Improving clinical trials with machine learning

Machine learning could improve our ability to determine whether a new drug works in the brain, potentially enabling researchers to detect drug effects that would be missed entirely by conventional statistical tests, finds a new UCL study published in Brain.

“Current statistical models are too simple. They fail to capture complex biological variations across people, discarding them as mere noise. We suspected this could partly explain why so many drug trials work in simple animals but fail in the complex brains of humans. If so, machine learning capable of modelling the human brain in its full complexity may uncover treatment effects that would otherwise be missed,” said the study’s lead author, Dr Parashkev Nachev (UCL Institute of Neurology).

To test the concept, the research team looked at large-scale data from patients with stroke, extracting the complex anatomical pattern of brain damage caused by the stroke in each patient, creating in the process the largest collection of anatomically registered images of stroke ever assembled. As an index of the impact of stroke, they used gaze direction, objectively measured from the eyes as seen on head CT scans upon hospital admission, and from MRI scans typically done 1-3 days later.

They then simulated a large-scale meta-analysis of a set of hypothetical drugs, to see if treatment effects of different magnitudes that would have been missed by conventional statistical analysis could be identified with machine learning. For example, given a drug treatment that shrinks a brain lesion by 70%, they tested for a significant effect using conventional (low-dimensional) statistical tests as well as by using high-dimensional machine learning methods.

The machine learning technique took into account the presence or absence of damage across the entire brain, treating the stroke as a complex “fingerprint”, described by a multitude of variables.

“Stroke trials tend to use relatively few, crude variables, such as the size of the lesion, ignoring whether the lesion is centred on a critical area or at the edge of it. Our algorithm learned the entire pattern of damage across the brain instead, employing thousands of variables at high anatomical resolution. By illuminating the complex relationship between anatomy and clinical outcome, it enabled us to detect therapeutic effects with far greater sensitivity than conventional techniques,” explained the study’s first author, Tianbo Xu (UCL Institute of Neurology).

The advantage of the machine learning approach was particularly strong when looking at interventions that reduce the volume of the lesion itself. With conventional low-dimensional models, the intervention would need to shrink the lesion by 78.4% of its volume for the effect to be detected in a trial more often than not, while the high-dimensional model would more than likely detect an effect when the lesion was shrunk by only 55%.

“Conventional statistical models will miss an effect even if the drug typically reduces the size of the lesion by half, or more, simply because the complexity of the brain’s functional anatomy–when left unaccounted for–introduces so much individual variability in measured clinical outcomes. Yet saving 50% of the affected brain area is meaningful even if it doesn’t have a clear impact on behaviour. There’s no such thing as redundant brain,” said Dr Nachev.

The researchers say their findings demonstrate that machine learning could be invaluable to medical science, especially when the system under study–such as the brain–is highly complex.

“The real value of machine learning lies not so much in automating things we find easy to do naturally, but formalising very complex decisions. Machine learning can combine the intuitive flexibility of a clinician with the formality of the statistics that drive evidence-based medicine. Models that pull together 1000s of variables can still be rigorous and mathematically sound. We can now capture the complex relationship between anatomy and outcome with high precision,” said Dr Nachev.

“We hope that researchers and clinicians begin using our methods the next time they need to run a clinical trial,” said co-author Professor Geraint Rees (Dean, UCL Faculty of Life Sciences).

Southern Star Horse Show – 2017

1. The equestrian sport patronized by the Maharajas of Rajasthan has transformed house riding into an adventure & competitive sport at national & international levels. While the equestrian sport is competed in various disciplines at national level, Show Jumping, Eventing and Dressage are the prime competitive events at the Olympics. As a unique initiative, Southern Command has combined the Regional Equestrain League with Southern Star Horse Show with the dual aim of spotting the talent for a medal in Olympics as also to provide a visual treat to the horse lovers of Pune. The event will be conducted at Race Course Grounds, Pune Camp from 16 November 2017 to 19 November 2017.

2. Though the National Equestrian championship has been in existance for many years but Regional Equestrian League (REL) commenced in the recent past. Apart from providing an opportunity and platform to the budding riders of both the civil & the Services to compete at various levels, REL also helps to identify the talent at regional level while simultaneously filtering the meritorious & deserving riders for National Championship in various Equestrian sports. It is pertinent to mention that inspite of the prevalence of Equestrian foot marks in the country for decades, an Olympic podium finish has been elusive for the Nation. Set to realise this elusive dream, the journey started with the country joining the league of Federation Equestre Internationale (FEI) thus acquiring the eligibility for competing at International events. Riders like JS Ahluwalia, Mohammed Khan, Hussain Khan & Daya Singh, the first ones to represent India in Olympic, were devoid of medals because of their lack of experience and exposure in cross country phase of Eventing. Determined to make a mark at the International level, the sport infrastructure has now been developed in India & also its awareness has risen manifold.

3. Equestrian Federation of India (EFI), the regulating body of Equestrian sports in India started organising Equestrian sports competitions in India for Show Jumping, Eventing & Dressage. With the strong tent pegging contingent garnering country’s first gold medal in 1982 Asiad, equestrianism was brought to the attention of millions. Though the interest in sport has grown but the medals continue to elude the country in Show Jumping & Eventing. Contributions from Services riders like GM Khan, Indrajeet Lamba, AJ Singh, Rajesh Pattu, Palwinder Singh and civ rider Imtiaz Anees have made a mark at International arena. Imtiaz became the first civilian rider to represent India abroad. With the development of the Equestrian Node, sports infrastructure and provision of quality horses, riders like Rajesh Pattu and Bhagirath Singh were able to remain in contention for individual medals in Asian games in 2002 & 2006. In the last ten to fifteen years the civilian involvement has grown enormously as a result of increased equestrian activity in various regions.

4. It is against this back drop that Regional Equestrian League and Southern Star Horse Show is being organised for Puneities with effect from 16 to 19 November 2017 in which participation by promising riders from all over the country is confirmed. To make it a holistic adventure sports and recreational activity, Army band, Dog show, Air show, free pleasure horse riding etc are also being offered as a onetime opportunity for the spectators. The event would be held with its usual pomp and show everyday from 10 AM to 1 PM & 3 to 5.30 PM at the Race Course Grounds, Pune Camp. It’s time for Puneites to avail this unique opportunity with their families and children to break the monotony and witness an enchanting and entertaining competitive equestrian events.

PM greets the people of Jharkhand on their Statehood Day

Prime Minister, Shri Narendra Modi, has greeted the people of Jharkhand on their Statehood Day.

“झारखंड के स्थापना दिवस पर राज्य की जनता को हार्दिक शुभकामनाएं। Greetings to the people of Jharkhand on their statehood day. I pray that Jharkhand continues to scale new heights of progress and prosperity”, the Prime Minister said.

300 Cyber security experts to attend first ever Asia Pacific Computer Emergency Response Team Conference

The Indian Computer Emergency Response Team (CERT-In) under the aegis of Ministry of Electronics & Information Technology organizing the Asia Pacific Computer Emergency Response Team (APCERT) Conference from November 12-15, 2017 in New Delhi. This is the 15th Conference of APCERT and first ever conference in India and South Asia and is expected to be attended by 21 economies.

The conference theme is “Building Trust in the Digital Economy”. November 12-14 are closed for AGM and other APCERT meetings. The open session including industry, academia, civil society and Government stakeholders will be held on November 15, 2017 at Hotel The Ashok, New Delhi.

This will be inaugurated by Shri Ravi Shankar Prasad, Minister of Electronics & Information Technology, and is expected to be attended by over 300 cyber security professionals from the Asia Pacific region, USA, Europe, Industry, Academia, Government and Media.

This conference would cover contemporary topics around strategies of CERTs, Technology and Instruments for building trust in digitally evolving economies and best practices for handling cyber security in mobile and social media.

Curtain Raiser Event held for the Founding Ceremony of International Solar Alliance in Bonn

A Curtain Raiser Event for the Founding Ceremony of the International Solar Alliance (ISA) was held at Bonn, Germany on Monday, November 13, 2017.

Speaking at the event, Shri Anand Kumar, Secretary, Ministry of New and Renewable Energy, Government of India hoped that, in the spirit of affirmative action, developed countries will earmark a percentage of Overseas Development Assistance (ODA) towards solar energy projects in developing countries. He suggested that Multilateral Development Banks and other financial institutions provide wholehearted support for solar projects through low cost finance, and research & technology institutions worldwide try their utmost to bring the cost of solar power and storage within the reach of all. Shri Kumar also invited corporates and other institutions to support solar energy development and deployment in every possible manner.

Recalling that the ISA initiative is the vision of Prime Minister of India, Shri Narendra Modi, Shri Kumar reaffirmed Indian Government’s continued support for the ISA. He also spoke about the Government plans to increase the share of renewable energy in India’s energy mix, especially towards achieving cumulative installed renewable power capacity of 175GW by 2022.

Secretary, Environment, Forest and Climate Change, Government of India, Shri C.K. Mishra, underlined the need for visualising solar energy in the context of sustainable development goals. He emphasised upon the need for arranging technologies, finance and capacity building for solar energy projects, as well as for developing storage technologies. He also suggested that there is a need to work in the areas of renewable power evacuation and application of off-grid solar energy.

Interim Director General of the ISA, Shri Upendra Tripathy, informed that ISA will become a treaty-based international intergovernmental organisation on 6 December 2017. 44 countries have already signed the ISA treaty, and many more are set to join. He spoke on the ISA’s three ongoing programmes: facilitating affordable finance for solar, scaling up solar applications for agriculture, and promoting solar mini-grids in Member Nations. The discussions also covered the ISA’s Common Risk Mitigation Mechanism (CRMM) project, aimed at de-risking investments into solar energy projects in developing countries, and thereby, encouraging flow of funds into the sector.

Speaking at the occasion, H.E. Ségolène Royal, Special Envoy for the implementation of the ISA, Government of France, emphasised upon five key points to accelerate global solar deployment: setting concrete goals, developing and leveraging common tools, enhancing projects, establishing decentralised PV solutions, and forging new partnerships that capitalise on complementary capabilities.

The ISA was jointly launched on 30 November 2015 by Prime Minister of India, Shri Narendra Modi, and then-President of France, H.E. François Hollande, on the side lines of the UNFCCC Conference of Parties 21 (CoP21) at Paris, France. The ISA is a treaty-based alliance of 121 prospective solar-rich Member Nations situated fully or partially between the Tropics, and aims at accelerating development and deployment of solar energy globally.

President Inaugurates 37th India International Trade Fair-2017

President Ram Nath Kovind, inaugurated the 37th India International Trade Fair (IITF) -2017, on Tuesday, November 14, 2017 in New Delhi.

Speaking on the occasion, the President said that IITF is more than just a trade fair or exhibition. Commencing every year on November 14, it is a showcase of India on the global stage. It is also a symbol of India’s ancient and enduring commitment to international trade.

The President said that instinctively we have been an open society – free to trade winds and cultural exchanges. We have valued a liberal, rules-based international trading order. This is part of our DNA. And this is the legacy that modern India and IITF are building on.

The President said that this year’s IITF takes place at a point when India is recognised as one of the bright spots of the global economy. The world has acknowledged the changed business environment in India and the strides made in ease of doing business. The introduction of the Goods and Services Tax has been a milestone. It has broken down barriers between states. As a result of these efforts, there has been a sharp rise in FDI in the past three years – from US$ 36 billion in 2013-14 to US$ 60 billion in 2016-17, he said.

The President said that 3,000 exhibitors, including 222 companies from abroad, are participating at IITF 2017. Thirty-two of India’s states and Union territories are represented. Institutions that are present range from self-help groups to big business houses, and from small and medium manufacturing enterprises to digital start-ups. IITF is a mini-India. It is a snapshot of the diversity and the sheer energy of this subcontinent.

The President said that the focus of India’s economic reforms and policies is to eliminate poverty and enhance the prosperity of millions of ordinary families. Trade must help common people. They are the ultimate stakeholders. The government of India’s key initiatives – such as Make in India, Digital India, Start-up India, Stand-up India, Skill India, Smart Cities, and the resolve to double farmers’ incomes – are all an attempt to make economic reforms more meaningful to those at the grassroots.

Children’s Day 2017: President Gives Away National Child Awards

President of India Ram Nath Kovind, presented the National Child Awards on Tuesday, November 14, 2017 at Rashtrapati Bhavan on the occasion of Children’s Day.

The National Child Awards include the National Child Awards for Exceptional Achievement that give recognition to children with exceptional abilities and outstanding achievements in the fields of innovation, scholastic achievements, sports, arts, culture, social service and music; National Awards for Child Welfare to institutions and individuals for their outstanding work in the field of child welfare; and the Rajiv Gandhi Manav Seva Awards to individuals for their outstanding contribution towards service for children.

In a message sent to the Ministry of Women and Child Development on the occasion of the Children’s Day, the President said, “Children are the future of our country. We must make every effort to ensure their welfare. We should also make all possible efforts to ensure that children in our country have a safe and happy childhood. Every child is a bud waiting to blossom. By awarding children, we recognise and encourage their talent and potential for nation building. We should also recognise the significant contribution of individuals and institutions who work for causes related to children.”

Later in the day, the President celebrated Children’s Day with students/children from various schools/institutions at Rashtrapati Bhavan.

Ileana Once Thought of Committing Suicide!

Hindi and Telugu actress Ileana D’Cruz revealed that she once thought of committing suicide due to depression and Body Dysmorphic Disorder. However, she had overcome the illness and started feeling better.

Speaking at the 21st World Congress of Mental Health in New Delhi on Sunday, November 5, Ileana told Organising Chairman Sunil Mittal on her fight with depression and Body Dysmorphic Disorder.

Ileana was awarded the Woman of Substance Award for her efforts towards raising awareness about mental health at the event. The World Congress was organised by the World Federation for Mental Health (WFMH), a global alliance of doctors, health associations, NGOs, policy experts and other institutions.

She said she was always a very self-conscious person and used to feel low and sad all the time but didn’t know that she was suffering from depression and Body Dysmorphic Disorder.

“At one point, I even had suicidal thoughts and wanted to end things. However, all of it changed when I accepted myself and what I was going through. I think that is the first step towards fighting depression,” she revealed.

Ileana, who shot to fame with Telugu film ‘Pokiri’ and Hindi films ‘Barfi!’ and ‘Rustom’ joins another Bollywood fame Deepika Padukone who had revealed openly about her fight to overcome depression a year ago. Ileana reiterated that people shouldn’t shy away from seeking help for depression.

“It is a chemical imbalance in your brain, and needs to be treated. Don’t sit back and think it will get okay but go get help. Like you have a sprain and go get yourself checked, if you have depression, seek help,” she said.

Ileana said her mother was her biggest pillar of strength throughout the period of depression. Speaking about her fans, “You may look at us actors and think that ‘Oh my God, they are so pretty, so perfect’. But that’s not how it is. It takes two hours to get ready and look like this. Love yourself for who you are and trust me if you are happy from within, you are the most beautiful person and your smile is your best asset.”

She said she wanted to open up about her depression to help those who can overcome similar problem looking at her as inspiration.

Kamal Haasan to launch App Ahead of New Party

As Prime Minister Narendra Modi is going to visit Chennai on Monday, actor Kamal Haasan has decided to launch his mobile software app a day after on Tuesday, November 7 – his 63rd birthday just to be in touch with his fans.

At a function to mark the 39th anniversary of his fan/welfare club on Sunday November 5, he confirmed the launch of his new political party but the app comes first. He has appealed his fans to contribute funds for the political party and the mobile app will help in maintaining proper accounts, he said.

Instead of cutting a cake, he said his birthday would be celebrated to cut canals in view of the flooding in Chennai. The actor said wryly that the natural disasters do not differentiate between rich and poor and all should join hands to take preventive measures.

Accusing major parties of suppressing the common man, he said people should not feel threatened but react and do something. Even if there is beating, it could be one or twice but not always like “mridangam” which gets hit again and again.

Otherwise, Prime Minister Narendra Modi is visiting Chennai on Monday to participate in the 75th anniversary celebrations of the Daily Thanthi newspaper.

Film on 1983 Cricket World Cup Winning set for Release in April 2019

Upcoming Bollywood film ’83’ on India’s 1983 cricket World Cup victory, will release on April 5, 2019, said producers Reliance Entertainment and Phantom Films in association with Vibri Media and Kabir Khan Films.

Directed by Kabir Khan, the film will feature actor Ranveer Singh as star cricketer Kapil Dev under whose captaincy India achieved the great honour in 1983 first time in cricket history.

The film surrounds on how Kapil Dev, then Indian cricket team defeated West Indies, making the cricket team noticeable among the cricketing world.

Khan said,”As a young school boy, when I watched India win the 1983 Cricket World Cup, I had no idea that from that day onwards cricket in India will change forever. As a filmmaker, for me, the journey to that win, filled with raw energy and sheer passion of that young Indian team, is probably one of the most exciting stories I have worked on. And it’s great to have Ranveer come on board to play Kapil Dev, as honestly, I could see no one else for the role, ever since I started finalizing the script.”

Shibasish Sarkar, COO of Reliance Entertainment, said: “Winning the ’83 cricket World Cup was a very proud moment for us as Indians and we at Reliance Entertainment aim to bring back those glorious moments for the current and future generations through this film.”

Madhu Mantena of Phantom Films and Vishnu Vardhan Induri of Vibri Media said the story was waiting to be told to the nation how it underwent the transformation into a big league cricket playing and winning teams among the cricket-playing nations. The “country needs to know” the story, they added.

2.24 lakh Companies deleted from list by Corporate Ministry

Based on the massive drive undertaken by the Ministry of Corporate Affairs (MCA), Government of India, around 2.24 lakh companies have been struck-off till date for remaining inactive for a period of two (2) years or more.

Following the action of striking-off defaulting companies, restrictions have been imposed on operation of their bank accounts in accordance with the law. Further, Preliminary Enquiry on the basis of information received from 56 banks in respect of 35,000 companies involving 58,000 accounts has revealed that an amount of over Rs. 17,000 crore was deposited and withdrawn post demonetization. In one case, a company which had a negative Opening Balance on 8th November, 2016, deposited and withdrew Rs.2,484 crore post-demonetization.

Apart from the restrictions on bank accounts, action has also been taken to restrict sale and transfer of moveable and immoveable properties of struck-off companies until they are restored. The State Governments have been advised to take necessary action in this regard by disallowing registration of such transactions.

One company was found to have as many as 2,134 accounts. The information with respect to such companies have been shared with enforcement authorities, including Central Board of Direct Taxes(CBDT), Financial Intelligence Unit (FIU), Department of Financial Services (DFS) and Reserve Bank of India (RBI) etc., for further necessary action. Companies have also been identified for inquiry/inspection/investigation under the Companies Act, 2013 and necessary action is underway.

The Prime Minister’s Office has constituted a Special Task Force (STF) under the Joint Chairmanship of Revenue Secretary and Secretary, Corporate Affairs, to oversee the drive against such defaulting companies with the help of various enforcement agencies. The Special Task Force has so far met five (5) times and action has been initiated against several defaulting companies, which is expected to help in the drive against black money.

Separately, action has also been taken to disqualify Directors on the Board of Companies that have failed to file Financial Statements and/or Annual Returns for a continuous period of three (3) financial years during 2013-14 to 2015-16. Around 3.09 lakh Directors have been affected by this action. Preliminary enquiry has shown that over 3,000 disqualified Directors are Directors in more than 20 companies each, which is beyond the limit prescribed under the Law.

Further, in the light of the evidence with respect to abuse of the Corporate Structure through multi-layering, not more than two (2) layers are now permitted beyond the wholly owned subsidiary. This is in addition to the existing restriction which prohibits a company to make investment through more than two layers of investment companies.

In order to address the criminality angle, the Director, Additional Director or Assistant Director of SFIO have been recently authorized to arrest any person believed to be guilty of any fraud punishable under the Act. Under Section 447 of the Act, which defines fraud, stringent punishment including imprisonment up to 10 years is stipulated. Further, reference has been made to the Ministry of Finance to include it as a Scheduled Offence under the Prevention of Money Laundering Act.

Action is also being initiated against Professionals guilty of fraud and all complaints against them are being reviewed. A High Level Committee (HLC) has been constituted for suggesting revamp of the disciplinary systems of Chartered Accountants, Company Secretaries and Cost Accountants. Further, steps are underway for setting-up National Financial Reporting Authority (NFRA), an independent body, to test check Financial Statements, prescribe Accounting Standards and take disciplinary action against errant professionals.

With a view to checking the problem of Dummy Directors, action is underway to seed DIN with PAN and Aadhaar at the stage of DIN application through biometric matching for new applications. The same may be extended to legacy data in due course.

Finally, a separate initiative is underway to develop a State-of-the-Art software application to put in place an ‘Early Warning System’ (EWS), which will be housed in SFIO. The objective is to strengthen the Regulatory Mechanism.

Clean Ganga Mission Organises Ek Shaam Ganga Ke Naam

River Ganga has been an unceasing source of livelihood for more than 40 percent of India’s population. It has been unconditionally providing for our needs and has been the very essence of spirituality. In order to acknowledge the river’s importance and celebrate its magnificence, National Mission for Clean Ganga (NMCG) organised a cultural evening – “Ek Shaam Ganga ke Naam” yesterday in New Delhi. On this date in 2008, Ganga was declared as the National River of India.

Intended to evoke Ganga consciousness, the event was attended by hundreds of people from all walks of life including bureaucrats, academicians, researchers, artists, students, teachers, water and river experts, engineers, media, and other stakeholders. The purpose of the evening was to bring all stakeholders together for a wonderful cause of Ganga rejuvenation and forge ahead in unison. Secretary, Ministry of Water Resources, River Development and Ganga Rejuvenation Amarjit Singh also graced the occasion.

Addressing the gathering, Director General, National Mission for Clean Ganga, UP Singh said: “Ganga is not just a water resource; it is linked deeply with the sentiments of millions of people. It is essential to rid the river of pollution. While the government is working hard to rejuvenate the river, the participation of people is of utmost importance.”

The main attraction of the event was an enthralling dance drama – Namami Gange – produced by Padma Bhushan Dr. Saroja Vaidyanathan. The performance, a Bharatnatyam recital, depicted river Ganga’s story with the contemporary relevance. The dance drama while illustrating the endurance the river observes, called for urgency to restore this flowing lifeline to its pristinity. The act beautifully captured the necessity of public participation in clean Ganga campaign, which under Namami Gange programme, has picked up pace. The audience witnessed in awe as the story of Ganga was told in a beautiful way.

The dance drama was preceded by a singing performance on popular songs on Ganga. Partha Purshotam Dutta, his wife Binapani Dutta and their band charmed the audience by presenting the songs in their own unique style.

The evening began with a dance-ballet by the students of Heritage Public School on Namami Gange theme song that has been composed and sung by Trichur Brothers. It depicted an episode of Indian mythology where King Bhagirath does Tapasya to bring Ganga on earth to give salvation to his ancestors and Lord Shiva locks Ganga in his tresses before releasing it only after Bhagirath’s plea. The brilliant performance of the students of 5th to 9th standard left the audience mesmerized.

Not English but mother tongue helps marriages to last longer: Study

Amid rising number of intercultural marriages, more and more couples use English as the lingua franca but speaking in common native language helped many marriages to last longer, said a new study.

Kaisa Pietikainen from the University of Helsinki, who has studied the interactions of these so-called ELF couples in her doctoral dissertation, says:”It’s often thought that when the partners learn to speak each other’s native languages, they will pick either language as their shared language. But when one is used to speaking a certain language to one another, it becomes difficult to change.”

Usually couples have an open attitude toward language-mixing. Features from other languages become such an integrated part of their ‘couple tongue’ that after a while, they may not even notice when they switch languages, she says.

ELF couples identify mainly as English-speaking couples, but they are also aware of the presence of other languages in their interactions.

“The previously held idea that a lingua franca can’t become a language of identification or that one can’t use it to express feelings doesn’t hold true when it comes to ELF couples.”

Ensuring understanding with creative means Pietikaiinen says that misunderstandings are not very common in ELF couples’ conversation. The couples invest in practices that support understanding, for example, they paraphrase difficult words and check whether the partner has understood them. ELF couples even utilise onomatopoetic expressions and drawing as an aid for achieving mutual understanding.

Silence matters in conflicts

Silence in ELF couples’ conflict interactions does not only mean that the partners disagree or that one is offended by what the other one has said or done. It can also be used to avoid giving self-incriminating answers, or in resisting the partner’s attempt to defuse the conflict with the use of humour.

“These observations have, however, nothing to do with the fact that the partners use non-native English between them. I’m sure these kinds of silences are very familiar for every long-term relationship,” Pietikaiinen adds.

PM Congratulates India Women’s Hockey Team on winning Asia Cup 2017

Prime Minister Narendra Modi, has congratulated the Indian Women’s hockey team on winning Asia Cup 2017. Last time in 2004 India Women’s Team lifted the Asia Cup after beating Japan.

“Congratulations to our hockey team on winning the Women’s Asia Cup 2017. India is delighted by their stellar performance.”,the Prime Minister said.

India beat China 5-4 via shootouts to win the women’s Asia Cup hockey title in Japan on Sunday and also qualified for next year’s World Cup as Continental Champions.

Skipper Rani scored the winning goal for India and Savita made a great save in sudden death to ensure India the 5-4 score in the penalty shootout. Earlier, Navjot Kaur scored India’s lone goal in the 25th minute.

When the first quarter ended in a stalemate, Indiaan forwards kept the pressure on China and Navjot Kaur came close to a field goal in the 17th minute but in vain. Again at the 25th minute, she took a clear shot on goal.

With 1-0 lead, India countered China attack and in the third quarter they dominated the ball testing China’s patience. In the final quarter, China won a penalty corner through a successful video referral in the 47th minute.

When both teams are at par, China won their fourth penalty corner with less than three minutes to go for the end.

In the penalty shootout Rani scored twice, Monica, Lilima Minz and Navjot scored a goal each to ensure India reclaimed the Asia Cup title after 13 years. Savita was chosen Goalkeeper of the Tournament and Monica got the Woman of the Match award.

Artificial intelligence: Is this the future of early cancer detection?

A new endoscopic system powered by artificial intelligence (AI) has today been shown to automatically identify colorectal adenomas during colonoscopy. The system, developed in Japan, has recently been tested in one of the first prospective trials of AI-assisted endoscopy in a clinical setting, with the results presented today at the 25th UEG Week in Barcelona, Spain.

AI-assisted endocytoscopy – how it works:

The new computer-aided diagnostic system uses an endocytoscopic* image – a 500-fold magnified view of a colorectal polyp – to analyse approximately 300 features of the polyp after applying narrow-band imaging (NBI) mode or staining with methylene blue. The system compares the features of each polyp against more than 30,000 endocytoscopic images that were used for machine learning, allowing it to predict the lesion pathology in less than a second. Preliminary studies demonstrated the feasibility of using such a system to classify colorectal polyps, however, until today, no prospective studies have been reported.

Prospective study in routine practice:

The prospective study, led by Dr Yuichi Mori from Showa University in Yokohama, Japan, involved 250 men and women in whom colorectal polyps had been detected using endocytoscopy1. The AI-assisted system was used to predict the pathology of each polyp and those predictions were compared with the pathological report obtained from the final resected specimens. Overall, 306 polyps were assessed real-time by using the AI-assisted system, providing a sensitivity of 94%, specificity of 79%, accuracy of 86%, and positive and negative predictive values of 79% and 93% respectively, in identifying neoplastic changes.

Speaking at the Opening Plenary at UEG Week, Dr Mori explained; “The most remarkable breakthrough with this system is that artificial intelligence enables real-time optical biopsy of colorectal polyps during colonoscopy, regardless of the endoscopists’ skill. This allows the complete resection of adenomatous polyps and prevents unnecessary polypectomy of non-neoplastic polyps.”

“We believe these results are acceptable for clinical application and our immediate goal is to obtain regulatory approval for the diagnostic system” added Dr Mori.

Moving forwards, the research team is now undertaking a multicentre study for this purpose and the team are also working on developing an automatic polyp detection system. “Precise on-site identification of adenomas during colonoscopy contributes to the complete resection of neoplastic lesions” said Dr Mori. “This is thought to decrease the risk of colorectal cancer and, ultimately, cancer-related death.”

MHA gives a boost to “Make in India” in the field of manufacturing of arms

The Ministry of Home Affairs has liberalised the Arms Rules to boost “Make in India” manufacturing policy of the Government as also to promote employment generation in the field of manufacturing of arms and ammunition.
The liberalisation of the Arms Rules will encourage investment in the manufacturing of arms and ammunition and weapon systems as part of the “Make in India” programme. The liberalised rules are expected to encourage the manufacturing activity and facilitate availability of world class weapons to meet the requirement of Armed Forces and Police Forces in sync with country’s defence indigenization programme. The liberalised rules will apply to licences granted by MHA for small arms & ammunition and licences granted by Department of Industrial Policy and Promotion (DIPP), under powers delegated to them, for tanks and other armoured fighting vehicles, defence aircrafts, space crafts, warships of all kinds, arms and ammunition and allied items of defence equipment other than small arms.
The salient features of the liberalised rules are:
(i) The licence granted for manufacturing shall now be valid for the life-time of the licensee company. The requirement of renewal of the license after every 5 years has been done away with.
(ii) Similarly, condition that the small arms and light weapons produced by manufacturer shall be sold to the Central Government or the State Governments with the prior approval of the Ministry of Home Affairs has been done away with.
(iii) Further, enhancement of capacity up to 15% of the quantity approved under licence will not require any further approval by the Government. The manufacturer will be required to give only prior intimation to the licensing authority in this regard.
(iv) The licence fee has been reduced significantly. Earlier the licence fee was Rs. 500/- per firearm which added up to very large sums and was a deterrent to seeking manufacturing licenses. The licence fee will now range from Rs. 5,000/- to the maximum of Rs. 50,000/-.
(v) The fee for manufacturing licence shall be payable at the time of grant of license rather than at the time of application.
(vi) Single manufacturing licence will be allowed for a multi-unit facility within the same State or in different States within the country.
A notification for the Arms (Amendment) Rules, 2017 has been issued by MHA on October 27, 2017.

Teamwork makes the dream work?

Numbered jerseys effectively increase overall teamwork performance during cardiac arrest.

In new research from CHEST 2017, a team from Montefiore Medical Center in New York aimed to create a team-driven atmosphere in the hospital and hypothesized that the use of personalized numbered jerseys for each member of the code team would help to improve teamwork and overall time to perform critical clinical actions.

The study included ten critical care medicine fellows who were randomized into two groups. One group received personalized number jerseys for each code team member, while the control team wore their regular clothes. Each of the groups were asked to participate in six cardiac arrest scenarios using high-fidelity simulation, and participants alternated between team leader and team member roles for each case. Trained faculty using the validated16-item Mayo High Performance Teamwork scale graded teamwork.

Results found that the Mayo Teamwork score was significantly higher in the group donning team jerseys as compared with the control group. (23.5 vs 17.5, P <.01). In addition, there was a statistically significant difference in the percent of directed commands in the experimental vs control groups (35.63% vs 19.58%, P<.01).

“This study demonstrated that the use of numbered jerseys for individual code team members is an effective way to significantly increase the overall teamwork performance during a CA event,” says Dr. Yekaterina Kim, lead searcher, “in addition, the use of such jerseys significantly increased the number of direct commands by team leaders during such scenarios, thereby reducing the percent of ineffective commands.”

Further results from this study will be shared at CHEST Annual Meeting 2017 in Toronto on Wednesday, November 1, 1:30 PM-2:30 PM at the Metro Toronto Convention Centre, Exhibit Hall, Poster Number 130. The study abstract can be viewed on the journal CHEST® website.

 

Rapid cellphone charging getting closer to reality

The ability to charge cellphones in seconds is one step closer after researchers at the University of Waterloo used nanotechnology to significantly improve energy-storage devices known as supercapacitors.

Their novel design roughly doubles the amount of electrical energy the rapid-charging devices can hold, helping pave the way for eventual use in everything from smartphones and laptop computers, to electric vehicles and high-powered lasers.

“We’re showing record numbers for the energy-storage capacity of supercapacitors,” said Michael Pope, a professor of chemical engineering who led the Waterloo research. “And the more energy-dense we can make them, the more batteries we can start displacing.”

Supercapacitors are a promising, green alternative to traditional batteries–with benefits including improved safety and reliability, in addition to much faster charging–but applications have been limited so far by their relatively low storage capacity.

Existing commercial supercapacitors only store enough energy, for example, to power cellphones and laptops for about 10 per cent as long as rechargeable batteries.

To boost that capacity, Pope and his collaborators developed a method to coat atomically thin layers of a conductor called graphene with an oily liquid salt in supercapacitor electrodes.

The liquid salt serves as a spacer to separate the thin graphene sheets, preventing them from stacking like pieces of paper. That dramatically increases their exposed surface area, a key to maximizing energy-storage capacity.

At the same time, the liquid salt does double duty as the electrolyte needed to actually store electrical charge, minimizing the size and weight of the supercapacitor.

“That is the really cool part of this,” Pope said. “It’s a clever, elegant design.”

The innovation also uses a detergent to reduce the size of the droplets of oily salt – which is combined with water in an emulsion similar to salad dressing – to just a few billionths of a metre, improving their coating action. The detergent also functions like chemical Velcro to make the droplets stick to the graphene.

Increasing the storage capacity of supercapacitors means they can be made small and light enough to replace batteries for more applications, particularly those requiring quick-charge, quick-discharge capabilities.

In the short term, Pope said better supercapacitors could displace lead-acid batteries in traditional vehicles, and be used to capture energy otherwise lost by buses and high-speed trains when they brake.

Further out, although they are unlikely to ever attain the full storage capacity of batteries, supercapacitors have the potential to conveniently and reliably power consumer electronic devices, electric vehicles and systems in remote locations like space.

“If they’re marketed in the correct ways for the right applications, we’ll start seeing more and more of them in our everyday lives,” Pope said.

First white-box testing model finds thousands of errors in self-driving cars

Researchers from Lehigh University and Columbia University have created DeepXplore, the first efficient testing approach for deep learning platforms used in self-driving cars, malware-detection and other systems.

How do you find errors in a system that exists in a black box?

That is one of the challenges behind perfecting deep learning systems like self-driving cars. Deep learning systems are based on artificial neural networks that are modeled after the human brain, with neurons connected together in layers like a web. This web-like neural structure enables machines to process data with a non-linear approach–essentially teaching itself to analyze information through what is known as training data.

When an input is presented to the system after being “trained”–like an image of a typical two-lane highway presented to a self-driving car platform–the system recognizes it by running an analysis through its complex logic system. This process largely occurs in a black box and is not fully understood by anyone, including a system’s creators.

Any errors also occur in a black box, making it difficult to identify them and fix them. This opacity presents a particular challenge to identifying corner case behaviors. A corner case is an incident that occurs outside normal operating parameters. A corner case example: a self-driving car system might be programmed to recognize the curve in a two-lane highway in most instances. However, if the lighting is lower or brighter than normal, the system may not recognize it and an error could occur. One recent example is the 2016 Tesla crash which was caused in part…

Shining a light into the black box of deep learning systems is what Yinzhi Cao of Lehigh University and Junfeng Yang and Suman Jana of Columbia University–along with the Columbia Ph.D. student Kexin Pei–have achieved with DeepXplore, the first automated white-box testing of such systems. Evaluating DeepXplore on real-world datasets, the researchers were able to expose thousands of unique incorrect corner-case behaviors. They will present their findings at the 2017 biennial ACM Symposium on Operating Systems Principles (SOSP) conference in Shanghai, China on October 29th in Session I: Bug Hunting.

“Our DeepXplore work proposes the first test coverage metric called ‘neuron coverage’ to empirically understand if a test input set has provided bad versus good coverage of the decision logic and behaviors of a deep neural network,” says Cao, assistant professor of computer science and engineering.

In addition to introducing neuron coverage as a metric, the researchers demonstrate how a technique for detecting logic bugs in more traditional systems–called differential testing–can be applied to deep learning systems.

“DeepXplore solves another difficult challenge of requiring many manually labeled test inputs. It does so by cross-checking multiple DNNs and cleverly searching for inputs that lead to inconsistent results from the deep neural networks,” says Yang, associate professor of computer science. “For instance, given an image captured by a self-driving car camera, if two networks think that the car should turn left and the third thinks that the car should turn right, then a corner-case is likely in the third deep neural network. There is no need for manual labeling to detect this inconsistency.”

The team evaluated DeepXplore on real-world datasets including Udacity self-driving car challenge data, image data from ImageNet and MNIST, Android malware data from Drebin, and PDF malware data from Contagio/VirusTotal, and production quality deep neural networks trained on these datasets, such as these ranked top in Udacity self-driving car challenge.

Their results show that DeepXplore found thousands of incorrect corner case behaviors (e.g., self-driving cars crashing into guard rails) in 15 state-of-the-art deep learning models with a total of 132, 057 neurons trained on five popular datasets containing around 162 GB of data.

The team has made their open-source software public for other researchers to use, and launched a website, DeepXplore, to let people upload their own data to see how the testing process works.

More neuron coverage

According to a paper to be published after the conference (see preliminary version here), DeepXplore is designed to generate inputs that maximize a deep learning (DL) system’s neuron coverage.

The authors write: “At a high level, neuron coverage of DL systems is similar to code coverage of traditional systems, a standard metric for measuring the amount of code exercised by an input in a traditional software. However, code coverage itself is not a good metric for estimating coverage of DL systems as most rules in DL systems, unlike traditional software, are not written manually by a programmer but rather is learned from training data.”

“We found that for most of the deep learning systems we tested, even a single randomly picked test input was able to achieve 100% code coverage–however, the neuron coverage was less than 10%,” adds Jana, assistant professor of computer science.

The inputs generated by DeepXplore achieved 34.4% and 33.2% higher neuron coverage on average than the same number of randomly picked inputs and adversarial inputs (inputs to machine learning models that an attacker has intentionally designed to cause the model to make a mistake) respectively.

Differential testing applied to deep learning

Cao and Yang show how multiple deep learning systems with similar functionality (e.g., self-driving cars by Google, Tesla, and Uber) can be used as cross-referencing oracles to identify erroneous corner-cases without manual checks. For example, if one self-driving car decides to turn left while others turn right for the same input, one of them is likely to be incorrect. Such differential testing techniques have been applied successfully in the past for detecting logic bugs without manual specifications in a wide variety of traditional software.

In their paper, they demonstrate how differential testing can be applied to deep learning systems.

Finally, the researchers’ novel testing approach can be used to retrain systems to improve classification accuracy. During testing, they achieved up to 3% improvement in classification accuracy by retraining a deep learning model on inputs generated by DeepXplore compared to retraining on the same number of randomly picked or adversarial inputs.

“DeepXplore is able to generate numerous inputs that lead to deep neural network misclassifications automatically and efficiently,” adds Yang. “These inputs can be fed back to the training process to improve accuracy.”

Adds Cao: “Our ultimate goal is to be able to test a system, like self-driving cars, and tell the creators whether it is truly safe and under what conditions.”

 

President of India addresses members of Karnataka Legislature on 60th anniversary of VidhanaSoudha

The President of India, Shri Ram NathKovind, graced the ‘Vajramahothsava’ – Diamond Jubilee Celebrations on completion of 60 years of VidhanaSoudha, and addressed the members of both Houses of the Karnataka Legislature at Bengaluru, today (October 25, 2017).

Speaking on the occasion, the President said that it is not just the 60th birthday of this building (VidhanaSoudha) that we are marking. This is also the diamond jubilee of the debates and discussions in the two Houses, of legislations that have been passed and policies that have been shaped for the betterment of the lives of the people of Karnataka. Both Houses of the Legislature jointly and collectively represent the will and aspirations of the people of Karnataka. Not just that, the two Houses also represent the ideals and optimism and the energy and dynamism of the Kannadiga people. This building is a monument to the history of public service in Karnataka. A galaxy of political stalwarts has participated in the proceedings of the two Houses that meet here. They have spoken in many memorable debates.

The President said that Karnataka’s dreams are not for Karnataka alone; they are dreams for all of India. Karnataka is an engine of the Indian economy. It is a mini-India that draws – without losing its cultural and linguistic distinctiveness – youth from all over the country. They come here for knowledge and for jobs, and they give their labour and intellect. Everybody gains.

The President said that legislators are both public servants as well as nation builders. Indeed, anybody who performs his or her duties with honesty and dedication is a nation builder. Those who maintain this building are nation builders. Those who provide it security are nation builders. It is by the efforts of ordinary citizens, who diligently carry out everyday tasks, that nations are built. As legislators sit and work in this VidhanSoudha, he was confident they will never forget this and will continue to draw inspiration from it.

The President said that we are aware of the three D’s of the legislature,that it is a place to debate, dissent and finally decide. And if we add the fourth D, decency, then the fifth D, namely democracy, becomes a reality. The legislature is an embodiment of the will, aspirations and hopes of the people of Karnataka, irrespective of political belief, caste and religion, gender or language. It needs the collective wisdom of both Houses of the Legislature to fulfil the dreams of our people.

The President said that it is for the Legislative Assembly and the Legislative Council to function as sacred temples of democracy, and contribute to raising the level of political and policy discourse. As representatives of the people of Karnataka, the members of the two Houses here have a special responsibility. He called upon legislators to make the diamond jubilee not just the celebration of a proud past – but a commitment to an even greater future.