Gaza: Aid trucks still waiting for Israeli green light inside enclave

Existing supplies of basic necessities have been running dangerously low and on Wednesday the UN Children’s Fund, UNICEFsaid that its nutrition stocks to prevent increasing malnutrition “are almost gone”.

Humanitarian assistance is being weaponised to serve and support political and military objectives,” said Philippe Lazzarini, head of the UN agency for Palestinian refugees, UNRWA.

Speaking at the European Humanitarian Forum, Mr. Lazzarini insisted that significant stocks of aid remain blocked at the enclave’s borders.

“UNRWA is a lifeline for people in face of immense needs,” he said, noting that the whole humanitarian community in Gaza remains ready to scale up the delivery of critical supplies and services.

The development comes a day after UN humanitarians said that they had been allowed to send “around 100” more aid trucks loaded with supplies into Gaza.

Too little, too late

While such a move would be welcome in light of the desperate humanitarian emergency created by Israel’s total blockade, relief teams have pointed out that this would be a fraction of the 500 trucks that entered the enclave every day before the war erupted in Gaza in October 2023.

Today, one in five Gazans faces starvation, according to respected food security experts from the UN-backed Integrated Food Security Phase Classification platform – or IPC.

UN agencies have repeatedly stressed that they have stockpiles of relief supplies ready to enter Gaza.

Economic ‘paralysis’

Inside Gaza, the daily struggle to find food and water continues because of the Israeli blockade of all commercial and humanitarian access.

According to the UN World Food Programme (WFP), markets are “severely paralyzed”, supply chains have collapsed and prices have spiked.

“The population is now facing extreme levels of poor dietary diversity, with most people unable to access even the most basic food groups,” the UN agency warned in its latest update on Gaza.

“Several essential food items, including eggs and frozen meat, have disappeared from the market,” it said. “Wheat flour has reached exorbitant prices, with increases of over 3,000 per cent compared to pre-conflict levels and more than 4,000 per cent” compared to the ceasefire period from January to March.

While the Gazan economy is now in “near-total paralysis”, the West Bank is also staring down a deep recession, with combined overall output shrunk by 27 per cent.

Given that this is the deepest contraction in the Occupied Palestinian Territory in over a generation, WFP cited projections that Gaza will require 13 years to recover to pre-crisis levels and the West Bank three years.

West Bank demolitions crisis

In the occupied West Bank, meanwhile, further demolitions of Palestinian buildings were reported on Monday and Tuesday, in Beit Sahur, Shu’fat and Nahhalin.

Since the start of the year, Israeli settlers have damaged water infrastructure in the West Bank more than 60 times, according to OCHA. It noted that herding communities have been impacted most severely.

More to come…

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Not just chemotherapy, now phototherapy is here for cancer treatment [Details]

One approach to treating cancer is photodynamic therapy using photo-uncaging systems, in which light is used to activate a cancer-fighting agent in situ at the tumor. However, suitable agents must be stable under visible light, have an anti-tumor effect in low-oxygen environments, and have the ability to be activated by low-energy tissue-penetrative red light – a combination of properties that is difficult to achieve. Now, a team from The Institute of Industrial Science at The University of Tokyo has developed a new platform that uses, for the first time, organorhodium(III) phthalocyanine complexes to achieve this combination of traits.

Conventional photodynamic techniques depend on the formation of reactive oxygen species to destroy tumor cells, but many tumors contain environments that lack oxygen. Photo-uncaging systems, where the agent is administered in an inactive form and then activated, or “uncaged”, in the location of the tumor, address this issue. They uncage alkyl radicals, which are known to be capable of inducing cell death both with and without the presence of oxygen. Alkyl radicals are converted into terminal aldehydes in the presence of oxygen, and these terminal aldehydes can also induce cell death. The team used molecules called “organorhodium(III) phthalocyanine (Pc) complexes” to develop, for the first time, a novel platform for photo-uncaging therapy.

Researchers from The Institute of Industrial Science, The University of Tokyo have developed a streamlined photo-uncaging system for photodynamic cancer therapy, using a pulse of light for tumor-specific activation of a cancer-fighting agent/CREDIT
Institute of Industrial Science, The University of Tokyo

“The organorhodium(III) phthalocyanine (Pc) complexes we developed are highly stable under ambient light during the processes of synthesis, purification, and measurement, but can be activated by a laser that gives out nanosecond pulses of red light,” explains lead author Kei Murata. These nanosecond-pulsing lasers (pulsing for a billionth of a second) are relatively easy for medical staff to handle.

They went on to show that the compounds that were released after the organorhodium(III) phthalocyanine (Pc) complexes were activated showed toxicity to HeLa cells, a cell line developed from cancer, indicating that these compounds would have the ability to fight cancer if released inside a tumor.

“Our new technology could allow the photochemical generation of a wide variety of alkyl radicals and aldehydes, making possible the site-selective release of various bioactive molecules,” says senior author Kazuyuki Ishii. As an improvement on other photo-uncaging systems, it opens an exciting new avenue for the treatment of cancer by phototherapy.

New type of supercomputer could be based on ‘magic dust’ combination of light and matter

A team of researchers from the UK and Russia have successfully demonstrated that a type of ‘magic dust’ which combines light and matter can be used to solve complex problems and could eventually surpass the capabilities of even the most powerful supercomputers.

The researchers, from Cambridge, Southampton and Cardiff Universities in the UK and the Skolkovo Institute of Science and Technology in Russia, have used quantum particles known as polaritons – which are half light and half matter – to act as a type of ‘beacon’ showing the way to the simplest solution to complex problems. This entirely new design could form the basis of a new type of computer that can solve problems that are currently unsolvable, in diverse fields such as biology, finance or space travel. The results are reported in the journal Nature Materials.

Our technological progress — from modelling protein folding and behaviour of financial markets to devising new materials and sending fully automated missions into deep space — depends on our ability to find the optimal solution of a mathematical formulation of a problem: the absolute minimum number of steps that it takes to solve that problem.

The search for an optimal solution is analogous to looking for the lowest point in a mountainous terrain with many valleys, trenches, and drops. A hiker may go downhill and think that they have reached the lowest point of the entire landscape, but there may be a deeper drop just behind the next mountain. Such a search may seem daunting in natural terrain, but imagine its complexity in high-dimensional space. “This is exactly the problem to tackle when the objective function to minimise represents a real-life problem with many unknowns, parameters, and constraints,” said Professor Natalia Berloff of Cambridge’s Department of Applied Mathematics and Theoretical Physics and the Skolkovo Institute of Science and Technology, and the paper’s first author.

Modern supercomputers can only deal with a small subset of such problems when the dimension of the function to be minimised is small or when the underlying structure of the problem allows it to find the optimal solution quickly even for a function of large dimensionality. Even a hypothetical quantum computer, if realised, offers at best the quadratic speed-up for the “brute-force” search for the global minimum.

Berloff and her colleagues approached the problem from an unexpected angle: What if instead of moving along the mountainous terrain in search of the lowest point, one fills the landscape with a magical dust that only shines at the deepest level, becoming an easily detectible marker of the solution?

“A few years ago our purely theoretical proposal on how to do this was rejected by three scientific journals,” said Berloff. “One referee said, ‘Who would be crazy enough to try to implement this?!’ So we had to do it ourselves, and now we’ve proved our proposal with experimental data.”

Their ‘magic dust’ polaritons are created by shining a laser at stacked layers of selected atoms such as gallium, arsenic, indium, and aluminium. The electrons in these layers absorb and emit light of a specific colour. Polaritons are ten thousand times lighter than electrons and may achieve sufficient densities to form a new state of matter known as a Bose-Einstein condensate, where the quantum phases of polaritons synchronise and create a single macroscopic quantum object that can be detected through photoluminescence measurements.

The next question the researchers had to address was how to create a potential landscape that corresponds to the function to be minimised and to force polaritons to condense at its lowest point. To do this, the group focused on a particular type of optimisation problem, but a type that is general enough so that any other hard problem can be related to it, namely minimisation of the XY model which is one of the most fundamental models of statistical mechanics. The authors have shown that they can create polaritons at vertices of an arbitrary graph: as polaritons condense, the quantum phases of polaritons arrange themselves in a configuration that correspond to the absolute minimum of the objective function.

“We are just at the beginning of exploring the potential of polariton graphs for solving complex problems,” said co-author Professor Pavlos Lagoudakis, Head of the Hybrid Photonics Lab at the University of Southampton and the Skolkovo Institute of Science and Technology, where the experiments were performed. “We are currently scaling up our device to hundreds of nodes, while testing its fundamental computational power. The ultimate goal is a microchip quantum simulator operating at ambient conditions.”

 

Outdoor light at night linked with increased breast cancer risk in women

  • A large long-term study found that breast cancer risk may be higher for women who live in areas with high levels of outdoor light at night.
  • The link between outdoor light at night and breast cancer was found only among women who were premenopausal and were current or past smokers, and was stronger among those who worked night shifts.

Women who live in areas with higher levels of outdoor light at night may be at higher risk for breast cancer than those living in areas with lower levels, according to a large long-term study from Harvard T.H. Chan School of Public Health. The link was stronger among women who worked night shifts.

The study will be published online August 17, 2017 in Environmental Health Perspectives.

“In our modern industrialized society, artificial lighting is nearly ubiquitous. Our results suggest that this widespread exposure to outdoor lights during nighttime hours could represent a novel risk factor for breast cancer,” said lead author Peter James, assistant professor at Harvard Medical School’s Department of Population Medicine at Harvard Pilgrim Health Care Institute, who did the work while a research fellow in the Departments of Epidemiology and Environmental Health at Harvard Chan School.

Previous studies have suggested that exposure to light at night may lead to decreased levels of the hormone melatonin, which can disrupt circadian rhythms–our internal “clocks” that govern sleepiness and alertness–and, in turn, lead to increased breast cancer risk.

The new study, the most comprehensive to date to examine possible links between outdoor light at night and breast cancer, looked at data from nearly 110,000 women enrolled in the Nurses’ Health Study II from 1989-2013. The researchers linked data from satellite images of Earth taken at nighttime to residential addresses for each study participant, and also considered the influence of night shift work. The study also factored in detailed information on a variety of health and socioeconomic factors among participants.

Women exposed to the highest levels of outdoor light at night–those in the top fifth–had an estimated 14% increased risk of breast cancer during the study period, as compared with women in the bottom fifth of exposure, the researchers found. As levels of outdoor light at night increased, so did breast cancer rates.

The association between outdoor light at night and breast cancer was found only among women who were premenopausal and those who were current or past smokers. In addition, the link was stronger among women who worked night shifts, suggesting that exposure to light at night and night shift work contribute jointly to breast cancer risk, possibly through mechanisms involving circadian disruption. The authors acknowledged that further work is required to confirm the study findings and clarify potential mechanisms.