In a coordinated operation at sea, Narcotics Control Bureau (NCB) and Indian Navy apprehended a suspicious vessel carrying more than 200 kgs of narcotics.
The boat with its crew, has been escorted to Kochi for further investigation. This is significant not only in terms of quantity and cost but also signifies a focus on collaborative efforts for disruption of the illegal narcotics smuggling routes, which emanate from the Makran coast and flow towards various IOR countries.
Narcotics Control Bureau (NCB) and Indian Navy apprehended a suspicious vessel carrying more than 200 kgs of narcotics.
Apart from the human costs from drug addiction, the spoils of narcotics trade feed syndicates involved in terrorism, radicalization and criminal activities. Successful conduct of this operation reaffirms our strong commitment and resolve of not allowing seas as global commons being used for illegal activities especially in India’s maritime neighborhood.
SARS-CoV-2, the virus that causes COVID-19, is an airborne disease transmitted via aerosols, which are spread from the oral and nasal cavities—the mouth and the nose. In addition to the well-known division and spread of the virus in the cells of the respiratory tract, SARS-CoV-2 is also known to infect the cells of the lining of the mouth and the salivary glands.
A team of researchers led by Professor Kyoko Hida at Hokkaido University have shown that low concentrations of the chemical cetylpyridinium chloride, a component of some mouthwashes, has an antiviral effect on SARS-CoV-2. Their findings were published in the journal Scientific Reports.
Commercially available mouthwashes contain a number of antibiotic and antiviral components that act against microorganisms in the mouth. One of these, cetylpyridinium chloride (CPC), has been shown to reduce the viral load of SARS-CoV-2 in the mouth, primarily by disrupting the lipid membrane surrounding the virus. While there are other chemicals with similar effects, CPC has the advantage of being tasteless and odorless.
Cetylpyridinium chloride (CPC), the chemical tested in the study (Photo: Ryo Takeda)/CREDIT:Ryo Takeda
The researchers were interested in studying the effects of CPC in Japanese mouthwashes. Mouthwashes in Japan typically contain a fraction of the CPC compared to previously tested mouthwashes. They tested the effects of CPC on cell cultures that express trans-membrane protease serine 2 (TMPRSS2), which is required for SARS-CoV-2 entry into the cell.
They found that, within 10 minutes of application, 30–50 µg/mL of CPC inhibited the infectivity and capability for cell entry of SARS-CoV-2. Interestingly, commercially available mouthwashes that contain CPC performed better than CPC alone. They also showed that saliva did not alter the effects of CPC. Most significantly, they tested four variants of SARS-CoV-2—the original, alpha, beta and gamma variants—and showed that the effects of CPC were similar across all strains.
Covid/commons.wikimedia.org
This study shows that low concentrations of CPC in commercial mouthwash suppress the infectivity of four variants of SARS-CoV-2. The authors have already begun assessing the effect on CPC-containing mouthwashes on viral loads in saliva of COVID-19 patients. Future work will also focus on fully understanding the mechanism of effect, as lower concentrations of CPC do not disrupt lipid membranes.
B-type procyanidins, made of catechin oligomers, are a class of polyphenols found abundantly in foods like cocoa, apples, grape seeds, and red wine. Several studies have established the benefits of these micronutrients in reducing the risk of cardiovascular diseases and strokes. B-type procyanidins are also successful in controlling hypertension, dyslipidemia, and glucose intolerance. Studies attest to the physiological benefits of their intake on the central nervous system (CNS), namely an improvement in cognitive functions. These physiological changes follow a pattern of hormesis—a phenomenon in which peak benefits of a substance are achieved at mid-range doses, becoming progressively lesser at lower and higher doses.
The dose-response relationship of most bioactive compounds follows a monotonic pattern, in which a higher dose shows a greater response. However, in some exceptional cases, a U-shaped dose-response curve is seen. This U-shaped curve signifies hormesis—an adaptive response, in which a low dose of usually a harmful compound induces resistance in the body to its higher doses. This means that exposure to low levels of a harmful trigger can induce the activation of stress-resistant pathways, leading to greater repair and regeneration capabilities. In case of B-type procyanidins, several in vitro studies support their hormetic effects, but these results have not been demonstrated in vivo.
To address this knowledge gap, researchers from Shibaura Institute of Technology (SIT), Japan, led by Professor Naomi Osakabe from the Department of Bioscience and Engineering, reviewed the data from intervention trials supporting hormetic responses of B-type procyanidin ingestion. The team, comprising Taiki Fushimi and Yasuyuki Fujii from the Graduate School of Engineering and Science (SIT), also conducted invivo experiments to understand possible connections between B-type procyanidin hormetic responses and CNS neurotransmitter receptor activation. Their article was made available online on June 15, 2022 and has been published in volume 9 of Frontiers of Nutrition on September 7, 2022.
The researchers noted that a single oral administration of an optimal dose of cocoa flavanol temporarily increased the blood pressure and heart rate in rats. But the hemodynamics did not change when the dose was increased or decreased. Administration of B-type procyanidin monomer and various oligomers produced similar results. According to Professor Osakabe, “These results are consistent with those of intervention studies following a single intake of food rich in B-type procyanidin, and support the U-shaped dose-response theory, or hormesis, of polyphenols.”
To observe whether the sympathetic nervous system (SNS) is involved in the hemodynamic changes induced by B-type procyanidins, the team administered adrenaline blockers in test rats. This successfully decreased the temporary increase in heart rate induced by the optimal dose of cocoa flavanol. A different kind of blocker—a1 blocker—inhibited the transient rise in blood pressure. This suggested that the SNS, which controls the action of adrenaline blockers, is responsible for the hemodynamic and metabolic changes induced by a single oral dose of B-type procyanidin.
The researchers next ascertained why optimal doses, and not high doses, are responsible for the thermogenic and metabolic responses. They co-administered a high dose of cocoa flavanol and yohimbine (an α2 blocker) and noted a temporary but distinct increase in blood pressure in test animals. Similar observations were made with the use of B-type procyanidin oligomer and yohimbine. Professor Osakabe surmises, “Since α2 blockers are associated with the down-regulation of the SNS, the reduced metabolic and thermogenic outputs at a high dose of B-type procyanidins seen in our study may have induced α2 auto-receptor activation. Thus, SNS deactivation may be induced by a high dose of B-type procyanidins.”
Previous studies have proven the role of the gut-brain axis in controlling hormetic stress-related responses. The activation of the hypothalamus-pituitary-adrenal (HPA) axis by optimal stress has a strong influence on memory, cognition, and stress tolerance. This article highlights how HPA activation occurs after a single dose of B-type procyanidin, suggesting that stimulation with an oral dose of B-type procyanidin might be a stressor for mammals and cause SNS activation.
Hormesis and its triggering biochemical pathways deliver protection against various pathological and aging processes, enhancing our general health and making us resilient to future stress. Though the exact relation between B-type procyanidins and the CNS needs more research, the health benefits of B-type procyanidin-rich foods remains undisputed.
The Royal Swedish Academy of Sciences has awarded the 2022 Nobel Prize in Chemistry to Carolyn Bertozzi, Morten Meldal, and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
Bertozzi, a professor of chemistry at Stanford University, is the eighth woman to be awarded the prize. From 1996 to 2015, before joining Stanford, she was a faculty scientist at the Department of Energy’s Lawrence Berkeley National Laboratory and a UC Berkeley professor. She also served as the director of the Molecular Foundry, a DOE Office of Science nanoscience user facility located at Berkeley Lab, from 2006 to 2010.
The award to Bertozzi brings the number of Nobel Prizes associated with Berkeley Lab scientists to sixteen. (Earlier this week, on Tuesday, Oct. 4, former Lab postdoc John Clauser’s 2022 Nobel Prize in Physics brought the Lab’s tally to fifteen.)
According to today’s Nobel Prize announcement, “The Nobel Prize in Chemistry 2022 is about making difficult processes easier. Barry Sharpless and Morten Meldal have laid the foundation for a functional form of chemistry – click chemistry – in which molecular building blocks snap together quickly and efficiently. Carolyn Bertozzi has taken click chemistry to a new dimension and started utilising it in living organisms.”
Carolyn Bertozzi/CREDIT:Jenny Nuss/Berkeley Lab
“Carolyn Bertozzi had a profound impact at Berkeley Lab, not only through her brilliant science, but as someone who created new institutions that encouraged team science,” said Berkeley Lab Director Mike Witherell.
By pioneering a method for mapping biomolecules on the surface of cells, Bertozzi helped create a suite of techniques comprising “bioorthogonal chemistry,” a term Bertozzi coined, which means “not interacting with biology.” The method describes chemical reactions that allow scientists to explore cells and track biological processes without disrupting the normal chemistry of the cell.
Bertozzi’s lab first developed the method in the late 1990s and early 2000s. During that time, she was one of the six scientists who helped establish the Molecular Foundry, a nanoscience research facility that provides scientists from around the world access to cutting-edge expertise and instrumentation. She served as the Molecular Foundry’s director when the facility first opened its doors to the research community in 2006, and she founded the Foundry’s Biological Nanostructures Facility, where scientists study the synthesis, analysis and mimicry of biological nanostructures.
“Carolyn Bertozzi’s impact on nanoscience is huge,” said Jeff Neaton, associate laboratory director of Berkeley Lab’s Energy Sciences Area. “The chemistry she developed paved the way for the science and engineering of living-nonliving interfaces, a frontier of nanoscience which also became a major theme of the Foundry.”
Under Bertozzi’s leadership, the Foundry grew immensely, bringing in scientists from across the disciplines. This multidisciplinary approach inspired collaborations with visiting scientists, including longtime Foundry user K. Barry Sharpless, co-recipient of the Nobel Prize in Chemistry with Bertozzi and Morten Meldal.
“Carolyn put the Foundry on the map,” said Bruce Cohen, a staff scientist in the Foundry’s Biological Nanostructures facility since 2006. “She oversaw the opening of the facility, which is a major administrative and scientific feat.” He added that Bertozzi’s “science is so creative and original, as well as technically on point, and it’s opened up entire new areas of study. This is a well-deserved Nobel Prize. I couldn’t be happier for her.”
Cohen said that Bertozzi is also “a great mentor to all of the scientists around her, and has always been an inspirational role model for both women and LGBTQ people in science.”
Bertozzi and others have used her methods to answer fundamental questions about the role of sugars in biology, to study how cells build proteins and other molecules, to develop new cancer medicines, and to produce new materials for energy storage, among many other applications.
The Nobel committee said in a statement that “click chemistry and bio-orthogonal reactions have taken chemistry into the era of functionalism,” adding that “this is bringing the greatest benefit to humankind.”
Among her many awards, Bertozzi is a recipient of the 2014 Ernest Orlando Lawrence Award, the Department of Energy’s highest scientific honor. She was named a MacArthur Fellow in 1999. She won the Wolf Prize in Chemistry in 2022.
Bertozzi completed her undergraduate degree in chemistry at Harvard University and her Ph.D. at UC Berkeley. She has been a Howard Hughes Medical Institute Investigator since 2000. She joined Stanford in 2015.
India emerges as the world’s largest producer and consumer of sugar and world’s 2nd largest exporter of sugar.
Records over 5000 LMT sugarcane produced in sugar season 2021-22; 35 LMT sugar used to ethanol production and 359 LMT sugar produced by sugar mills in the season.
Records highest sugar exports of 109.8 LMT.
Sugar mills/distilleries generate ₹ 18,000 crore from sale of ethanol.
95% of all cane dues cleared by the millers by end of the season; for Sugar Season 2020-21, more than 99.9% cane dues have been cleared.
In Sugar Season (Oct-Sep) 2021-22, a record of more than 5000 Lakh Metric Tons (LMT) sugarcane was produced in the country out of which about 3574 LMT of sugarcane was crushed by sugar mills to produce about 394 LMT of sugar (Sucrose). Out of this, 35 LMT sugar was diverted to ethanol production and 359 LMT sugar was produced by sugar mills. With this, India has emerged as the world’s largest producer and consumer of sugar as well as the world’s 2nd largest exporter of sugar.
The season has proven to be a watershed season for Indian Sugar Sector. All records of sugarcane production, sugar production, sugar exports, cane procured, cane dues paid and ethanol production were made during the season.
Another shining highlight of the season is the highest exports of about 109.8 LMT that too with no financial assistance which was being extended upto 2020-21. Supportive international prices and Indian Government Policy led to this feat of Indian Sugar Industry. These exports earned foreign currency of about Rs. 40,000 crores for the country.
The success story of sugar industry is the outcome of synchronous and collaborative efforts of Central and State Governments, farmers, sugar mills, ethanol distilleries with very supportive overall ecosystem for business in the country. Timely Government interventions since last 5 years have been crucial in building the sugar sector step by step from taking them out of financial distress in 2018-19 to the stage of self-sufficiency in 2021-22.
During SS 2021-22, sugar mills procured sugarcane worth more than 1.18 lakh crore and released payment of more than 1.12 lakh crore with no financial assistance (subsidy) from Government of India. Thus, cane dues at the end of sugar season are less than ₹ 6,000 crore indicating that 95% of cane dues have already been cleared. It is also noteworthy that for SS 2020-21, more than 99.9% cane dues are cleared.
Government has been encouraging sugar mills to divert sugar to ethanol and also to export surplus sugar so that sugar mills may make payment of cane dues to farmers in time and also mills may have better financial conditions to continue their operations.
Growth of ethanol as biofuel sector in last 5 years has amply supported the sugar sector as use of sugar to ethanol has led to better financial positions of sugar mills due to faster payments, reduced working capital requirements and less blockage of funds due to less surplus sugar with mills. During 2021-22, revenue of about ₹ 18,000 crore has been made by sugar mills/distilleries from sale of ethanol which has also played its role in early clearance of cane dues of farmers. Ethanol production capacity of molasses/sugar-based distilleries has increased to 605 crore litres per annum and the progress is still continuing to meet targets of 20% blending by 2025 under Ethanol Blending with Petrol (EBP) Programme. In new season, the diversion of sugar to ethanol is expected to increase from 35 LMT to 50 LMT which would generate revenue for sugar mills amounting to about ₹ 25,000 crores.
There is an optimum closing balance of 60 LMT of sugar which is essential to meet domestic requirements for 2.5 months. The diversion of sugar to ethanol and exports led to unlocking of value chain of the whole industry as well as improved financial conditions of sugar mills leading to more optional mills in ensuing season.
The neurohormone oxytocin is well-known for promoting social bonds including trust, empathy, positive memories, processing of bonding cues, and positive communication and generating pleasurable feelings, for example from art, exercise, or intimacy.
Now, researchers from Michigan State University show that in zebrafish and human cell cultures, oxytocin has yet another, unsuspected, function: it stimulates stem cells derived from the heart’s outer layer (epicardium) to migrate into its middle layer (myocardium) and there develop into cardiomyocytes, muscle cells that generate heart contractions. This discovery could one day be used to promote the regeneration of the human heart after a heart attack.
“Here we show that oxytocin, a neuropeptide also known as the love hormone, is capable of activating heart repair mechanisms in injured hearts in zebrafish and human cell cultures, opening the door to potential new therapies for heart regeneration in humans,” said Dr Aitor Aguirre, an assistant professor at the Department of Biomedical Engineering of Michigan State University, and the study’s senior author.
Stem-like cells can replenish cardiomyocytes
Cardiomyocetes typically die off in great numbers after a heart attack. Because they are highly specialized cells, they can’t replenish themselves. But previous studies have shown that a subset of cells in the epicardium can undergo reprogramming to become stem-like cells, called Epicardium-derived Progenitor Cells (EpiPCs), which can regenerate not only cardiomyocytes, but also other types of heart cells.
“Think of the EpiPCs as the stonemasons that repaired cathedrals in Europe in the Middle Ages,” explained Aguirre.
Unfortunately for us, the production of EpiPCs is inefficient for heart regeneration in humans under natural conditions.
Zebrafish could teach us how to regenerate hearts more efficiently
Enter the zebrafish: famous for their extraordinary capacity for regenerating organs, including the brain, retina, internal organs, bone, and skin. They don’t suffer heart attacks, but its many predators are happy to take a bite out of any organ, including the heart – so zebrafish can regrow their heart when as much as a quarter of it has been lost. This is done partly by proliferation of cardiomyocytes, but also by EpiPCs. But how do the EpiPCs of zebrafish repair the heart so efficiently? And can we find a ‘magic bullet’ in zebrafish that could artificially boost the production of EpiPCs in humans?
Yes, and this ‘magic bullet’ appears to be oxytocin, argue the authors.
To reach this conclusion, the authors found that in zebrafish, within three days after cryoinjury – injury due to freezing – to the heart, the expression of the messenger RNA for oxytocin increases up to 20-fold in the brain. They further showed that this oxytocin then travels to the zebrafish epicardium and binds to the oxytocin receptor, triggering a molecular cascade that stimulates local cells to expand and develop into EpiPCs. These new EpiPCs then migrate to the zebrafish myocardium to develop into cardiomyocytes, blood vessels, and other important heart cells, to replace those which had been lost.
zebrafish/wikipedia
Similar effect on human tissue cultures
Crucially, the authors showed that oxytocin has a similar effect on human tissue in vitro. Oxytocin – but none of 14 other neurohormones tested here – stimulates cultures of human Induced Pluripotent Stem Cells (hIPSCs) to become EpiPCs, at up to twice the basal rate: a much stronger effect than other molecules previously shown to stimulate EpiPC production in mice. Conversely, genetic knock-down of the oxytocin receptor prevented the the regenerative activation of human EpiPCs in culture. The authors also showed that the link between oxytocin and the stimulation of EpiPCs is the important ‘TGF-β signaling pathway’, known to regulate the growth, differentiation, and migration of cells.
Aguirre said: “These results show that it is likely that the stimulation by oxytocin of EpiPC production is evolutionary conserved in humans to a significant extent. Oxytocin is widely used in the clinic for other reasons, so repurposing for patients after heart damage is not a long stretch of the imagination. Even if heart regeneration is only partial, the benefits for patients could be enormous.”
We all grow old and die, but we still don’t know why. Diet, exercise and stress all effect our lifespan, but the underlying processes that drive ageing remain a mystery. Often, we measure age by counting our years since birth and yet our cells know nothing of chronological time—our organs and tissues may age more rapidly or slowly regardless of what we’d expect from counting the number of orbits we tale around the sun.
For this reason, many scientists search to develop methods to measure the “biological age” of our cells -– which can be different from our chronological age. In theory, such biomarkers of ageing could provide a measure of health that could revolutionize how we practice medicine. Individuals could use a biomarker of ageing to track their biological age over time and measure the effect of diet, exercise, and drugs and predict their effects to extend lifespan or improve quality of life. Medicines could be designed and identified based on their effect on biological age. In other words, we could start to treat ageing itself.
However, no accurate and highly predictive test for biological age has been validated to date. In part, this is because we still don’t know what causes ageing and so can’t measure it. Definitive progress in the field will require validating biomarkers throughout a patient’s lifetime, an impractical feat given human life expectancy.
To understand the irreducible components of ageing, and how these can be measured and tested, researchers turn to laboratory animals. Unlike humans, the nematode C. elegans lives for an average of two weeks, making it easier to collect behavioural and lifespan data that would otherwise require centuries.
The nematode C. elegans begin adulthood vigorously exploring their environment. Over time, they slow and stop crawling, a behavioural stage known as vigorous movement cessation (VMC). VMC is a biomarker of ageing and a proxy for nematode health. Studies of genetically identical nematodes have shown it is a powerful predictor of a worm’s lifespan, but at the same time, interventions designed to alter ageing can disproportionately affect VMC in comparison to lifespan and vice versa. Researchers at the Centre for Genomic Regulation (CRG) in Barcelona seek to understand why this happens and what this means for the ageing process in humans.
A team lead by Dr. Nicholas Stroustrup, Group Leader at the CRG’s Systems Biology research programme, has developed the ‘Lifespan Machine’, a device that can follow the life and death of tens of thousands of nematodes at once. The worms live in a petri dish under the watchful eye of a scanner that monitors their entire lives. By imaging the nematodes once per hour for months, the device gathers data at unprecedented statistical resolution and scale.
The research team found that nematodes have at least two partially independent ageing processes taking place at the same time – one that determines VMC and the other determines time of death. While both processes follow different trajectories, their rates are correlated to each other, in other words, in individuals for whom VMC occurred at an accelerated rate, so did time of death, and vice versa. In other words, the study revealed that each individual nematode has at least two distinct biological ages.
The researchers made the finding by building a genetic tool that lets them control the nematodes’ rate of ageing – effectively choosing an average lifespan for the population that can range from between two weeks and a few days. The tool works by tagging RNA polymerase II – the enzyme that makes mRNA – with a small molecule. Worms were fed different amounts of the hormone auxin, which finely controls the activity of RNA polymerase II, which in turn changes their lifespan.
Each individual C. elegans worm lives in a petri dish under the watchful eye of the Lifespan Macine’s scanner, which monitors their entire lives. By imaging the nematodes once per hour for months, the device gathers data at unprecedented statistical resolution and scale./CREDIT:Nicholas Stroustrup/CRG
Humans are larger and, in many ways, more complex than nematodes, and so are likely to have an even higher number of distinct biological ages than nematodes. Altogether, the study demonstrates how multiple, mostly independent ageing processes can work in tandem to cause different parts of the animal to age at different rates. The findings challenge the concept that animals have a single, unitary measure of biological age that can be indicative of an individual’s overall health.
The researchers also found that no matter which lifespan-altering mutations and interventions they gave the nematodes, the statistical correlation between the distinct biological ages remained constant. This suggests the existence of an invisible chain of command – or hierarchical structure – that regulates the worm’s ageing processes, the mechanisms of which are yet to be discovered. This means that, while ageing processes can be independent, it is also true that some individuals are ‘fast agers’ and others ‘slow agers’, in that many of their ageing processes move similarly faster or slower than their peers.
The study calls into question a crucial assumption of ageing biomarkers, that when interventions such as exercise or diet “rejuvenate” a biomarker, it’s a good sign that the underlying biology of ageing has similarly changed. “Our model shows that biomarkers can be trivially decoupled from outcomes because they measure an ageing process that is not directly involved in the outcome but simply correlates with it in a system of hierarchical processes,” explains Dr. Stroustrup. “In simple terms, just because two parts of an individual tend to correlate in their biological age across individuals, it doesn’t mean that one causes the other, or that they are likely to involve shared ageing mechanisms.”
The findings have implications for consumers being offered commercial products that assess their biological age. Biological age tests use panels of biomarkers that are purported as being meaningfully diverse. These can measure a thousand different parts of an individual, but those parts might all be confounded in an identical way.
According to Dr. Stroustrup, the solution lies in finding biomarkers that measure distinct, interacting ageing processes that also minimally correlate with each other. “Biomarkers used to assess biological age can be changed without actually turning a ‘fast ager’ into ‘slow ager’. Researchers should focus on measuring the effect of interventions on functional outcomes rather than assuming that changes in biomarkers will predict outcomes in a straightforward way,” he concludes.
BGI Genomics, in collaboration with Southwest University, the State Key Laboratory of Silkworm Genome Biology, and other partners, has constructed a high-resolution pangenome dataset representing almost the entire genomic content in a silkworm.
Previously, due to the scarcity of wild silkworms and technical limitations of former studies, many trait-associated sites were missing. This is the first research ever to digitize silkworm gene pool and create a “digital silkworm”, greatly facilitating functional genomic research, promoting precise breeding, and thus enabling additional silk use cases.
The team deeply re-sequence 1,078 silkworms (B. mori, including 205 local strains, 194 improved varieties, and 632 genetic stocks and 47 wild silkworms, B. mandarina) and assemble long-read genomes on 545 of these samples, generating 55.57 T of genomic data.
This pangenome dataset contains the most comprehensive information on the genomes of domestic and wild silkworm, and is the largest long-read pangenome in the world for plants and animals to date. At the same time, in-depth studies on various genetic variation, population structure, artificial selection and ecological adaptations and economic traits of silkworm have been carried out, yielding fruitful results.
Phenotypic diversity in silkworms/CREDIT:BGI Genomics
The origins of the domestic silkworm:
The domestic silkworm, B. mori, domesticated from the wild mulberry silkworm, B. mandarina. It has an history of over 5,000 years, but its domestication origin location has long been an open question, due to a lack of strong biological evidence.
The study found out that endemic species from China’s lower and middle Yellow River region are distributed at the base of the domestic silkworm branch on the evolutionary tree, thus suggesting that the domestic silkworm originated in this region. The available archaeological evidence, including a half cocoon excavated in 1926 at Xiyin Village, Xia County, Shanxi Province, and a stone-carved silkworm pupa excavated in 2019 at Shicun in the same county, provide important support to this conclusion.
Breaking the bottleneck in silkworm breeding:
The traditional breeding of silkworms has a long and unique history, but since the 1990s remained stuck in a bottleneck. Systematic analysis of the genetic basis of domestication and improvement selection is essential to solve the unresolved issues in silkworm breeding. The team has identified 468 domestication-associated genes and 198 improvement-associated genes, of which respectively 264 and 185 are newly identified. These genes will be important candidate targets for molecular improvement of silkworm.
At the same time, it was found out that the Chinese and Japanese utility species share less than 3% of the improvement loci. This not only reveals the relatively independent breeding histories of Chinese and Japanese silkworm, but also explains why this shared genetic basis provides such hybrid advantages for both species. This result sheds new insights for future breeding of the silkworm.
Economic traits of silkworm breeding:
Yield and quality of silk have long been targeted as the main economic criteria for artificial selection of silkworm. However, up to this date, little is known about how genes and loci control these quantitative traits. The pangenome is arguably the ‘nearest bridge’ between phenotypes, especially complex traits.
A case in point is the regulation of silk production by the cell cycle-related transcription factor BmE2F1, which was revealed through selection signalling and structural variation. CRISPR-cas9 mediated knockout of BmE2F1 reduces the number of silk gland cells by 7.68% and silk yield by 22%. Conversely, the transgenic overexpression of BmE2F1 increases the number of silk gland cells by 23% and silk yield by 16%.
Fine silk has unique applications and higher economic value, but the genetic basis of fiber fineness remained previously unknown. Analysis of rare variants in the genomes of slender varieties led to the identification of BmChit β-GlcNAcase, a gene controlling silk fineness that can significantly be detected in fine varieties, and CRISPR-cas9 mediated knockout, resulting in coarser silk fineness produced by domestic silkworms. This suggests this gene plays a key role in determining silk fineness.
Adaptive traits of silkworm breeding:
Diapause is a common ecological adaptive trait in insects that ensures that insects can survive despite unfavorable environmental conditions. Although the diapause hormone was first identified in the silkworm in 1957, little information is available on the embryonic dipause gene. In this study, based on the analysis of the pnd strain and genomic structural variation in the silkworm, and functional validation by gene editing, the BmTret1-like gene revealed itself to be an important determinant of post-embryonic stalling. This is the first time that a post-embryonic determinant gene has been identified in an insect.
This study reveals the complete pan-genome of the silkworm to unlock artificial selection and ecological adaptation insights. Shuaishuai Tai, co-author and BGI Genomics senior researcher commented, “With comprehensive sampling and dataset combined with a variety of experiments to identify genes for future potential study, we hope to accelerate the process of silkworm molecular design breeding.”
“I’m a professional pin-in-a-haystack seeker,” geneticist Thijn Brummelkamp responds when asked why he excels at tracking down proteins and genes that other people did not find, despite the fact that some have managed to remain elusive for as long as forty years. His research group at the Netherlands Cancer Institute has once again managed to track down one of these “mystery genes” – the gene that ensures that the final form of the protein actin is created, a main component of our cell skeleton.
Cell biologists are very interested in actin, because actin – a protein of which we produce more than 100 kilograms in our lifetime – is a main component of the cell skeleton and one of the most abundant molecules in a cell. Large quantities can be found in every cell type and it has many purposes: it gives shape to the cell and makes it firmer, it plays an important role in cell division, it can propel cells forward, and provides strength to our muscles. People with faulty actin proteins often suffer from muscle disease. Much is known about the function of actin, but how the final form of this important protein is made and which gene is behind it? “We didn’t know,” says Brummelkamp, whose mission is to find out the function of our genes.
Multi-purpose method for genetics in human cells
Together with other researchers, Brummelkamp uses this multi-purpose method to find the genetic causes of particular conditions. He has already shown how the Ebola virus and a number of other viruses, as well as certain forms of chemotherapy, manage to enter a cell. He also investigated why cancer cells are resistant to certain types of therapy and discovered a protein found in cancer cells that acts as a brake on the immune system. This time he went looking for a gene that matures actin – and as a result, the skeleton of the cell.
Microscopy image of actine. (Actine is yellow, cell core is blue)/CREDIT:Peter Haarh, Netherlands Cancer Institute
In search of scissors
Before a protein is completely “finished” – or mature, as the researchers describe it in Science – and can fully perform its function in the cell, it usually has to be stripped of a specific amino acid first. This amino acid is then cut from a protein by a pair of molecular scissors. This is also what occurs with actin. It was known on which side of the actin the relevant amino acid is cut off. However, no one managed to find the enzyme that acts as scissors in this process.
Peter Haahr, postdoc in Brummelkamp’s group, worked on the following experiment: first he caused random mutations (mistakes) in random haploid cells. Then he selected the cells containing the immature actin by adding a fluorescently labeled antibody to his cells that fit in the exact spot where the amino acid is cut off. As a third and final step, he investigated which gene mutated after this process.
They called it ‘ACTMAP’
Then came the “eureka”-moment: Haahr had traced down the molecular scissors that cut the essential amino acid from actin. Those scissors turned out to be controlled by a gene with a previously unknown function; one no researcher had ever worked with. This means that the researchers were able to name the gene themselves, and they settled on ACTMAP (ACTin MAturation Protease).
More scissors found in the skeleton of the cell
ACTMAP is not the first mystery gene discovered by Brummelkamp that plays a role in our cell skeleton function. Using the same method, his group has been able to detect three unknown molecular scissors over recent years that cut an amino acid from tubulin, the other main component of the cell skeleton. These scissors allow tubulin to perform its dynamic functions properly inside the cell. The last scissors (MATCAP) were discovered and described in Science this year. Through this earlier work on the cell skeleton, Brummelkamp managed to arrive at actin.
Taken as a share of the market price, the climate change impacts of mining the digital cryptocurrency Bitcoin is more comparable to the impacts of extracting and refining crude oil than mining gold, according to an analysis published in Scientific Reports by researchers at The University of New Mexico.
The authors suggest that rather than being considered akin to ‘digital gold’, Bitcoin should instead be compared to much more energy-intensive products such as beef, natural gas, and crude oil.
“We find no evidence that Bitcoin mining is becoming more sustainable over time,” said UNM Economics Associate Professor Benjamin A. Jones. “Rather, our results suggest the opposite: Bitcoin mining is becoming dirtier and more damaging to the climate over time. In short, Bitcoin’s environmental footprint is moving in the wrong direction.”
In December 2021, Bitcoin had an approximately 960 billion US dollars market capitalization with a roughly 41 percent global market share among cryptocurrencies. Although known to be energy intensive, the extent of Bitcoin’s climate damages is unclear.
Researchers at The University of New Mexico find digital cryptocurrency Bitcoin is more comparable to the impacts of extracting and refining crude oil than mining gold./CREDIT: University of New Mexico
Jones and colleagues Robert Berrens and Andrew Goodkind present economic estimates of climate damages from Bitcoin mining between January 2016 and December 2021. They report that in 2020 Bitcoin mining used 75.4 terawatt hours of electricity (TWh) – higher electricity usage than Austria (69.9 TWh) or Portugal (48.4 TWh) in that year.
“Globally, the mining, or production, of Bitcoin is using tremendous amounts of electricity, mostly from fossil fuels, such as coal and natural gas. This is causing huge amounts of air pollution and carbon emissions, which is negatively impacting our global climate and our health,” said Jones. “We find several instances between 2016-2021 where Bitcoin is more damaging to the climate than a single Bitcoin is actually worth. Put differently, Bitcoin mining, in some instances, creates climate damages in excess of a coin’s value. This is extremely troubling from a sustainability perspective.”
The authors assessed Bitcoin climate damages according to three sustainability criteria: whether the estimated climate damages are increasing over time; whether the climate damages of Bitcoin exceeds the market price; and how the climate damages as a share of market price compare to other sectors and commodities.
They find that the CO2 equivalent emissions from electricity generation for Bitcoin mining have increased 126-fold from 0.9 tonnes per coin in 2016, to 113 tonnes per coin in 2021. Calculations suggest each Bitcoin mined in 2021 generated 11,314 US Dollars (USD) in climate damages, with total global damages exceeding 12 billion USD between 2016 and 2021. Damages peaked at 156% of the coin price in May 2020, suggesting that each 1 USD of Bitcoin market value generated led to 1.56 USD in global climate damages that month.
“Across the class of digitally scarce goods, our focus is on those cryptocurrencies that rely on proof-of-work (POW) production techniques, which can be highly energy intensive,” said Regents Professor of Economics Robert Berrens. “Within broader efforts to mitigate climate change, the policy challenge is creating governance mechanisms for an emergent, decentralized industry, which includes energy-intensive POW cryptocurrencies. We believe that such efforts would be aided by measurable, empirical signals concerning potentially unsustainable climate damages, in monetary terms.”
Finally, the authors compared Bitcoin climate damages to damages from other industries and products such as electricity generation from renewable and non-renewable sources, crude oil processing, agricultural meat production, and precious metal mining. Climate damages for Bitcoin averaged 35% of its market value between 2016 and 2021. This share for Bitcoin was slightly less than the climate damages as a share of market value of electricity produced by natural gas (46%) and gasoline produced from crude oil (41%), but more than those of beef production (33%) and gold mining (4%).
The authors conclude that Bitcoin does not meet any of the three key sustainability criteria they assessed it against. Absent voluntary switching away from proof-of-work mining, as very recently done for the cryptocurrency Ether, then potential regulation may be required to make Bitcoin mining sustainable.
Two of NASA’s Great Observatories, the James Webb Space Telescope and the Hubble Space Telescope, have captured views of a unique NASA experiment designed to intentionally smash a spacecraft into a small asteroid in the world’s first-ever in-space test for planetary defense. These observations of NASA’s Double Asteroid Redirection Test (DART) impact mark the first time that Webb and Hubble simultaneously observed the same celestial target.
On Sept. 26, 2022, at 7:14 pm EDT, DART intentionally crashed into Dimorphos, the asteroid moonlet in the double-asteroid system of Didymos. It was the world’s first test of the kinetic impact mitigation technique, using a spacecraft to deflect an asteroid that poses no threat to Earth, and modifying the object’s orbit. DART is a test for defending Earth against potential asteroid or comet hazards.
The coordinated Hubble and Webb observations are more than just an operational milestone for each telescope – there are also key science questions relating to the makeup and history of our solar system that researchers can explore when combining the capabilities of these observatories.
“Webb and Hubble show what we’ve always known to be true at NASA: We learn more when we work together,” said NASA Administrator Bill Nelson. “For the first time, Webb and Hubble have simultaneously captured imagery from the same target in the cosmos: an asteroid that was impacted by a spacecraft after a seven-million-mile journey. All of humanity eagerly awaits the discoveries to come from Webb, Hubble, and our ground-based telescopes – about the DART mission and beyond.”
Observations from Webb and Hubble together will allow scientists to gain knowledge about the nature of the surface of Dimorphos, how much material was ejected by the collision, and how fast it was ejected. Additionally, Webb and Hubble captured the impact in different wavelengths of light – Webb in infrared and Hubble in visible. Observing the impact across a wide array of wavelengths will reveal the distribution of particle sizes in the expanding dust cloud, helping to determine whether it threw off lots of big chunks or mostly fine dust. Combining this information, along with ground-based telescope observations, will help scientists to understand how effectively a kinetic impact can modify an asteroid’s orbit.
Webb Captures Impact Site Before and After Collision
Webb took one observation of the impact location before the collision took place, then several observations over the next few hours. Images from Webb’s Near-Infrared Camera (NIRCam) show a tight, compact core, with plumes of material appearing as wisps streaming away from the center of where the impact took place.
Observing the impact with Webb presented the flight operations, planning, and science teams with unique challenges, because of the asteroid’s speed of travel across the sky. As DART approached its target, the teams performed additional work in the weeks leading up to the impact to enable and test a method of tracking asteroids moving over three times faster than the original speed limit set for Webb.
“I have nothing but tremendous admiration for the Webb Mission Operations folks that made this a reality,” said principal investigator Cristina Thomas of Northern Arizona University in Flagstaff, Arizona. “We have been planning these observations for years, then in detail for weeks, and I’m tremendously happy this has come to fruition.”
Scientists also plan to observe the asteroid system in the coming months using Webb’s Mid-Infrared Instrument (MIRI) and Webb’s Near-Infrared Spectrograph (NIRSpec). Spectroscopic data will provide researchers with insight into the asteroid’s chemical composition.
Webb observed the impact over five hours total and captured 10 images. The data was collected as part of Webb’s Cycle 1 Guaranteed Time Observation Program 1245 led by Heidi Hammel of the Association of Universities for Research in Astronomy (AURA).
Hubble Images Show Movement of Ejecta After Impact
Hubble also captured observations of the binary system ahead of the impact, then again 15 minutes after DART hit the surface of Dimorphos. Images from Hubble’s Wide Field Camera 3 show the impact in visible light. Ejecta from the impact appear as rays stretching out from the body of the asteroid. The bolder, fanned-out spike of ejecta to the left of the asteroid is in the general direction from which DART approached.
Some of the rays appear to be curved slightly, but astronomers need to take a closer look to determine what this could mean. In the Hubble images, astronomers estimate that the brightness of the system increased by three times after impact, and saw that brightness hold steady, even eight hours after impact.
Description of the above images: These images from NASA’s Hubble Space Telescope, taken (left to right) 22 minutes, 5 hours, and 8.2 hours after NASA’s Double Asteroid Redirection Test (DART) intentionally impacted Dimorphos, show expanding plumes of ejecta from the asteroid’s body. The Hubble images show ejecta from the impact that appear as rays stretching out from the body of the asteroid. The bolder, fanned-out spike of ejecta to the left of the asteroid is in the general direction from which DART approached. These observations, when combined with data from NASA’s James Webb Space Telescope, will allow scientists to gain knowledge about the nature of the surface of Dimorphos, how much material was ejected by the collision, how fast it was ejected, and the distribution of particle sizes in the expanding dust cloud.
Credits: Science: NASA, ESA, Jian-Yang Li (PSI); image processing: Alyssa Pagan (STScI)
Hubble plans to monitor the Didymos-Dimorphos system 10 more times over the next three weeks. These regular, relatively long-term observations as the ejecta cloud expands and fades over time will paint a more complete picture of the cloud’s expansion from the ejection to its disappearance.
“When I saw the data, I was literally speechless, stunned by the amazing detail of the ejecta that Hubble captured,” said Jian-Yang Li of the Planetary Science Institute in Tucson, Arizona, who led the Hubble observations. “I feel lucky to witness this moment and be part of the team that made this happen.”
Hubble captured 45 images in the time immediately before and following DART’s impact with Dimorphos. The Hubble data was collected as part of Cycle 29 General Observers Program 16674.
“This is an unprecedented view of an unprecedented event,” summarized Andy Rivkin, DART investigation team lead of the Johns Hopkins University Applied Physics Laboratory in Laurel, Maryland.
The James Webb Space Telescope is the world’s premier space science observatory. Webb will solve mysteries in our solar system, look beyond to distant worlds around other stars, and probe the mysterious structures and origins of our universe and our place in it. Webb is an international program led by NASA with its partners, ESA (European Space Agency) and CSA (Canadian Space Agency).
The Hubble Space Telescope is a project of international cooperation between NASA and ESA. NASA’s Goddard Space Flight Center in Greenbelt, Maryland, manages the telescope. The Space Telescope Science Institute (STScI) in Baltimore, Maryland, conducts Hubble and Webb science operations. STScI is operated for NASA by the Association of Universities for Research in Astronomy, in Washington, D.C.
For billions of years, the Milky Way’s largest satellite galaxies – the Large and Small Magellanic Clouds – have followed a perilous journey. Orbiting one another as they are pulled in toward our home galaxy, they have begun to unravel, leaving behind trails of gaseous debris. And yet – to the puzzlement of astronomers – these dwarf galaxies remain intact, with ongoing vigorous star formation.
“A lot of people were struggling to explain how these streams of material could be there,” said Dhanesh Krishnarao, assistant professor at Colorado College. “If this gas was removed from these galaxies, how are they still forming stars?”
With the help of data from NASA’s Hubble Space Telescope and a retired satellite called the Far Ultraviolet Spectroscopic Explorer (FUSE), a team of astronomers led by Krishnarao has finally found the answer: the Magellanic system is surrounded by a corona, a protective shield of hot supercharged gas. This cocoons the two galaxies, preventing their gas supplies from being siphoned off by the Milky Way, and therefore allowing them to continue forming new stars.
Description of the above image:
Researchers have used spectroscopic observations of ultraviolet light from quasars to detect and map out the Magellanic Corona, a diffuse halo of hot, supercharged gas surrounding the Small and Large Magellanic Clouds. Shown here in purple, the corona stretches more than 100,000 light-years from the main mass of stars, gas, and dust that make up the Magellanic Clouds, intermingling with the hotter and more extensive corona that surrounds the Milky Way. The Magellanic Clouds, dwarf galaxies roughly 160,000 light-years from Earth, are the largest of the Milky Way’s satellites and are thought to be on their first in-falling passage around the Milky Way. This journey has begun to unravel what were once barred spirals with multiple arms into more irregular-shaped galaxies with long tails of debris. The corona is thought to act as a buffer protecting the dwarf galaxies’ vital star-forming gas from the gravitational pull of the much larger Milky Way. The detection of the Magellanic Corona was made by analyzing patterns in ultraviolet light from 28 distant background quasars. As the quasar light passes through the corona, certain wavelengths (colors) of ultraviolet light are absorbed. The quasar spectra become imprinted with the distinct signatures of carbon, oxygen, and silicon ions that make up the corona gas. Because each quasar probes a different part of the corona, the research team was also able to show that the amount of gas decreases with distance from the center of the Large Magellanic Cloud. This study used archival observations of quasars from Hubble’s Cosmic Origins Spectrograph (COS) and the Far Ultraviolet Spectroscopic Explorer (FUSE). Quasars have also been used to probe the Magellanic Stream, outflows from the Milky Way , and the halo surrounding the Andromeda Galaxy./Illustration Credits: STScI, Leah Hustak
This discovery, which was just published in Nature, addresses a novel aspect of galaxy evolution. “Galaxies envelope themselves in gaseous cocoons, which act as defensive shields against other galaxies,” said co-investigator Andrew Fox of the Space Telescope Science Institute in Baltimore, Maryland.
Astronomers predicted the corona’s existence several years ago. “We discovered that if we included a corona in the simulations of the Magellanic Clouds falling onto the Milky Way, we could explain the mass of extracted gas for the first time,” explained Elena D’Onghia, a co-investigator at the University of Wisconsin–Madison. “We knew that the Large Magellanic Cloud should be massive enough to have a corona.”
But although the corona stretches more than 100,000 light-years from the Magellanic clouds and covers a huge portion of the southern sky, it is effectively invisible. Mapping it out required scouring through 30 years of archived data for suitable measurements.
Researchers think that a galaxy’s corona is a remnant of the primordial cloud of gas that collapsed to form the galaxy billions of years ago. Although coronas have been seen around more distant dwarf galaxies, astronomers had never before been able to probe one in as much detail as this.
There’re lots of predictions from computer simulations about what they should look like, how they should interact over billions of years, but observationally we can’t really test most of them because dwarf galaxies are typically just too hard to detect,” said Krishnarao. Because they are right on our doorstep, the Magellanic Clouds provide an ideal opportunity to study how dwarf galaxies interact and evolve.
In search of direct evidence of the Magellanic Corona, the team combed through the Hubble and FUSE archives for ultraviolet observations of quasars located billions of light-years behind it. Quasars are the extremely bright cores of galaxies harboring massive active black holes. The team reasoned that although the corona would be too dim to see on its own, it should be visible as a sort of fog obscuring and absorbing distinct patterns of bright light from quasars in the background. Hubble observations of quasars were used in the past to map the corona surrounding the Andromeda galaxy.
By analyzing patterns in ultraviolet light from 28 quasars, the team was able to detect and characterize the material surrounding the Large Magellanic Cloud and confirm that the corona exists. As predicted, the quasar spectra are imprinted with the distinct signatures of carbon, oxygen, and silicon that make up the halo of hot plasma that surrounds the galaxy.
The ability to detect the corona required extremely detailed ultraviolet spectra. “The resolution of Hubble and FUSE were crucial for this study,” explained Krishnarao. “The corona gas is so diffuse, it’s barely even there.” In addition, it is mixed with other gases, including the streams pulled from the Magellanic Clouds and material originating in the Milky Way.
By mapping the results, the team also discovered that the amount of gas decreases with distance from the center of the Large Magellanic Cloud. “It’s a perfect telltale signature that this corona is really there,” said Krishnarao. “It really is cocooning the galaxy and protecting it.”
How can such a thin shroud of gas protect a galaxy from destruction?
“Anything that tries to pass into the galaxy has to pass through this material first, so it can absorb some of that impact,” explained Krishnarao. “In addition, the corona is the first material that can be extracted. While giving up a little bit of the corona, you’re protecting the gas that’s inside of the galaxy itself and able to form new stars.”
Despite a long-standing hypothesis that personality traits are relatively impervious to environmental pressures, the COVID-19 pandemic may have altered the trajectory of personality across the United States, especially in younger adults, according to a new study published this week in the open-access journal PLOS ONE by Angelina Sutin of Florida State University College of Medicine, and colleagues.
Previous studies have generally found no associations between collective stressful events—such as earthquakes and hurricanes—and personality change. However, the coronavirus pandemic has affected the entire globe and nearly every aspect of life.
In the new study, the researchers used longitudinal assessments of personality from 7,109 people enrolled in the online Understanding America Study. They compared five-factor model personality traits—neuroticism, extraversion, openness, agreeableness and conscientiousness—between pre-pandemic measurements (May 2014 – February 2020) and assessments early (March – December 2020) or later (2021-2022) in the pandemic. A total of 18,623 assessments, or a mean of 2.62 per participant, were analyzed. Participants were 41.2% male and ranged in age from 18 to 109.
A crowd of people at a pedestrian crossing./CREDIT:Brian Merrill, Pixabay, CC0(https://creativecommons.org/publicdomain/zero/1.0/)
Consistent with other studies, there were relatively few changes between pre-pandemic and 2020 personality traits, with only a small decline in neuroticism. However, there were declines in extraversion, openness, agreeableness, and conscientiousness when 2021-2022 data was compared to pre-pandemic personality. The changes were about one-tenth of a standard deviation, which is equivalent to about one decade of normative personality change. The changes were moderated by age, with younger adults showing disrupted maturity in the form of increased neuroticism and decreased agreeableness and conscientiousness, and the oldest group of adults showing no statistically significant changes in traits.
The authors conclude that if these changes are enduring, it suggests that population-wide stressful events can slightly bend the trajectory of personality, especially in younger adults.
The authors add: “There was limited personality change early in the pandemic but striking changes starting in 2021. Of most note, the personality of young adults changed the most, with marked increases in neuroticism and declines in agreeableness and conscientiousness. That is, younger adults became moodier and more prone to stress, less cooperative and trusting, and less restrained and responsible.”
The public is invited to participate in NASA’s celebration of “International Observe the Moon Night” on Saturday, Oct. 1. This annual, worldwide public engagement event takes place when the Moon is close to first quarter – a great phase for evening observing. Last year about 500,000 people participated from 122 countries and all seven continents.
This celebration provides opportunities to learn about lunar science and exploration, observe celestial bodies, and honor personal and cultural connections to the Moon.
How to participate:
Host an event in your community; participate in an event; or observe with your family, friends, or on your own. Events can be in-person, virtual, or hybrid.
Register your participation to add yourself to the map of lunar observers worldwide.
Connect with lunar enthusiasts around the world and share your Moon viewing experience on social media, tagging #ObserveTheMoon.
On October 1, tune into a NASA TV Broadcast from 7p.m.–8p.m. EST and find views of the Moon from telescopes around the world on the program’s Live Streams page.
The Moon is a stepping stone to learning more about our solar system, galaxy, and universe. NASA is preparing to launch its Artemis I test flight to the Moon, a major step forward in a new era of human deep-space exploration.
Celebrate ‘International Observe the Moon Night’ with NASA/Credits: NASA/Vi Nguyen
Through Artemis missions, NASA will land the first woman and the first person of color on the Moon, using innovative technologies to explore more of the lunar surface than ever before for the benefit of all.
International Observe the Moon Night is sponsored by NASA’s Lunar Reconnaissance Orbiter (LRO) mission and the Solar System Exploration Division of NASA’s Goddard Space Flight Center in Greenbelt, Maryland, with support from many partners. Launched on June 18, 2009, LRO has collected a treasure trove of data with its seven powerful instruments, making an invaluable contribution to our knowledge about the Moon. LRO is managed by NASA Goddard for the Science Mission Directorate at NASA Headquarters in Washington, D.C.
Voice control smart devices, such as Alexa, Siri, and Google Home, might hinder children’s social and emotional development, argues an expert in the use of artificial intelligence and machine learning in healthcare, in a viewpoint published online in the Archives of Disease in Childhood.
These devices might have long term effects by impeding children’s critical thinking, capacity for empathy and compassion, and their learning skills, says Anmol Arora of the University of Cambridge.
While voice control devices may act as ‘friends’ and help to improve children’s reading and communication skills, their advanced AI and ‘human’ sounding voices have prompted concerns about the potential long term effects on children’s brains at a crucial stage of development.
There are three broad areas of concern, explains the author. These comprise inappropriate responses; impeding social development; and hindering learning.
He cites some well publicised examples of inappropriate responses, including a device suggesting that a 10-year old should try touching a live plug with a coin.
Children-wikipedia
“It is difficult to enforce robust parental controls on such devices without severely affecting their functionality,” he suggests, adding that privacy issues have also arisen in respect of the recording of private conversations.
These devices can’t teach children how to behave politely, because there’s no expectation of a “please” or “thank you”, and no need to consider the tone of voice, he points out.
“The lack of ability to engage in non-verbal communication makes use of the devices a poor method of learning social interaction,” he writes. “While in normal human interactions, a child would usually receive constructive feedback if they were to behave inappropriately, this is beyond the scope of a smart device.”
Preliminary research on the use of voice assistants as social companions for lonely adults is encouraging. But it’s not at all clear if this also applies to children, he notes.
“This is particularly important at a time when children might already have had social development impaired as a result of COVID-19 restrictions and when [they] might have been spending more time isolated with smart devices at home,” he emphasises.
Devices are designed to search for requested information and provide a concise, specific answer, but this may hinder traditional processes by which children learn and absorb information, the author suggests.
When children ask adults questions, the adult can request contextual information, explain the limitations of their knowledge and probe the child’s reasoning—a process that these devices can’t replicate, he says.
Searching for information is also an important learning experience, which teaches critical thinking and logical reasoning, he explains.
“The rise of voice devices has provided great benefit to the population. Their abilities to provide information rapidly, assist with daily activities, and act as a social companion to lonely adults are both important and useful, the author acknowledges.
“However, urgent research is required into the long-term consequences for children interacting with such devices,” he insists.
“Interacting with the devices at a crucial stage in social and emotional development might have long-term consequences on empathy, compassion, and critical thinking,” he concludes.
WhatsApp owner Meta has revealed that a critical bug in older installations was fixed now and advised all users to update their devices with latest software version.
It said the vulnerability could allow an attacker to exploit a code error known as an integer overflow. “An integer overflow in WhatsApp for Android prior to v2.22.16.12, Business for Android prior to v2.22.16.12, iOS prior to v2.22.16.12, Business for iOS prior to v2.22.16.12 could result in remote code execution in an established video call,” WhatsApp said in an update.
Remote code executions (RCEs) usually occur due to malicious malware downloaded by the host and can happen regardless of the device’s geographic location and a hacker can remotely execute commands on someone else’s computing device.
The recently disclosed vulnerability called CVE-2022-36934, with a severity score of 9.8 out of 10 on the CVE scale and another bug that could have caused remote code execution when receiving a crafted video file – have been patched in the latest WhatsApp version, said the company.
WhatsApp is also rolling out Call Links to make it easier to start and join a call in just one tap and is testing secured and encrypted group video calls for up to 32 people on WhatsApp.
Alphabet and Google CEO Sundar Pichai has defended the company’s move to save costs of the company and advised employees not to see earning money alone as fun as little things in life can bring more joy than what money can do.
In a reply when asked why the company has shifted from “rapidly hiring and spending to equally aggressive cost saving,” he said: “”I’m a bit concerned that you think what we’ve done is what you would define as aggressive cost saving. I think it’s important we don’t get disconnected. You need to take a long-term view through conditions like this.”
Pichai plans to make the company 20 per cent more efficient, hinting at job cuts and going by reports, Google and its parent Alphabet are giving some workers 60 days time to apply for a new role at the company if their jobs are set to be cut.
in August, Google fired more than 50 workers at its incubator Area 120 and gave them extra 30 days to find another job at the company and a Google spokesman said that nearly 95 per cent of those employees found new roles within the notice period.
Pichai said the company is “still investing in long-term projects like quantum computing.” He added, “We’re committed to taking care of our employees. I think we’re just working through a tough moment macroeconomically and I think it’s important we as a company align and work together,” said Pichai.
Earlier, at the Code Conference, Pichai said that the more the company tries to understand the macroeconomic conditions, the more uncertain it is about it. “The macroeconomic performance is correlated to ad spend, consumer spend and so on,” he told the audience.
Google has suspended hiring new employees and reportedly told some existing employees to “shape up or ship out” if they fail to meet expectations.
Just before it sank, the RMS Titanic ship was sent an iceberg warning by other ships but the message never reached the bridge on the fateful night of 15th April 1912. Ironic, one merchant steamship SS Mesaba which had sent the message also met with similar fate six years later.
In 1912 the merchant steamship SS Mesaba was crossing the Atlantic and sent a warning radio message to the RMS Titanic, the supposedly unsinkable ship that was destined to sink on its first voyage after it hit an iceberg, taking 1,500 lives and becoming the world’s most infamous shipwreck that prompted the blockbuster movie The Titanic.
According to Geoffrey Marcus, author of The Maiden Voyage, the message never reached the bridge, but instead was shoved under a paperweight.
The SS Mesaba continued as a merchant ship over the next six years before being torpedoed whilst in convoy in 1918. Using state-of-the art multibeam sonar, researchers at Bangor University have finally been able to positively identify the wreck and have revealed her position for the first time.
For the marine archaeologist, multibeam sonar has the potential to be as impactful as the use of aerial photography was for landscape archaeology. Multibeam sonar enables seabed mapping of such detail that superstructure details can be revealed on the sonar images.
Multibeam sonar image of the SS Mesaba lying on the sea bed in the Irish Sea./CREDIT:Bangor University
Currently, the SS Mesaba was one among 273 shipwrecks lying in 7,500 square miles of Irish Sea, which were scanned and cross-referenced against the UK Hydrographic Office’s database of wrecks and other sources.
It was thought that 101 wrecks were unidentified, but the number of newly identified wrecks was far higher, as many, the SS Mesaba included, had been wrongly identified in the past.
Details of all the wrecks have been published in a new book, Echoes from the Deep by Dr Innes McCartney of Bangor University, conducted under a Leverhulme Fellowship while at Bournemouth University.
Titanic/wikipedia
Innes said, “The results of the work described in the book has validated the multidisciplinary technique employed and it is a ‘game-changer’ for marine archaeology.
“Previously we would be able to dive to a few sites a year to visually identify wrecks. The Prince Madog’s unique sonar capabilities has enabled us to develop a relatively low-cost means of examining the wrecks. We can connect this back to the historical information without costly physical interaction with each site.”
Dr Michael Roberts who led the sonar surveys at the University’s School of Ocean Sciences explained:
Titanic/wikipedia
“The expertise and unique resources we have at Bangor University, such as the ‘Prince Madog’ enable us to deliver high quality scientific research in an extremely cost-effective manner. Identifying shipwrecks such as those documented in the publication for historical research and environmental impact studies is just one example of this.”
Stressful life circumstances can affect how married couples interact, but can they affect how partners see each other? A person experiencing stress is more likely to notice their spouse’s negative behavior than positive, according to a new study published in Social Psychological and Personality Science.
Prior research has focused on how stress influences behavior, but this study suggests that stress could affect what actions partners notice in the first place. The negative actions being monitored included a spouse breaking a promise, showing anger or impatience, or criticizing their partner.
“We found that individuals who reported experiencing more stressful life events outside of their relationship, such as problems at work, were especially likely to notice if their partner behaved in an inconsiderate manner,” says lead author Dr. Lisa Neff, of the University of Texas at Austin.
Researchers asked 79 heterosexual newlywed couples to complete a short survey each night for 10 days, in which they documented both their own and their partner’s behavior. Before beginning this portion of the study, participants completed a questionnaire in which they shared details on stressful events in their life.
Stress
Studying newlyweds drives home the significance of the results, Dr. Neff notes, because couples are especially likely to focus on each other’s positive behavior and overlook negative actions during the “honeymoon” period.
“For many people, the past few years have been difficult – and the stress of the pandemic continues to linger,” says Dr. Neff. “If stress focuses individuals’ attention toward their partner’s more inconsiderate behaviors, this is likely to take a toll on the relationship.”
Researchers noted a single stressful day was not enough to make someone zero in on their partner’s negative behavior, but a longer accumulation of stressful life circumstances could cause this shift in focus. The findings also suggest that those under stress were not any less likely to notice their partner’s positive behavior, but they were more likely to notice inconsiderate actions.
While it’s possible that being aware of the effects of stress could allow couples to correct their behavior and limit harm to the relationship, Dr. Neff notes that this will remain speculation until it is studied further. She also says that future research would do well to expand this study beyond the honeymoon phase.
“One direction would be to examine if the harmful effects of stress might be even stronger among couples no longer in the newlywed phase of their relationships,” says Dr. Neff, “but the fact that we found these effects in a sample of newlyweds speaks to how impactful the effects of stress can be.”
Scientists estimate that more than 95 percent of Earth’s oceans have never been observed, which means we have seen less of our planet’s ocean than we have the far side of the moon or the surface of Mars.
The high cost of powering an underwater camera for a long time, by tethering it to a research vessel or sending a ship to recharge its batteries, is a steep challenge preventing widespread undersea exploration.
MIT researchers have taken a major step to overcome this problem by developing a battery-free, wireless underwater camera that is about 100,000 times more energy-efficient than other undersea cameras. The device takes color photos, even in dark underwater environments, and transmits image data wirelessly through the water.
The autonomous camera is powered by sound. It converts mechanical energy from sound waves traveling through water into electrical energy that powers its imaging and communications equipment. After capturing and encoding image data, the camera also uses sound waves to transmit data to a receiver that reconstructs the image.
Because it doesn’t need a power source, the camera could run for weeks on end before retrieval, enabling scientists to search remote parts of the ocean for new species. It could also be used to capture images of ocean pollution or monitor the health and growth of fish raised in aquaculture farms.
“One of the most exciting applications of this camera for me personally is in the context of climate monitoring. We are building climate models, but we are missing data from over 95 percent of the ocean. This technology could help us build more accurate climate models and better understand how climate change impacts the underwater world,” says Fadel Adib, associate professor in the Department of Electrical Engineering and Computer Science and director of the Signal Kinetics group in the MIT Media Lab, and senior author of the paper.
Joining Adib on the paper are co-lead authors and Signal Kinetics group research assistants Sayed Saad Afzal, Waleed Akbar, and Osvy Rodriguez, as well as research scientist Unsoo Ha, and former group researchers Mario Doumet and Reza Ghaffarivardavagh. The paper is published in Nature Communications.
The battery-free, wireless underwater camera could help scientists explore unknown regions of the ocean, track pollution, or monitor the effects of climate change./CREDIT-Image: Adam Glanzman
Going battery-free
To build a camera that could operate autonomously for long periods, the researchers needed a device that could harvest energy underwater on its own while consuming very little power.
The camera acquires energy using transducers made from piezoelectric materials that are placed around its exterior. Piezoelectric materials produce an electric signal when a mechanical force is applied to them. When a sound wave traveling through the water hits the transducers, they vibrate and convert that mechanical energy into electrical energy.
Those sound waves could come from any source, like a passing ship or marine life. The camera stores harvested energy until it has built up enough to power the electronics that take photos and communicate data.
To keep power consumption as a low as possible, the researchers used off-the-shelf, ultra-low-power imaging sensors. But these sensors only capture grayscale images. And since most underwater environments lack a light source, they needed to develop a low-power flash, too.
They solved both problems simultaneously using red, green, and blue LEDs. When the camera captures an image, it shines a red LED and then uses image sensors to take the photo. It repeats the same process with green and blue LEDs.
Even though the image looks black and white, the red, green, and blue colored light is reflected in the white part of each photo, Akbar explains. When the image data are combined in post-processing, the color image can be reconstructed.
Nature/water/Ians
Sending data with sound
Once image data are captured, they are encoded as bits (1s and 0s) and sent to a receiver one bit at a time using a process called underwater backscatter. The receiver transmits sound waves through the water to the camera, which acts as a mirror to reflect those waves. The camera either reflects a wave back to the receiver or changes its mirror to an absorber so that it does not reflect back.
A hydrophone next to the transmitter senses if a signal is reflected back from the camera. If it receives a signal, that is a bit-1, and if there is no signal, that is a bit-0. The system uses this binary information to reconstruct and post-process the image.
“This whole process, since it just requires a single switch to convert the device from a nonreflective state to a reflective state, consumes five orders of magnitude less power than typical underwater communications systems,” Afzal says.
The researchers tested the camera in several underwater environments. In one, they captured color images of plastic bottles floating in a New Hampshire pond. They were also able to take such high-quality photos of an African starfish that tiny tubercles along its arms were clearly visible. The device was also effective at repeatedly imaging the underwater plant Aponogeton ulvaceus in a dark environment over the course of a week to monitor its growth.
Now that they have demonstrated a working prototype, the researchers plan to enhance the device so it is practical for deployment in real-world settings. They want to increase the camera’s memory so it could capture photos in real-time, stream images, or even shoot underwater video.
They also want to extend the camera’s range. They successfully transmitted data 40 meters from the receiver, but pushing that range wider would enable the camera to be used in more underwater settings.
This research is supported, in part, by the Office of Naval Research, the Sloan Research Fellowship, the National Science Foundation, the MIT Media Lab, and the Doherty Chair in Ocean Utilization.
