High BMI may improve cancer survival, says study by Australian scientist

Above average or high BMI – often linked to cancers, diabetes, cardiovascular and other diseases – may in some cases improve the chance of survival among certain cancers, showed new research from Flinders University that focused on clinical trials of atezolizumab, a common immunotherapy treatment for non-small-cell lung cancer (NSCLC), the Australian cancer researchers found improved responsiveness to the drug in those with a high body mass index (BMI).

The surprising result, published in JAMA Oncology, goes against the established warnings about the health risks of patients who are overweight and obese. “This is an interesting outcome and it raises the potential to investigate further with other cancers and other anti-cancer drugs,” says lead investigator Dr Ganessan Kichenadasse, a medical oncology researcher at the Flinders Centre for Innovation in Cancer.

Yanagawa-Matsuda, et. al, Oncology Reports

This is a comparison of cancer cells and normal cells after being infected with the dl355 adenovirus. The top four cell types listed on the left (HeLa, C33A, A549, and H1299) are cancer cells, and the bottom two (BJ and WI38) are normal cells. As the amount of dl355 virus administered to the cancer cells increased (represented by MOI), more cancer cells died in 7 days, while the normal cells continued to live. Credit

Previous studies have explored a concept called as ‘obesity paradox’ where obesity is associated with increased risks for developing certain cancers and, counter-intuitively, may protect and give greater survival benefits in certain individuals. But he said, “Our study provides new evidence to support the hypothesis that high BMI and obesity may be associated with response to immunotherapy.”

The Flinders researchers found NSCLC patients with high BMI (BMI = 25 kg/m2) in four clinical trials had a significant reduction in mortality with atezolizumab, apparently benefiting from immune checkpoint inhibitor (ICI) therapy. Treatment options for this form of lung cancer are rapidly evolving and includes ICIs, molecular targeted drugs and chemotherapies.

The WHO estimates at least 2.8 million people die each year as a result of being overweight or obese. Overweight and obesity leads to adverse metabolic effects on blood pressure, cholesterol, triglycerides and insulin resistance. Risks of coronary heart disease, ischemic stroke and type 2 diabetes mellitus increase steadily with increasing body mass index (BMI), a measure of weight relative to height.

Of the 1,434 participants studied in the Australian research, 49% were normal weight, 34% were overweight and 7% were obese.

Life on Venus? Possible in mid-air clouds, says Indian origin scientist

Decades-long search for alien life has given momentum to biologists unearth the pre-requisites of life, hoping to find life form sooner or later. Mars probe has revealed that water was there on its surface once and now present in its sub-surface layers. Even Saturn’s moons Titan and Enceladus and Jupiter’s moons Europa, Ganymede and Callisto are standing up as possible havens for life under their icy crusts.

Venus, which was almost ruled out has become a candidate now and Indian-origin scientist planetary scientist Sanjay Limaye of the University of Wisconsin–Madison’s Space Science and Engineering Center and his team of researchers have begun dusting off an old idea that the atmosphere of Venus could be a possible niche for extraterrestrial microbial life.

Ever since the habitability of Venus’ clouds was first raised in 1967 by biophysicist Harold Morowitz and astronomer Carl Sagan, the idea has been expanding among the researchers. Planetary scientists David Grinspoon, Mark Bullock and their colleagues have supported the notion that Venus’ atmosphere could be a plausible niche for life.

A series of space probes to Venus launched between 1962 and 1978 by NASA and other space agencies showed that the temperature and pressure conditions in the lower and middle portions of the Venusian atmosphere, between 40 and 60 km altitude, would not preclude microbial life. But the immediate surface is known to be inhospitable, with temperatures soaring above 450 degrees Celsius.

Some models have suggested that Venus once had a habitable climate with liquid water on its surface for more than 2 billion years, much longer than what is believed to have occurred on Mars. “Venus has had plenty of time to evolve life on its own,” explains Limaye.

Since Earth’s surface has supported microorganisms or bacteria, which are found to be capable of being alive even at altitudes of 41 kilometers above the surface, the study co-author David J. Smith of NASA’s Ames Research Center, is confident that the microbial life could be found in the mid-atmosphere of Venus, if not on the surface.

Microbes can inhabit even in incredibly harsh environments such as the hot springs of Yellowstone, deep ocean hydrothermal vents, the toxic sludge of polluted areas, and in acidic lakes worldwide on the Earth, he said.

"Life can thrive in very acidic conditions, can feed on carbon dioxide, and produce sulfuric acid,” says Rakesh Mogul, a professor of biological chemistry at California State Polytechnic University, Pomona, and a co-author on the new paper. He notes that the cloudy, highly reflective and acidic atmosphere of Venus is composed mostly of carbon dioxide and water droplets containing sulfuric acid.

Limaye, who is a NASA participating scientist at the Japan Aerospace Exploration Agency’s Akatsuki mission to Venus, quoting a co-author Grzegorz Słowik of Poland’s University of Zielona Góra on light-absorbing properties of bacteria, said the famous dark patches on Venus atmosphere could be composed of concentrated sulfuric acid and other unknown light-absorbing particles.

“Venus shows some episodic dark, sulfuric rich patches, with contrasts up to 30–40 percent in the ultraviolet, and muted in longer wavelengths. These patches persist for days, changing their shape and contrasts continuously and appear to be scale dependent,” said Limaye.

Limaye said he was inspired when he visited Tso Kar, a high-altitude salt lake in northern India where he observed the powdery residue of sulfur-fixing bacteria on decaying grass at the edge of the lake being wafted into the atmosphere.
“To really know, we need to go there and sample the clouds,” echoed Mogul. “Venus could be an exciting new chapter in astrobiology exploration.”

A Venus Atmospheric Maneuverable Platform, or VAMP, which is an aircraft being sent to Venus to explore its atmosphere and Russia’s Roscosmos Venera-D mission will undertake missions to Venus, sometime in the late 2020s. Venera-D is likely to include an orbiter, a lander and a NASA-contributed surface station and maneuverable aerial platform.

The findings, supported by NASA, have been published in the journal Astrobiology.


A Venus Atmospheric Maneuverable Platform, or VAMP aircraft, would fly like a plane and float like a blimp, to explore the atmosphere of Venus, which has temperature and pressure conditions that do not preclude the possibility of microbial life. [Photo: NORTHROP GRUMMAN]