Tag Archives: stress

Under stress? This wearable polygraph finds out instantly

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Northwestern University engineers have developed a small, wireless polygraph system you can wear.

Unlike polygraphs used in television crime dramas, this wearable version isn’t optimized to detect lies. Instead, engineers and physicians designed it to sense underlying stress hidden deep within the body — no interrogation room required.

The lightweight, bandage-like device gently adheres to the chest, where it simultaneously measures heart activity, breathing patterns, sweat response, blood flow and temperature. Together, these signals capture a real-time, whole-body view of stress.

By continuously tracking multiple physiological signals at once, the device could help clinicians detect stress and potential discomfort in patients — including infants or the elderly — who may be unable to communicate, diagnose sleep disorders without cumbersome in-laboratory equipment, monitor mental health over time and even sense early warning signs of medical complications.

“Sometimes, the body manifests signs of stress before a person is consciously aware of it,” said Northwestern’s John A. Rogers, who led the device development. “Even if people don’t realize how much pressure they are under, stress is quietly affecting their health. Prolonged stress can have adverse consequences, especially for pregnant mothers, children and critically ill patients. An ability to track stress based on quantitative measurements could empower people to take stress-relieving actions with direct benefits to their health. Importantly, we aimed to design a device, conceptually like a polygraph system, that operates on the basis of biophysical body responses, without requiring access to chemical biomarkers found in body fluids.”

A world-renowned bioelectronics pioneer, Rogers is the Louis Simpson and Kimberly Querrey Professor of Materials Science and Engineering, Biomedical Engineering and Neurological Surgery at Northwestern, where he has appointments in the McCormick School of Engineering and Northwestern University Feinberg School of Medicine. He also directs the Querrey Simpson Institute for Bioelectronics and the Querrey Simpson Institute for Translational Engineering and Advanced Medical Systems. Rogers is co-corresponding author of the study along with Dr. Debra E. Weese-Mayer, the Beatrice Cummings Mayer Professor of Pediatric Autonomic Medicine and professor of pediatrics (neurology) at Feinberg and Jae-Young Yoo of Sungkyunkwan University in Korea.

A voice for the vulnerable

The project started as a request from pediatricians at Ann & Robert H. Lurie Children’s Hospital of Chicago. Over the years, Rogers’ team has developed a suite of wireless, wearable electronics for infants and children — to track vital signs, monitor illness

, treat congenital conditions and diagnose disease. Now, pediatricians asked Rogers to create a soft, non-invasive device to detect and continuously track stress levels in babies throughout hospital stays, without measuring stress’ biochemical signatures in saliva and blood.

Currently, detecting babies’ stress often depends on what caregivers can see and hear — crying, facial expressions and movement — along with basic vital signs. But these signals can be subtle, inconsistent or even entirely absent.

“Stress is often scored using survey sheets and nursing assessments,” Rogers said. “The entries include things like tonality and volume of crying. Infants obviously cannot describe their own pain levels. So, unlike with adults, determining stress in babies can be incredibly challenging. We wanted to take subjectivity out of these assessments.”

“This new device tracks the body’s stress signals around the clock, helping quantify how long someone is stressed each day and how intense that stress is,” said Weese-Mayer, Rogers’ long-time collaborator. “The beauty of the device is that both individuals and healthcare providers can now identify stress and objectively monitor the effectiveness of interventions to decrease stress and restore a healthy balance, in a completely non-invasive manner.”

All-in-one stress sensing

To do that, Rogers and his team found inspiration in a surprising place: polygraphs. Although they are colloquially called “lie detectors,” polygraphs actually don’t detect lies. They measure the body’s response to stress, which can be triggered by many factors besides deception. Rogers saw an opportunity to build on that core idea. But, while traditional polygraph machines rely on a patchwork of bulky, wired sensors, Rogers aimed to capture those same physiological signals — and then some — in a more comprehensive, fully integrated, accurate and wearable form.

The resulting technology combines several tiny sensors into a single, soft device. Together, these sensors continuously track multiple physiological signals, all of which respond when the body senses stress. A built-in motion sensor and miniature microphone capture subtle mechanical and acoustic signals from the heart and lungs. Other sensors detect skin temperature and heat flow associated with near-surface blood circulation. And another sensor measures changes in the skin’s electrical conductivity caused by sweat gland activity — a well-known marker of stress.

“Measuring stress is a complex task because it’s multi-dimensional,” Rogers said. “It’s not possible to reliably determine stress by measuring just one or two, or even three or four, parameters. A broad collection of factors is necessary. So, we crammed as many sensors of physiological processes into this device platform as we could, while maintaining a compact size and lightweight construction and avoiding the need to access biofluids.”

The system wirelessly transmits these synchronized data streams to a smartphone, smart watch or tablet, where machine learning algorithms analyze patterns associated with stress in real time. Weighing less than 8 grams (equivalent to eight paperclips) and designed to move naturally with the skin, the device can operate continuously for more than 24 hours.

Proven across realistic scenarios

After developing the system, Rogers’ team validated it across a wide range of scenarios, including controlled experiments and real-world environments. During simulated lie-detector tests, the wearable device accurately captured stress responses triggered by sensitive questions and closely matched measurements from commercial polygraph systems.

In cognitive tests, such as understanding speech in noisy environments, the device detected clear increases in stress-related signals as tasks increased in difficulty. The results aligned with simultaneous, independent measurements of pupil dilation, a common method to determine stress.

In another experiment, study participants placed their hands in ice-cold water, and the system recorded coordinated changes across cardiac activity, breathing patterns, sweat responses and temperature signals. In pediatric sleep studies, the wearable device identified key clinical events, including breathing irregularities and nighttime awakenings, with accuracy comparable to hospital-grade sleep tests but with far fewer disruptions.

And, finally, during emergency room training sessions with medical students, the device revealed a striking pattern. Participants with stronger stress responses tended to perform worse, suggesting stress may impair decision-making in high-pressure situations.

“Ultimately, the device could send an alert to a user or caregiver when stress levels hit a certain limit,” Rogers said. “Many people might not fully appreciate the level of stress they are under and might not realize it’s affecting their performance.”

What’s next

Next, the team aims to move its technology beyond validation studies and into broader clinical use. Next steps will include testing the device in larger patient groups, refining its ability to personalize stress detection and integrating it into hospital and at-home monitoring systems to provide continuous, real-time insight into patient health.

Rogers also is exploring opportunities for incorporating even more sensors into the device, including the ability to measure brain activity. Adding electroencephalogram (EEG) capabilities would allow the device to move beyond measuring the body’s stress response to capturing how the brain perceives that stress. That could bring scientists closer to distinguishing stress from pain — even in the home setting — and understanding how it is experienced in the context of the simultaneously recorded stress biomarkers.

“We are living in stressful times, without sufficient measures to proactively detect stress,” Weese-Mayer said. “By identifying stress — whether environmental or disease-induced — earlier, we can introduce intervention before stress’ effects become irreversible.”

The study, “Wireless, skin-interfaced multimodal sensing system for continuous psychophysiological monitoring — a wearable polygraph device,” was supported by the Querrey Simpson Institute for Bioelectronics.

 

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Stressful life make people focus more on their romantic partner’s negative behavior

 

 

Researchers find potential one-two punch against triple-negative breast cancer

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  • Many breast cancer therapies work by causing DNA replication stress, but triple-negative breast cancer (TNBC) cells survive this stress, even at high levels
  • TNBC cells overexpress an enzyme, RNase H2, that helps them survive the DNA damage caused by replication stress
  • In this preclinical study, blocking RNase H2 directly damaged cancer cells and also activated the immune system, making this a promising therapeutic approach.

Blocking RNase H2 Enzyme Shows Promise Against Aggressive Breast Cancer

Scientists at University of Texas MD Anderson Cancer Center have identified a crucial enzyme that helps one of the most difficult forms of breast cancer withstand treatment, opening up a potential new therapeutic pathway.

The study, published in Cell Reports Medicine, focuses on RNase H2—an enzyme that appears to enable triple-negative breast cancer (TNBC) cells to survive intense DNA damage caused during treatment. TNBC is widely considered one of the most aggressive breast cancer subtypes due to its resistance to many standard therapies.

Led by researcher Shiaw-Yih Lin, the team found that RNase H2 plays a dual role. While it helps cancer cells cope with DNA replication stress, blocking the enzyme both damages tumour DNA and triggers the body’s immune system, effectively turning the cancer’s survival mechanism against itself.

Lin described this as a “one-two punch,” where inhibiting RNase H2 not only disrupts the tumour’s ability to manage stress but also activates immune signals that draw T cells to attack the cancer.

Why replication stress matters

Replication stress occurs when cells struggle to copy their DNA accurately, leading to structural damage. Many cancer treatments deliberately induce this stress to kill tumour cells. However, TNBC cells have developed ways to tolerate and survive it, allowing the disease to persist and progress.

One key contributor to this stress is the build-up of RNA fragments within DNA. RNase H2 typically removes these fragments to maintain genomic stability.

The enzyme’s hidden role in cancer survival

The researchers discovered that RNase H2 is significantly overproduced in TNBC tumours and is linked to poorer patient outcomes. This suggests that the enzyme helps cancer cells adapt to and survive high levels of DNA damage.

When the team blocked RNase H2—either through genetic methods or experimental drugs—tumour cells experienced heightened replication stress, leading to reduced tumour growth in preclinical models. At the same time, the resulting DNA damage activated the innate immune system, which then signalled T cells to target the cancer.

Implications for future treatment

Although the findings are still at a preclinical stage, they point to RNase H2 as a promising drug target. Inhibitors of the enzyme are already under development, and the study suggests they could be used alongside existing therapies.

Notably, blocking RNase H2 was found to enhance the effectiveness of ATR and PARP inhibitors—two classes of drugs already used in cancer treatment—raising the possibility of combination therapies in future clinical trials.

If validated in humans, this approach could offer a more effective strategy against TNBC, a cancer subtype that has long posed challenges due to its limited treatment options.

Also Read:

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Study Links High-Fat Diets To More Aggressive Breast Cancer Behavior

UN agencies warn of rising heat stress risks for workers worldwide

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The new joint report, Climate change and workplace heat stress, underscores the mounting risks as climate change fuels longer, more extreme, and more frequent heatwaves.

Stressing that workers in agriculture, construction, and fisheries are already suffering the impacts of dangerous temperatures, the report points out that vulnerable groups in developing countries – including children, older adults, and low-income communities – face increasing dangers.

“Heat stress is already harming the health and livelihoods of billions of workers, especially in the most vulnerable communities,” said Dr. Jeremy Farrar, WHO Assistant Director-General for Health Promotion, Disease Prevention and Care.

“This new guidance offers practical, evidence-based solutions to protect lives, reduce inequality, and build more resilient workforces in a warming world”, he added.

Drawing on five decades of research, the report highlights how rising temperatures are hitting both health and productivity.

WMO confirmed that 2024 was the hottest year on record, at 1.55 degrees Celsius above pre-industrial temperatures, and with daytime highs above 40 °C becoming commonplace – and in some areas, even exceeding 50 °C. 

“Occupational heat stress has become a global societal challenge, which is no longer confined to countries located close to the equator – as highlighted by the recent heatwave in Europe,” said Ko Barrett, WMO Deputy Secretary-General. “Protection of workers from extreme heat is not just a health imperative but an economic necessity.”

Alarming findings

The report details how extreme heat is reshaping the world of work. It finds that worker productivity drops by 2 to 3 per cent for every degree above 20°C.

The health consequences are wide-ranging, including heatstroke, dehydration, kidney dysfunction, and neurological disorders. Overall, nearly half of the world’s population is now experiencing negative effects from high temperatures.

Path forward

Calling for urgent occupational heat action plans tailored to industries and regions, WHO and WMO guidance includes several recommendations:

  • Develop targeted occupational heat-health policies based on local weather and workforce vulnerabilities.
  • Prioritize protections for middle-aged and older workers, those with chronic health conditions, and individuals with lower physical fitness.
  • Train health professionals, employers, and workers to recognize and treat heat stress, which is often misdiagnosed.
  • Involve workers, unions, and local authorities in shaping heat-health strategies.
  • Promote affordable, sustainable, and scalable solutions, alongside innovation and new technologies.
  • Strengthen research and monitoring to ensure measures remain effective.

The guidance builds on International Labour Organization (ILO) findings that more than 2.4 billion workers are exposed to excessive heat globally, resulting in over 22.85 million occupational injuries each year.

‘Critical milestone’

“This report represents a critical milestone in our collective response to the growing threat of extreme heat in the world of work,” said Joaquim Pintado Nunes, ILO Chief of Occupational Safety and Health and the Working Environment.

“Aligned with the ILO’s mandate to promote safe and healthy working environments as a fundamental right, it offers robust, evidence-based guidance to help governments, employers and workers confront the escalating risks of climate change.”

A call to action

Both UN agencies stress that addressing heat stress is central to safeguarding lives, livelihoods, and economies. The guidance supports the UN Sustainable Development Goals (SDGs), urging decisive action to protect vulnerable workers, reduce poverty, and promote sustainable growth.

Urgent and coordinated action is no longer optional – it is essential, the report says.

Did the pandemic change our personalities? Increased neuroticism among young adults seen: Study

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Despite a long-standing hypothesis that personality traits are relatively impervious to environmental pressures, the COVID-19 pandemic may have altered the trajectory of personality across the United States, especially in younger adults, according to a new study published this week in the open-access journal PLOS ONE by Angelina Sutin of Florida State University College of Medicine, and colleagues.

Previous studies have generally found no associations between collective stressful events—such as earthquakes and hurricanes—and personality change. However, the coronavirus pandemic has affected the entire globe and nearly every aspect of life.

In the new study, the researchers used longitudinal assessments of personality from 7,109 people enrolled in the online Understanding America Study. They compared five-factor model personality traits—neuroticism, extraversion, openness, agreeableness and conscientiousness—between pre-pandemic measurements (May 2014 – February 2020) and assessments early (March – December 2020) or later (2021-2022) in the pandemic. A total of 18,623 assessments, or a mean of 2.62 per participant, were analyzed. Participants were 41.2% male and ranged in age from 18 to 109.

A crowd of people at a pedestrian crossing./CREDIT:Brian Merrill, Pixabay, CC0(https://creativecommons.org/publicdomain/zero/1.0/)

Consistent with other studies, there were relatively few changes between pre-pandemic and 2020 personality traits, with only a small decline in neuroticism. However, there were declines in extraversion, openness, agreeableness, and conscientiousness when 2021-2022 data was compared to pre-pandemic personality. The changes were about one-tenth of a standard deviation, which is equivalent to about one decade of normative personality change. The changes were moderated by age, with younger adults showing disrupted maturity in the form of increased neuroticism and decreased agreeableness and conscientiousness, and the oldest group of adults showing no statistically significant changes in traits.

The authors conclude that if these changes are enduring, it suggests that population-wide stressful events can slightly bend the trajectory of personality, especially in younger adults.

The authors add: “There was limited personality change early in the pandemic but striking changes starting in 2021. Of most note, the personality of young adults changed the most, with marked increases in neuroticism and declines in agreeableness and conscientiousness. That is, younger adults became moodier and more prone to stress, less cooperative and trusting, and less restrained and responsible.”

Stressful life make people focus more on their romantic partner’s negative behavior

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Stressful life circumstances can affect how married couples interact, but can they affect how partners see each other? A person experiencing stress is more likely to notice their spouse’s negative behavior than positive, according to a new study published in Social Psychological and Personality Science.

Prior research has focused on how stress influences behavior, but this study suggests that stress could affect what actions partners notice in the first place. The negative actions being monitored included a spouse breaking a promise, showing anger or impatience, or criticizing their partner.

“We found that individuals who reported experiencing more stressful life events outside of their relationship, such as problems at work, were especially likely to notice if their partner behaved in an inconsiderate manner,” says lead author Dr. Lisa Neff, of the University of Texas at Austin.

Researchers asked 79 heterosexual newlywed couples to complete a short survey each night for 10 days, in which they documented both their own and their partner’s behavior. Before beginning this portion of the study, participants completed a questionnaire in which they shared details on stressful events in their life.

Stress

Studying newlyweds drives home the significance of the results, Dr. Neff notes, because couples are especially likely to focus on each other’s positive behavior and overlook negative actions during the “honeymoon” period.

“For many people, the past few years have been difficult – and the stress of the pandemic continues to linger,” says Dr. Neff. “If stress focuses individuals’ attention toward their partner’s more inconsiderate behaviors, this is likely to take a toll on the relationship.”

Researchers noted a single stressful day was not enough to make someone zero in on their partner’s negative behavior, but a longer accumulation of stressful life circumstances could cause this shift in focus. The findings also suggest that those under stress were not any less likely to notice their partner’s positive behavior, but they were more likely to notice inconsiderate actions.

While it’s possible that being aware of the effects of stress could allow couples to correct their behavior and limit harm to the relationship, Dr. Neff notes that this will remain speculation until it is studied further. She also says that future research would do well to expand this study beyond the honeymoon phase.

“One direction would be to examine if the harmful effects of stress might be even stronger among couples no longer in the newlywed phase of their relationships,” says Dr. Neff, “but the fact that we found these effects in a sample of newlyweds speaks to how impactful the effects of stress can be.”

Washable, wearable sensors made from ‘PECOTEX’ styled into t-shirts and face masks to monitor body activities

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Wearable sensors styled into t-shirts and face masks

Imperial researchers have embedded new low-cost sensors that monitor breathing, heart rate, and ammonia into t-shirts and face masks.

Potential applications range from monitoring exercise, sleep, and stress to diagnosing and monitoring disease through breath and vital signs.

Spun from a new Imperial-developed cotton-based conductive thread called PECOTEX, the sensors cost little to manufacture. Just $0.15 produces a metre of thread to seamlessly integrate more than ten sensors into clothing, and PECOTEX is compatible with industry-standard computerised embroidery machines.

First author of the research Fahad Alshabouna, PhD candidate at Imperial’s Department of Bioengineering, said: “The flexible medium of clothing means our sensors have a wide range of applications. They’re also relatively easy to produce which means we could scale up manufacturing and usher in a new generation of wearables in clothing.”

The research team embroidered the sensors into a face mask to monitor breathing, a t-shirt to monitor heart activity, and textiles to monitor gases like ammonia, a component of the breath that can be used to track liver and kidney function. The ammonia sensors were developed to test whether gas sensors could also be manufactured using embroidery.

Fahad added: “We demonstrated applications in monitoring cardiac activity and breathing, and sensing gases. Future potential applications include diagnosing and monitoring disease and treatment, monitoring the body during exercise, sleep, and stress, and use in batteries, heaters, anti-static clothing.”

The research is published today in Materials Today. 

Mask

Seamless sensors 

Wearable sensors, like those on smartwatches, let us continuously monitor our health and wellbeing non-invasively. Until now, however, there has been a lack of suitable conductive threads, which explains why wearable sensors seamlessly integrated into in clothing aren’t yet widely available.

Enter PECOTEX. Developed and spun into sensors by Imperial researchers, the material is machine washable, and is less breakable and more electrically conductive than commercially available silver-based conductive threads, meaning more layers can be added for to create complex types of sensor.[1]

Lead author Dr Firat Guder, also of the Department of Bioengineering, said: “PECOTEX is high-performing, strong, and adaptable to different needs. It’s readily scalable, meaning we can produce large volumes inexpensively using both domestic and industrial computerised embroidery machines.

“Our research opens up exciting possibilities for wearable sensors in everyday clothing. By monitoring breathing, heart rate, and gases, they can already be seamlessly integrated, and might even be able to help diagnose and monitor treatments of disease in the future.”

Next, the researchers will explore new application areas like energy storage, energy harvesting and biochemical sensing, as well as finding partners for commercialisation.

This study was funded by the Saudi Ministry of Education, Engineering and Physical Sciences Research Council (EPSRC, part of the UKRI), Cytiva, Imperial’s Department of Bioengineering, Bill and Melinda Gates Foundation, and the US Army.

Imperial College London press release.