After disconnecting the ground and rocket-side plates on the interface, called a quick disconnect, for the liquid hydrogen fuel feed line, teams have replaced the seals on the Space Launch System rocket’s core stage associated with the liquid hydrogen leak detected during the Artemis I launch attempt Sept. 3.
Both the 8-inch line used to fill and drain liquid hydrogen from the core stage and the 4-inch bleed line used to redirect some of the propellant during tanking operations were removed and replaced this week.
NASA’s Space Launch System (SLS) rocket is seen at Launch Pad 39B Thursday, Sept. 8, 2022, at NASA’s Kennedy Space Center in Florida as teams work to replace the seal on an interface, called the quick disconnect, between the liquid hydrogen fuel feed line on the mobile launcher and the rocket. Photo Credit: (NASA/Chad Siwik)
Coming up, technicians will reconnect the umbilical plates and perform inspections over the weekend before preparing for a tanking demonstration as soon as Saturday, Sept. 17. This demonstration will allow engineers to check the new seals under cryogenic, or supercold, conditions as expected on launch day and before proceeding to the next launch attempt.
NASA/Photo: Nasa.gov
During the operation, teams will practice loading liquid hydrogen and liquid oxygen in the rocket’s core stage and interim cryogenic propulsion stage and getting to a stable replenish state for both propellants.
Teams will confirm the leak has been repaired and also perform the kick-start bleed test and a pre-pressurization test, whichwill validate the ground and flight hardware and software systems can perform the necessary functions required to thermally condition the engines for flight. Following the test, teams will evaluate the data along with plans for the next launch opportunity.
Engineers are making progress repairing the area where a liquid hydrogen leak was detected during the Artemis I launch attempt Sept. 3, and NASA is preserving options for the next launch opportunity as early as Friday, Sept. 23.
Technicians constructed a tent-like enclosure around the work area to protect the hardware and teams from weather and other environmental conditions at Launch Pad 39B. They have disconnected the ground- and rocket-side plates on the interface, called a quick disconnect, for the liquid hydrogen fuel feed line, performed initial inspections, and began replacing two seals – one surrounding the 8-inch line used to fill and drain liquid hydrogen from the core stage, and another surrounding the 4-inch bleed line used to redirect some of the propellant during tanking operations. The SLS rocket and Orion spacecraft are in good condition while remaining at the launch pad.
Once the work is complete, engineers will reconnect the plates and perform initial tests to evaluate the new seals. Teams will check the new seals under cryogenic, or supercold, conditions no earlier than Sept. 17 in which the rocket’s core stage and interim cryogenic propulsion stage will be loaded with liquid oxygen and liquid hydrogen to validate the repair under the conditions it would experience on launch day. Engineers are in the process of developing a full plan for the checkouts.
Artemis I logo/NASA
NASA has submitted a request to the Eastern Range for an extension of the current testing requirement for the flight termination system. NASA is respecting the range’s processes for review of the request, and the agency continues to provide detailed information to support a range decision.
In the meantime, NASA is instructing the Artemis team to move forward with all preparations required for testing, followed by launch, including preparations to ensure adequate supplies of propellants and gases used in tanking operations, as well as flight operations planning for the mission. NASA has requested the following launch opportunities:
Sept 23: Two-hour launch window opens at 6:47 a.m. EDT; landing on Oct. 18
Sept. 27: 70-minute launch window opens at 11:37 a.m.; landing on Nov. 5
NASA’s teams internally are preparing to support additional dates in the event flexibility is required. The agency will evaluate and adjust launch opportunities and alternate dates based on progress at the pad and to align with other planned activities, including DART’s planned impact with an asteroid, the west coast launch of a government payload, and the launch of Crew-5 to the International Space Station.
NASA/Photo: Nasa.gov
Listen to a replay of today’s media teleconference on the status of the Artemis I mission. Artemis I is an uncrewed flight test to provide a foundation for human exploration in deep space and demonstrate our commitment and capability to extend human existence to the Moon and beyond.
NASA is awarding more than $4 million to institutions across the U.S. to help bring the excitement of authentic NASA experiences to groups of middle and high school students who are traditionally underserved and underrepresented in STEM.
The new Space Grant K-12 Inclusiveness and Diversity in STEM (SG KIDS) opportunity will boost these students’ sense of belonging in STEM subjects, a critical first step toward STEM degrees and careers.
SG KIDS is a pilot program made possible through NASA’s National Space Grant and Fellowship Project, which comprises Space Grant Consortia led by an institution in each of the 50 states, the District of Columbia, and Puerto Rico. This opportunity represents a new approach by asking the awarded consortia to reach beyond state boundaries to create regional projects tailored to students in those areas. Through partnerships, the awardees will be able to share these exciting STEM opportunities with students residing in other states.
sg_kids_award/Photo: NASA
“Through Space Grant KIDS, we’ve asked the nation’s Space Grant consortia to deploy educational activities across state lines to share the excitement of NASA and STEM with students who otherwise might not have that opportunity,” said Mike Kincaid, NASA’s associate administrator for the Office of STEM Engagement, which administers NASA Space Grant. “We’re looking forward to seeing how these regional partnerships will make a lasting difference for the Artemis Generation.”
SG KIDS addresses the White House Executive Order on Advancing Racial Equity and Support for Underserved Communities Through the Federal Government, as well as NASA Administrator Bill Nelson’s focus on providing authentic STEM opportunities to K-12 students.
The projects funded under SG KIDS will provide students with hands-on experiences and lessons that bring NASA’s missions to life, provide training and resources to the educators teaching those students, and boost the STEM ecosystem in these regions.
NASA/Photo: Nasa.gov
“Space Grant KIDS is designed to establish networks that deliver enriching NASA STEM experiences to underserved student populations,” said Dr. Erica Alston, NASA’s deputy Space Grant manager. “We can leverage these networks to reach traditionally overlooked groups in future DEIA efforts.”
Each of the four grantees, Virginia Space Grant Consortium, Georgia Space Grant Consortium, Ohio Space Grant Consortium and Texas Space Grant Consortium, will receive approximately $1,050,000 in cooperative agreements to put their proposals into action during the next three years.
Ovarian cancer is most often found in people of middle-age or older as the Wilmot study showed that the mean age of participants was 56.
Of the 183 participants, 42 were found to have ovarian cancer, which is 23 percent. The technology also discovered that 20 other participants had non-ovarian cancers.
Ovarian cancer symptoms can be vague, such as gas and bloating, but there are some that should not be ignored, Moore said: pelvic pain or pressure, feeling full quickly after eating, vaginal discharge or abnormal bleeding, urgency to urinate frequently, fatigue, upset stomach, pain during sex, constipation, or menstrual changes.
Because ovarian cancer is most often diagnosed in later stages.
A new type of technology can capture stray ovarian cancer cells from a simple blood test and successfully predict cancer in people who have a lesion or cyst in the pelvic region, according to a new study by a Wilmot Cancer Institute physician/scientist.
Nearly 200 local people participated in the study.
One of those local participants, Toni Masci, 51, of Fairport, took part in Moore’s study by providing blood samples for analysis. She had an ovarian cyst that burst — only to find out that a large tumor was also in her abdomen. She was treated with surgery and six rounds of chemotherapy in 2017 for stage 1 ovarian cancer, and just celebrated the milestone of five years in remission.
“I feel lucky to be part of this,” Masci said. “As most people know, ovarian cancer usually doesn’t get detected early. If Dr. Moore hadn’t been doing this research, we might not have had this advance and I might not be here.”
Currently, there is no routine ovarian cancer screening method available for people who do not have symptoms or a known lesion. And yet, the new technology, called a “liquid biopsy,” developed by United Kingdom-based ANGLE PLC, and the URMC team at Wilmot, advances the field in a couple of important ways, according to the study:
It confirmed for physicians quickly and accurately that cancer was present in patients who were scheduled for surgery or other procedures. The detection enabled physicians to classify which patients needed immediate care from a specially trained gynecological oncologist to improve survival.
The study analyzed gene expression from captured cells in blood and evaluated 72 different gene transcripts and seven blood biomarkers related to ovarian cancer (including CA125). From this collection, the study identified nine gene transcripts and four biomarkers that were useful for detecting cancers. They were used to develop an algorithm known as MAGIC (Malignancy Assessment using Gene Identification in Captured Cells). The algorithm achieved a sensitivity of 95 percent and an accuracy of 83 percent for detecting ovarian cancer.
In the clinical trial, MAGIC also was able to detect ovarian cancer in early and late stages. Early-stage detection is critical for survival and difficult to achieve. And, the test picked up other types of cancer that had spread to the pelvic region or originated there.
“This is an important step forward for the detection of ovarian cancer in patients with a pelvic mass,” Moore said. “The fact that we can capture circulating tumor cells and analyze them from a simple blood draw is extremely exciting.”
Being able to find circulating tumor cells is the key, Moore said. These are rare, living cells that break off from the original tumor. They have an estimated ratio in the blood of one in 100 million to one in one billion. The technology captures the rare cells and allows for genetic analysis in a single tool within a couple of hours.
Currently, if a person has a suspicious lesion, surgery is necessary to diagnose ovarian cancer, and annually, more than 200,000 people in the U.S. are in this situation. A non-invasive test that predicts malignancy beforehand would enable people with the highest risk to have surgery done by an oncology specialist with greater experience and surgical volume for these types of cases, Moore said.
Masci, a U.S. Navy veteran and esthetician at a local salon, was 46 years old in January 2017 when her cancer was diagnosed.
“I was in such shock,” she said. “Looking back, I did have some symptoms: bloating, my back hurt, weight loss, and when I would sit down to eat I would feel full right away.”
She enrolled in the study a month later, and Moore performed her ovarian cancer surgery.
“I had wonderful care from everyone at Wilmot,” Masci added, “but I can’t say enough good things about Dr. Moore. He needs to clone himself a million times.”
ANGLE Europe Limited funded the study. Moore has worked extensively with the company to test its detection system. Earlier this summer, the FDA gave approval for the same tool to be used to track breast cancer cells that have spread. Moore’s lab was the sole location nationally to test the reproducibility of the breast cancer tests, and local residents were also involved in that clinical trial.
Nature likes spirals – from the whirlpool of a hurricane, to pinwheel-shaped protoplanetary disks around newborn stars, to the vast realms of spiral galaxies across our universe.
Now astronomers are bemused to find young stars that are spiraling into the center of a massive cluster of stars in the Small Magellanic Cloud, a satellite galaxy of the Milky Way.
The outer arm of the spiral in this huge, oddly shaped stellar nursery called NGC 346 may be feeding star formation in a river-like motion of gas and stars. This is an efficient way to fuel star birth, researchers say.
The Small Magellanic Cloud has a simpler chemical composition than the Milky Way, making it similar to the galaxies found in the younger universe, when heavier elements were more scarce. Because of this, the stars in the Small Magellanic Cloud burn hotter and so run out of their fuel faster than in our Milky Way.
Though a proxy for the early universe, at 200,000 light-years away the Small Magellanic Cloud is also one of our closest galactic neighbors.
The massive star cluster NGC 346, located in the Small Magellanic Cloud, has long intrigued astronomers with its unusual shape. This shape is partly due to stars and gas spiraling into the center of this cluster in a river-like motion. ILLUSTRATION: NASA, ESA, Andi James (STScI)
Learning how stars form in the Small Magellanic Cloud offers a new twist on how a firestorm of star birth may have occurred early in the universe’s history, when it was undergoing a “baby boom” about 2 to 3 billion years after the big bang (the universe is now 13.8 billion years old).
The new results find that the process of star formation there is similar to that in our own Milky Way.
Only 150 light-years in diameter, NGC 346 boasts the mass of 50,000 Suns. Its intriguing shape and rapid star formation rate has puzzled astronomers. It took the combined power of NASA’s Hubble Space Telescope and the European Southern Observatory’s Very Large Telescope (VLT) to unravel the behavior of this mysterious-looking stellar nesting ground.
“Stars are the machines that sculpt the universe. We would not have life without stars, and yet we don’t fully understand how they form,” explained study leader Elena Sabbi of the Space Telescope Science Institute in Baltimore. “We have several models that make predictions, and some of these predictions are contradictory. We want to determine what is regulating the process of star formation, because these are the laws that we need to also understand what we see in the early universe.”
Researchers determined the motion of the stars in NGC 346 in two different ways. Using Hubble, Sabbi and her team measured the changes of the stars’ positions over 11 years. The stars in this region are moving at an average velocity of 2,000 miles per hour, which means that in 11 years they move 200 million miles. This is about 2 times the distance between the Sun and the Earth.
Tarantula Nebula star-forming region in a new light, including tens of thousands of never-before-seen young stars that were previously shrouded in cosmic dust./Photo:NASA, ESA, CSA, STScI, Webb ERO Production Team
But this cluster is relatively far away, inside a neighboring galaxy. This means the amount of observed motion is very small and therefore difficult to measure. These extraordinarily precise observations were possible only because of Hubble’s exquisite resolution and high sensitivity. Also, Hubble’s three-decade-long history of observations provides a baseline for astronomers to follow minute celestial motions over time.
The second team, led by Peter Zeidler of AURA/STScI for the European Space Agency, used the ground-based VLT’s Multi Unit Spectroscopic Explorer (MUSE) instrument to measure radial velocity, which determines whether an object is approaching or receding from an observer.
“What was really amazing is that we used two completely different methods with different facilities and basically came to the same conclusion, independent of each other,” said Zeidler. “With Hubble, you can see the stars, but with MUSE we can also see the gas motion in the third dimension, and it confirms the theory that everything is spiraling inwards.”
But why a spiral?
“A spiral is really the good, natural way to feed star formation from the outside toward the center of the cluster,” explained Zeidler. “It’s the most efficient way that stars and gas fueling more star formation can move towards the center.”
Half of the Hubble data for this study of NGC 346 is archival. The first observations were taken 11 years ago. They were recently repeated to trace the motion of the stars over time. Given the telescope’s longevity, the Hubble data archive now contains more than 32 years of astronomical data powering unprecedented, long-term studies.
“The Hubble archive is really a gold mine,” said Sabbi. “There are so many interesting star-forming regions that Hubble has observed over the years. Given that Hubble is performing so well, we can actually repeat these observations. This can really advance our understanding of star formation.”
Observations with NASA’s James Webb Space Telescope should be able to resolve lower-mass stars in the cluster, giving a more holistic view of the region. Over Webb’s lifespan, astronomers will be able to repeat this experiment and measure the motion of the low-mass stars. They could then compare the high-mass stars and the low-mass stars to finally learn the full extent of the dynamics of this nursery.
The Hubble Space Telescope is a project of international cooperation between NASA and ESA. NASA’s Goddard Space Flight Center in Greenbelt, Maryland, manages the telescope. The Space Telescope Science Institute (STScI) in Baltimore conducts Hubble science operations. STScI is operated for NASA by the Association of Universities for Research in Astronomy, in Washington, D.C.
The U.S. Postal Service will issue a stamp celebrating NASA’s new James Webb Space Telescope, the largest, most powerful, and most complex science telescope ever put in space. The stamp, which features an illustration of the observatory, will be dedicated in a ceremony Thursday, Sept. 8, at the Smithsonian’s National Postal Museum in Washington.
“When anyone who uses these stamps looks at this telescope, I want them to see what I see: its incredible potential to reveal new and unexpected discoveries that help us understand the origins of the universe, and our place in it,” said NASA Associate Administrator Bob Cabana. “This telescope is the largest international space science program in U.S. history, and I can’t wait to see the scientific breakthroughs it will enable in astronomy.”
Webb, a mission led by NASA in partnership with ESA (European Space Agency) and CSA (Canadian Space Agency), launched Dec. 25, 2021, from Europe’s Spaceport in French Guiana. Over the following months, Webb traveled to its destination nearly one million miles (1.5 million kilometers) away from Earth, underwent weeks of complex deployments to unfold into its final configuration, and prepared its mirrors and science instruments to capture never-before-seen views of the universe.
The U.S. Postal Service will issue a stamp highlighting NASA’s James Webb Space Telescope on Sept. 8, 2022. U.S. Postal Service Art Director Derry Noyes designed the stamp using existing art by James Vaughan and an image provided by NASA and the Space Telescope Science Institute. Credits: U.S. Postal Service
NASA released Webb’s first full-color images and spectra July 12 – providing a first look at the observatory’s powerful capabilities. The U.S. Postal Service stamp honors these achievements as Webb continues its mission to explore the unknown in our universe and study every phase in cosmic history.
“I am excited to add this beautiful stamp to our collection, as we watch from the ground as humanity’s newest and most capable telescope unlocks the greatest secrets of our cosmos that have been waiting to be revealed since the beginning of time,” said Thomas Zurbuchen, associate administrator for NASA’s Science Mission Directorate. “The Webb Telescope represents the start to a new era of what we can accomplish for the benefit of all.”
The stamp features an artist’s digital illustration of Webb against a background of stars. The selvage around each set of stamps showcases a sharp image of a star, captured while setting up the telescope in space to confirm precise alignment of Webb’s 18 hexagonal mirror segments.
The U.S. Postal Service’s first day of issue event is free and open to the public on Thursday, Sept. 8, at 11 a.m. EDT at the National Postal Museum. NASA Associate Administrator Bob Cabana; Lee Feinberg, Webb optical telescope element manager at NASA’s Goddard Space Flight Center; and Erin Smith, Webb deputy observatory project scientist at NASA Goddard will be among the speakers providing remarks.
NASA/Photo: Nasa.gov
To follow along with NASA’s Webb Telescope as it begins its mission to unfold the infrared universe, visit:
The James Webb Space Telescope is the world’s premier infrared space science observatory. Webb will solve mysteries in our solar system, look beyond to distant worlds around other stars, and probe the mysterious structures and origins of our universe and our place in it. Webb is an international program led by NASA with its partners, ESA (European Space Agency) and CSA (Canadian Space Agency).
A potential new treatment combining natural manuka honey with a widely used drug has been developed by scientists at Aston University to treat a potentially lethal lung infection and greatly reduce side effects of one of the current drugs used for its treatment.
Manuka honey can also be used to help treat wounds, injuries, improve oral health, soothe a sore throat and treat ulcers. The findings are published in the journal Microbiology.
The scientists in the Mycobacterial Research Group in the College of Health and Life Sciences at Aston University were able to combine manuka honey and the drug amikacin in a lab-based nebulisation formulation to treat the harmful bacterial lung infection Mycobacterium abscessus, said lead author and PhD researcher Victoria Nolan.
Manuka honey is long known to have wide ranging medicinal properties, but more recently has been identified for its broad spectrum antimicrobial activity. Now scientists have found that manuka honey has the potential to kill a number of drug resistant bacterial infections such as Mycobacterium abscessus – which usually affects patients with cystic fibrosis (CF) or bronchiectasis.
Manuka honey could help to clear deadly drug-resistant lung infection –research/Photo:Microbiology Society
According to the Cystic Fibrosis Trust, CF is a genetic condition affecting around 10,800 people – one in every 2,500 babies born in the UK – and there are more than 100,000 people with the condition worldwide. The NHS defines bronchiectasis as a long-term condition where the airways of the lungs become widened, leading to a build-up of excess mucus that can make the lungs more vulnerable to infection..
In the study, the researchers used samples of the bacteria Mycobacterium abscessus taken from 16 infected CF patients. They then tested the antibiotic amikacin, combined with manuka honey, to discover what dosage was required to kill the bacteria.
Dr Jonathan Cox, senior lecturer in microbiology, Aston University said: “By combining a totally natural ingredient such as manuka honey with amikacin, one of the most important yet toxic drugs used for treating Mycobacterium abscessus, we have found a way to potentially kill off these bacteria with eight times less drug than before.”
As part of the study the team used a lab-based lung model and nebuliser – a device that produces a fine spray of liquid often used for inhaling a medicinal drug. By nebulising manuka honey and amikacin together, it was found they could improve bacterial clearance, even when using lower doses of amikacin, which would result in less life-changing side-effects to the patient.
In the UK, of the 10,800 people living with CF, Mycobacterium abscessus infects 13% of all patients with the condition. This new approach is advantageous not only because it has the potential to kill off a highly drug resistant infection, but because of the reduced side effects, benefitting quality of life and greatly improving survival chances for infected CF patients.
Mycobacterium abscessus is a bacterial pathogen from the same family that causes tuberculosis, but this bug differs by causing serious lung infections in people (particularly children) with pre-existing lung conditions, such as CF and bronchiectasis, as well as causing skin and soft tissue infections. The bacteria is also highly drug resistant.
Currently, patients are given a cocktail of antibiotics, consisting of 12 months or more of antimicrobial chemotherapy and often doesn’t result in a cure. The dosage of amikacin usually used on a patient to kill the infection is 16 micrograms per millilitre. But the researchers found that the new combination using manuka honey, required a dosage of just 2 micrograms per millitre of amikacin – resulting in a one eighth reduction in the dosage of the drug.
Until now Mycobacterium abscessus has been virtually impossible to eradicate in people with cystic fibrosis. It can also be deadly if the patient requires a lung transplant because they are not eligible for surgery if the infection is present.
A Portugal woman has revealed recently that her twin children has DNA of both sex partners with whom she had sex on the same day.
Now one year and four months old, these twins were tested for their DNA and the doctors were surprised to see that both of them had the DNA of both fathers.
The woman, who preferred not to be identified, said after having sex with them on the same day, she became pregnant with the twins. The woman hails from the town of Mineiros in the state of Goias in Portugal.
What’s heteroparental superfecundation?
The case has become what the medical doctors said was the rarest of the rare 20th case of ‘heteroparental superfecundation’ ever recorded in the world.
Representational picture of twins / https://www.womenshealth.gov/
It means a pregnancy that produces twins with two different fathers. Dr Tulio Jorge Franco, who has been studying the unusual pregnancy since the beginning said, “two eggs from the same mother are fertilized by different men. The babies share the mother’s genetic material, but they grow in different placentas”.
According to Jason Kasraie, the chair of the Association of Clinical Embryologists, a woman can release two eggs at the same time. Since sperm can survive for a few days in the female reproductive tract, loitering in the corner of the womb and the fallopian tube, it would be possible to have sex with one father-to-be in advance of the egg being released, and another just after ovulation.” Or it could be possibel when the woman releases two eggs a few days apart but in the same reproductive cycle.
It was realized only when one boy’s DNA did not fully match with the father, one of the two men who fathered the twins. The woman recollected: “I remembered that I had had sex with another man and called him to take the test, which was positive… I was surprised by the results. I didn’t know this could happen and the babies are very similar.”
However, the birth certificate of both of them is in the name of one father and “he takes care of both of them, helps me a lot and gives them all the necessary support that they need,” she told media.
Doctor confirms
Dr Tulio Jorge Franco recently confirmed the details in a talk with the Portuguese news outlet G1. “Two eggs from the same mother are fertilized by different men. The babies share the mother’s genetic material, but they grow in different placentas,” he explained.
He further added that it is an extremely rare case that happens once in a million. “I never imagined that I would see such a case in my life,” he noted.
Emotional eating, or eating as a coping mechanism for negative, positive, or stress-driven emotions, is associated with unhealthy dietary patterns and weight gain. A research article featured in the Journal of Nutrition Education and Behavior, published by Elsevier, discusses adolescent vulnerability to emotional eating and how various feeding practices used by parents, such as restriction, food as reward, and child involvement, influence eating behavior.
“Emotional eating was previously found to be more learned than inherited. This study examined not only the interaction between parents when feeding their children, but also what children learned from watching their parents eat,” said lead author Joanna Klosowska, MSc, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.
Eating/Photo:en.wikipedia.org
Over the four years between 2013 −2017, covering the time from late childhood to middle adolescence, changes occurred in some parental practices. Parents reported higher monitoring and healthy modeling feeding practices, while the reported levels of food restriction and the healthy environment remained unchanged. During the same time period, adolescents reported a considerable increase in emotional eating from below the average in 2013 to above the average in 2017, according to the norms for the Dutch population. Additionally, the maladaptive way in which they regulated their emotions was also associated with emotional eating.
Dining/Photo:en.wikipedia.org
Food as a reward and monitoring food increased emotional eating especially in instances where the adolescent employed maladaptive strategies in regulating their emotions. Child involvement in meals had an opposite effect since it was associated with higher levels of emotion regulation and lower levels of emotional eating. Interestingly, a parent’s restrained eating behavior was linked to less emotional eating in adolescents.
“This study suggests that parents continue to play an important role in their child’s eating behavior into their teen years,” said Klosowska. “Additional research is needed to understand the impact restrained eating demonstrated by a parent impacts the emotional eating of a child.”
Young Australians can now access a free DNA saliva test to learn whether they face increased risk of some cancers and heart disease, which can be prevented or treated early if detected, in a world-first DNA screening study.
The nationally collaborative project, led by Monash University and supported by researchers and clinicians across Australia, will screen at least 10,000 people aged 18-40 for genes that increase risk of certain types of cancers and heart disease that often go undetected.
Those found to be at high risk after DNA testing – about one in 75 or 1.3 per cent – will have their situation explained by experts and be offered genetic counselling and prevention measures, such as regular scans and check-ups.
cancer/photo:en.wikipedia.org
Until now, genetic testing for the DNA changes that increase disease risk has only been available on a small scale for those with a known family history or prior disease diagnosis. Population testing, open to everyone, has the potential to drastically improve access and maximize the preventive benefits of DNA testing.
Monash University’s Associate Professor Paul Lacaze said the project enabled a more efficient and equitable approach to genetic testing, identifying far more people at high risk than current testing methods.
“We hope to identify those at risk while they are young and healthy, not after the fact, and empower them to make more informed decisions about their health,” he said. “For some people, this could save their lives through early detection and prevention of cancer and heart disease. This will also save considerable health system costs in Australia through prevention.
“Providing genetic testing based on family history alone is not enough. Up to 90 per cent of those at high risk in the general population are not identified by current family history-based testing. Most people don’t find out about their genetic risk until it’s too late, like after an incurable cancer or heart attack is diagnosed. We want to change that.”
DNA Screen will identify people with DNA variants in the BRCA1 and BRCA2 genes that lead to an increased risk of hereditary breast and ovarian cancer in women. These genes are also linked to breast and prostate cancer in men, although not as strongly. Men and women who carry DNA variants in the BRCA1 and BRCA2 genes can also pass them onto their children.
The DNA Screen test will also focus on Lynch Syndrome – another condition that increases risk for colorectal, endometrial, and other gastrointestinal cancers. Both cancer-related conditions have effective, proven interventions available to reduce risk if identified early.
This includes attending annual check-ups and screens from age 30, and the option of risk-reducing surgery for some people. Early detection and prevention are often life-saving for cancer.
The DNA test also encompasses heart disease risk, focusing on familial hypercholesterolemia (FH) or ‘genetic high cholesterol’, which results in high risk of heart disease from a young age. Despite effective medications such as statins being available to reduce risk, an estimated 95 per cent of FH carriers are currently undiagnosed.
Associate Professor Lacaze, from the Monash University School of Public Health and Preventive Medicine, is leading a team of national collaborators who were awarded a $2.97 million Medical Research Future Fund (MRFF) grant for the project. The project is supported by the Precision Medicine laboratory at Monash University and the state-of-the-art Biobanking Victoriafacility.
The eventual goal is to develop a new population-based DNA screening program that could be offered through the Australian public healthcare system, available to everyone but targeted on certain medically-actionable conditions where early detection is key.
“We expect to identify about 1 in 75 people at high risk of these diseases. Those found to be high risk won’t necessarily get the disease, but pinpointing risk before symptoms appear enables prevention through regular check-ups, medication, or risk-reducing surgery. It could save their life.
DNA Screen, which is recruiting young people via social media, is expected to save lives and could lead to a wide scale preventive DNA testing program for cancer and heart disease risk, where early detection and prevention can be life-saving.
DNA Screen is the world’s first preventive DNA screening study designed specifically to assess population DNA screening through a national healthcare system. The test is free and involves placing a saliva sample into a small tube received by mail, and sending it back in a postage paid envelope. People can sign up online at dnascreen.monash.edu
Artificial intelligence (AI) can be used to detect COVID-19 infection in people’s voices by means of a mobile phone app, according to research to be presented on Monday at the European Respiratory Society International Congress in Barcelona, Spain [1].
The AI model used in this research is more accurate than lateral flow/rapid antigen tests and is cheap, quick and easy to use, which means it can be used in low-income countries where PCR tests are expensive and/or difficult to distribute.
Ms Wafaa Aljbawi, a researcher at the Institute of Data Science, Maastricht University, The Netherlands, told the congress that the AI model was accurate 89% of the time, whereas the accuracy of lateral flow tests varied widely depending on the brand. Also, lateral flow tests were considerably less accurate at detecting COVID infection in people who showed no symptoms.
COVID-19 infection usually affects the upper respiratory track and vocal cords, leading to changes in a person’s voice.
Covid/commons.wikimedia.org
“These promising results suggest that simple voice recordings and fine-tuned AI algorithms can potentially achieve high precision in determining which patients have COVID-19 infection,” she said.Moreover, they enable remote, virtual testing and have a turnaround time of less than a minute. They could be used, for example, at the entry points for large gatherings, enabling rapid screening of the population.”
The app is installed on the user’s mobile phone, the participants report some basic information about demographics, medical history and smoking status, and then are asked to record some respiratory sounds. These include coughing three times, breathing deeply through their mouth three to five times, and reading a short sentence on the screen three times.
The researchers used a voice analysis technique called Mel-spectrogram analysis, which identifies different voice features such as loudness, power and variation over time.
“In this way we can decompose the many properties of the participants’ voices,” said Ms Aljbawi. “In order to distinguish the voice of COVID-19 patients from those who did not have the disease, we built different artificial intelligence models and evaluated which one worked best at classifying the COVID-19 cases.”
Its overall accuracy was 89%, its ability to correctly detect positive cases (the true positive rate or “sensitivity”) was 89%, and its ability to correctly identify negative cases (the true negative rate or “specificity”) was 83%.
“These results show a significant improvement in the accuracy of diagnosing COVID-19 compared to state-of-the-art tests such as the lateral flow test,” said Ms Aljbawi.
The patients were “high engagers”, who had been using the app weekly over months or even years to record their symptoms and other health information, record medication, set reminders, and have access to up-to-date health and lifestyle information. Doctors can assess the data via a clinician dashboard, enabling them to provide oversight, co-management and remote monitoring.
An international team led by researchers at the RIKEN Cluster for Pioneering Research (CPR) has engineered a system for creating remote controlled cyborg cockroaches, equipped with a tiny wireless control module that is powered by a rechargeable battery attached to a solar cell. Despite the mechanic devices, ultrathin electronics and flexible materials allow the insects to move freely. These achievements, reported in the scientific journal npj Flexible Electronics on September 5, will help make the use of cyborg insects a practical reality.
Researchers have been trying to design cyborg insects—part insect, part machine—to help inspect hazardous areas or monitor the environment. However, for the use of cyborg insects to be practical, handlers must be able to control them remotely for long periods of time. This requires wireless control of their leg segments, powered by a tiny rechargeable battery. Keeping the battery adequately charged is fundamental—nobody wants a suddenly out-of-control team of cyborg cockroaches roaming around. While it’s possible to build docking stations for recharging the battery, the need to return and recharge could disrupt time-sensitive missions. Therefore, the best solution is to include an on-board solar cell that can continuously ensure that the battery stays charged.
All of this is easier said than done. To successfully integrate these devices into a cockroach that has limited surface area required the research team to develop a special backpack, ultrathin organic solar cell modules, and an adhesion system that keeps the machinery attached for long periods of time while also allowing natural movements.
Researchers at RIKEN, Japan have created remote controlled cyborg cockroaches, equipped with a tiny wireless control module that is powered by a rechargeable battery attached to a solar cell/RIKEN
Led by Kenjiro Fukuda, RIKEN CPR, the team experimented with Madagascar cockroaches, which are approximately 6 cm long. They attached the wireless leg-control module and lithium polymer battery to the top of the insect on the thorax using a specially designed backpack, which was modeled after the body of a model cockroach. The backpack was 3D printed with an elastic polymer and conformed perfectly to the curved surface of the cockroach, allowing the rigid electronic device to be stably mounted on the thorax for more than a month.
The ultrathin 0.004 mm thick organic solar cell module was mounted on the dorsal side of the abdomen. “The body-mounted ultrathin organic solar cell module achieves a power output of 17.2 mW, which is more than 50 times larger than the power output of current state-of-the art energy harvesting devices on living insects,” according to Fukuda.
cockroach/Photo:en.wikipedia.org
The ultrathin and flexible organic solar cell, and how it was attached to the insect, proved necessary to ensure freedom of movement. After carefully examining natural cockroach movements, the researchers realized that the abdomen changes shape and portions of the exoskeleton overlap. To accommodate this, they interleaved adhesive and non-adhesive sections onto the films, which allowed them to bend but also stay attached. When thicker solar cell films were tested, or when the films were uniformly attached, the cockroaches took twice as long to run the same distance, and had difficulty righting themselves when on their backs.
Once these components were integrated into the cockroaches, along with wires that stimulate the leg segments, the new cyborgs were tested. The battery was charged with pseudo-sunlight for 30 minutes, and animals were made to turn left and right using the wireless remote control.
“Considering the deformation of the thorax and abdomen during basic locomotion, a hybrid electronic system of rigid and flexible elements in the thorax and ultrasoft devices in the abdomen appears to be an effective design for cyborg cockroaches,” says Fukuda. “Moreover, since abdominal deformation is not unique to cockroaches, our strategy can be adapted to other insects like beetles, or perhaps even flying insects like cicadas in the future.”
Experiments on streaming electricity wirelessly have been underway for over half-a-century but a new milestone has been reached last week when South Korean scientists successfully achieved it across a room through thin air. The could transmit 400 megawatts of electricity over nearly 100 feet using infrared laser light.
The research has been published in the journal Optics Express.
“The ability to power devices wirelessly could eliminate the need to carry around power cables for our phones or tablets. It could also power various sensors such as those used for monitoring processes in manufacturing plants,” said research team leader Jinyong Ha from Sejong University.
Four hundred MW is just enough power to charge small sensors but paves the way for larger amounts of power being able to be sent wirelessly gradually increasing the distance, possibly to charge mobile phones.
Currently, wireless charging over very small distances has been possible mostly for mobile phones and it is based on inductive charging, where a copper coil generates a magnetic field that facilitates the movement of a charge from the charging pad into the phone’s battery.
Using laser charging, the new method allows it at distances over 98 feet and provides “safe high-power illumination with less light loss.”
“While most other approaches require the receiving device to be in a special charging cradle or to be stationary, distributed laser charging enables self-alignment without tracking processes as long as the transmitter and receiver are in the line of sight of each other,” Ha said. “It also automatically shifts to a safe low power delivery mode if an object or a person blocks the line of sight.”
“The ability to power devices wirelessly could eliminate the need to carry around power cables for our phones or tablets,” research team leader Jinyong Ha from Sejong University in South Korea said in a statement. “It could also power various sensors such as those used for monitoring processes in manufacturing plants.”
“Using the laser charging system to replace power cords in factories could save on maintenance and replacement costs,” Ha said. “This could be particularly useful in harsh environments where electrical connections can cause interference or pose a fire hazard.”
Roving the Red Planet. Perseverance landed on Mars in February 2021 and has been gathering data on the planet’s geology and climate and searching for signs of ancient life.
What lies beneath. The rover’s subsurface radar experiment, co-led by UCLA’s David Paige, has returned images showing unexpected variations in rock layers beneath the Jezero crater.
Probing the past. The variations could indicate past lava flows or possibly a river delta even older than the one currently being explored on the crater floor.
After a tantalizing year-and-a-half wait since NASA’s Mars Perseverance rover touched down on our nearest planetary neighbor, new data is arriving — and bringing with it a few surprises.
The rover, which is about the size of car and carries seven scientific instruments, has been probing Mars’ 30-mile-wide Jezero crater, once the site of a lake and an ideal spot to search for evidence of ancient life and information about the planet’s geological and climatic past.
Rendering of Perseverance, whose RIMFAX technology is exploring what lies beneath the Martian surface. Photo: NASA/JPL/Caltech/FFI
In a paper published today in the journal Science Advances, a research team led by UCLA and the University of Oslo reveals that rock layers beneath the crater’s floor, observed by the rover’s ground-penetrating radar instrument, are unexpectedly inclined. The slopes, thicknesses and shapes of the inclined sections suggest they were either formed by slowly cooling lava or deposited as sediments in the former lake.
Perseverance is currently exploring a delta on the western edge of the crater, where a river once fed the lake, leaving behind a large deposit of dirt and rocks it picked up along its course. As the rover gathers more data, the researchers hope to clear up the complex history of this part of the Red Planet.
“We were quite surprised to find rocks stacked up at an inclined angle,” said David Paige, a UCLA professor of Earth, planetary and space sciences and one of the lead researchers on the Radar Imager for Mars Subsurface Experiment, or RIMFAX. “We were expecting to see horizontal rocks on the crater floor. The fact that they are tilted like this requires a more complex geologic history. They could have been formed when molten rock rose up towards the surface, or, alternatively, they could represent an older delta deposit buried in the crater floor.”
Paige said that most of the evidence gathered by the rover so far points to an igneous, or molten, origin, but based on the RIMFAX data, he and the team can’t yet say for certain how the inclined layers formed. RIMFAX obtains a picture of underground features by sending bursts of radar waves below the surface, which are reflected by rock layers and other obstacles. The shapes, densities, thicknesses, angles and compositions of underground objects affect how the radar waves bounce back, creating a visual image of what lies beneath.
During Perseverance’s initial 3-kilometer traverse, the instrument has obtained a continuous radar image that reveals the electromagnetic properties and bedrock stratigraphy — the arrangement of rock layers — of Jezero’s floor to depths of 15 meters, or about 49 feet. The image reveals the presence of ubiquitous layered rock strata, including those that are inclined at up to 15 degrees. Compounding the mystery, within those inclined areas are some perplexing highly reflective rock layers that in fact tilt in multiple directions.
“RIMFAX is giving us a view of Mars stratigraphy similar to what you can see on Earth in highway road cuts, where tall stacks of rock layers are sometimes visible in a mountainside as you drive by,” Paige explained. “Before Perseverance landed, there were many hypotheses about the exact nature and origin of the crater floor materials. We’ve now been able to narrow down the range of possibilities, but the data we’ve acquired so far suggest that the history of the crater floor may be quite a bit more complicated than we had anticipated.”
The data collected by RIMFAX will provide valuable context to rock samples Perseverance is collecting, which will eventually be brought back to Earth.
“RIMFAX is giving us the backstory of the samples we’re going to analyze. It’s exciting that the rover’s instruments are producing data and we’re starting to learn, but there’s a lot more to come,” Paige said. “We landed on the crater floor, but now we’re driving up on the actual delta, which is the main target of the mission. This is just the beginning of what we’ll hopefully soon know about Mars.”
The paper, “Ground penetrating radar observations of subsurface structures in the floor of Jezero crater, Mars,” is one of three simultaneously published papers discussing some of the first data from Perseverance.
World’s water tainted. Synthetic PFAS, which have been linked to cancer and other diseases, have contaminated nearly every drop of water on the planet.
Unbreakable bond. These chemicals contain a carbon-fluorine bond that is almost impossible to break, making it extremely difficult to eradicate them from water supplies.
Off with their heads! Researchers devised a “guillotine” solution that uses moderate heat and inexpensive reagents to remove the “heads” of PFAS, initiating their destruction.
If you’re despairing at recent reports that Earth’s water sources have been thoroughly infested with hazardous human-made chemicals called PFAS that can last for thousands of years, making even rainwater unsafe to drink, there’s a spot of good news.
Chemists at UCLA and Northwestern University have developed a simple way to break down almost a dozen types of these nearly indestructible “forever chemicals” at relatively low temperatures with no harmful byproducts.
Simple method destroys dangerous ‘forever chemicals,’ making water safe
In a paper published today in the journal Science, the researchers show that in water heated to just 176 to 248 degrees Fahrenheit, common, inexpensive solvents and reagents severed molecular bonds in PFAS that are among the strongest known and initiated a chemical reaction that “gradually nibbled away at the molecule” until it was gone, said UCLA distinguished research professor and co-corresponding author Kendall Houk.
The simple technology, the comparatively low temperatures and the lack of harmful byproducts mean there is no limit to how much water can be processed at once, Houk added. The technology could eventually make it easier for water treatment plants to remove PFAS from drinking water.
Per- and polyfluoroalkyl substances — PFAS for short — are a class of around 12,000 synthetic chemicals that have been used since the 1940s in nonstick cookware, waterproof makeup, shampoos, electronics, food packaging and countless other products. They contain a bond between carbon and fluorine atoms that nothing in nature can break.
PFAS used in shampoos
When these chemicals leach into the environment through manufacturing or everyday product use, they become part of the Earth’s water cycle. Over the past 70 years, PFAS have contaminated virtually every drop of water on the planet, and their strong carbon-fluorine bond allows them to pass through most water treatment systems completely unharmed. They can accumulate in the tissues of people and animals over time and cause harm in ways that scientists are just beginning to understand. Certain cancers and thyroid diseases, for example, are associated with PFAS.
For these reasons, finding ways to remove PFAS from water has become particularly urgent. Scientists are experimenting with many remediation technologies, but most of them require extremely high temperatures, special chemicals or ultraviolet light and sometimes produce byproducts that are also harmful and require additional steps to remove.
The impact of breathing diesel exhaust fumes may be more severe for females than males, according to new research that will be presented at the European Respiratory Society International Congress in Barcelona, Spain [1].
Researchers looked for changes in people’s blood brought about by exposure to diesel exhaust. In both females and males, they found changes in components of the blood related to inflammation, infection and cardiovascular disease, but they found more changes in females than males.
The research was presented by Dr Hemshekhar Mahadevappa, from the University of Manitoba, Winnipeg, Canada and was a collaboration between two research groups led by Professor Neeloffer Mookherjee at the University of Manitoba and Professor Chris Carlsten at the University of British Columbia, Vancouver, Canada. Dr Mahadevappa told the Congress: “We already know that there are sex differences in lung diseases such as asthma and respiratory infections.
Air pollution/Photo:en.wikipedia.org
Research showed that breathing diesel exhaust creates inflammation in the lungs and has an impact on how the body deals with respiratory infections. In this study, we wanted to look for any effects in the blood and how these differ in females and males.”
The study involved ten volunteers, five female and five male, who were all healthy non-smokers. Each volunteer spent four hours breathing filtered air and four hours breathing air containing diesel exhaust fumes at three different concentrations – 20, 50 and 150 micrograms of fine particulate matter (PM2.5) per cubic metre – with a four-week break in between each exposure.
Volunteers donated blood samples 24 hours after each exposure and the researchers made detailed examinations of the volunteers’ blood plasma. Plasma is the liquid component of the blood that carries blood cells as well as hundreds of proteins and other molecules around the body. Using a well-established analysis technology called liquid chromatography–mass spectrometry, the researchers looked for changes in the levels of different proteins following exposure to diesel exhaust and compared the changes in females and males.
Airpollution/Photo:en.wikipedia.org
Comparing the plasma samples, the researchers found levels of 90 proteins that were distinctly different between female and male volunteers following exposure to diesel exhaust. Among the proteins that differed between females and males, were some that are known to play a role in inflammation, damage repair, blood clotting, cardiovascular disease and the immune system. Some of these differences became clearer when volunteers were exposed to the higher levels of diesel exhaust.
Professor Mookherjee explained: “These are preliminary findings, however they show that exposure to diesel exhaust has different effects in female bodies compared to male and that could indicate that air pollution is more dangerous for females than males.
“This is important as respiratory diseases such as asthma are known to effect females and males differently, with females more likely to suffer severe asthma that does not respond to treatments. Therefore, we need to know a lot more about how females and males respond to air pollution and what this means for preventing, diagnosing and treating their respiratory disease.”
Air pollution/photo:en.wikipedia.org
Professor Zorana Andersen from the University of Copenhagen, Denmark, is Chair of the European Respiratory Society Environment and Health Committee and was not involved in the research. She said: “We know that exposure to air pollution, especially diesel exhaust, is a major risk factor in diseases such as asthma and chronic obstructive pulmonary disease. There is very little we can do as individuals to avoid beathing polluted air, so we need governments to set and enforce limits on air pollutants.
Letting children play with hand-me-down plastic toys could constitute a health risk. When researchers at the University of Gothenburg tested a large number of old toys and dress-up items made of plastic, 84 per cent of the items were found to contain toxins that can disrupt growth and development and reproductive capacities in children. These toxins are an obstacle for the circular economy in the future involving reuse and recycling, the researchers explain.
The current use-and-discard behaviour is wasteful with resources and a drain on the Earth’s finite resources. In 2021, the European Parliament adopted a Circular Economy Action Plan. It encourages the re-use, repair and recycling of products and materials. But the question is whether all products are good to reuse again?
Researchers from the University of Gothenburg have recently published an article in the Journal of Hazardous Materials Advances which shows that old toys and dress-up items may contain toxic chemicals that can cause cancer, damage DNA or disrupt the future reproductive capacities of children.
plastic toys/Photo: en.wikipedia.org
Toxic chemicals in most old toys
The hazardous chemicals that were discovered included phthalates and short chain chlorinated paraffins used as plasticizers and flame retardants in toys.
Professor Bethanie Carney Almroth at the University of Gothenburg conducts research on the environmental impact of plastics and plastic-related chemicals, and has led the research study conducted at the interdisciplinary Centre for Future Chemical Risk Assessment and Management Strategies (FRAM). For the study, researchers selected 157 different toys, new and old, and measured their chemical content.
The study showed that most of the older toys and items (84 per cent) contained quantities of chemicals that exceed current legal limits. A total of 30 per cent of the newer toys and items also exceeded the legal limits. By far however, the older toys were significantly worse.
“The concentrations of toxic substances were significantly higher in the older items. For example, many of the old balls were found to have concentrations of phthalates totalling more than 40 per cent of the toy’s weight, which is 400 times over the legal limit,” says Bethanie Carney Almroth.
Many of the older toys contained toxins.
Toxins an obstacle to a circular economy
EU legislation on the chemical content of toys, known as the Toy Safety Directive, regulates the permissible quantities of a number of chemical substances found in toys in an attempt to protect the health and safety of children. At present, the permissible limit values for new toys under the Toy Safety Directive are 0.1 per cent by weight for phthalates and 0.15 per cent by weight for short chain chlorinated paraffins.
“The study indicates that reuse and recycling is not always automatically a good thing. The transition to a more circular economy requires bans and other policy measures that get rid of hazardous chemicals from plastic and other materials. Although the Toy Safety Directive has been crucial in reducing the incidence of hazardous chemicals in toys, it has only been applicable to new toys, not old ones,” explains Daniel Slunge, Environmental Economist at the University of Gothenburg.
Digital content creators are invited to register to attend the launch of the fifth SpaceX Crew Dragon spacecraft and Falcon 9 rocket that will carry astronauts to the International Space Station for a science expedition mission. This mission is part of NASA’s Commercial Crew Program.
The earliest targeted launch date for the agency’s SpaceX Crew-5 mission is Oct. 3, from Kennedy’s Launch Complex 39A. The launch will carry NASA astronauts Nicole Mann, commander; Josh Cassada, pilot; and mission specialists Koichi Wakata, of JAXA (Japan Aerospace Exploration Agency), and Roscosmos cosmonaut Anna Kikina.
If your passion is to communicate and engage the world online, then this is the event for you! Seize the opportunity to be on the front line to see and share the #Crew5 mission launch.
A maximum of 35 social media users will be selected to attend this two-day event and will be given access similar to news media.
NASA Social participants will have the opportunity to:
View a launch of the SpaceX Falcon 9 rocket
Tour NASA facilities at Kennedy Space Center
Meet and interact with Crew-5 subject matter experts
Meet fellow space enthusiasts who are active on social media
NASA Social registration for the Crew-5 launch opens on August 31 and the deadline to apply is September 6 at 3 p.m. EDT. All social applications will be considered on a case-by-case basis.
Do I need to have a social media account to register?
Yes. This event is designed for people who:
Actively use multiple social networking platforms and tools to disseminate information to a unique audience.
Regularly produce new content that features multimedia elements.
Have the potential to reach a large number of people using digital platforms.
Reach a unique audience, separate and distinctive from traditional news media and/or NASA audiences.
Must have an established history of posting content on social media platforms.
Have previous postings that are highly visible, respected and widely recognized.
Users on all social networks are encouraged to use the hashtag #NASASocial, and #Crew5. Updates and information about the event will be shared on Twitter via @NASASocial and @NASAKennedy, and via posts to Facebook and Instagram.
How do I register?
Registration for this event opens August 31 and closes at 3 p.m. EDT on September 6. Registration is for one person only (you) and is non-transferable. Each individual wishing to attend must register separately. Each application will be considered on a case-by-case basis.
Can I register if I am not a U.S. citizen?
Because of the security deadlines, registration is limited to U.S. citizens. If you have a valid permanent resident card you will be processed as a U.S. citizen.
When will I know if I am selected?
After registrations have been received and processed, an email with confirmation information and additional instructions will be sent to those selected. We expect to send the first notifications on September 13 and waitlist notifications on September 14.
What are NASA Social credentials?
All social applications will be considered on a case-by-case basis. Those chosen must prove through the registration process they meet specific engagement criteria.
If you do not make the registration list for this NASA Social, you still can attend the launch offsite and participate in the conversation online. Find out about ways to experience a launch here.
What are the registration requirements?
Registration indicates your intent to travel to NASA’s Kennedy Space Center in Florida and attend the two-day event in person. You are responsible for your own expenses for travel, accommodation, food, and other amenities.
Some events and participants scheduled to appear at the event are subject to change without notice. NASA is not responsible for loss or damage incurred as a result of attending. NASA, moreover, is not responsible for loss or damage incurred if the event is cancelled with limited or no notice. Please plan accordingly.
Kennedy is a government facility. Those who are selected will need to complete an additional registration step to receive clearance to enter the secure areas.
IMPORTANT: To be admitted, you will need to provide two forms of unexpired government-issued identification; one must be a photo ID and match the name provided on the registration. Those without proper identification cannot be admitted. For a complete list of acceptable forms of ID, please visit: NASA Credentialing Identification Requirements.
All registrants must be at least 18 years old.
Photo: Nasa.gov
What if the launch date changes?
Hundreds of different factors can cause a scheduled launch date to change multiple times. The launch date will not be official until after the Flight Readiness Review. If the launch date changes prior to then, NASA may adjust the date of the NASA Social accordingly to coincide with the new target launch date. NASA will notify registrants of any changes by email.
If the launch is postponed, attendees will be invited to attend a later launch date. NASA cannot accommodate attendees for delays beyond 72 hours.
NASA Social attendees are responsible for any additional costs they incur related to any launch delay. We strongly encourage participants to make travel arrangements that are refundable and/or flexible.
What if I cannot come to the Kennedy Space Center?
If you cannot come to the Kennedy Space Center and attend in person, you should not register for the NASA Social. You can follow the conversation using the #NASASocial hashtag on Twitter. You can watch the launch on NASA Television or www.nasa.gov/live. NASA will provide regular launch and mission updates on @NASA, @NASAKennedy, and @Commercial_Crew.
What are the safety protocols for this event? COVID-19 safety protocols for this event will be communicated closer to the date of the event.
If you cannot make this NASA Social, don’t worry; NASA is planning many other Socials in the near future at various locations! Check back here for updates.
Twitter rival Koo has laid off at least 40 people in India to prune redundant staff as per its current business requirements, hinting at another failure in overcrowded social media platforms. Currently, WhatsApp and Twitter are the two laeding social platforms in India.
The development was reported by news portal Inc42, which said that Koo CEO Aprameya Radhakrishna is currently abroad, seeking a fresh round of funding. The platform is seeking rapid growth as it plans expansion into other Indian languages soon.
“We recently attained a major milestone of 45 million downloads, growing 10x in the last 2 months. The growth that we are witnessing in our business is reflected in our employee strength of 350+ people strong,” said a spokesperson, as reported by IANS.
Koo, which is aiming to reach the 100 million-download mark, said that it wants to diversify recruitment of machine learning teams.
“Our workforce is streamlined to ensure it is aligned to the current business requirements. As a people-first company, we appreciate the talent and contributions of each of our associates,” the spokesperson added.
Launched in March 2020, Koo is currently available in 10 languages — Hindi, Marathi, Gujarati, Punjabi, Kannada, Tamil, Telugu, Assamese, Bengali and English. So far, the platform has over 45 million downloads but actively leveraged by 7,000 people from across the spectrum.
In February this year, Koo raised nearly $10 million in two different trances from investors, including Capsier Venture Partner, Ravi Modi Family Trust, Ashneer Grover, FBC Venture Partners, and Adventz Finance. Earlier, Koo raised its Series B funding from Tiger Global, Accel Partners, and Blume Ventures.
Changes in cell chemistry from blue light exposure observed in fruit flies could also potentially cause detrimental effects on our body, including accelerated aging.
Too much screen use has been linked to obesity and psychological problems. Now a new study has identified a new problem – a study in fruit flies suggests our basic cellular functions could be impacted by the blue light emitted by these devices. These results are published in Frontiers in Aging.
“Excessive exposure to blue light from everyday devices, such as TVs, laptops, and phones, may have detrimental effects on a wide range of cells in our body, from skin and fat cells, to sensory neurons,” said Dr Jadwiga Giebultowicz, a professor at the Department of Integrative Biology at Oregon State University and senior author of this study. “We are the first to show that the levels of specific metabolites – chemicals that are essential for cells to function correctly – are altered in fruit flies exposed to blue light.“
“Our study suggests that avoidance of excessive blue light exposure may be a good anti-aging strategy,” advised Giebultowicz.
Mobile Phone/Photo:indiainternationaltimes
Turn off the light
The researchers at Oregon State University have previously shown that fruit flies exposed to light ‘turn on’ stress protective genes, and that those kept in constant darkness lived longer.
“To understand why high-energy blue light is responsible for accelerating aging in fruit flies, we compared the levels of metabolites in flies exposed to blue light for two weeks to those kept in complete darkness,” explained Giebultowicz.
Blue light exposure caused significant differences in the levels of metabolites measured by the researchers in the cells of fly heads. In particular, they found that the levels of the metabolite succinate were increased, but glutamate levels were lowered.
“Succinate is essential for producing the fuel for the function and growth of each cell. High levels of succinate after exposure to blue light can be compared to gas being in the pump but not getting into the car,” said Giebultowicz. “Another troubling discovery was that molecules responsible for communication between neurons, such as glutamate, are at the lower level after blue light exposure.”
Accelerating aging
The changes recorded by the researchers suggest that the cells are operating at suboptimal level, and this may cause their premature death, and further, explain their previous findings that blue light accelerates aging.
“LEDs have become the main illumination in display screens such as phones, desktops and TVs, as well as ambient lighting, so humans in advanced societies are exposed to blue light through LED lighting during most of their waking hours. The signaling chemicals in the cells of flies and humans are the same, so the there is potential for negative effects of blue light on humans,“ explains Giebultowicz.
Future work hopes to study the effects directly on human cells.
“We used a fairly strong blue light on the flies – humans are exposed to less intense light, so cellular damage may be less dramatic. The results from this study suggests that future research involving human cells is needed to establish the extent to which human cells may show similar changes in metabolites involved in energy production in response to excessive exposure to blue light,“ concluded Giebultowicz.
