World News in Brief: Cholera surges worldwide, DR Congo update, WHO leads global health emergency exercise

The UN health agency registered almost 810,000 cases and 5,900 deaths from the preventable disease in 2024; that’s about 50 per cent higher than the previous year, according to Dr Philippe Barboza, who leads WHO’s cholera team.

He said the latest reported cases are almost certainly underestimates and that the disease continues to affect countries that were previously cholera-free.

Funding cuts

Recent cuts to international aid funding are also hindering the response, Dr Barboza said, giving the example of how in the previous two years, a donation of $6 million would have allowed WHO to fully control any outbreak occurring in either Malawi or Zambia.

“But this amount of money is not available. So, this is a very major concern…outbreaks are getting worse and worse, deadlier and deadlier, but the funds are getting smaller and smaller.”

WHO data indicates that for the first time in 10 years, Namibia reported infections this year, while Kenya, Malawi, Zambia and Zimbabwe are also experiencing a resurgence.

Angola has also reported nearly 10,000 cholera infections so far during 2025 and 380 people have died from the disease up to the end of March.

Its capital city Luanda has been badly affected. In the past 28 days, the country reported almost 3,500 cases – making up 56 per cent of all the cases across Africa.

Conflict, mass displacement, natural disasters and climate change have intensified outbreaks, particularly in rural and flood-affected areas, with poor infrastructure and limited access to healthcare.  

But it’s not all doom and gloom. In September, production of cholera vaccines reached record levels, with the highest number of doses since 2013.

“We also need to increase funding to support the response effort,” Dr. Barboza said. 

Situation remains critical in Eastern DR Congo, say peacekeepers

The UN peacekeeping mission in the Democratic Republic of the Congo, MONUSCO, continues to implement its mandates amidst a still critical security situation in the restive east, said UN Spokesperson Stéphane Dujarric on Friday.

While reciprocal attacks between the CODECO and Zaire militias are continuing to target civilians in Ituri, MONUSCO continues to “push for an effective process of local political dialogue and to negotiate the safe release of abducted civilians,” including children.

Regarding the situation in the regional capital Goma which was overrun by Rwanda-backed M23 rebels in January, Mr. Dujarric said that “non-essential international staff for the UN are returning to Goma,” although “the protection situation under the M23 occupation remains challenging”.

Mass displacements

On the humanitarian end, renewed hostilities in North Kivu between armed groups in Rutshuru have “triggered the displacement of some 7,500 people,” said Mr. Dujarric.

Local partners have also reported a raid on Mukongola General Referral Hospital by armed elements in the South Kivu province. “They vandalized the maternity ward, the pharmaceutical supplies and injured at least one individual,” he added.

While Mr. Dujarric said that “humanitarian partners [were] working tirelessly to scale up assistance despite the insecurity and the constraints,” UN colleagues on the ground have reported that “ongoing military operations continue to impede humanitarian access.”

“We reiterate our call for immediate, safe and sustained access to all areas,” the UN Spokesperson concluded.

Pandemic control exercise puts WHO emergency system to the test

The World Health Organization (WHO has successfully concluded a two-day exercise simulating the outbreak of a fictional virus spreading across the world – and what it will take to contain it.

Convened by more than 15 countries, 20 regional health agencies, health emergency networks and other partners, “Exercise Polaris” was designed to test a new global coordination mechanism for health emergencies, under the umbrella of the WHO’s Global Health Emergency Corps (GHEC).

“This exercise proves that when countries lead and partners connect, the world is better prepared,” said WHO chief Tedros Adhanom Ghebreyesus.

Coordination and collaboration

GHEC’s structure, which emphasises the importance of coordinating the deployment of surge teams and experts – and of enhancing collaboration between countries – “shows that global cooperation is not only possible, it is essential,” said Tedros. “No country can face the next pandemic alone.”

Throughout the simulation, while countries were leading their own response efforts, WHO provided technical guidance and emergency support.

“The Global Health Emergency Corps has evolved into a powerful platform, building on practice, trust and connection,” said Dr Mike Ryan, Executive Director of WHO’s Health Emergencies Programme. “Exercise Polaris showed what is possible when countries operate with urgency and unity supported by well-connected partners.”

Aid cuts threaten to roll back progress in ending maternal mortality

Furthermore, unprecedented aid cuts are putting global progress to end maternal deaths at risk, UN agencies have warned in a new report that calls for greater investment in midwives and other health workers.

The Trends in maternal mortality report was published by the UN Children’s Fund (UNICEF), the World Health Organization (WHO) and UN sexual and reproductive health agency UNFPA, in observance of World Health Day on 7 April.

It shows that maternal deaths declined by 40 per cent between 2000 and 2023, largely due to improved access to essential health services.

However, the pace of improvement has slowed significantly since 2016, and an estimated 260,000 women died in 2023 due to complications during pregnancy and childbirth, or roughly one death every two minutes.

Deadly peril in Sudan

Frontline health workers have long raised alarms about the perils of giving birth in conflict settings.

In Sudan’s Al Jazirah State, a midwife named Awatef told UNFPA that she helped four women deliver babies while fleeing violence: “I delivered them in the bush, with only very basic sterilization – I had nothing but water and soap.”

One woman, Amina, had to give birth by Caesarean section – on the floor of a stranger’s home where a local doctor was assisting deliveries – while listening to the drum of gunfire just outside. “I had to start walking again just six hours later, carrying my baby while my wounds were still fresh and painful,” she said.

Urgent action needed

As aid funding cuts force countries to roll back vital services for maternal, newborn and child health, the UN agencies appeal for urgent action to prevent maternal deaths, particularly in humanitarian settings where numbers are already alarmingly high.

“While this report shows glimmers of hope, the data also highlights how dangerous pregnancy still is in much of the world today – despite the fact that solutions exist to prevent and treat the complications that cause the vast majority of maternal deaths,” said WHO Director-General Tedros Adhanom Ghebreyesus.

“In addition to ensuring access to quality maternity care, it will be critical to strengthen the underlying health and reproductive rights of women and girls – factors that underpin their prospects of healthy outcomes during pregnancy and beyond.”

Pregnancy and the pandemic

The report also provides the first global account of the COVID-19 pandemic’s impact on maternal survival.

An estimated 40,000 more women died due to pregnancy or childbirth in 2021, rising to 282,000 in 2022, and to 322,000 the following year.

This increase was linked not only to direct complications caused by COVID-19 but also widespread interruptions to maternity services, highlighting the importance of ensuring that this care is available during pandemics and other emergencies.

Invest in midwives

“When a mother dies in pregnancy or childbirth, her baby’s life is also at risk. Too often, both are lost to causes we know how to prevent,” said UNICEF Executive Director Catherine Russell.

With global funding cuts putting more mums-to-be at risk, especially in the most fragile settings, “the world must urgently invest in midwives, nurses, and community health workers to ensure every mother and baby has a chance to survive and thrive,” she added.

Inequalities and slowdowns

The report also highlights persistent inequalities between regions and countries, as well as uneven progress.

With maternal mortality declining by around 40 per cent between 2000 and 2023, sub-Saharan Africa achieved significant gains. It was also among just three UN regions to see significant drops after 2015, with the others being Australia and New Zealand, and Central and Southern Asia.

Yet, sub-Saharan Africa still accounted for approximately 70 per cent of the global burden of maternal deaths in 2023 due to high rates of poverty and multiple conflicts.

Meanwhile, five regions saw progress stagnate after 2015: Northern Africa and Western Asia, Eastern and South-Eastern Asia, Oceania (excluding Australia and New Zealand), Europe and North America, and Latin America and the Caribbean.

A midwife visiting pregnant women in a shelter for internally displaced persons in Sudan.

A global responsibility

Dr. Natalia Kanem, UNFPA’s Executive Director, upheld that access to quality maternal health services is a right, not a privilege.

She stressed the urgent responsibility to build well-resourced health systems that safeguard the lives of pregnant women and newborns.

“By boosting supply chains, the midwifery workforce, and the disaggregated data needed to pinpoint those most at risk, we can and must end the tragedy of preventable maternal deaths and their enormous toll on families and societies,” she said.

Childbirth in crisis settings

The report also highlighted the plight of pregnant women living in humanitarian emergencies, who face some of the highest risks globally.  Nearly two-thirds of global maternal deaths now occur in countries affected by fragility or conflict.

Beyond ensuring critical services during pregnancy, childbirth and the postnatal period, the report emphasized the importance of efforts to enhance women’s overall health by improving access to family planning services, as well as preventing underlying health conditions that increase risks, such as anaemia, malaria and noncommunicable diseases.

Furthermore, it is also vital to ensure that girls stay in school, and that they and women have the knowledge and resources to protect their health.

Source: WHO/UNICEF/UNFPA/World Bank/UN Population Division

Maternal mortality ratio (MMR) trends by region.

One preventable death every 7 seconds during pregnancy or childbirth

Close to 300,000 women continue to die during pregnancy or childbirth each year. More than two million babies die in their first month of life and around two million more are stillborn, says the World Health Organization (WHO) which is kicking off a year-long campaign on maternal and newborn health.

The data adds up to one preventable death every seven seconds, according to the UN health agency.

The Healthy beginnings, hopeful futures campaign is asking governments and health policy makers to ramp up efforts to end preventable maternal and newborn deaths, and prioritize women’s longer-term health and well-being.

Helping every woman and baby survive and thrive

Through a series of strategic actions, WHO aims to not only save lives but ensure both mothers and infants thrive. In collaboration with partners, it will focus on empowering healthcare professionals and sharing crucial information about healthy pregnancies, safe childbirth, and postnatal care.

Listening to women

Access to high-quality, compassionate care is essential for women and families everywhere, WHO emphasises. Health systems must evolve to address a wide range of health concerns, including obstetric complications, mental health issues, non-communicable diseases, and family planning – ensuring that women’s needs are met both before, during, and after childbirth.

Girls affected by the ongoing conflict in Gaza receive a care and protection package distributed by UNICEF.

Women in war zones

At the same time, the proportion of women and girls caught in conflict zones has skyrocketed in the past year, with women now making up 40 per cent of all civilian deaths in armed conflicts.

Today, over 600 million women and girls live in areas affected by violence – an alarming 50 per cent increase since 2017.

As conflict intensifies across the globe, women and girls are bearing a heavy mental health toll. From Afghanistan and Gaza to Georgia and Ukraine, millions are grappling with Post Traumatic Stress Disorder (PTSD), anxiety, depression and trauma, with limited access to support and care.

Around one in five people affected by a humanitarian crisis will develop long-term mental health conditions. Despite this, only two per cent of those in need receive the care they require. Mental health funding globally represents between one and two percent of health spending.

Stark divide on mental health

The gap between high and low-income countries in mental health services is stark. In wealthy nations, there are more than 70 mental health workers for every 100,000 people. In contrast, in low-income countries, that number drops to fewer than one.

As conflicts drag on, the number of affected women continues to rise, making this crisis even more urgent. UN gender equality agency, UN Women, spoke to women in Afghanistan, Gaza, Georgia, and Ukraine to understand how these conflicts are stoking a mental health crisis.

UNFPA’s mobile psychosocial support teams travel across Ukraine, including to the front lines, offering immediate emergency interventions as well as access to longer-term assistance.

Women in Gaza trapped in trauma

In Gaza, relentless bombing, displacement, and deprivation have created a humanitarian catastrophe. Living under siege and the constant threat of violence, women and girls face extreme levels of fear, trauma, and exhaustion. 

Data from UN Women shows that 75 per cent feel regular depression, 62 per cent cannot sleep, and 65 per cent suffer from nightmares and anxiety – most are left to cope alone.

“My mental and psychological health is suffering,” said one 27-year-old pregnant mother of three from Khan Younis. “Sometimes I go to the toilet just to cry and cry until I feel better.”

Women are not only dealing with their own trauma – they are also trying to care for their children.

“I have not prioritized my health because I am the primary caregiver for my children, assuming the roles of both father and mother,” the 27-year-old mother added. 

Afghanistan: Women Erased from Public Life

In Afghanistan, the return of the Taliban has dealt a crushing blow to women’s rights and mental health. Alison Davidian, UN Women’s Country Representative, warns that nearly four years of Taliban decrees have “eviscerated” women’s autonomy.

With no women in leadership roles and 98 per cent reporting no influence over local decisions, many feel trapped in a life of isolation and despair.

“Three years ago, an Afghan woman could run for president. Now, she may not even be able to decide when to buy groceries,” Davidian says. The result is overwhelming psychological distress, with 68 per cent of women in Afghanistan reporting their mental health as “bad” or “very bad.”

An IOM mental health and psychosocial support counsellor leads a session with women in Paktika province, Afghanistan.

Georgia: Antidepressant use on the rise

In Georgia, ongoing displacement and conflict have left many women with no access to adequate mental healthcare. Approximately 200,000 people remain internally displaced, with nearly 40 per cent living in shelters under dire conditions.

Mental health issues are widespread, with 23 per cent suffering from PTSD, 10 per cent reporting depression, and 9 per cent dealing with anxiety. Yet only about a third of those affected have sought care.

“We saw a sharp increase in antidepressant use, particularly in areas with high numbers of displaced people,” said Elene Rusetskaia of the Women’s Information Centre. “The mental health problem is very serious, especially among children.”

Ukraine: Domestic Violence and Depression Soar Amid War

In Ukraine, the war stemming from Russia’s invasion has pushed women’s mental health into crisis. Gender-based violence has surged 36 per cent since 2022, and women are shouldering more unpaid care work – up to 56 hours per week. Forty-two percent are now at risk of depression, while 23 per cent report needing counseling.

Displaced women, many of them refugees, are facing some of the worst mental health challenges, with limited access to support services.

A recent survey by the International Migration Organization (IOM) found that 53 per cent of internally displaced people in Ukraine suffer from depression, yet assistance remains scarce.

In response, UN Women has provided protection, legal aid, and psychosocial support to more than 180,000 women and girls in Ukraine through the Women’s Peace and Humanitarian Fund.

Healthcare funding

The current humanitarian funding crisis, exacerbated by declining health spending in host countries, is affecting the scope and quality of public health and nutrition programmes for refugees and host communities, the UN refugee agency, UNHCRhas said.

In Jordan, 335,000 women of reproductive age are at risk of losing essential maternal health. Without enough funding, prenatal care, safe delivery and newborn health services will disappear.

In Bangladesh, around a million Rohingya refugees face a severe health crisis due to the funding freeze, threatening access to essential medical services. In UNHCR-supported programmes, over 40,000 pregnant women may lose access to critical antenatal care, with 5,000 at risk of delivering in unsafe conditions.

In Burundi, the suspension of nutrition programmes in several camps means that thousands of refugee children under five may not receive adequate treatment for malnutrition.

Necessity, not luxury

For women and girls in conflict zones, mental health care is a critical need, not a luxury. Recovery, dignity, and survival depend on access to trauma care, counseling, and community-based services.

As conflicts continue to devastate communities, the need for mental health support becomes more urgent than ever. Countries must invest in mental health as a core part of humanitarian response, especially in conflict settings, UN Women, emphasized, calling on governments to listen – and act.

Listen to an interview with the Representative ad interim of the UN reproductive health agency, UNFPA, in Sudan: 

WHO warns of severe disruptions to health services amid funding cuts

Speaking on Thursday at a press conference in Geneva, Tedros said that in around 25 per cent of countries, some health facilities have had to close completely due to cuts, according to figures from more than 100 countries compiled by WHO.

Severe disruptions

Out-of-pocket payments for health services have led to disruptions to the supply of medicines and other health products, as well as rising job losses in the healthcare sector.

As a result, “countries are revising budgets, cutting costs and strengthening fundraising and partnerships,” said the UN health agency chief.

From aid dependency to self-reliance

Having to revise budgets, cut costs and strengthen partnerships and fundraising, some countries are relying on WHO’s support to transition away from aid dependency towards sustainable self-reliance.

We are now supporting countries to accelerate that transition,” said Tedros, citing examples of countries such as South Africa and Kenya, who are successfully working towards averting the health impacts of sudden and unplanned cuts.

WHO recommendations

Tedros provided countries with several recommendations on ways to mitigate funding cuts:

  • The world’s poorest populations need prioritising by limiting their exposure to out-of-pocket spending
  • Resist reductions in public health spending and protect health budgets
  • Channel donor funds through national budgets, rather than parallel donation systems
  • Avoid cutting services or closing facilities, and absorb as much of the impact as possible through efficiency gains in health system

New revenue sources

Through short and long-term tools, WHO also encourages countries to generate new sources of revenues.

Immediate measures such as introducing or increasing taxes on products that harm public health is another effective tool to maintain spending on health, he added.

Countries such Colombia and the Gambia, which in recent years have introduced such taxes, have seen revenues increase and consumption fall, said Tedros.

In the longer term, WHO is advocating for social and community-based health insurance policies, where individuals or families can contribute a small amount to a fund which boosts health service financing.

Although not all measures will be right for every country, WHO is “working with affected countries to identify which measures are best for them, and to tailor those measures accordingly.”

Preventable ‘meningitis belt’ deaths targeted in health agency action plan

People anywhere, at any age can be infected with meningitis, which is transmitted through respiratory secretions or droplets in close human contact. Low and middle-income nations are worst-affected.  

The so-called “meningitis belt” in sub-Saharan Africa sees most cases and outbreaks. It stretches from Senegal and The Gambia in the west of the continent all the way to Ethiopia in the east.  

The most dangerous form of the disease, bacterial meningitis, can kill within just 24 hours – and one in six people dies once infected.

“Every family who has had a meningitis case knows about what fear this disease can bring,” said Dr Marie-Pierre Preziosi, WHO Team Lead for Meningitis and R&D Blueprint.

Life sentence

Around 20 per cent of people who contract bacterial meningitis develop long-term complications, including disabilities with a devastating, life-long impact, WHO said in a statement.

Extra attention must be paid to vaccination coverage to avoid critical problems including impairment of brain function, warned Dr Tarun Dua, WHO Unit Head for Brain Health, speaking to journalists at the launch of the new guidelines.

Class divide 

Hearing loss is just one side-effect of the disease; it is often particularly harmful for children whose education suffers. But if it can be detected quickly as per the new WHO guidelines “you can provide treatment and the child can be well included” at school and in society”, Dr. Dua explained.

A cluster of three or four cases amongst schoolchildren can be treated with antibiotics but only if vaccination levels are high, according to Dr Lorenzo Pezzoli, WHO Team Lead for Meningitis and Epidemic Bacterial Diseases.

Worth a shot 

But many countries lack the means to provide vaccine protection to ensure collective immunity against many diseases, not only meningitis. In addition, they also lack the advanced technology required to diagnose the disease in the first place, which isn’t as easy as a COVID-19 swab test.

“You need to insert the needle in the spine and test the liquid that comes out,” Dr Pezzoli said, highlighting the difficulty facing many low-income countries held back by poor health facilities.

In a growing number of countries impacted by emergencies crisis or conflict, people cannot get the treatment they need as quickly as they should, creating “fertile grounds for meningitis epidemics”, said Dr Pezzoli, who added that his two-year-old son has had his jab for the disease.  

The UN health agency guidelines form part of its efforts to eradicate meningitis by 2030. It works with partners including the MenAfrinet network to support countries collect and analyze high quality disease surveillance data. This enables monitoring the impact of control strategies including the Meningitis A vaccine.

Prevention is “the most important piece of the puzzle”, Dr Pezzoli insisted. 

 

Millions displaced, health system in ruins as Sudan war fuels famine

With fighting showing no sign of abating and humanitarian access extremely limited, the crisis in Sudan has become one of the world’s largest emergencies, the UN Office of the High Commissioner for Refugees (UNHCR) warned on Monday.

“This is a very, very sad milestone,” Mamadou Dian Balde, UNHCR Regional Director for East Africa said, marking two years since the outbreak of war.

We are seeing massive violations, massive displacements and a devastating impact on millions of people.

A humanitarian catastrophe

The war, which erupted in April 2023 between the Sudanese Armed Forces (SAF) and the paramilitary Rapid Support Forces (RSF), has triggered a full-blown humanitarian catastrophe.

More than half the population – around 25 million people – require humanitarian assistance and protection, but funding shortfalls and insecurity have left vast swaths of the country beyond reach.

The UNHCR-led $1.8 billion Regional Refugee Response Plan for 2025 – which aimed to support 4.8 million refugees and host community members – remains only 10 per cent funded, Mr. Balde said, jeopardizing essential services such as food, shelter, education and healthcare.

“Communities that have very little are sharing what they have with the refugees. It is an extraordinary show of solidarity,” he added, urging the international community to step up support for the most vulnerable across the region.

Thousands of lives at risk

Hunger has reached catastrophic levels in Sudan, with famine confirmed in 10 areas and 17 more at risk, according to the UN World Food Programme (WFP).

In some areas, emergency food assistance is the only barrier preventing starvation. However, vital operations are constrained by insecurity and lack of funds.

Without immediate assistance, especially in famine or famine-risk areas, thousands of lives are at risk,” said Makena Walker, WFP Acting Country Director in Sudan.

“We can scale up – but we need all parties to guarantee safe, unhindered access for humanitarian convoys,” she added.

© UNICEF/Ahmed Mohamdeen Elfatih

A mother sits alongside her eight-year-old daughter at a hospital in Sudan.

Children hit hardest

Children remain among the hardest hit.

According to the UN Children’s Fund (UNICEF), child casualties this year have surged by 83 per cent compared to early 2024. Children are also at severe risk of sexual and gender-based violence or being forced into armed groups, on top of already losing out on education.

In addition, an estimated 146,000 children are projected to suffer from severe acute malnutrition this year, leaving them up to 11 times more likely to die than a well-nourished child.

A public health emergency

The crisis has also spiralled into a public health emergency, with over 20.3 million people now in urgent need of medical care. Cholera, measles, malaria and dengue are spreading rapidly across two-thirds of Sudan’s states, with cholera alone claiming over 1,500 lives.

This situation is unravelling against a health infrastructure on the brink of collapse: 38 per cent of hospitals in the worst affected regions are non-functional and the remaining only partially operational, according to the UN World Health Organization (WHO).

Attacks on healthcare have surged, with 156 attacks verified over the past two years, resulting in hundreds of deaths and injuries.

“In addition to being a famine crisis, the humanitarian situation in Sudan is also a protection and health crisis,” said Shible Sahbani, WHO Representative in the country.

The UN health agency is determined to continue working to improve health access for Sudan’s people. However, recent funding cuts have forced WHO to scale back operations, potentially affecting health services.

If funding does not flow, 4.7 million people targeted for health interventions this year will be affected. Services at 335 health facilities will also have to be reduced, including trauma and emergency care.

© UNICEF/Mohammed Abdulmajid

A woman carries water to her shelter in a camp for internally displaced persons in eastern Sudan.

Working against the odds

Despite the challenges, UN humanitarians and partners continue their efforts to reach the most vulnerable communities with lifesaving assistance.

Since the war began, WFP has provided over 13 million people with food and nutrition support. For its part WHO, has supported over one million people with health services, treated 75,000 severely malnourished children and helped vaccinate 11.5 million children against polio and measles.

But aid workers warn the situation is deteriorating fast, particularly in the states of Darfur and parts of Khartoum and Al-Jazirah (also spelled Gezira), where active fighting and sieges are cutting civilians off from assistance.

Mr. Balde reiterated the urgent need for the international community to help silence the guns, “we call for peace, protection and sustained support – [only then] normalcy can return, and refugees can return home.

Thousands of Gaza patients waiting for urgent medical evacuation

On Monday, World Health Organisation (WHO) Representative Rik Peeperkorn told UN News about the desperate conditions he had seen at Al-Ahli before the attack, and the severe restriction on movement that is preventing thousands being evacuated for medical treatment outside of Gaza.

“I was in Gaza several weeks ago and I came out in early March, just before the aid blockade started and the attacks started up again.

When I was there, during the ceasefire, we were organising polio vaccinations and medevacs (medical evacuations), and we stocked up on essential medicine and medical supplies. This was also the only time there were proper food stocks in Gaza.

There was almost a ray of hope among all the misery. Places I’d been before, like Rafah in the south, or Jabalia in the north, were utterly devastated wastelands, but people, including our own staff, were going back to their homes, trying to repair destroyed houses or building makeshift camps. You saw commercial activities restarting, and a choice of food.

But then, of course, with the blockade, food, water and essential medicines very quickly began running out. Even though we stocked up during the ceasefire, we are now critically low on supplies and it is challenging to keep hospitals even partly open.

We have completely run out of therapeutic milk, antibiotics, to treat severe infections, trauma painkillers, insulin, ambulance spare parts, oxygen tanks etc.

Medical evacuation of patients from Gaza (file)

A couple of days before the attack on Al Ahli, a medical specialist there told us that the hospital was already overflowing because it’s one of the key hospitals in the north for trauma patients [those who have suffered severe and life-threatening injuries], and that they were forced to perform surgery under questionable sterile conditions.

They were lacking enough surgical gowns, drapes or gloves. They even had to wear the same gloves from one operation to the next. Because of the lack of equipment, surgeries could take hours, increasing the risk of permanent disability or amputations.

The staff asked us for the supplies that we have in our two warehouses in the south of Gaza, but we were not allowed.

This aid blockade needs to be lifted, and we have to get back to an arrangement whereby we can have humanitarian corridors throughout Gaza, without being denied or delayed entry. Even when a war is going on, humanitarian supplies should be allowed in and aid workers should be able to do their work.

Today I spoke to my team leads in Gaza, who have been to Al-Shifa hospital. Al-Shifa, now the major surgical and trauma centre for the north, is completely overwhelmed and under-supported. We are looking at the possibility of getting some patients from Al-Shifa to the south but everything is complex.

Far too few patients have been able to leave Gaza for the urgent care they so desperately need. We estimate that up to 12,000 patients need medical evacuation but, since the blockade we have only been able to evacuate 121 people, including 73 children.

“We call for the immediate resumption of medical evacuation through all possible routes. That should happen now.”

Israeli strike on hospital ‘further cripples’ Gaza’s fragile health system

Several staff members, including two nurses, were injured in the strike on the Kuwaiti Field Hospital in Khan Younis according to Gaza’s Ministry of Health and health agencies, UN Spokesperson Stéphane Dujarric told journalists at the regular news briefing in New York.

The incident follows a separate strike on Sunday on Al-Ahli Arab Hospital in Gaza City, which had been a key facility treating victims of Israeli airstrikes in the north.

“The latest strikes on hospitals further cripples Gaza’s health care system,” Mr. Dujarric said.

“There are currently very few beds available in hospitals and patients are being accommodated in tents.”

He added that according to the UN World Health Organization (WHO), only 21 of Gaza’s 36 hospitals remain “just partially functional” and almost all have sustained some damage in the conflict.

He further reported that, according to health partners, there is an urgent need for thousands of blood units for life-saving operations.

Furthermore, there are serious concerns that food warehouses have reached “very low levels” as no aid has entered Gaza in weeks.

Meanwhile, amid the devastation a rare moment of relief came as humanitarians in Gaza successfully installed a backup generator at Kamal Adwan Hospital to power a water system producing 20 cubic metres of clean water per hour.

Mr. Dujarric reiterated the UN’s call on all parties to ensure that civilians are respected and always protected, and that they have the basic necessities to survive.

“All hostages must be released immediately and unconditionally, and a ceasefire must be restored and renewed without delay,” he added.

Countries finalize historic pandemic agreement after three years of negotiations

Developed after over three years of negotiations under the auspices of the World Health Organization (WHO), the draft outlines a framework for strengthening international collaboration, equity and resilience in the face of future global health threats.

The nations of the world made history in Geneva today,” said WHO Director-General Tedros Adhanom Ghebreyesus.

“In reaching consensus on the Pandemic Agreement, not only did they put in place a generational accord to make the world safer. They have also demonstrated that multilateralism is alive and well and that in our divided world – nations can still work together to find common ground and a shared response to shared threats.

‘One health’ approach

Negotiations began in December 2021 at the height of the COVID-19 pandemic, when WHO member States agreed on the urgent need for a legally binding international instrument and established the Intergovernmental Negotiating Body (INB).

The process involved 13 formal rounds of negotiations, many of which were extended into the early hours, culminating in Wednesday’s consensus after a final overnight session.

Key elements of the proposed agreement include a commitment to a “One Health” approach to pandemic prevention, stronger national health systems, setting up a coordinating financial mechanism, and creating a globally coordinated supply chain and logistics network for health emergencies.

The draft also proposes a new pathogen access and benefit-sharing system, increased support for technology and knowledge transfer as well as capacity-building, and outlines a skilled, trained and multidisciplinary national and global health emergency workforce.

National sovereignty upheld

The text further affirms national sovereignty in public health decisions. It states explicitly that nothing in the agreement gives WHO the authority to mandate health measures such as lockdowns, vaccination campaigns, or border closures.

The draft will now be submitted for consideration to the 78th World Health Assembly – UN’s highest forum for global health – set to begin on 19 May. If adopted, it will be subject to ratification by individual nations.

According to media reports, the United States did not participate in the final round of negotiations, following its January announcement to withdraw from the global health body, and would not be bound by the pact.

Five Facts: Proposed pandemic agreement.

A breakthrough for health equity

Speaking at the conclusion of the meeting, WHO Director-General Tedros praised the negotiating teams and the INB leadership for their perseverance and shared purpose.

This achievement is not just a diplomatic success,” he said. “It reflects your resilience, unity and unwavering commitment to the health and wellbeing of people everywhere.”

INB Co-Chair Precious Matsoso of South Africa called the outcome a breakthrough for health equity.

“The negotiations, at times, have been difficult and protracted. But this monumental effort has been sustained by the shared understanding that viruses do not respect borders – that no one is safe from pandemics until everyone is safe,” she said.

Fellow Co-Chair Anne-Claire Amprou of France added that the agreement lays the foundation for a stronger, more equitable global health security architecture.

“This is a historic agreement for health security, equity and international solidarity,” she said.

Learning from COVID-19, looking to the future

The agreement emerges in the aftermath of the COVID-19 pandemic, which exposed critical vulnerabilities in global health systems and stark inequalities in access to diagnostics, treatments, and vaccines. The virus claimed nearly seven million lives worldwide, severely disrupted economies, and overwhelmed healthcare services across the globe.

At the same time, the pandemic triggered the largest vaccination campaign in history, with over 13.3 billion doses administered globally by April 2023.

Looking ahead, Tedros emphasised the agreement’s long-term significance.

“The importance of this agreement goes beyond our current challenges,” he said.

It is vital for future generations – for our children and grandchildren. By building a strong framework for pandemic preparedness and response, we ensure they inherit a safer and healthier world.

A view of the closing session of Intergovernmental Negotiating Body (INB).

Myanmar: 'The pain of earthquake-affected women and girls has shocked me'


On March 28, a magnitude 7.7 earthquake in Myanmar brought a terrible destruction with them. Many states and regions of the country including Mandale, Sagaiing, Magway, Bago have lost mass and property, and huge human needs are steeped. The United Nations Agency (UNFPA) for sexual and reproductive health, along with its partners organizations in this difficult time, is engaged in providing life -saving help to the needy population, especially women and girls.

Food Poisoning In NMIMS Telangana, Over 50 Students Affected; Campus Response Under Scrutiny

In a shocking incident at the Narsee Monjee Institute of Management Studies (NMIMS) in Jadcherla, Telangana, over 50 students fell ill due to suspected food poisoning. The incident, which occurred on Thursday, has raised serious concerns about food safety and emergency response on the campus.

The students began exhibiting symptoms of nausea, vomiting, stomach pain, and fever shortly after consuming food from the campus canteen. In an attempt to manage the situation, the varsity administration arranged for private doctors to treat the affected students on the premises and makeshift medical facilities were set up in common rooms and the library.

However, the administration’s response was met with criticism. The students alleged that the management was trying to suppress the incident and shield those responsible.

Campus Crisis: Allegations and MLA’s Intervention

The students claimed that the administration’s failure extended beyond the provision of safe and hygienic food, pointing out the lack of emergency medical transportation. No ambulances were arranged for students requiring urgent care, exacerbating the crisis.

The situation escalated when Jadcherla MLA P. Anirudh Reddy visited the NMIMS campus. Expressing shock at the lack of proper medical infrastructure, Reddy confronted university officials and questioned the qualifications of the doctors attending to the students.

Reddy demanded immediate action, stating, “You are only trying to protect the university. Protect the children. Shift them to hospitals immediately.” Following Reddy’s intervention, around 15-20 affected students were transferred to hospitals in Mahabubnagar and Hyderabad for specialized treatment.

However, the students’ ordeal didn’t end there. They voiced longstanding complaints about poor food hygiene in the campus canteen, citing low-quality groceries, vegetables, and cooking oil used in the preparation of meals.

Longstanding Complaints and Media Intervention

The students claimed that despite several representations over the poor quality of food and drinking water provided to them, the college administration had been acting with negligence. They alleged that the mess in charge had consistently denied all their allegations, leading to a situation that could have been avoided with timely action.

The incident at NMIMS is not an isolated one. It brings to light the larger issue of food safety and hygiene in educational institutions. In the past, similar incidents have occurred in various parts of the country, underscoring the need for stringent food safety measures and emergency response systems on campuses.

The university administration, which also tried to prevent the media from entering the campus to report the incident, was compelled to let them in after they protested. This incident has not only exposed the administration’s negligence but also highlighted the importance of media in bringing such issues to light.

Odyssey Nears Deal to Acquire Honeywell’s PPE Unit

Private equity firm Odyssey is reportedly in advanced negotiations to acquire Honeywell’s face mask unit, a potential deal valued at around $1.5 billion. This acquisition marks a strategic move by Odyssey to capitalize on the surging demand for personal protective equipment (PPE), driven by the global pandemic. The deal would be a significant milestone in the PPE industry, as face masks have become an essential commodity worldwide.

The ongoing talks, initially reported by Bloomberg News, suggest Odyssey’s growing interest in expanding its investment portfolio within the PPE sector. Honeywell, a global conglomerate known for its diversified product offerings, including aerospace systems and engineering services, has played a key role in meeting the massive demand for PPE during the COVID-19 crisis.

While the reasons behind Odyssey’s interest in Honeywell’s face mask division remain unspecified, the acquisition is seen as a calculated effort to tap into the lucrative market. The surge in demand for PPE since the pandemic began has transformed the sector, making it an attractive investment opportunity for private equity firms.

PPE Market

If the deal proceeds, it could have broader implications for both companies and the PPE market. Honeywell’s face mask unit, known for its production capacity and established reputation, has been a leader in addressing global PPE needs. Odyssey’s acquisition could further shake up the competitive landscape as private equity firms continue to show interest in PPE-related assets.

This is not the first time a private equity firm has targeted the PPE industry. In 2016, Blackstone acquired a majority stake in Ansell Limited’s industrial and medical gloves business for $600 million, a deal that highlighted the profitability of the sector even before the pandemic. Odyssey’s potential acquisition of Honeywell’s unit could be viewed in a similar light, setting the stage for more deals as the industry continues to expand.

While the deal is still in its negotiation phase, the final terms could evolve as discussions progress. The outcome will not only impact Odyssey’s investment portfolio but also shape Honeywell’s future business strategy. Industry stakeholders are watching closely, as this acquisition could set a benchmark for future investments in the PPE market.

Novo Nordisk Seeks AI Partnerships in India

Novo Nordisk, the Danish pharmaceutical company known for its popular weight-loss drug Wegovy, is scaling up its operations in India to meet rising global demand. The company plans to double its senior leadership team in India and increase its total workforce by 16%, bringing its headcount to 5,000 by next year. This move underscores India’s growing importance in the global pharmaceutical landscape, offering cost-effective operations and a flourishing ecosystem of AI start-ups.

In a strategic push, Novo Nordisk is partnering with local AI firms to streamline various functions such as document summarization and insight extraction. These collaborations aim to improve efficiency, with AI tools reducing the time required for regulatory submissions from 40 hours to just 40 minutes, according to John Dawber, Novo Nordisk’s managing director for global business services. The company already uses these AI solutions across its global operations.

India has been a key location for Novo Nordisk for 17 years, particularly its Bengaluru operations, which handle vast amounts of data related to drug safety and efficacy. This includes monitoring clinical trials and tracking reports of side effects. Dawber foresees the Bengaluru center becoming a near mirror image of the company’s headquarters in Bagsvaerd, Denmark, within the next three years, playing a pivotal role in research and development.

Novo Nordisk’s expansion aligns with a broader trend of pharmaceutical giants betting big on India. Companies like Sanofi and Bristol Myers Squibb are also increasing their investments in the country, recognizing the potential for AI and digital technologies to enhance drug development.

A Competitive Landscape

The rising global profile of Wegovy, along with its diabetes counterpart Ozempic, has boosted Novo Nordisk’s standing. Half of the company’s global safety assessment work, which includes monitoring drug side effects and submitting reports to health regulators, is already handled by its India-based team. In addition, the team contributes to key processes like safety update reports and risk management plans.

While Novo Nordisk did not disclose the financial details of its expansion or AI partnerships, it confirmed that it is open to further collaborations with Indian start-ups.

As Novo Nordisk and rivals like Eli Lilly race to capture the burgeoning global weight-loss market, which analysts predict could hit $150 billion in the next decade, the company’s Indian operations are set to play a crucial role in driving innovation and maintaining competitiveness.

Dozee Launches AI-Powered Remote Health Monitoring for NRIs to Care for Aging Parents

Bengaluru, Oct 8 – Dozee, a leading Indian health-tech company, has introduced a breakthrough service for non-resident Indians (NRIs) to monitor their parents’ health remotely in real-time.

The new offering, Dozee Shravan, is an AI-powered Remote Parent Monitoring (RPM) solution, designed to alleviate the concerns of NRIs who struggle to manage their elderly parents’ health from abroad. This innovative service leverages clinical-grade technology to provide continuous, contactless health monitoring and real-time alerts for early detection of potential health issues.

Dozee Shravan’s launch addresses a critical gap in healthcare for millions of NRIs. Managing the health of aging parents from overseas often involves infrequent check-ins, reliance on extended family, and limited telemedicine—systems that frequently fail during emergencies.

Furthermore, current monitoring solutions are often cumbersome, relying on wearables or manual intervention, which many elderly people find uncomfortable or difficult to maintain. The lack of continuous monitoring and real-time alerts exacerbates the problem, leading to overlooked health issues and delayed medical intervention.

“Caring for our parents is deeply rooted in Indian culture. With Dozee Shravan, NRIs can now be reassured that their parents in India are continuously monitored and cared for, allowing them more quality time and peace of mind,” said Mudit Dandwate, CEO & Co-Founder of Dozee.

The Dozee Shravan system operates on AI-powered Ballistocardiography, using advanced algorithms to track vital signs such as heart rate, respiration, non-contact blood pressure, and sleep patterns. By providing real-time alerts for any abnormalities, it allows for prompt medical attention before conditions worsen. Health data is securely shared with both families and healthcare providers in India, adhering to international standards for data privacy, including US FDA clearance.

Dozee’s technology is already trusted by over 280 hospitals across India, the USA, and Africa, where it has proven effective in reducing critical care admissions and improving patient outcomes. The introduction of Shravan marks a significant expansion into personal healthcare monitoring, offering a solution tailored specifically for NRIs managing elderly care from afar.

Key Features of Dozee Shravan:

  1. Contactless, Continuous Monitoring: Unlike traditional wearables, Dozee Shravan offers AI-based monitoring without physical devices, ensuring minimal disruption to daily life.
  2. Real-Time Alerts and Notifications: Any deviation in vital signs triggers immediate notifications to both NRIs and healthcare providers, enabling timely interventions.
  3. Integration with Healthcare Providers: Dozee collaborates with top hospitals across India, ensuring parents receive comprehensive care, from routine check-ups to emergency responses.
  4. Proactive Health Management: The system provides monthly health reports and trends, allowing families to track long-term patterns and make informed decisions.
  5. Ease of Use: Shravan’s simple, user-friendly interface is designed to be accessible for elderly users, seamlessly integrating into their daily routine.

The introduction of Shravan highlights Dozee’s commitment to transforming healthcare in India and globally. With this launch, the company aims to empower NRIs to take an active role in their parents’ health, ensuring that early warnings are captured and acted upon, reducing the risk of critical health events.

This latest innovation builds on Dozee’s proven track record in hospital settings, where its Early Warning System has been instrumental in preventing life-threatening emergencies and optimizing patient care. By bringing this technology into homes, Dozee is offering NRIs a much-needed solution to the challenge of long-distance caregiving.

The launch of Dozee Shravan not only fills a crucial gap in the healthcare system but also reinforces India’s role as a global leader in health-tech innovation. As more NRIs turn to advanced, AI-driven solutions for elder care, Shravan is poised to become a trusted tool for safeguarding the health of elderly parents across India.

What are Forever Chemicals? Study Reveals They’re Linked to Sleep Disruptions

A groundbreaking study led by the University of South California (USC) has unveiled a concerning link between high levels of per- and polyfluoroalkyl substances (PFAS), also known as ‘forever chemicals’, and sleep disruptions.

This research, published in the journal Environmental Advances, has shed light on the potential health risks associated with these pervasive chemicals. PFAS are a group of man-made chemicals that have been used in a variety of industries around the globe since the 1940s. They are found in a wide range of consumer products that people use daily such as cookware, pizza boxes, and stain repellants.

Due to their chemical structure, PFAS are resistant to heat, water, and oil, earning them the moniker forever chemicals. They do not break down easily and can persist in the environment and the human body for extended periods. The USC study examined the blood samples and sleep patterns of 144 participants aged between 19 and 24.

The researchers found that higher levels of four specific types of PFAS – PFDA, PFHxS, PFOA, and PFOS – were significantly associated with less sleep or worse quality of sleep.

The Impact of PFAS on Sleep and Health

Young adults with higher levels of these toxic chemicals in their blood had 80 fewer minutes of sleep at night. They also had trouble falling asleep, staying asleep, waking up, or feeling tired during waking hours. Sleep is a fundamental pillar of health.

A person must sleep 7-8 hours daily. Prolonged poor sleep may raise chronic health issues, including diabetes and Alzheimer’s disease. The study’s findings are particularly concerning given the widespread presence of PFAS in our environment and daily lives.

Previous studies have shown that PFAS have contaminated water, food, and people through products such as Teflon pans, waterproof clothing, stain-resistant carpets and fabrics, and food packaging. They have also been linked to cancers of the breast, ovary, skin, and uterus in women, among other diseases.

The USC study also examined the overlap between genes affected by the four forever chemicals and genes related to sleep disorders. Out of 600-plus candidate genes, seven activated by PFAS seemed to influence sleep.

Historical Parallels and Reducing Exposure

This included HSD11B1, which helps produce the hormone cortisol that plays an important role in regulating the rhythm of sleep and wakefulness. Another gene was cathepsin B, related to cognitive function and memory. Disruption in this gene was linked to Alzheimer’s.

The study’s findings echo historical events where chemicals once deemed safe were later found to have harmful effects on human health. For instance, lead was widely used in paint, gasoline, and plumbing until research revealed its toxic effects, particularly in children. Similarly, asbestos was a popular building material until its fibers were found to cause lung diseases.

The USC study adds to the growing body of evidence suggesting that PFAS could be the next major public health concern.

To reduce exposure to PFAS, individuals can avoid using products that are stain-resistant, waterproof, or nonstick, as these often contain PFAS. They can also choose natural fiber clothing, use glass, stainless steel, or ceramic cookware instead of Teflon or other nonstick pans, and be cautious with food packaging, especially for microwave meals.

Filtering drinking water with a system designed to remove PFAS, if necessary, and being mindful of personal care products, checking labels for PFAS ingredients, can also help. As we continue to learn more about these forever chemicals, it is crucial that we take steps to minimize our exposure and protect our health.

Snoring Linked to High Blood Pressure, Australian Study Finds

A new Australian study has revealed that regular snoring may lead to higher blood pressure. Researchers from Flinders University in South Australia found that people who snore often are more likely to suffer from elevated blood pressure and uncontrolled hypertension.

The study monitored 12,287 participants over six months, using home-based sleep tracking technology. It showed that 15% of the participants snored for more than 20% of the night. Those who snored heavily had a 3.8 mmHg higher systolic blood pressure and 4.5 mmHg higher diastolic pressure compared to non-snorers.

Hypertension, commonly known as high blood pressure, occurs when blood vessels have consistently high pressure. This condition can cause heart attacks, strokes, heart failure, and other serious heart diseases.

“For the first time, we can say there’s a strong link between frequent snoring at night and high blood pressure,” said Bastien Lechat, lead author of the research from the College of Medicine and Public Health at Flinders University in Australia. He stressed the importance of addressing snoring in managing hypertension.

The World Health Organization estimates that 1.28 billion adults globally have hypertension, with nearly half of them unaware of their condition.

FDA Approves Bristol Myers Squibb’s New Antipsychotic Drug Cobenfy for Schizophrenia Treatment

The U.S. Food and Drug Administration (FDA) has approved Cobenfy (xanomeline and trospium chloride), for the treatment of schizophrenia, a chronic mental health disorder. Developed by Karuna Therapeutics and now owned by Bristol Myers Squibb, Cobenfy works by targeting cholinergic receptors unlike traditional antipsychotic medications that target dopamine receptors.

This marks a significant departure from the conventional approach to schizophrenia treatment, according to the FDA. Schizophrenia is a debilitating mental illness characterized by hallucinations, delusions, disorganized thinking, and behavioral disturbances. Those affected often struggle to maintain a grasp on reality and may experience cognitive impairments.

Globally, about 24 million people are living with schizophrenia, including 2.8 million in the U.S., where it ranks as one of the top 15 causes of disability. Tragically, the condition is linked to a shortened lifespan, with approximately 5% of patients dying by suicide, the FDA noted.

The approval of Cobenfy is seen as a hopeful development for individuals affected by schizophrenia. “Schizophrenia is a leading cause of disability worldwide. It is a severe, chronic mental illness that profoundly impacts quality of life,” said Tiffany Farchione, Director of the Division of Psychiatry at the FDA’s Center for Drug Evaluation and Research. “This drug offers the first new approach to treating schizophrenia in decades, providing an alternative to previously prescribed antipsychotic medications.”

The effectiveness of Cobenfy was demonstrated in two clinical studies. Over a five-week period, patients’ symptoms were measured using the Positive and Negative Syndrome Scale (PANSS), a 30-item tool used to assess schizophrenia symptoms. Results showed that patients treated with Cobenfy experienced a significant reduction in symptoms compared to those on a placebo.

However, the FDA highlighted several side effects associated with the drug, including nausea, constipation, vomiting, increased heart rate, and diarrhea. Due to the risk of severe side effects, the agency advised against prescribing Cobenfy to patients with urinary retention, kidney, or liver disease.

Earlier this year, in March, Bristol Myers Squibb acquired Karuna Therapeutics for $14 billion, gaining exclusive rights to KarXT (Cobenfy). The company plans to launch the drug by the end of October, with a monthly cost of $1,850, or around $22,500 annually, according to Reuters.

Sales are projected to reach $2.5 billion in the U.S. by 2030. Bristol aims to provide insurance coverage for 80% of patients within the first 12 to 18 months of the drug’s release. To further assist patients, Bristol has introduced a support program called “COBENFY Cares.”

Managing diabetes key to prevent dementia: Study

An Indian-origin scientist has found that reducing the risk of dementia in Alzheimer’s is possible by keeping diabetes under control.

Narendra Kumar, an associate professor at Texas A&M University in the US, spearheaded a study featured in the ‘American Society for Biochemistry and Molecular Biology’ journal, uncovering a robust connection between diabetes and Alzheimer’s disease.

“Implementing preventative or mitigative measures for diabetes could potentially stall or mitigate the advancement of dementia symptoms in Alzheimer’s,” he emphasized.

Diabetes and Alzheimer’s represent two burgeoning health challenges worldwide. Diabetes disrupts the body’s energy conversion from food and affects approximately one in ten US adults. Meanwhile, Alzheimer’s ranks among the top ten leading causes of death in the US, as highlighted in the research.

The team delved into how dietary patterns might influence Alzheimer’s progression in individuals with diabetes.

Their investigation unveiled that a high-fat diet diminishes the expression of Jak3, a specific protein in the gut. Mice lacking this protein showcased a cascade of inflammation from the intestines to the liver and brain. Consequently, these mice exhibited Alzheimer’s-like manifestations in the brain alongside cognitive decline.

The researchers propose that the route from the gut to the brain involves the liver. “As the primary metabolizer of our dietary intake, we hypothesize that the pathway from gut to brain involves the liver,” explained Kumar.

Their long-standing exploration of Jak3’s functions revealed that alterations in its expression due to dietary factors can lead to intestinal permeability, resulting in chronic inflammation, diabetes, diminished brain capacity to eliminate toxins, and dementia-like symptoms akin to Alzheimer’s disease.

Genetic Mutation in Kids? Blame it on Old Father’s sperms

A study by Rockefeller University scientists has nailed down reasons why older male fruit flies are more likely to pass mutations onto their offspring, with implications for a similar impact in humans with inherited diseases.

Since male reproductive system acts as the pivotal point for new genes, new mutations are inherited from fathers than from mothers, said the study though it did not clarify why younger fathers do not pass on more mutations to their off springs.

Though the trend has been observed for long, the reason remained a mystery. Now, the new study published in the journal Nature Ecology & Evolution explored mutations that occur during the production of sperm from germline cells, known as spermatogenesis.

RNA sequencing data from fruit fly testes showing the marked difference between older sperm-related cells (teal, at left) and younger ones / Laboratory of Evolutionary Genetics and Genomics

The scientists found that mutations are common in the testes of both young and old fruit flies, but more abundant in older flies compared to the younger fruit flies during spermatogenesis since the body’s genomic repair mechanisms remain active in them but fail to fix it in the testes of older flies.

“We were trying to test whether the older germline is less efficient at mutation repair, or whether the older germline just starts out more mutated,” says first author Evan Witt, a former graduate student in the lab. “Our results indicate that it’s actually both. At every stage of spermatogenesis, there are more mutations per RNA molecule in older flies than in younger flies.”

Self-care vital among the young

Genomes keep themselves busy using repair mechanisms and when it comes to testes, they work overtime as testes have the highest rate of gene expression of any organ. Moreover, genes that are highly expressed in spermatogenesis tend to have fewer mutations than those that are not. This sounds counterintuitive, but it makes sense: One theory to explain why the testes express so many genes holds that it might be a sort of genomic surveillance mechanism — a way to reveal, and then weed out, problematic mutations.

But when it comes to older sperm, the researchers found, the weed-whacker apparently sputters out. Previous research suggests that a faulty transcription-coupled repair mechanism, which only fixes transcribed genes, could be to blame.

Inherited or new mutations?

To get these results, scientists in the Laboratory of Evolutionary Genetics and Genomics did single-cell sequencing on the RNA from the testes of about 300 fruit flies, roughly half of them young (48 hours old) and half old (25 days old), advancing a line of inquiry they began in 2019.

In order to understand whether the mutations they detected were somatic, or inherited from the flies’ parents, or de novo—arising in the individual fly’s germline—they then sequenced the genome of each fly.

They were able to document that each mutation was a true original. “We can directly say this mutation was not present in the DNA of that same fly in its somatic cells,” says Witt. “We know that it’s a de novo mutation.”

This unconventional approach—inferring genomic mutations from single-cell RNA sequencing and then comparing them to the genomic data—allowed the researchers to match mutations to the cell type in which they occurred. “It’s a good way to compare mutational load between cell types, because you can follow them throughout spermatogenesis,” Witt says.

The human connection

The next step is to expand the analysis to more age groups of flies and test whether or not this transcription repair mechanism can occur—and if it does, identify the pathways responsible, Witt says. “What genes,” he wonders, “are really driving the difference between old and young flies in terms of mutation repair?”

Because fruit flies have a high reproductive rate, investigating their mutation patterns can offer new insights into the effect of new mutations in human health and evolution, says Zhao.

Witt adds, “It’s largely unknown whether a more mutated male germline is more or less fertile than a less mutated one. There’s not been very much research on it except for at a population level. And if people inherit more mutations from aging fathers, that increases the odds of de novo genetic disorders or certain types of cancers.”

“Walnuts” the new brain food for stressed university students

Stressed university students might want to add walnuts to their daily diet in the weeks leading up to their next exam.

A new  clinical trial of undergraduate students during their university studies has shown positive effects of walnut consumption on self-reported measures of mental health and biomarkers of general health.

The University of South Australia study, published in the journal Nutrients, also suggests that walnuts may counteract the effects of academic stress on the gut microbiota during periods of stress, especially in females.

Lead researchers, PhD student Mauritz Herselman and Associate Professor Larisa Bobrovskaya, say the results add to the growing body of evidence linking walnuts with improved brain and gut health.

Walnuts may counteract the effects of academic stress on the gut microbiota during periods of stress, especially in women./CREDIT:Open Verse

“Students experience academic stress throughout their studies, which has a negative effect on their mental health, and they are particularly vulnerable during exam periods,” Herselman says.

Eighty undergraduate students split into treatment and control groups were clinically assessed in three intervals, at the beginning of a 13-week university semester, during the examination period and two weeks after the examination period. Those in the treatment group were given walnuts to consume daily for 16 weeks over these three intervals.

“We found that those who consumed about half a cup of walnuts every day showed improvements in self-reported mental health indicators.  Walnut consumers also showed improved metabolic biomarkers and overall sleep quality in the longer term.”

Students in the control group reported increased stress and depression levels in the leadup to exams but those in the treatment group did not. The walnut consumers also reported a significant drop in feelings associated with depression between the first and final visits, compared to the controls.

Previous research has shown that walnuts are full of omega-3 fatty acids, antioxidants, as well as melatonin (sleep inducing hormone), polyphenols, folate and vitamin E, all of which promote a healthy brain and gut.

“The World Health Organization has recently stated that at least 75 per cent of mental health disorders affect people under the age of 24 years, making undergraduate students particularly vulnerable to mental health problems,” Herselman says.

Assoc Prof Larisa Bobrovskaya says mental health disorders are common in university students and can adversely affect students’ academic performance and long-term physical health.

“We have shown that consuming walnuts during stressful periods can improve mental health and general wellbeing in university students, as well as being a healthy and delicious snack and a versatile ingredient in many recipes, to fight some negative effects of academic stress,” Assoc Prof Bobrovskaya says.

“Due to fewer numbers of males in the study, more research is needed to establish sex-dependent effects of walnuts and academic stress in university students. It’s also possible that a placebo effect might have come into play as this was not a blind study.”

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