New recombinant mpox strain detected in UK and India, WHO urges continued monitoring

WHO confirmed that two cases of the recombinant strain – combining genomic elements of clades Ib and IIb of the monkeypox virus (MPXV) – have been identified to date: one in the United Kingdom and one in India. Both patients had recent travel histories, and neither experienced severe illness.

No secondary cases were detected following contact tracing.

WHO has published a detailed update on the two cases and the national responses.

Recombination is a natural process that can occur when two related viruses infect the same person and exchange genetic material, producing a new variant.

According to WHO, detailed genomic analysis shows the two individuals “fell ill several weeks apart with the same recombinant strain,” suggesting that additional undetected cases may exist.

What is mpox?

Mpox is an infectious disease caused by the monkeypox virus (MPXV), part of the Orthopoxvirus genus, which also includes the virus that causes smallpox.

It spreads through close physical contact, including sexual contact, and in some cases through contaminated materials or respiratory droplets.

Symptoms typically include fever, swollen lymph nodes, and rash and/or lesions.

Click here for the WHO factsheet on mpox.

Two detected cases

The case in the United Kingdom was detected in December 2025 in a traveller returning from a country in the Asia Pacific region. Initial laboratory testing identified the virus as clade Ib, but whole genome sequencing later revealed that it contained genetic regions from both clade Ib and clade IIb strains. Repeat sequencing confirmed the findings and demonstrated that the virus “can replicate and presents potential for onward transmission.”

In India, a patient who developed symptoms in September 2025 was initially classified as infected with clade II MPXV. However, following updates to global genomic databases, the virus was reclassified as the same recombinant strain identified in the UK. The Indian case represents the earliest known detection of this strain.

“Due to the small number of cases found to date, conclusions about transmissibility or clinical characterization of mpox due to recombinant strains would be premature, and it remains essential to maintain vigilance regarding this development,” WHO said.

Clinical presentations in both cases were consistent with known mpox infections.

Risk assessment unchanged

WHO’s overall risk assessment remains unchanged: the risk is assessed as moderate for men who have sex with men with new and/or multiple partners and for sex workers or others with multiple casual sexual partners, and low for the general population without specific risk factors.

At the same time, WHO cautioned that clade differentiation PCR tests alone “may not reliably identify recombinant MPXV strains,” meaning genomic sequencing is essential for detection.

“All countries should remain alert to the possibility of MPXV genetic recombination,” WHO said, urging continued epidemiological surveillance, sequencing, vaccination of at-risk groups, and infection prevention and control measures.

WHO advised that no travel or trade restrictions are warranted based on current information.

Syria transition gains ground with Kurdish deal, but violence and humanitarian strain persist

Briefing ambassadors for the first time as Deputy Special Envoy, Claudio Cordone pointed to the 30 January ceasefire and integration agreement between the Syrian Government and the Syrian Democratic Forces (SDF) as a potentially transformative development.

The deal provides for a phased military and administrative integration of northeast Syria and includes provisions on the return of displaced people and the protection of Kurdish civil and educational rights, building on Presidential Decree 13 on linguistic, cultural and citizenship rights.

“Hostilities have ended and work on an implementation plan has been progressing in a positive manner,” Mr. Cordone said, noting deployments of Ministry of Interior forces in Al-Hasakeh and Qamishli, and discussions on local governance and political appointments.

The Secretary-General on 30 January welcomed the agreement, appealing for all sides “to work swiftly to ensure its implementation, especially in terms of the peaceful integration of northeast Syria, the rights of Syrian Kurds, the safe, dignified and voluntary return of the displaced.”

In a presidential statement issued on Thursday, Council members likewise welcomed the “comprehensive agreement” and stressed the need to adhere to it to “minimize civilian suffering” and prevent any “security vacuum” around ISIL (Da’esh) detention facilities.

What is the UN doing in Syria now?

The UN is supporting Syria’s political transition while continuing large-scale humanitarian operations across the country.

The Office of the Special Envoy is engaging with the Government and a broad range of stakeholders to help advance the political process, including implementation of the recent agreement on northeast Syria, support for inclusive governance, and the protection and promotion of human rights.

At the same time, humanitarian agencies are delivering life-saving assistance to millions of Syrians.

UN teams and partners are providing food, water, medical supplies, shelter and protection services, while supporting mine action, restoring basic services and helping create conditions for safe, dignified and voluntary returns.

Visit the UN News Focus on Syria section to read more about UN’s work in and engagement with Syria.

Situation remains sensitive

The evolving situation around those facilities remains sensitive.

Mr. Cordone said the UN is closely following transfers of Syrian and non-Syrian Da’esh suspects to Iraq, adding that Iraqi proceedings must “fully respect fair trial standards” and urging Member States to repatriate their nationals “as swiftly as possible.”

While the northeast has seen relative stabilization, tensions persist elsewhere.

In Sweida, renewed clashes between Government forces and local armed groups have caused damage and electricity outages. Protests calling for self-determination have resurfaced, and the UN reiterated calls for confidence-building measures within “the full respect of Syria’s sovereignty and territorial integrity.”

In southern Syria, Israeli incursions and search operations have continued, alongside reports of aerial herbicide spraying damaging crops. The UN envoy called for “full respect for international law” and urged Israel to withdraw from areas it occupies “in violation of the 1974 Disengagement of Forces Agreement,” while supporting “mutually acceptable security arrangements between Israel and Syria.”

Humanitarian challenges persist

Humanitarian conditions remain severe despite modest improvements.

Lisa Doughten, Director of Financing at the UN Office for the Coordination of Humanitarian Affairs (OCHA), said recent clashes displaced tens of thousands; although many have returned, about 130,000 people remain uprooted across Al-Hasakeh, Ar-Raqqa and Aleppo governorates. More than 90 per cent are women and girls, with many sheltering in overcrowded camps or with host families already under strain.

Heavy flooding this week in Idleb and northern Latakia killed two children and damaged or destroyed some 2,000 tents, affecting over 5,000 displaced people.

Still, access and basic services are gradually improving in parts of the northeast. UN teams have reached 200,000 people and organized more than 170 truck movements. In Ain al-Arab (Kobane), electricity supply has reportedly resumed after repairs.

Participants at a UN workshop on recovery priorities, challenges and response planning.

Meaningful representation of all Syrians crucial

Politically, the next milestone in the transition is the formation of the People’s Assembly. Voting for most elected seats took place in October 2025 – with additional seats, including in Raqqa, due to be filled. Confirmation is awaited on the appointment of 70 members by President Ahmed al-Sharaa, as well as of the date of the opening session.

Mr. Cordone reiterated the importance of meaningful representation of Syria’s regions and diverse groups, stressing that “the protection and promotion of human rights – including addressing the issue of the missing and transitional justice – are fundamental elements for a credible and successful political transition.

‘Extraordinary role’ of Syrian women

He highlighted the “extraordinary role” of Syrian women and civil society over the decade-long conflict, saying women’s political participation at all levels is “a pillar for a state committed to plurality, inclusion and opportunity for all.”

“I salute the Syrian people for their determination in overcoming decades of oppression and brutal conflict. I look forward to strengthening the UN’s partnership with Syria in pursuit of a stable, peaceful and prosperous future,” he said in Arabic as he concluded his briefing.

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Syria: Ceasefire under strain as violence and aid access issues persist in Sweida

The 19 July truce followed weeks of sectarian clashes, Israeli airstrikes and grave human rights violations in the southern governorate, also known as As-Sweida.

As a result, more than 190,000 people have been displaced there and in neighbouring Dar’a and Rural Damascus governorates.

The fighting also caused severe damage to infrastructure and to livelihoods.  Electricity networks, water production assets including wells, and key public facilities were impacted.

Volatility, surveillance and demonstrations

Between 1 and 5 August, the security situation in Sweida and surrounding areas remained volatile, with clashes reported in three places, according to the OCHA flash update.

“Additionally, aerial surveillance activity attributed to the Israeli Defence Forces (IDF) has been observed over multiple locations in Dar’a and As-Sweida, contributing to regional tension,” the agency said.

During the same period, public demonstrations occurred across multiple locations in Sweida, reiterating calls for improved humanitarian access and protection.

Parallel demonstrations also took place in Dar’a and Damascus governorates which emphasised the importance of national unity. 

Aid efforts continue

Humanitarian access remains constrained, OCHA said, as the UN and partners continue to support response efforts.  

The main highway between Sweida and the capital, Damascus, has been inaccessible since 12 July due to security concerns. 

Furthermore, the southern corridor via Busra Esh-Sham in eastern Dar’a was temporarily closed for 24 hours but reopened on Monday, affecting aid delivery.

“Humanitarian actors scaled up response efforts, including fuel and food deliveries to As-Sweida and Dar’a, commercial convoy facilitation, and shelter support for displaced populations,” OCHA said.

Inter-agency mission

Since the escalation of hostilities, humanitarians have provided bread assistance to nearly 1.5 million people.

OCHA also led an inter-agency mission to Dar’a to assess shelter conditions and to discuss medium-term housing options for displaced people.

Meanwhile, restoration of essential services is ongoing in Sweida, with partial electricity restored through emergency repairs.  

However widespread telecommunication and internet outages persist across the governorate, and maintenance of water and power networks continues in rural areas. 

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