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New recombinant mpox strain detected in UK and India, WHO urges continued monitoring

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WHO confirmed that two cases of the recombinant strain – combining genomic elements of clades Ib and IIb of the monkeypox virus (MPXV) – have been identified to date: one in the United Kingdom and one in India. Both patients had recent travel histories, and neither experienced severe illness.

No secondary cases were detected following contact tracing.

WHO has published a detailed update on the two cases and the national responses.

Recombination is a natural process that can occur when two related viruses infect the same person and exchange genetic material, producing a new variant.

According to WHO, detailed genomic analysis shows the two individuals “fell ill several weeks apart with the same recombinant strain,” suggesting that additional undetected cases may exist.

What is mpox?

Mpox is an infectious disease caused by the monkeypox virus (MPXV), part of the Orthopoxvirus genus, which also includes the virus that causes smallpox.

It spreads through close physical contact, including sexual contact, and in some cases through contaminated materials or respiratory droplets.

Symptoms typically include fever, swollen lymph nodes, and rash and/or lesions.

Click here for the WHO factsheet on mpox.

Two detected cases

The case in the United Kingdom was detected in December 2025 in a traveller returning from a country in the Asia Pacific region. Initial laboratory testing identified the virus as clade Ib, but whole genome sequencing later revealed that it contained genetic regions from both clade Ib and clade IIb strains. Repeat sequencing confirmed the findings and demonstrated that the virus “can replicate and presents potential for onward transmission.”

In India, a patient who developed symptoms in September 2025 was initially classified as infected with clade II MPXV. However, following updates to global genomic databases, the virus was reclassified as the same recombinant strain identified in the UK. The Indian case represents the earliest known detection of this strain.

“Due to the small number of cases found to date, conclusions about transmissibility or clinical characterization of mpox due to recombinant strains would be premature, and it remains essential to maintain vigilance regarding this development,” WHO said.

Clinical presentations in both cases were consistent with known mpox infections.

Risk assessment unchanged

WHO’s overall risk assessment remains unchanged: the risk is assessed as moderate for men who have sex with men with new and/or multiple partners and for sex workers or others with multiple casual sexual partners, and low for the general population without specific risk factors.

At the same time, WHO cautioned that clade differentiation PCR tests alone “may not reliably identify recombinant MPXV strains,” meaning genomic sequencing is essential for detection.

“All countries should remain alert to the possibility of MPXV genetic recombination,” WHO said, urging continued epidemiological surveillance, sequencing, vaccination of at-risk groups, and infection prevention and control measures.

WHO advised that no travel or trade restrictions are warranted based on current information.

Syria transition gains ground with Kurdish deal, but violence and humanitarian strain persist

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A new agreement between the Syrian government and Kurdish-led forces in the country’s northeast is being viewed by the United Nations as a potentially significant step toward stabilising a region long shaped by conflict and competing authorities.

Briefing members of the UN Security Council for the first time in his role as Deputy Special Envoy for Syria, Claudio Cordone highlighted the ceasefire and integration agreement signed on January 30 between Damascus and the Syrian Democratic Forces (SDF). The arrangement, he said, could mark an important turning point if implemented effectively.

Agreement Aims To Integrate Northeast Syria

The deal outlines a gradual process to integrate the military and administrative structures of northeast Syria with the Syrian state. It also contains provisions aimed at facilitating the return of displaced residents and safeguarding Kurdish cultural and educational rights.

Officials say the framework builds upon earlier government measures, including Presidential Decree 13, which recognised certain linguistic, cultural and citizenship rights for Kurdish communities.

Cordone told the Council that hostilities in the region had largely subsided and that work on implementing the agreement had begun.

Security deployments by Syria’s Ministry of Interior have already taken place in key cities such as Al-Hasakeh and Qamishli, while talks are underway regarding local governance arrangements and political appointments.

The United Nations Secretary-General welcomed the agreement soon after it was announced, urging all sides to move quickly to ensure its full implementation. He emphasised that the deal should guarantee the peaceful integration of the northeast, protect Kurdish rights and enable displaced Syrians to return home voluntarily and safely.

Security Council members echoed that message in a presidential statement this week, describing the deal as a comprehensive step that could help prevent further civilian suffering and reduce risks surrounding detention facilities holding suspected fighters from the Islamic State group, also known as ISIL or Da’esh.

UN Continues Political And Humanitarian Engagement

Alongside political mediation, the United Nations remains heavily involved in humanitarian operations across Syria.

The office of the UN Special Envoy continues to engage with the Syrian government and other political actors in an effort to advance the broader political transition. These discussions include implementing the northeast agreement, encouraging inclusive governance and promoting respect for human rights.

At the same time, UN agencies and partner organisations are delivering food, water, healthcare and shelter to millions of Syrians affected by years of war. Aid teams are also supporting mine clearance operations, restoring damaged infrastructure and helping communities rebuild basic services.

These efforts aim to create conditions that would allow displaced families to return home in safety and dignity.

Security Concerns Persist In Several Regions

Despite the relative calm in parts of the northeast, the situation across Syria remains fragile.

Cordone said the United Nations is closely monitoring the transfer of suspected Islamic State fighters from Syria to Iraq. He stressed that legal proceedings must meet international fair-trial standards and urged countries to repatriate their citizens detained in Syria as quickly as possible.

Elsewhere in the country, tensions continue to flare. In the southern province of Sweida, clashes between government forces and local armed groups have caused damage to infrastructure and triggered electricity outages. Protests calling for greater local autonomy have also resurfaced.

In southern border areas, Israeli military operations and search activities have continued. Reports have also emerged of aerial herbicide spraying damaging farmland. UN officials have called for adherence to international law and urged Israel to withdraw from territories it occupies in violation of the 1974 Disengagement of Forces Agreement.

Participants at a UN workshop on recovery priorities, challenges and response planning /UN

Displacement And Humanitarian Needs Remain High

Humanitarian conditions remain difficult for many Syrians despite some limited improvements.

According to the UN humanitarian coordination office, recent clashes in the northeast displaced tens of thousands of people. Although many have since returned, around 130,000 individuals remain displaced across the governorates of Al-Hasakeh, Ar-Raqqa and Aleppo.

More than 90 percent of those affected are women and girls, many of whom are living in overcrowded camps or staying with host families already facing economic hardship.

Heavy flooding this week in Idlib and northern Latakia further compounded the crisis, killing two children and destroying or damaging around 2,000 tents sheltering displaced families.

Still, aid groups say access to some areas is gradually improving. UN teams have reached around 200,000 people in recent weeks, delivering assistance through more than 170 aid convoys.

Electricity supply has also reportedly resumed in the town of Ain al-Arab, also known as Kobane, following repairs to damaged infrastructure.

Political Transition Moves Forward

Attention is now turning to the next stage in Syria’s political transition: the formation of a new People’s Assembly.

Elections for most seats were held in October 2025, though additional seats, including those representing Raqqa, remain to be filled. Confirmation is still awaited regarding the appointment of 70 members by President Ahmed al-Sharaa and the date of the assembly’s opening session.

Cordone stressed that the success of the transition would depend on meaningful representation from Syria’s diverse communities and regions.

He also underscored the need to address long-standing issues such as the fate of missing persons and mechanisms for transitional justice.

Highlighting the contributions of Syrian women throughout years of conflict, the UN envoy said their participation in politics and civil society would be essential for building a more inclusive and stable future.

He concluded his remarks by praising the resilience of the Syrian people and expressing hope that continued cooperation between Syria and the United Nations would help lay the foundations for lasting peace and recovery.

Syria: Ceasefire under strain as violence and aid access issues persist in Sweida

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The 19 July truce followed weeks of sectarian clashes, Israeli airstrikes and grave human rights violations in the southern governorate, also known as As-Sweida.

As a result, more than 190,000 people have been displaced there and in neighbouring Dar’a and Rural Damascus governorates.

The fighting also caused severe damage to infrastructure and to livelihoods.  Electricity networks, water production assets including wells, and key public facilities were impacted.

Volatility, surveillance and demonstrations

Between 1 and 5 August, the security situation in Sweida and surrounding areas remained volatile, with clashes reported in three places, according to the OCHA flash update.

“Additionally, aerial surveillance activity attributed to the Israeli Defence Forces (IDF) has been observed over multiple locations in Dar’a and As-Sweida, contributing to regional tension,” the agency said.

During the same period, public demonstrations occurred across multiple locations in Sweida, reiterating calls for improved humanitarian access and protection.

Parallel demonstrations also took place in Dar’a and Damascus governorates which emphasised the importance of national unity. 

Aid efforts continue

Humanitarian access remains constrained, OCHA said, as the UN and partners continue to support response efforts.  

The main highway between Sweida and the capital, Damascus, has been inaccessible since 12 July due to security concerns. 

Furthermore, the southern corridor via Busra Esh-Sham in eastern Dar’a was temporarily closed for 24 hours but reopened on Monday, affecting aid delivery.

“Humanitarian actors scaled up response efforts, including fuel and food deliveries to As-Sweida and Dar’a, commercial convoy facilitation, and shelter support for displaced populations,” OCHA said.

Inter-agency mission

Since the escalation of hostilities, humanitarians have provided bread assistance to nearly 1.5 million people.

OCHA also led an inter-agency mission to Dar’a to assess shelter conditions and to discuss medium-term housing options for displaced people.

Meanwhile, restoration of essential services is ongoing in Sweida, with partial electricity restored through emergency repairs.  

However widespread telecommunication and internet outages persist across the governorate, and maintenance of water and power networks continues in rural areas. 

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