchers minimize cells in diabetic kidney disease

The results of these researchers in Jacksonville, Fla., are that a drug-and-supplement combination therapy can be used to lessen the harmful effects of senescent cells, or, to be more exact, zombie cells, in diabetic kidney disease.

In an article published by the Lancet, the team has found that the combination of the cancer drug dasatanib and a naturally occurring substance quercetin reduced inflammation and enhanced protective factors in the kidney.

Diabetic kidney disease is the number one cause of renal failure and goes over 12 million individuals in the U.S. Whereas there is a partial cure in newer treatments to slow the loss of kidney function, it has no cure at all.

According to LaTonya Hickson, a nephrologist with Mayo Clinic in Florida and the main researcher of the study, the combination therapy, administered on a short term basis, decreased the amount of senescent cells within a preclinical diabetes kidney disease model and also led to the enhancement of kidney functioning. In order to prolong the health of the kidney, researchers have been keen on the solution to the existence of senescent cells, which do not get to pass through the natural process of death and instead hang around in tissues leading to aging and disease.

Therapy to Attack Senescent Cells

The therapeutic strategy is senolytics, natural and synthetic substances that in combination selectively attack senescent cells.

In a clinical trial that was previously carried out and was a pilot study, researchers at the Mayo Clinic led by Hickson discovered that dasatanib combination with quercetin diminished senescent cells of skin and fat tissues in diabetic kidney disease patients. The impact of the combination therapy on senescence and protective factors on the diabetic kidney, however, had not been described yet.

“The need to demonstrate that this single, momentary, treatment has an outcome on the kidneys was informed by the necessity to do so without the use of invasive procedures in the patients,” says Xiaohui Bian, a nephrologist who did the work as a post-doctoral fellow at Mayo Clinic and leads the study.

The group identified that the combination therapy enhanced kidney performance and protective mechanisms and minimized injury, senescent cells, and inflammation in a preclinical model of diabetic kidney disease. The combination therapy also lowered the number of senescent cells and the inflammatory response caused by them in cultured human kidney cells.

According to Hickson, the results indicate that this combination treatment has a potential to assist in reducing and stopping the damage of kidneys caused by diabetes. These two studies are now promising and indicate that larger scale research in patients with senolytics is warranted to enhance the health of the kidneys.

IEA Release of Emergency Reserves to Ease Oil Flow in 120 Days, Impact Seen in India Already

The International Energy Agency’s 32 member countries have unanimously agreed to release 400 million barrels of oil from emergency reserves, the largest such action in the agency’s history, following the US-Israel war on Iran that resulted in the latter choking Strait of Hormuz shipment flows to less than 10% of pre-conflict levels.

Under the IEA measure, the US alone will contribute 172 million barrels from its Strategic Petroleum Reserve, but the full release will take at least 120 days to complete.

The escalating war involving Iran, the US, and Israel has triggered the biggest oil supply shock. Tanker traffic through the vital Strait of Hormuz has plummeted from ~20 million barrels per day to almost nothing, as ships avoid the danger zone.

Gulf producers like Saudi Arabia, Iraq, UAE, Kuwait, and Qatar have slashed output by at least 10 million barrels daily because storage is full and exports can’t leave.

The IEA warns global supply could drop ~8 million bpd this month, with some refineries shut and refined fuels stalled too.
Demand is dipping too
Meanwhile, fewer flights and LPG issues could cut it by ~1 million bpd. To ease the crisis, the IEA coordinated a record release of 400 million barrels from emergency stocks. Global inventories are still high, offering a short-term buffer, but without quick resumption of Hormuz flows, things could worsen fast.

Despite the announcement, oil prices climbed back above $90 a barrel, with markets warning that the reserves offer no structural fix unless safe passage through the Strait of Hormuz is restored completely.
India imports around 85–90% of its crude oil requirement, which means domestic fuel prices are highly sensitive to global benchmarks such as Brent Crude Oil and West Texas Intermediate (WTI).

gas price

When crude rises sharply—as it has this week due to Middle East tensions and supply fears—oil marketing companies typically face higher input costs. If prices remain elevated for long, those costs eventually feed into retail petrol and diesel prices.

What may happen in the next few weeks

1. Short-term: Prices may stay unchanged for now: State-run retailers such as Indian Oil Corporation, Bharat Petroleum, and Hindustan Petroleum often absorb temporary spikes. If crude volatility lasts only a few days, pump prices may remain stable.

2. If crude stays near or above $100: Sustained levels above $100 per barrel could start putting pressure on fuel retailers. Historically, prolonged rallies at such levels have led to gradual price revisions.

3. Government intervention is possible: Before major elections or during inflation spikes, the government has sometimes cut excise duty or asked oil companies to delay hikes to cushion consumers.

4. Inflation risk: Higher fuel costs also raise transportation expenses, which can push up prices of food and other essentials—an issue closely monitored by the Reserve Bank of India.

If crude stays near $100–110 per barrel for several weeks, analysts typically estimate petrol and diesel prices could rise by roughly ₹2–₹6 per litre, depending on taxes and exchange rate movements.

For now, the oil spike is a warning signal rather than an immediate price hike. The key factor will be whether geopolitical tensions in the Middle East continue to disrupt supply routes like the Strait of Hormuz.

New NASA DART mission data reveals asteroids throw ‘cosmic snowballs’ at each other

Binary asteroid systems are not uncommon in our cosmic neighborhood with about 15 percent of asteroids around the Earth having small moons around them.

A team of astronomers (headed by the University of Maryland) has since found that these binary asteroid systems are much more dynamic than they thought- involving active exchange of rocks and dust in slow, slow-motion collisions that reform them over millions of years.

Upon the analysis of the images captured by the NASA Double Asteroid Redirection Test (DART) spacecraft just before deliberately colliding with the asteroid moon Dimorphos in 2022, the team observed bright, fan-shaped streaks across the surface of the moon, which is the first direct evidence of the material naturally traveling between two asteroids. The implications of the findings given by the researchers in The Planetary Science Journal on March 6, 2026, regarding the information about asteroids that may pose a threat to the earth are far reaching.

Initially, we assumed that it must have been a problem with the camera, then we assumed it must have been a problem with our processing of the images, said the lead author of the paper, Jessica Sunshine, a professor with joint appointments in both the Department of Astronomy and Department of Geological, Environmental, and Planetary Sciences of UMD. However, once we cleared it up we found the marks we were observing were quite regular with respect to low velocity collisions, such as tossing cosmic snowballs. We possessed the first direct evidence of material movement within the recent past in a binary asteroid system.

The results of the team were also the first, visual confirmation of the Yarkovsky-O Keefe Radzievskii Paddak (YORP) effect wherein small asteroids rapidly rotate due to the presence of sunlight, causing material to be thrown off their surfaces to form moons. This was probably true of Didymos and its smaller satellite Dimorphos in the case of Sunshine reported the remnants of the so-called cosmic snowballs which had been deposited on the surface of Dimorphos.

How they found these traces?

They took months of investigative efforts to find these traces. The original images captured by the DART spacecraft could not see the fan-shaped streaks yet, UMD astronomy research scientist Tony Farnham and former postdoctoral researcher Juan Rizos developed more intricate methods to eliminate the boulder shadow and lightning effects in the images and exposed the eye-opening streaks that were left behind by the ‘cosmic snowballs’.

We finally saw these rays wrapping round Dimorphos, something no one has ever seen, you see, Farnham said. At the initial stages, it could not be believed because it was gentle and distinct.

To the researchers, the path of the DART mission provided a peculiar challenge. The space ship flew directly into the target with only slight distinctions in lighting and viewpoint that made it hard to differentiate actual features and any potential lighting possibilities. To demonstrate the authenticity of the streaks the team traced them to the source in one of the areas near the edge of Dimorphos- clearly out of phase with where the sun was overhead. Having done this, the team came to the conclusion that the traces left by the so-called cosmic snowballs were not really a light illusion.

Not fainter as we smoothed out the 3D image of the moon the fan-shaped streaks became more distinct, Farnham said. “It made us sure that we were dealing with a reality.

Earlier researchers noted an indirect evidence of the sunlight causing small asteroids to spin faster triggering the expulsion of material off their surfaces. However, the recently perfected models of the asteroid moon Dimorphos created by the UMD team give the first graphic assurance of the process and the precise sites of the shed material of its original asteroid, Didymos. Additional calculations by UMD alumnus Harrison Agrusa (M.S. ’19, Ph.D. ’22, astronomy) also indicated that the material moved Didymos at 30.7 centimeters per second, which is slower than the typical pace of a human walking.

Fan-shaped marks

“That would be why it had the fan-shaped marks,” Sunshine said. “These slow moving effects would not cause a crater as they would cause a deposit instead of being evenly distributed. And they are focused on the equator as theorized on modeling material ripped off the primary.”

The researchers headed by the former UMD postdoctoral associate Esteban Wright conducted a battery of experiments in their laboratories to test their hypotheses at the UMD Institute of Physical Science and Technology. To replicate boulders on Dimorphos, they tossed marbles into a sand filled with painted gravel. The experiment was recorded with high-speed cameras, and it was found that boulders filtered some material and allowed other particles to stream in-between the boulders- forming ray-like patterns similar to those found on Dimorphos.

The results were verified in computer simulations of effects of loose clumps of dust done at Lawrence Livermore National Laboratory. The shape of the fan-shaped rays on the surface of the asteroid was naturally formed by boulders that formed the cosmic snowballs on the surface of the asteroid whether the impactor was a compact rock such as the marble or a loose clump of material.

These marks could be seen on Dimorphos in that film taken by the DART spacecraft immediately before the large collision, evidence that there was an exchange of material between it and Didymos, said Sunshine. The fan line deposit must stretch up to the side of the moon that we did not strike and there is a chance that it was not smashed in by the blow.

These features could be found to be still present on Didymos as the Hera mission of the European Space Agency will possibly arrive in December 2026 and see them. Sunshine and her colleagues give an estimate as to how Hera will also witness new ray patterns formed when boulders are struck by the DART spacecraft, knocking them loose, which gives them a different perspective of the asteroids that have the potential to threaten the earth.

According to Sunshine, these new findings which arise out of this research play a critical part in our knowledge about the near-Earth asteroids and their evolutionary patterns. It has been discovered that they are much more dynamic than we thought before and this will assist us in streamlining our models and our planetary defense efforts.

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Young people who have AI meal plans might be consuming less calories, but missing a meal

A large number of teenagers who have some weight problem are resorting to AI models as they seek to design meal plans in a bid to lose weight. A new study, however, indicates that the plans that are a result of this could not, at least in all cases, cover the required nutrients and calorie consumption.

In Turkey, five different AI models were compared in regard to their meal planning capabilities, which led researchers to develop meal plans to help teenagers lose weight and evaluated their findings against the recommendations of a registered dietician. They described their results in Frontiers in Nutrition.

According to Dr Ayse Betul Bilen, an assistant professor of the Faculty of Health Sciences at the Istanbul Atlas University, there is a significant underestimation of total energy and the main nutrient intake of diet plans generated by AI models compared to plans prepared by a dietitian based on guidelines. It is known that adherence to this type of imbalanced or excessively restrictive meal plans in the teenage years can have a detrimental influence on growth, metabolic health, and eating habits.

Missing a meal

The researchers were prompted to generate meal plans using five AI models, which were ChatGPT 4, Gemini 2.5 Pro, Bing Chat-5GPT, Claude 4.1 and Perplexity, using free versions of these models. Some of the prompts were age, height and weight of the individual the plan would be based on, and the directive to develop a 3 days plan that included three meals and two snacks a day. Four teenagers aged 15 years, one boy and one girl, who were in the overweight percentile and one boy and one girl who fell in the obese percentile were put on meal plans.

Comparing the results of AIs to generate meal plans to those of a dietician who specializes in adolescent diseases, it was found that the energy requirement that was estimated by the AI models was on average nearly 700 calories lower than the dietitian. This is a full meal worth of difference that has severe clinical implications. The intake of some macronutrients had been overcalculated whereas the intake of some caloric nutrients was grossly undercalculated.

The AI-generated diet plans never adhered to the recommended mix of macronutrients, which is quite dangerous among adolescents, as Bilen indicated.

In comparison, AI models suggested more protein intake (20g higher than the dietician), and this scheme led to about 21-24% of the energy intake as protein. Recommendations of lipid provided by AI were also significantly more than in the plans developed by dieticians, and lipids constituted 41-45% of energy intake.

The quantity of carbohydrates, however, was much inferior in AI plans and the difference was about 115g on average, that is, only about 32-36 percent of the energy intake would be derived as carbs. In comparison, the National Academies of Sciences, Engineering and medicine in the US advise that the proportion of lipids, proteins and carbs should be 30-35, 15-20 and 45-50 percent respectively.

Favoring plans to balanced diets

Although numerous pieces of information about healthy diet guidelines are found on national and international health organizations websites, such as the Turkish Nutritional Guidelines or WHO Adolescent Nutritional Guidelines, AI tools do not necessarily use evidence-based nutritional guidelines in their production. Bilen stated that AI models are mostly trained to produce answers that are most plausible and user-friendly, and not necessarily accurate, clinically. According to their findings, they might be dependent on generalized or popular diet patterns rather than incorporating the nutritional requirements of age.

Since not every teenager can hire the service of a dietician to help them plan their meals, the team recommended that a person using AI tools to create a diet plan should be cautious. The teenagers are also to remember that the diets that are too restrictive or that are constructed on the basis of extreme diets that are based on the dominance of either protein or fat.

The researchers claimed that they hope that their findings will contribute to the increased awareness of the narrow capability of AI tools to create well-balanced meal plans and assist in developing safer tools that are more consistent with the guidelines created by professionals. Although AI models are fast developing and models might be better now than they were at the time of analysis, AI models are not an alternative to professional dietary counseling especially to the vulnerable groups.

Bilen concluded that adolescence is a critical period with regard to physical development, bone development and cognitive maturation. The risks of a lower energy and carbohydrate intake and higher ratios of protein and fat could be dangerous at the adolescent growth stage.

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Oval orbit casts new light on black hole, neutron star mergers

Scientists have uncovered the first robust evidence of a black hole and neutron star crashing together but orbiting in an oval path rather than a perfect circle just before they merged. This discovery challenges long-standing assumptions about how these cosmic pairs form and evolve.

Researchers from the University of Birmingham, Universidad Autónoma de Madrid, and Max Planck Institute for Gravitational Physics published their findings today (11 Mar) in The Astrophysical Journal Letters.

Most neutron star-black hole pairs are expected to adopt circular orbits long before merging. But the analysis of the gravitational-wave event GW200105 shows that this system travelled on an oval orbit long before merging to form a black hole 13 times more massive than the Sun. An oval orbit is something never seen before in this kind of collision.

Dr Patricia Schmidt, from the University of Birmingham, said: “This discovery gives us vital new clues about how these extreme objects come together. It tells us that our theoretical models are incomplete and raises fresh questions about where in the Universe such systems are born.”

The researchers analysed data from LIGO and Virgo detectors using a new gravitational‑wave model developed at the University of Birmingham’s Institute of Gravitational Wave Astronomy. This allowed them to measure both how ‘oval’ the orbit was (eccentricity) and any spin‑induced wobbling (precession). This is the first time these two effects have been measured together in a neutron star–black hole event.

Geraint Pratten, a Royal Society University Research Fellow from the University of Birmingham, said: “The orbit gives the game away. Its elliptical shape just before merger shows this system did not evolve quietly in isolation but was almost certainly shaped by gravitational interactions with other stars, or perhaps a third companion.”

A Bayesian analysis comparing thousands of theoretical predictions to the real data, showed that a circular orbit is extremely unlikely, ruling it out with 99.5% confidence.

Past analyses of GW200105, which assumed a circular orbit, underestimated the black hole mass and overestimated the neutron star mass. The new study corrects these values and finds no compelling evidence of precession, indicating that the eccentricity was imprinted by its formation rather than by spins.

Gonzalo Morras, from the Universidad Autónoma de Madrid and the Max Planck Institute for Gravitational Physics, said: “This is convincing proof that not all neutron star–black hole pairs share the same origin. The eccentric orbit suggests a birthplace in an environment where many stars interact gravitationally.”

This discovery challenges the prevailing view that all neutron star–black hole mergers arise from a single dominant formation channel and highlights the need for more advanced waveform models capable of capturing the full complexity of these systems.

The study helps to explain the growing diversity seen in compact-binary mergers and opens the door to identifying even more unusual pathways as the number of gravitational-wave detections continues to grow.

DRDO, Indian Navy conduct trials of Air Droppable Container from P8I aircraft

Defence Research & Development Organisation (DRDO) and the Indian Navy jointly conducted four successful in-flight release trials of the indigenous Air Droppable Container ‘ADC-150’ from the P8I aircraft off the coast of Goa between February 21 to March 01, 2026, at different extreme release conditions. Indigenously designed and developed to deliver 150 kg payload, the Air Droppable Container enhances the naval operational logistics capabilities for providing quick response to naval vessels under distress, needing critical stores/equipment, medical assistance etc. at blue sea deployed far from the coast.

The Naval Science & Technological Laboratory, Visakhapatnam is the nodal laboratory for the activity. Aerial Delivery Research & Development Establishment, Agra has developed the parachute system and Centre for Military Airworthiness & Certification, Bengaluru provided the flight clearance & certification. Defence Research & Development Laboratory, Hyderabad provided the instrumentation support for the trials.

To meet the requirement of the Indian Navy, the ADC-150 system for the P8I aircraft was developed and qualified in a short timeframe. As all the developmental flight trials have been completed successfully, the system is expected to be inducted into the Indian Navy soon.

How being squeezed contributes to risk of breast cancer cells

A recent study conducted by scientists working in Adelaide University and published in the journal Science Advances has shown the reason as to why certain cancers may grow and survive the body, whereas others do not. It happens that the hard mechanical stress to which the early cancer cells undergo as they are squeezed into a narrow area, causes some of the cancer cells to grow quicker, not to grow, as would otherwise be supposed.

This squeeze worked to the favor of the early breast cancer cells as scientists discovered.

The key point that was explained by the lead researcher, Professor Michael Samuel, of the Centre of Cancer Biology at Adelaide University and the Basil Hetzel Institute is that these breast cancer cells steal a particular sensor – one that our bodies rely on to sense touch – and use it to divide quickly and aid them in making their escape off the major tumour.

The process creates an indefinitely lasting mechanical memory in the breast cancer cells and it still contributes towards aggressive behaviour even after the pressure itself has been removed, Professor Samuel said.

The tumours which are solid are exposed to a lot of physical pressure when the disease is at its early stage of development, as the cancer cells grow in tissues that are limited in space, e.g. the milk ducts of the breast. Up to this day, the mechanism by which these cancer cells detect this pressure and whether or not it impacts the progression of the disease is unknown.

We have a tendency to believe that cancer is a genetic disease, but through this work we know that there is the same importance of physical forces within the tumours as the cause of cancer as there are genetic changes that cause cancer.

The researchers discovered that cancer cells respond to pressure via a molecule named PIEZO1, which is a hole in the cell that relates the interior of a cell to the exterior environment. Upon pressure stimulation, PIEZO1 enables the movement of calcium ions into the cell and subsequent signal transduction containing the Rho-ROCK pathway – a central regulator of cell movement, shape and growth.

The team demonstrated that mechanical pressure of a short duration that is obtained through compressing cancer tissue was sufficient to cause tumour growth to increase significantly. Mechanically compressed tumours in laboratory models of breast cancer became larger and the cancer cells in them fragmented faster than control groups.

In addition to promoting growth, compression was also identified to drive cancer cells into a more aggressive, invasive, state in a process known as epithelial-mesenchymal transition. When either of the PIEZO1 or the Rho-ROCK pathway had, however, been inhibited with the help of suitable drugs, compression did not propel cancer aggressiveness, making their role in this process definite.

Co-lead author Dr Sarah Boyle mentioned that one of the most significant findings was that the cancer aggressiveness effects of compression remained even after removal of the force itself.

According to Dr Boyle, even relatively short durations of pressure can lead to a mechanical memory by altering the way the DNA is packed into the cell, by chemically modifying the histone proteins.

These changes, which are called epigenetic changes, are modifications of the interpretation of the DNA code by the cell, which enables the process of switching on some genes that promote tumour growth and aggressiveness.

This type of epigenetic mechanical memory offers a molecular basis to the long term effects of short term mechanical forces on the cell level of the behaviour of tumours.

Notably, the research established that PIEZO1 is over-expressed in human breast cancers compared to normal breast tissue, and that the level of PIEZO1 differs among the patients. The high PIEZO1 levels have been linked to low patient survival implying that the identical pressure-detecting system found in test animals would probably be applicable in human cancer.

The results indicate a little-known role of mechanical pressure in the development of cancer aggressiveness and represent the PIEZO1 -Rho-ROCK pathway as a possible new therapeutic objective that can be used as an early intervention.

According to the researchers, future therapies can restrict tumour growth and invasiveness by interfering with the sensory and response of cancer cells to mechanical pressure. The results can also be applied in diagnosing the patients who are susceptible to aggressive breast cancers due to excessively high concentrations of PIEZO1.

That work has opened up a whole new field of so-called mechanotherapy – the use of treatments that disrupt the mechanical signals that tumours are dependent on to develop and spread out, as cancers grow to be mechanically responsive diseases, said Professor Samuel.

What makes a hit? On Tiktok and Spotify, listeners only partly decide

TikTok is built for people to create and share their own content, so dance music and indie artists fill the platform’s Top 100. On Spotify, love songs and music from major record labels dominate its top charts. On both platforms, people’s preferences only partly explain what songs become hits.

A new University of California, Davis, study examined how the data-driven business models of TikTok and Spotify shape both the music artists make, and the songs people listen to. The study was published Feb. 27 in the journal Information, Communication & Society, and co-authored by researchers from Renmin University of China, Chinese University of Hong Kong and Tsinghua University.

“Hit song charts represent both user feedback and selections curated by the platforms’ algorithms that also influence users’ choices,” said Cuihua (Cindy) Shen, a UC Davis professor of communication and the study’s corresponding author. “By publishing hit song charts, platforms are declaring what songs are visible and dominant.”

How hits happen

TikTok is a global leader in user-generated short videos, frequently featuring remixes and clips of popular songs. Spotify is a major player in distributing full-length albums. With TikTok’s roughly 1.6 billion monthly active users and Spotify’s 675 million, both platforms serve massive and truly global audiences.

In analyzing differences between the platforms and 2020-22 data from their respective Top 100 hit song charts, researchers found significant differences in what makes a hit.

On TikTok, popularity was driven more by dance genres that suit the platform’s emphasis on user engagement and its popular “dance challenges,” which promotes user videos featuring specific songs and dance moves.

On Spotify, songs about relationships were popular, while songs about politics were unpopular. Spotify had more hit songs produced by major labels and songs in the pop and hip-hop/rap/trap genres. It had a lower proportion of songs from R&B/soul and dance genres.

In the study, TikTok’s Top 100 charts — during the two years analyzed — had 321 songs compared to 1,707 on Spotify. Only 68 hit songs appeared on both platforms within the two-year study period, and a majority entered and exited Spotify’s daily Top 100 charts more quickly than on TikTok.

Different platforms, different hits

TikTok and Spotify differ from traditional media such as radio and even MTV. On both apps, user data, such as clicks and subscriptions, are fed into the platforms’ algorithms and influence the music that artists create to meet demand.

This study highlights how the differences between the two platforms affect what makes a Top 100 hit. Spotify focuses on streaming full-length music and provides detailed metadata, including lyrics. TikTok features clipped snippets of songs that serve as background to users’ video content.

“Our study suggests that Spotify acts as a primary distribution channel while TikTok serves as a space for creative re-interpretation,” said Shen.

Iran Players at AFC Women’s Cup in Australia Defect, Seek Asylum Citing Repercussions Back Home

Amid war flares at home front, seven members of Iran’s women’s national football team have been granted humanitarian visas by Australia, allowing them to remain in the country following their participation in the AFC Women’s Asian Cup. The players, who had refused to sing their national anthem before a match against South Korea, an act that drew sharp criticism from Iranian state media labeling them “wartime traitors,” feared severe repercussions if they returned home.

Captain Zahra Ghanbari and teammates Fatemeh Pasandideh, Zahra Sarbali, Atefeh Ramezanizadeh, and Mona Hamoudi were among the initial five to seek protection, slipping away from their team hotel with assistance from Australian authorities. Two more team members later joined them, though one individual ultimately changed their mind and requested to return to Iran.
Australian Home Affairs Minister Tony Burke confirmed the grants, noting that officials had individually approached the players at Sydney airport, offering support without Iranian officials present.
He described the women’s relief upon receiving the visas, emphasizing that they are now safe and welcome in Australia. Prime Minister Anthony Albanese added that the nation had been touched by the players’ courage, stating help was readily available. The situation even prompted a late-night call between Albanese and former U.S. President Donald Trump, who had publicly offered American asylum as an alternative and criticized any potential forced return.

Iranian officials have remained largely silent on specifics but accused Australia of essentially holding the players “hostage,” while the football federation suggested coercion was involved. The rest of the squad departed for home amid emotional scenes at the airport, with some diaspora supporters attempting to intervene in solidarity.

The latest episode fits into a longer pattern where international sporting events provide rare opportunities for athletes from repressive or unstable environments to seek asylum.

Here’s a short chronology of notable sports defections:

  • 1948 London Olympics: Czechoslovakian gymnastics coach Marie Provazníková became the first known Olympic defector, refusing to return home after the communist takeover in her country, citing a lack of freedom.
  • 1956 Melbourne Olympics: Following the Soviet invasion of Hungary, dozens of Hungarian athletes, about a quarter of their team, defected en masse, many eventually settling in the West, including the United States.
  • 1972 Munich Olympics: Over 100 athletes, primarily from Eastern Bloc nations, sought asylum amid Cold War tensions.
  • 2006 Melbourne Commonwealth Games: At least 26 athletes, including from Sierra Leone and Cameroon, claimed asylum in Australia due to political instability and personal safety concerns.
  • 2012 London Olympics: Seven Cameroonian athletes (boxers, a swimmer, and others) vanished from the village and later sought protection in the UK; three Sudanese runners also applied for asylum.
  • 2018 Gold Coast Commonwealth Games: More than 200 athletes and officials, mostly from African nations like Cameroon, Rwanda, and Uganda, went missing and requested refugee status in Australia.
  • 2021 Tokyo Olympics: Belarusian sprinter Krystsina Tsimanouskaya sought police protection at the airport to avoid forced repatriation after criticizing her coaches; she ultimately received asylum in Poland.

These moments highlight the dual role of global competitions on stages for athletic achievement and, sometimes, desperate escapes. For the Iranian players now starting anew in Australia, the path ahead involves uncertainty but also the promise of safety, a bittersweet trade-off familiar to many who have walked away from their teams and homelands in fear of persecution back home.

Embassies Under Fire: How Iran is Keeping US Diplomatic Missions On Battlefront

From a smoke-stained guard tower in Baghdad to a backpack bomb in Oslo and gunshots at dawn in Toronto, Iran has increasingly turned the world’s diplomatic consulates into combat zones.
The guard tower at the Baghdad Diplomatic Support Center had barely stopped smoking when the State Department alert went out Tuesday night. Six drones had been launched at the facility. Five were intercepted. The sixth found the tower. Somewhere inside the compound, a sprawling logistical hub near the Iraqi capital’s international airport that keeps America’s entire regional diplomatic operation running, a terse internal message ordered staff to “duck and cover,” noting that “accountability is ongoing.”
Nobody in the building was publicly confirmed hurt. Nobody claimed the strike officially. But the culprits, according to a U.S. security official who spoke without attribution, were almost certainly the Islamic Resistance in Iraq, an umbrella network of Iran-funded and Iran-commanded armed factions that have been carrying out strikes on American positions since February 28th.
That was the day the United States and Israel jointly opened what Washington called Operation Epic Fury and Tel Aviv dubbed Operation Roaring Lion, a joint air strike that, within hours, had killed Iran’s Supreme Leader Ayatollah Ali Khamenei and gutted the country’s air defence network. Iran’s answer, in the 11 days since, has been to bring the fight somewhere the Pentagon cannot so easily track on radar: the front doors of American embassies, consulates, and diplomatic compounds scattered across four continents.
THE SCORECARD: 11 DAYS OF ATTACKS ON DIPLOMATIC TARGETS
Feb 28  – Baghdad Green Zone — Katyusha rockets; U.S. Embassy, all consular services suspended.
Mar 1–2  Karachi, Pakistan — U.S. Consulate stormed; U.S. Marines fire on demonstrators.
Mar 2–3  Kuwait City — U.S. Embassy hit by drone; smoke reported; operations fully suspended Mar 5.
Mar 3 – Erbil, Iraq — U.S. Consulate and airport area struck; black smoke visible; consulate closed.
Mar 3–4  Dubai, UAE — U.S. Consulate targeted; six people injured by intercepted drone debris in Abu Dhabi.
Mar 3–5  Riyadh, Saudi Arabia — U.S. Embassy hit despite Saudi-Iran 2023 normalisation deal.
Mar 4–5  Bahrain — U.S. Navy Fifth Fleet HQ targeted; 75 missiles and 123 drones intercepted over five days.
Mar 5  Doha, Qatar — Voluntary departure ordered; 10 IRGC cell members arrested by Qatari authorities.
Mar 7  Baghdad Green Zone — Four Katyusha rockets hit the Green Zone; C-RAM systems engage.
Mar 8  Oslo, Norway — Backpack bomb detonates at U.S. Embassy consular entrance at 1 a.m.
Mar 8  Beirut, Lebanon — Israeli strike on Ramada Hotel kills four Iranian diplomats.
Mar 9  Toronto, Canada — Gunmen open fire on U.S. Consulate from a white Honda SUV at 4:30 a.m.
Mar 9  Liege, Belgium — Bomb explodes at synagogue; Iranian proxy network involvement suspected.
Mar 10  Baghdad — Baghdad Diplomatic Support Center struck; one drone hits guard tower.
Why Different Kind of Battle Front?
What makes this campaign different from anything Iran has attempted before is scale and geography. Tehran has always maintained what intelligence agencies call a “forward deterrence” doctrine, using proxy forces in Lebanon, Iraq, Yemen, and Gaza to keep the fight away from Iranian soil. But in 11 days, that doctrine has been turned outward, stretching from the Persian Gulf to Scandinavia to the Canadian lakeshore.
The numbers tell part of the story. The Islamic Resistance in Iraq alone claimed 67 separate drone and missile operations in the first three days. On Day Five, the IRGC announced it had fired 230 drones in a single coordinated wave at facilities hosting American troops across Iraq and Kuwait. Bahrain’s defence forces intercepted 75 missiles and 123 drones before the end of the first week. And still they kept coming.
Pentagon spokesman Sean Parnell put the U.S. position in the clearest possible terms at a Tuesday briefing, saying American forces had now struck more than 5,000 targets inside Iran and were not finished. Defence Secretary Pete Hegseth, speaking the same morning, was clearly confident: “Today will be, yet again, our most intense day of strikes inside Iran,” he said. “The most fighters, the most bombers, the most strikes. Intelligence more refined, and better than ever.” One drone hit the guard tower in Baghdad roughly four hours later.
Four Dead at Ramada, And a Letter Nobody Read
On the morning of March 8th, an Israeli airstrike hit the Ramada Hotel in Beirut. Inside were four Iranian diplomats: Majid Hassani Qandesar, second secretary at the Tehran embassy in Lebanon; Ali Reza Biazar, third secretary; Hossein Ahmadlou, Iran’s military attaché; and Ahmad Rasouli, a military mission officer. All four were killed.
Iran had moved them to the hotel specifically because the Israeli military had already announced its intent to strike Iranian diplomatic personnel in Lebanon. The relocation had been formally notified to the Lebanese Foreign Ministry under the terms of the Vienna Convention. Iran’s position is that Israel knew exactly where those men were, that Lebanon had been officially informed, and that the strike was therefore a premeditated assassination dressed up as a military operation.
Tehran’s UN Ambassador Amir Saeid Iravani sent a formal letter to Secretary-General António Guterres describing the strike as a criminal act and a fundamental breach of international protections afforded to diplomatic personnel. Iravani then went to the Security Council chamber and made the same argument to member states, accusing the Council of paralysis in the face of what he called an escalating pattern of impunity. The Council took note of his remarks and moved on to the next agenda item.
“The Council is turning a blind eye to this grave violation despite its primary responsibility under the UN Charter to maintain international peace and security,” said Iravani later.
Israel has not publicly commented on the specific targeting. Its broader position, maintained throughout the eleven days of operations, is that Iranian diplomatic cover in Lebanon has long served as camouflage for Quds Force commanders running operational networks against Israeli targets. Whether that justification holds under international law is a question being debated in academic journals and courtrooms that will take years to resolve. The four men at the Ramada will not see the verdict.
Oslo at 1 in the Morning
Two nights before the Toronto shooting, a backpack was left at the consular entrance of the United States Embassy in Oslo. It contained an improvised explosive device. The bomb detonated at approximately 1 a.m. on March 8th, causing minor structural damage to the entrance area and no injuries. Norwegian police launched an immediate investigation.
The timing, deep in the night, at a consular entry point, using a concealed device, carried the hallmarks of what European intelligence agencies have been tracking under the loose designation of Iran’s Foxtrot network: a series of clandestine proxy cells that, according to prior reporting by Swedish and Danish security services, have recruited members through criminal networks and social media platforms. The U.S. Embassy in Stockholm issued a warning about Iranian targeting operations through this network as far back as June 2025. In Oslo itself, a locally hired embassy guard had been convicted of espionage on behalf of Iranian intelligence just months earlier.
Norwegian Justice Minister Emilie Enger Mehl called the explosion unacceptable and said the government was treating it with the highest possible seriousness. No arrest had been made as of now.
4:30 A.M. in Toronto 
There is a particular kind of message that gets sent when gunmen choose 4:30 in the morning. The street is empty, the target is symbolic, the intent is to terrify without the risk of immediate apprehension. That calculation was made outside the United States Consulate in downtown Toronto on the morning of March 9th, when two men in a white Honda SUV pulled to the kerb, opened fire at the building’s glass-and-steel facade, and drove away. Nobody inside was hurt. The glass, as Toronto Police Deputy Chief Frank Barredo dryly noted, is reinforced.
Canadian Prime Minister Mark Carney called it a reprehensible act and an attempt at intimidation, expressing relief that there had been no casualties. Ontario Premier Doug Ford did not traffic in diplomatic language. Speaking to reporters, he said he was personally convinced that Iran had activated sleeper cells across North America and that the Toronto shooting was not an isolated incident. “We have to weed these people out and hold them accountable,” he said. “This is my personal opinion and I don’t think I’m too far off with saying that. It’s a different world now.”
In the days surrounding the shooting, two Toronto synagogues were also targeted by gunmen. An Iranian-Canadian boxing club was attacked. RCMP Chief Superintendent Chris Leather, heading the national security investigation, was careful to keep his language measured but acknowledged the self-evident: “Diplomatic premises everywhere,” he said, “currently warrant a sharply elevated level of vigilance.
I believe there are sleeper cells all over the world. They are in the U.S., they are in Canada. We have to weed these people out. It’s a different world now.

Washington’s number game

General Dan Caine, Chairman of the Joint Chiefs, told a Tuesday briefing that ballistic missile attacks originating from Iran had dropped by 90 percent since hostilities began and that one-way drone attacks had fallen by 83 percent. Hegseth called this strong evidence of military degradation. The inference he wanted reporters to draw was clear: “the campaign is working, Iran is running out of capacity, and the trajectory is toward resolution.”
Tehran’s newly installed parliamentary speaker Mohammad Bagher Qalibaf rejected any such reading on the same day, while senior official Ali Larijani posted a direct message to Donald Trump on social media: “Iran doesn’t fear your empty threats.” Trump, meanwhile, had issued his own posts warning that “any Iranian mines found in the Strait of Hormuz would trigger consequences at a level… never seen before.” The Strait remains effectively shut to commercial shipping.
A Quinnipiac University poll conducted over the preceding weekend found that roughly seven in ten registered American voters were worried the war would push energy prices higher, including approximately half of all Republican respondents. Gas stations in the Midwest were already showing it.
Ground Reality
The State Department’s formal tally as of Tuesday: nonessential personnel ordered out of Saudi Arabia, Kuwait, Qatar, Bahrain, Iraq, Jordan, the UAE, and the consulate in Adana, Turkey. Emergency departure assistance extended to approximately 23,000 private American citizens across the region. Secretary of State Marco Rubio waived the standard legal requirement for evacuees to reimburse the government for charter transport costs, a small procedural detail that signals how seriously Washington is treating the threat level.
In Iraq, Prime Minister Mohammed Shia al-Sudani publicly condemned the militia attacks as violations of his country’s sovereignty, a statement that would have carried more weight had his government the capacity to enforce it. The International Zone in Baghdad, which houses the U.S. Embassy along with dozens of other diplomatic missions, is now effectively sealed. The U.S. Consulate in Erbil has suspended all services. Al Jazeera correspondent Assed Baig, reporting from the Kurdish capital, put it plainly: “All these attacks taking place overnight and early this morning highlight how increasingly Iraq is becoming a battleground in this widening Middle East war.”
In Iran itself, the internet has been down for the better part of ten days. Cybersecurity monitoring group NetBlocks recorded the shutdown at over 240 consecutive hours by Tuesday, describing it as among the most severe government-imposed nationwide blackouts ever documented. Tens of thousands of civilians have left Tehran and other major cities for rural areas and family farms. A Tehran-based lawyer, speaking anonymously to an international broadcaster, described Basij paramilitaries in her neighbourhood as heavily armed and watching for any sign of domestic unrest even as bombs continued to fall.
Back in Baghdad, the smoke above the guard tower had cleared by nightfall Tuesday. The State Department alert remained the same. “Accountability,” is “ongoing.” Whether that accountability ever catches up with the drones, the backpacks, the drive-by shootings, and the hotel strikes is the question that eleven days of war have so far left entirely open.

US Energy Sec Chris Wright Quietly Deletes X Post on Navy Escorting Oil Tankers Cross Strait of Hormuz

U.S. Energy Secretary Chris Wright posted on X a little earlier today stating that the U.S Navy had escorted an oil tanker in the Strait of Hormuz, which is strategically important, in order to effectively guarantee that oil continued to flow into the world markets. The post was removed soon and it caused some confusion and quick backlash in the current U.S.-Israeli war against Iran.

The message that has been deleted mentioned that the Navy escort had done so to make sure that oil keeps flowing to world markets, as various sources and screenshots that were posted on social media confirm. The reason why Wright deleted the post is not clear, although the news outlets such as Reuters and others reported that no such escort operation had occurred. The U.S. Department of Defense and Central Command did not promptly confirm any escort operation and the claim to the passing of the Fox News was described by the military sources as not conforming to the reality.

Chris Wright

The conflict comes at a very sensitive moment when the traffic of tankers through the Strait of Hormuz, a narrow waterway between Iran and Oman through which about 20 percent of all the seaborne oil in the world passes, has been hard hit. Shipping has been much curbed by the skyrocketing war risk insurance rates, Iranian threats to attack ships, and a general caution among shipowners. Recent reports show that hundreds of tankers anchored or rerouted and some estimates show that millions of barrels of oil are trapped in the Persian Gulf.

The Revolutionary Guards of Iran were quick to disown the assertion. Spokesman Alimohammad Naini, who was quoted by the state media, termed it as a total lie and threatened to counter any movements of the U.S. or any other allied fleet with missiles and drones. Our missiles and drones will intercept any action of the US fleet and allies, said Naini.

Iran Puts Conditions Galore

It had the ability to momentarily affect the oil markets and some of the reports indicated that the prices dropped and then rose again above $80 per barrel as the deletion and the denials happened. This is after Wright had made previous remarks on TV that he minimized immediate dangers and that U.S. military activities were undermining the capacities of Iran to threaten shipping, and that flows would be restored soon again, possibly with naval escorts.

According to satellite and tracking information, the number of vessels passing through the Strait of Hormuz has reduced drastically since at the beginning of March and most of the tankers are concentrated in the relatively safer waters off the UAE and Oman.

The erasure has given rise to the speculation of miscommunication or prematureity in the administration since the administration of President Trump has indicated a number of times that it was willing to offer the protection of the commercial shipping should the conditions be in favor of it. But analysts observe that the masses of escorts are logistically difficult and dangerous considering the asymmetric threats of Iran. The trend highlights how unstable the world energy markets are during the conflict, as the oil prices fluctuate and the economic effects of the conflict continue to accumulate across the globe. More amendments are likely to follow with the Pentagon and the White House rectifying the discrepancy.

Less psychedelic, more medical magic mushrooms

The psychoactive substance of magic mushrooms, psilocybin, is under scientific scrutiny as being useful in the treatment of neuropsychiatric disorders such as depression, anxiety, substance use disorder and some neurodegenerative diseases. It can be limited to broader therapeutic uses, however, by the hallucinogenic effects. A study on the effects of psilocin, the active compound in psilocybin, on mice published in the Journal of Medicinal Chemistry by researchers synthesized modified versions of psilocin which preserve its properties but have fewer hallucinogenic-like effects than pharmaceutical-grade psilocybin.

In line with the emerging scientific view that psychedelic and serotonergic works can be decoupled, one correspondent author of the study, Andrea Mattarei, states that their findings align with this emerging school of thought. This creates the prospect of developing new therapies that are more biologically active but less hallucinogenic, which might allow developing safer and more practicable treatment options.

Mood disorders as well as certain neurodegenerative ailments such as the Alzheimer disease entail an imbalance of the neurotransmitter molecule serotonin that aids in controlling moods and other brain processes. Psychedelics have been studied to have therapeutic effects against serotonin-signaling pathways in decades by scientists. But the hallucinations that can be used along with these drugs can cause people to fear their use even in case there is a medical advantage.

Brain Image (NIH)

Therefore, a group supervised by Sara De Martin, Mattarei and Paolo Manfredi chemically engineered 5 psilocin analogs to release gradually, slowly and possibly non-hallucinogenic into the brain. The initial test of the five compounds was conducted using human plasma samples and the laboratory parameters that replicate gastrointestinal absorption. These tests have enabled the group to determine a compound they refer to as 4e as the best prospect since it exhibited desirable stability to be absorbed and allowed a slow release of psilocin – a trait that has the potential to reduce the effects of hallucinations. Notably, 4e was also active at major serotonin receptors, and at similar levels as psilocin.

The researchers then compared the impact of the same dosage of 4e on mice with pharmaceutical quality psilocybin. The team orally gave the compounds to mice and assessed the degree to which psilocin was absorbed by the bloodstream and the brain after 48 hours. The compound had the capability of penetrating the blood-brain barrier in mice treated with 4e and had a lower yet more prolonged presence of psilocin in their brain than did their psilocybin-treated counterparts. In examining the behavior of the mice, the researchers found that the 4e-treated mice had reduced the number of head twitches, a well-established oral psychiatric effect of psychedelics in rodents, with the 4e-treated mice compared to those treated with psilocybin having far fewer head twitches. This difference in behavior seemed to be linked with the quantity and the time that psilocin was released in the brain.

According to the researchers, the results of their experiments testify to the possibility of creating stable derivatives of psilocin penetrating the brain and preserving the function of serotonin receptors without acute psychotropic effects. Their mechanism of action and complete description of their biological effects will require further research before their therapeutic capacity and safety in human beings are evaluated.

The authors admit MGGM Therapeutics, LLC. funding in partnership with NeuroArbor Therapeutics Inc. Some of the authors state that they are patent holders regarding psilocin.

Australian researchers construct tiny AI chip that ‘travels’ at the speed of light

Australian scientists have developed a miniature-sized artificial intelligence (AI) chip that can perform computations based on the power of light, on a speed comparable to that of light.

The prototype of nano photonic chip, which uses the power of the light particles (photons) is entirely in-house in the Sydney Nano Hub in the University of Sydney.

According to the researchers, the prototype can be significant in creating more energy-efficient hardware in the field of artificial intelligence because the global demand of artificial intelligence is still increasing and such technology might reduce the total energy footprint of future computer systems.

Conventional computer chips are made using electricity to control information; that is, to move tiny and charged particles (electrons) with wire. This produces heat.

The prototype of nano photonic chip utilizes light. Light is able to pass through electrically non-resistant materials and hence does not produce heat in the same manner as electricity. The calculation is automatically done through the nanostructures as the light traverses the chip prototype.

The nanostructure of the chip occupies tens of micrometres, the thickness of a human hair. The combination of the nanostructures assists in creating a neural network: the artificial neurons that imitate the human brain to recognise and perform calculations.

The prototype is capable of calculations at the picosecond level, trillionths of a second – the duration in which light exits the nanostructure.

According to the researchers, the benefits of photonics use is that it is much faster and occurs at the speed of light. Light is also used to run the technology as opposed to electricity. This is in comparison to the existing data centres that use huge quantities of water and energy to operate them.

Professor Xiaoke Yi of the School of Electrical and Computer Engineering and director of the Photonics Research Group said that they had re-imagined how the photonics can be used to create new energy efficient and ultrafast computer processing chips.

Artificial intelligence becomes more or less limited to the energy consumption. This study carries out neural computation with light, which has been demonstrated to be faster, more energy-saving and can be made significantly smaller AI accelerators.

The study was published in Nature Communications, and it illustrates that AI models could be made into nanoscale photonic structures capable of manipulating light in such a way that the mathematical operations necessary to carry out machine learning could be implemented.

The researchers tested the nanophotonic chip by training it on over 10,000 biomedical images (breast, chest and abdomen MRI scans, etc.) and validated the technology.

The nanophotonic neural network demonstrated an approximation of 90 to 99 percent classification in simulations and experiments.

The technology provides a way forward to sustainable AI infrastructure which can facilitate the increasing needs of computing without the proportional increase in power usage.

Better, faster, stronger AI hardware

The science of light particles control is known as photonics, which is abbreviated to photon-based electronics. It has been applied in driving technology that is utilized in day-to-day lives like lasers, fiber-optic network and in medical imaging.

However, the harnessing of photonics to computer processing has been a relatively recent discovery and there has been a growing acuity as the need to harness AI demands grows.

The prototype demonstrates how intelligence can be incorporated directly in nanoscale photonic structures, according to PhD student Joel Sved who was instrumental in design and implementation of the prototype.

The Photonics Research Group of the University of Sydney has a long history of over 10 years of research on how to push the limits of photonics as well as how to upgrade our technology.

It involves application of photonics in solving problems in wireless communications and high-technology sensing that are able to detect and measure chemical or biological traces in the environment.

After the successful experiment with the prototype of the nanophotonic chip, the team headed by Professor Yi is currently developing the technology to the level of larger-scale photonic neural networks.

What is Rett Syndrome ? New study Opens Avenue to Cure This Rare Disorder

A group of researchers at the Texas Children Neurological Research Institute (NRI), Duncan, Baylor College of Medicine, found  a possible new therapy to cure Rett syndrome has been reported in the Science Translational Medicine journal, with the early signs of success in a neurodevelopmental disorder with no cure yet.

According to the corresponding author, Dr. Huda Zoghbi, the director of the Duncan NRI, Distinguished Service Professor at Baylor, and an investigator at the Howard Hughes Medical Institute, Rett syndrome is an uncommon genetic neurodevelopmental disorder that results in a developmental regression, usually past 6 to 18 months of normal development, followed by severe motor skill impairment, speech and communication impairment and communication impairment. The disorder affects girls mostly and it occurs in 1 out of 10,000 live births.

Loss-of-function mutations in MECP2 gene cause Rett syndrome, which plays a central role in normal brain functions since it controls the amount of various genes controlling neurological functions. These mutations cause the protein to disappear or code a faulty protein which cannot perform its normal function. Certain mutated forms of MeCP2 protein are also less abundant and/or reduced in terms of DNA binding, which is a key role in the functioning of this protein.

In mouse models of Rett syndrome, it has been demonstrated that the disorder is reversible, once normal MeCP2 protein is added in the brains of those mice, the conditions are reversible. Notably, it has been demonstrated by researchers that raising the concentration of a mutant MeCP2 protein that retains a minimal amount of functioning also enhances symptoms, such as survival, motor coordination and respiratory defects in mice.

The importance of this in that approximately 65 percent of patients with Rett syndrome have partially functional MeCP2, which is either less abundant or lacking DNA binding capacity, as compared to the normal level, according to the authors. Our study, on working with mouse models and cells obtained by patients with Rett syndrome, suggests evidence of concept that an increase in the levels of mutant MeCP2 in patients with the condition would be therapeutically beneficial.

Mechanism of the MECP2 gene 

The creation of therapeutics that regulate the level of MeCP2 is not that simple. A mutation to MeCP2 that is too small leads to Rett syndrome, but an excess of MeCP2 leads to another neurological disorder, MECP2 Duplication Syndrome. The balance of the question has been so delicate that it has been difficult to come up with safe and efficient treatments.

Zoghbi said that before this research, they had already learned that the brain normally forms two versions of the MeCP2 protein E1 and E2, which differ slightly. These versions are the result of the same gene, which gets processed in one direction to form E1 and in another to form E2.

Consider a gene as a blueprint of a protein. MeCP2 has four ingredients, which are e1, e2, e3 and e4. In order to produce the MeCP2-E1 protein, cells simply mix ingredients e1, e3 and e4. In order to create MeCP2-E2, the cells mix all four ingredients, which makes ingredient e2 peculiar to this form of the protein. Both versions are produced by the brain, but E1 is prevalent.

“We also learnt that no cases of Rett syndrome individuals have been reported to have mutations on E2 protein. The condition is only caused by mutations that interfere with E1 protein,” said Tirumala. This is supported in studies on mice.

“All in all, we have known that MeCP2-E2 is a single ingredient below MeCP2-E1 in the gene and it is not so abundant as E1 and not linked to Rett syndrome and is not required to support the MeCP2 activities in the brain,” Tirumala said. “This made us hypothesize that by instructing the brain cells to omit the e2 ingredient, the production of additional MeCP2-E1 protein in patients with Rett syndrome will be promoted and will lead to a better disease outcome. We have experimental evidence in the mice and cells of patients with Rett-syndrome to support our hypothesis.”

The researchers first genetically removed the ingredient e2 of normal Mecp2 gene in mice and evaluated the outcome of the deletion on the abundance of the protein and its neurological activity. Tirumala said that the results of this approach gave 50 to 60 percent MeCP2 protein increment in normal mice.

The researchers subsequently used the same strategy on the cells that were obtained using the patients with Rett syndrome that contained MECP2 mutations that decrease the abundance and activity of the protein. They removed the ingredient e2 in this mutant MECP2 gene and evaluated the impact of this mutation on the abundance of this protein and the attributes of these cells. Tirumala said that they were excited to find that MeCP2 production improved when ingredient e2 was deleted. Notably, with the degree of mutation, these cells reappeared with part or all of their usual structure, their usual electrical functions and their capability to control the level of other genes.

Lastly, the team evaluated the therapeutic potential of such an approach. Does a blocking drug of ingredient e2 elevate MeCP2 protein?

Tirumala said the value of morpholinos was tested to stimulate MeCP2 protein production in mice. “Morpholinos are artificial molecules to be used in this instance to inhibit the production of MeCP2-E2 protein by preventing the e2 ingredient to enter the cell,” explained Tirumala. “This was interesting because our morpholinos found to increase MeCP2 protein in mice tremendously.”

The work by Zoghbi and colleagues forms the basis and offers preclinical support to a treatment method of Rett syndrome involving the enhancement of MeCP2 and offering some functional recovery, Zoghbi said. Even though morpholinos are not an option due to their toxicity, analogous ones, such as antisense oligonucleotide therapies that are already being employed to treat other diseases, might be created in Rett syndrome.

Use of Boron in Proteins to Create New Treatments to Cure Cancer: Study

A large number of the most important proteins of modern medicine and science are insoluble. These comprise a host of signalling proteins and protein hormones, and all of the receptors embedded in the cell membranes, which are directed at approximately 60 percent of the active ingredients presently utilized in medicines. When the concentration of these proteins crosses some given level, they will form clumps and become useless.

This aggregation renders synthesis of these molecules in lab impossible. Since specialised production with specialised synthesing robots always needs more than a single fragment to be conjugated into a full protein, a single poorly soluble fragment of protein is usually sufficient to inhibit production. The reason is that the current techniques employed by chemists to assemble protein fragments merely perform successfully when the fragments exist in solution and in very high concentrations.

A team of researchers, headed by Jeffrey Bode, professor at the Laboratory of Organic Chemistry at ETH Zurich has now discovered how to couple even the poorly soluble portions of proteins into functional proteins. In order to do this, they utilized special properties of a chemical compound comprising an element named boron.

The slow carbon chemistry has a concentration constraint.

The only major difference between the ETH technique and the traditional strategies is in the rate of the coupling reaction. Unlike in biochemistry, which occurs extremely fast in cells of living organisms, through enzymes, reactions such as these typically need to be carried out at unnatural concentrations within the laboratory. The reason behind this is that the slower the reaction is taking place, the greater the concentration of the reacting substances should be so that the reaction processes take place as intended.

The novel coupling technique invented by the team of Bode is approximately 1000 times faster and thus was also applicable in 1000 times lower concentrations.

Boron opens up new opportunities bio-chemistry

The ETH chemists hastened the reaction by including Boron atoms to the carbon-based molecules. These are not found in natural molecules.

In several of its properties, the metalloid boron behaves in a somewhat different way. On bonding with metals, it forms very tough and heat-resistant metal alloys. Alternatively, it is capable of bonding with the nonmetals carbon, oxygen or nitrogen in the lab to form molecules that tend to have bizarre reaction characteristics. In 2010, Akira Suzuki, a Japanese researcher and Richard Heck, an American researcher, won the Nobel Prize in Chemistry due to the development of boron-based coupling reactions to enable laboratory synthesis of natural substances.

According to Bode, “We reach an ultimate limit of reaction rate with purely carbon based systems. It is further expansion into previously untapped boron based reagents that places us in a space where even the most recalcitrant reactions that bring large biological molecules together can occur in a very brief time.”

cancer cells/photo:en.wikipedia.org

Protective acids: a rocky road

As shown by Bode and colleagues in 2012, this was the first study to demonstrate that it was possible to add an element of a hitherto unexplored chemical group to proteins fragments and do so with great speed and stability. Nevertheless, this compound was not stable with strong acids hence could not be utilized in automated synthesis.

To endure the tough environment that was applied to the sensitive boron compound in normal laboratory robots, the compound would require protection in the form of a chemical packaging, but this was easier said than done. The researchers experimented with a number of strategies in four years to little effect.

The discovery was made by mistake and eventually, the discovery occurred when a doctoral student tried an experimental method that the team had indeed thought was ineffective. The resulting protective compound binds to the boron group on three sides, therefore, being unable to be terminated in the acids in protein production.

According to Bode, such fundamental research, in which there is no assurance of success, is feasible only due to the unrestricted funds provided by the Swiss National Science Foundation and ETH.

Inorganic amino acids and cancer treatment

The ETH method implies that new peptide and protein drugs or drugs of medical interest to cure cancer that are prone to clumping, can now be produced via the usual laboratory protocols.

Moreover, special amino acids that are not natural can also be incorporated in the location of choice on the poorly soluble proteins. As an example, the chemists can functionalized these building blocks in a protein in a specific way in case they wish to attach it to an active substance on a particular location. Some of the applications of antibody-drug conjugates prepared through this method include cancer treatment procedures that do not damage normal tissues.

The way in which the method will be applied to clinical practice is not yet clear. In 2020 Bode co-founded the ETH spin-out Bright Peak Therapeutics, which applications the technologies invented in his lab to build immunotherapies to fight cancer. A therapeutic agent has already entered clinical trials and the new method based on boron may assist in increasing the size of the product pipeline of the spin-off.

AI disclosure labels can be more harmful than good, finds Chinese Study

The increased application of AI-generated scientific and science-related texts, particularly social media, is the source of concern: they can include fake or highly persuasive information, which cannot be easily detected by the users, and can influence the way people think and make decisions.

Various jurisdictions and platforms are heading in the direction of explicitly disclosing AI-generated or AI-synthesised content to safeguard the population. Nevertheless, according to a recent study published in Jacom there is a risk that such labels can backfire, reducing the effectiveness of legitimate scientific knowledge and boosting alleged knowledge.

The Dangers of AI-Scientific Content.

AI content can be deceptive at least on two grounds. To start with, language models can hallucinate and make statements that are valid, but are factually incorrect. Second, the users can intentionally request AI systems to produce fake and plausible messages. Due to this reason, various nations have come up with transparency requirements whereby online content created or synthesized by AI should be clearly labeled.

Teng Lin, a PhD student at the School of Journalism and Communication, University of Chinese Academy of Social Sciences (UCASS), Beijing, and Yiqing Zhang, a Master student at the same school, in their new study tested whether these disclosure labels do what they claim they do; that is, protect the public against misinformation.

Experimental Study

According to Teng, they concentrated on science-related news posted on the social media.

The experimental research was conducted on 433 participants who were online recruited via the Credamo site in the month of March to May 2024. The authors developed four categories of social media posts, including correct information with or without an AI label, and misinformation with or without an AI label. The researchers used GPT-4 to adapt the texts based on the items published by the Science Rumour Debunking Platform in China to produce the correct and deceptive versions of the text in Weibo and were subsequently vetted by the researchers themselves. The participants were requested to provide a rating on the perceived credibility of each of the posts on the basis of 1 to 5. The negative attitudes of the participants toward AI and the level of engagement with this subject were also measured by the researchers.

A Paradoxical Effect

The findings showed an anti-intuitive trend. Teng says that its most significant result is what he refers to as a truth-falsity crossover effect. The same AI label creates two ways and two directions of credibility across messages as to whether the message is true or false where it lowers credibility of true messages and raises credibility of false messages. He further notes that it does not necessarily imply that the effect would be the same on all platforms or formats but in their experimentation the trend was evident.

In this regard, AI disclosure fails to assist individuals in selecting real and fake information. Rather, it seems to redistribute credibility in a counter-intuitive fashion.

Teng and Zhang also discovered that the personal attitudes towards AI are involved. The people with more negative attitudes to AI punished the correct information even more punishments when it was referred to as AI-generated. Nevertheless the credibility enhancement that was seen on misinformation did not entirely vanish in the negative attitudes, rather it was simply attenuated and was attenuated in topics specific manner, not being removed in general.

It implies that so-called algorithm aversion does not contribute to the homogeneous rejection of AI-generated content, but rather causes an even more sophisticated and asymmetrical response.

The necessity of a careful policy formulation.

Such studies emphasise the importance of thorough-testing the regulatory interventions before they are implemented because well-meaning transparency initiatives can have unintended effects.

Teng says, “We provide some recommendations in our paper but they have to be confirmed in order to be accepted as valid.” One of the suggestions is to use a dual-labeling protocol. Rather than just writing that the material is the result of the work of AI, a label might also contain a disclaimer, that the information has not been evaluated separately, or place a warning of a risk. In brief, it might not be enough to tell audiences that a text has been created by AI.

Another suggestion, Teng makes, is the use of graded or categorical system of labeling. Various forms of scientific information have varying risks. As an example, a warning can be more intense with medical or health-related information and less serious with information about new technologies. “Accordingly, we would propose various degrees of disclosure, based on the nature and the risk of the content.”

Europe Deforestation to Double, Predicts AI Study Citing Fires, Storms and Bark Beetles

A new study estimated the extent to which the area covered by Europe in forest could be disturbed by fire, storms, and bark beetles by the year 2100 in varying climate conditions. With satellite data and forest simulations, an artificial intelligence model predicted the disturbances on a continental scale using 13,000 points in Europe.

In every case, disturbances of the forests in the future were greater than it is today, with great impact on forests and services to the society.
There is a significant effect of wildfires, storms, and even bark beetles on forests and the benefits that they bring to people and environment.

This is the first time when a big international team of researchers at the Technical University of Munich (TUM) has computed how disrupts would alter the forests in Europe in the year 2100. In even the most optimistic of scenarios, the team does project a significant expansion of the damaged forest area, in the worst case, the disturbance might even be doubled.

It is not novel that trees die, and in fact, it is a normal process in the forest that is in the process of natural dynamics whereby old trees die, young trees regenerate and become the next generation of canopy trees.

The new thing is the magnitude of how wildfires, storms, and bark beetles are transforming forests due to the change of climate. The amount of forest destruction in Central Europe demonstrated dramatic figures in recent years, however until this time it was unknown how much the area covered by forests could be deterred by future disturbances. The disturbances define the carbon storage capacity of the forests, the timber they are capable of offering, and the habitats of which species they are able to offer, thus making the results very significant to the policymakers and society.

A great number of researchers headed by Professor of Ecosystem Dynamics and Forest Management, Rupert Seidl, TUM, has now filled this gap in knowledge. The researchers have approximated that, the space disrupted by fires, storms, and bark beetles might increase threefold by 2100 with a global warming of slightly above 4 degrees Celsius.

The researchers used remote sensed data as a reference point between 1986 and 2020, a timeframe that experienced abnormally high disturbance in the forests. Although it is in the best scenario, the researchers are projecting increased destruction of forests in future compared to this reference period even with the warming of about 2 degrees Celsius.

Regional differences

In combination with 13,000 simulations of forests in Europe, the model was an AI-based simulation, which was trained on 135 million data points of forest simulations and multi-decadal satellite data of forest disturbances. This enabled them to model how the forests would develop in future and how disturbances would occur and penetrate to the scale of a single hectare providing very accurate information on regional variation in future forest disturbance patterns.

A view of Białowieża Forest, Belarus-Poland. CREDIT: IUCN Elena Osipova

The study has indicated that forests in Southern and Western Europe will be affected especially and will experience the strongest forest disturbances.

The overall impact of the future on Northern Europe is less expected to be severe, though the hotspots of the future forest damage are predicted to appear as well. According to Rupert Seidl, disturbances are becoming a cross-regional problem, that is, they destroy timber markets in Europe and endanger the ecosystem services that forests bring to society.

The study authors hence regard the growing disturbance rates as being an urgent demand on forest policy and management to consider: “We should be ready to witness a lot of forest damage in the near future. On the one hand, this implies that we have to prepare and cushion against more severe changes in the services forests offer. Conversely, disruptions also provide a chance to create new and climate-resistant forests – they are agents of change,” said Seidl.

Forestry has to meet the threat and the opportunity of increasing the level of disturbance, with the help of new scientific techniques and knowledge, explained Seidl.

When Trump Came for Everyone With Tariffs, China Fought, Europe Flinched, Japan Bowed; India Simply Walked Away

There is a test that powerful countries administer to everyone else every few decades. It is not announced formally. There is no letter, no ceremony, no official notice. The test arrives disguised as a trade policy. You discover you are being tested only by watching how you respond.

Trump administered that test in 2025. The tariffs were the instrument. The real question underneath them was simpler and older: how much humiliation will you absorb to keep America happy?

Every major economy answered differently. The answers were more revealing than any diplomatic communiqué.

China Bled First, Then Negotiated

China did what China always does when cornered. It hit back.

The moment Trump’s tariffs landed, Beijing retaliated, hard, fast, and with surgical precision aimed at the American constituencies that hurt most. Agriculture. Soybeans. Pork. The farmers in Iowa and Kansas who had voted for the man now watching their export markets evaporate. Bilateral tariff rates escalated rapidly until both sides were effectively taxing each other’s goods at 125 per cent, a trade war in everything but name, conducted with the cold efficiency of two countries that understand leverage.

It lasted months. It cost both sides real money. And then, in May 2025, they sat down and cut a deal, tariffs rolled back to ten per cent, a 90-day truce extended in August, formalised for a full year by November.

China did not get everything it wanted. But it negotiated from a position of demonstrated willingness to inflict pain. Washington knew, going into those talks, that Beijing had already shown it could make the phone ring in congressional offices across the Farm Belt. That knowledge shaped every sentence of the agreement.

You do not get a good deal by being easy to ignore.

Canada Went Loud, Then Went Quiet

Canada’s response was emotional, immediate, and very Canadian, which is to say it was righteous, noisy, and ultimately pragmatic.

Within hours of Trump’s announcement, Prime Minister Trudeau slapped 25 per cent retaliatory tariffs on $155 billion worth of American goods. Ontario pulled every bottle of American alcohol from government-run liquor shelves. Provincial premiers held press conferences. The phrase “economic sovereignty” appeared in Canadian newspapers approximately ten thousand times in a single week.

Then, by June, Canada paused further retaliation and entered negotiations. The shelves were quietly restocked. The trade talks ground on behind closed doors, away from the cameras that had captured all the initial fury.

Canada had made its point. It had shown it was not a pushover. It had then returned to the business of being America’s largest trading partner and closest neighbour, because geography and economics do not pause for diplomatic theatre.

The noise was genuine. So was the accommodation that followed. Canada fought for its dignity and then negotiated for its interests. Both things can be true simultaneously.

Europe Built Its Weapons and Never Used Them

The European Union spent much of 2025 in a state that can only be described as armed paralysis.

Brussels prepared retaliatory lists covering nearly €72 billion of American goods. It drafted legislation activating the Anti-Coercion Instrument — a legal mechanism designed specifically for moments like this one. It threatened to go after American services, American tech platforms, American financial firms operating within EU borders. The paperwork was meticulous. The political will was not.

Europe blinked. Repeatedly. Quietly. Without ever formally announcing that it had blinked.

The reasons were not difficult to identify. European economies depend on American markets to a degree that makes genuine trade war genuinely painful. And Europe’s dependence on Washington’s military support for Ukraine, a war being fought on European soil, paid for partly with American weapons, meant that Brussels could not afford to turn a trade dispute into an alliance crisis. Trump knew this. He had always known it. The tariffs on Europe were, in part, a test of exactly that dependency.

Europe failed the test by passing on the opportunity to take it. It armed itself thoroughly and then stood very still, hoping the moment would pass.

It mostly did. The cost was invisible but real, the credibility of the threat had been spent without anything to show for it.

Japan Bent the Knee and Got a Discount

Japan’s response was, in historical context, entirely unsurprising. It notified the World Trade Organisation of its intent to suspend concessions on steel, aluminium, automobiles and parts. It made the appropriate official noises. Then it negotiated.

Tokyo’s instinct, refined across a century and a half of managing the American relationship, through gunboat diplomacy and occupation and Nixon’s triple shocks and Bush’s dinner table incident, is always to find the accommodation rather than force the confrontation. Japan reached a trade agreement setting tariffs on its goods, including automobiles, at 15 per cent. Significantly below the 25 per cent that had been threatened. Meaningfully better than nothing.

Japan conceded. Japan got a discount. Japan went home.

There is no contempt in that observation. Japan’s circumstances, 54,000 American troops on its soil, an American-authored pacifist constitution embedded in its foundational law, a security architecture built entirely around the US-Japan alliance, leave Tokyo with genuinely limited room to manoeuvre. Japan knows this. Washington knows Japan knows this. The discount was the acknowledgement that Japan had been a cooperative subject.

A discount is not the same as respect. But it is what cooperative subjects receive.

Brazil Made Speeches

Brazil’s President Lula gave several impassioned addresses about sovereignty, fairness, the rights of developing nations, and the injustice of a global trading system designed by the powerful for the powerful. The speeches were good. They were well-delivered. They contained several genuinely quotable passages.

Brazil did not fire a single retaliatory shot.

Not one.

It evaluated potential measures. It confirmed willingness to negotiate. It reserved its position. It talked loudly, at length, and carried nothing at all.

And Then There Comes India

India did not retaliate. It did not make speeches. It did not prepare retaliatory lists it never used or schedule press conferences to announce tariffs it never imposed.

It filed a WTO challenge, a legal mechanism, quiet and procedural, that signalled disagreement without escalation. It absorbed the blow. And then it got on with its own business, which turned out to be rather more interesting than anything Washington had planned for it.

When Trump publicly claimed credit for mediating the India-Pakistan ceasefire after the May 2025 conflict, India rejected the claim flatly. No US role in the military negotiations, New Delhi said. Full stop. No diplomatic softening. No grateful hedging.

When Trump claimed India had agreed to slash its duties to zero, purchase $500 billion in American goods, and stop buying Russian oil entirely, Indian authorities confirmed none of it. Oxford Economics described the claims as unrealistic. India said nothing publicly and kept buying Russian oil, which it had been doing all along, which it continued doing through February 2026, and for which it eventually received a waiver from the very Treasury Department that had spent months punishing it for exactly this behaviour.

When Trump intensified outreach to Pakistan, even as he was hitting India with 50 per cent tariffs, India noted the irony and said nothing.

When the EU came calling, India signed what European Commission President Ursula von der Leyen called the “mother of all deals” — a trade agreement delivering an estimated €30 billion in export gains for both sides, accompanied by a defence pact. Modi then signalled warming relations with China. Precisely the strategic drift that Washington’s tariff pressure had been designed to prevent was happening, visibly, in full public view.

India’s exports to the US dipped 12 per cent in the final quarter of 2025. India’s economy grew 8.2 per cent in the same period, driven by its domestic market, which is large enough to not need Washington’s permission to function.

The tariff eventually came down to 18 per cent in the February 2026 truce. Trump announced it as a triumph. India accepted it as a correction.

What the Answers Tell You

China showed that if you make the cost of the tariff high enough, Washington will negotiate. Canada showed that you can be angry and practical simultaneously. Europe showed that a threat only works if you are willing to pull the trigger. Japan showed that a century of accommodation produces a discount, not dignity. Brazil showed that rhetoric unaccompanied by action is indistinguishable from silence.

India showed something different. It showed that a country large enough, confident enough, and strategically patient enough does not need to choose between fighting and submitting. It can simply decline to play on those terms, grow its economy, sign deals with other partners, wait for the logic of geography and demography to reassert itself, and let Washington eventually arrive at the conclusion India had been sitting on all along.

Trump came for India with tariffs, public insults, selective punishment, and demands that India manage its energy policy according to American geopolitical convenience. India filed a WTO complaint, kept buying Russian oil, grew at 8.2 per cent, signed a landmark deal with Europe, and waited.

China fought. Canada shouted. Europe trembled. Japan bowed. Brazil talked.

India walked away.

And Washington eventually followed when it conceded Russian oil for India amid Iran war.

Trump Called Starmer ‘No Churchill’ But History Has a Different Tale for Trump, Unfolding in Iran

Donald Trump has a Churchill problem. Not the kind he thinks.

When British Prime Minister Keir Starmer hesitated to open UK military bases for the Iran strikes last week, Trump was furious. Standing in the Oval Office beside German Chancellor Friedrich Merz, he delivered his verdict on the special relationship in nine words: “This is not Winston Churchill that we’re dealing with.”

The implication was clear. Churchill would have said yes immediately, bombed enthusiastically, and never flinched. Starmer — cautious, legalistic, quietly horrified — was cast as the timid contrast to the great wartime bulldog.

But here is what Trump’s Churchill invocation leaves out: the real Churchill didn’t just bomb his enemies. He also tried to talk to them. He negotiated. He built alliances painstakingly. He worried constantly about unintended consequences. He wrote, after witnessing the Boer War as a young officer, that once the signal for conflict was given, statesmen lose control of events.

That warning has aged remarkably well. It is, in fact, the story of the past ten days.

“I Got Him Before He Got Me”

The strikes that killed Ayatollah Ali Khamenei on February 28 were not framed by the White House in the language of grand strategy. Trump was more direct than that. “I got him before he got me,” he told ABC News, referencing Iranian-backed plots to assassinate him during the 2024 election cycle. In a separate conversation with The Atlantic, he admitted that Iran had offered significant concessions in the final round of nuclear talks — but that his recent military successes, including the capture of Venezuela’s Nicolas Maduro, had made him feel he could demand more. “A year ago, it would have been great to accept that deal,” he said. “But we have become spoiled.”

Personal vendetta and military overconfidence, in other words, sat alongside any strategic calculation. The killing of Khamenei was, by Trump’s own account, partly about scores settled.

Then the consequences arrived — exactly as they always do.

The Heir Nobody Wanted, the Oil Shock Nobody Needed

Within nine days of Khamenei’s death, his son Mojtaba was installed as Supreme Leader. Brent crude punched above $114 a barrel. The Strait of Hormuz — through which roughly one fifth of the world’s daily oil supply travels — was effectively sealed. Iran kept launching missiles, now with the new supreme leader’s name inscribed on the warheads.

The regime did not crumble. It promoted from within and kept shooting.

This outcome was not unforeseeable. In fact, it was predicted — repeatedly, by historians, strategists, and the kind of sober analysts Trump tends to dismiss. The belief that removing one man from the top of a hostile state will unravel that state is among the most persistent and most thoroughly disproven assumptions in modern warfare. It doesn’t matter how precisely the strike is executed. The system underneath simply replaces whoever falls.

Yamamoto died over the Solomon Islands in 1943, shot down by American fighters after US codebreakers intercepted his travel plans. Japan kept fighting for two more years. Saddam Hussein survived the opening “decapitation strike” of the Iraq War, and when he was eventually caught, dishevelled and hiding underground, the country did not stabilise — it fractured along lines that bled for the next two decades. The CIA tried to kill Fidel Castro at least eight times between 1960 and 1965, deploying methods ranging from poison pills to an exploding cigar. Castro outlasted ten American presidents.

None of these precedents stopped Trump. None of them ever stop anyone, which is precisely the point.

What Churchill Actually Believed

Trump invoked Churchill as the archetype of resolve — the leader who never hesitated, never lawyered, never blinked. The historical record is more complicated.

Churchill’s actual strategic philosophy, documented across decades of speeches, memoirs and private correspondence, rested on a specific combination: negotiate from positions of strength, but always keep channels of communication open with adversaries. Even during the Cold War, at the height of his anxieties about Soviet power, he pursued the idea that western strength might eventually bring Moscow to the table. Firmness and diplomacy were, in his mind, not opposites but partners.

He was also deeply clear-eyed about Iran specifically. Churchill had attended the 1943 Tehran Conference, sitting between Roosevelt and Stalin as allied leaders carved up wartime arrangements. He emerged sobered, aware that Iran sat at the intersection of competing great-power interests and that interventions there carried long historical tails. A decade later, the Anglo-American coup that toppled Iranian Prime Minister Mohammad Mosaddegh in 1953 — in which Churchill’s government was intimately involved — produced exactly the kind of unintended consequence he feared: it handed the Islamic Republic its founding grievance, a story of western interference that the regime has weaponised for legitimacy ever since.

Trump’s Churchill, in other words, is a simplified cartoon of the man — the bulldog without the brain, the fighter stripped of the diplomat.

A War Trump Is Now Fighting Alone

The Churchill jibe has also exposed something Trump didn’t intend to reveal: just how isolated the United States is in this war.

After a year of tariff threats, diplomatic insults, and the systematic alienation of European partners, Trump launched a major military operation with only Israel beside him. Britain eventually allowed limited use of its bases for defensive strikes, but drew a clear legal boundary around wider involvement. France’s Emmanuel Macron declared the strikes illegal under international law. Spain barred American military planes from its jointly operated bases in Andalusia — and received a trade war threat in response. NATO intercepted an Iranian missile near Turkish airspace, but the alliance has moved carefully to avoid being dragged deeper in.

“This is not Winston Churchill we’re dealing with,” Trump said of Starmer. The irony is that Churchill’s entire doctrine of Western power rested on precisely the alliances Trump has spent years eroding.

The War That Was Supposed to End Quickly

Trump told ABC News the Iran operation could last weeks. He demanded Iran’s “unconditional surrender” on social media. He said the strike had been so successful it had killed most of the post-Khamenei candidates he had identified — “second or third place is dead” — as if the problem of Iranian governance could be resolved by eliminating enough people on a list.

At least 1,230 Iranians have been killed since the strikes began, according to the Iranian Red Crescent. Over 120 died in Lebanon. Ten Israelis have been killed by Iranian attacks. Oil is above $114 a barrel. Asian markets recorded their worst single session since the COVID crash of 2020. Mojtaba Khamenei is firing missiles under his own name.

Churchill wrote, reflecting on a lifetime of wars, that once the signal for conflict is given, statesmen lose control of events. That insight didn’t make him a pacifist. It made him careful.

Trump saw Churchill and thought: warrior. History offers a fuller picture — a man who understood that the hardest part of any war is not the killing. It is knowing what you want the morning after.

That morning is arriving in Tehran now. The question of what comes next has no clear answer. And the man who ordered the strike, confident and unilateral, is discovering what every leader who has walked this road before him eventually discovers:

Decapitation is easy. What follows is not.

Sensex Falls 1,097 Points, Nifty Down 315 as Iran Crisis Rattles Markets, Oil Above $100 per Barrel

Escalating tensions involving Iran have unsettled global financial markets, with Indian equities and the rupee facing pressure as investors react to rising crude oil prices and geopolitical uncertainty in West Asia.

Domestic benchmark indices slipped sharply in recent sessions as risk sentiment weakened. The BSE Sensex fell about 1,097 points, or 1.4 per cent, to close at 78,918.90, while the Nifty 50 dropped 315 points, or 1.3 per cent, to settle at 24,450.45 as investors turned cautious amid the growing geopolitical crisis.

The broader trend during the week also reflected heightened volatility. The Sensex recorded a weekly decline of about 3.08 per cent, tracking weakness in global markets as oil prices climbed amid concerns about potential disruptions to energy supplies from the Middle East.

For India, the primary risk from the Iran crisis lies in crude oil. Brent crude prices surged sharply, at one point rising above $100 per barrel for the first time in nearly four years as the Iran conflict escalated and Ayatollah Mojtaba Khamenei was chosen as supreme leader.

WTI crude was trading at $108.66, up $17.76 or 19.54%, while Brent crude was at $108.69, up $16.00 or 17.26%, as traders priced in the possibility that an escalation could affect shipments through the Strait of Hormuz, a crucial maritime route for global energy trade.

Heavily Dependent on Oil Imports

India is particularly vulnerable to such shocks because of its heavy dependence on imported oil. The country imports more than 85 per cent of its crude oil requirements, meaning any sustained rise in prices can quickly increase the import bill, put pressure on the rupee and add to inflationary concerns.

Market participants say geopolitical tensions have already injected volatility into equities, with investors shifting to safer assets while trimming exposure to riskier markets.

Ponmudi R., CEO of Enrich Money, said investors should brace for continued swings in the market as geopolitical developments unfold. He said “the week ahead is likely to remain volatile” as tensions in the Middle East continue to shape investor sentiment.

Sectoral impacts are expected to vary depending on exposure to crude oil and global trade flows. Industries that rely heavily on fuel or petrochemical inputs — such as aviation, paints and chemicals — could face pressure on margins if oil prices remain elevated. On the other hand, energy producers and some defence-linked companies could see gains as commodity prices rise and geopolitical tensions increase.

Strait of Hormuz Poses Real Challenge

Another key concern for India is the security of shipping routes. A large share of India’s crude imports passes through the Strait of Hormuz, making any disruption in that corridor a major risk for the economy. Even the threat of disruption can push up insurance and freight costs, raising expenses for importers and exporters alike.

Global investor sentiment has also turned more cautious as the crisis deepens. Analysts note that Indian equity markets have already fallen about 4 per cent within two days of the conflict escalating, underscoring how quickly geopolitical shocks can reverberate through financial markets.

Veteran investor Jim Rogers warned that oil prices could climb further if the conflict intensifies. He said crude “could definitely cross $100 a barrel again” if geopolitical tensions escalate.

Despite the immediate volatility, market observers say the long-term impact on Indian equities will depend on how prolonged the crisis becomes. If tensions ease and oil prices stabilise, markets may recover. However, a prolonged conflict that disrupts energy supplies or shipping lanes could keep Indian markets under pressure in the weeks ahead.