Tag Archives: stroke

These blood groups linked to your risk of stroke before age 60: Study

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Gene variants associated with a person’s blood type may be linked to their risk of early stroke, according to a new meta-analysis published in the latest online issue of Neurology.

Non-O blood types have previously been linked to a risk of early stroke, but the new findings by University of Maryland School of Medicine study showed a stronger link between these blood types with early stroke compared to late stroke, and in linking risk mostly to blood type A.

Study author Braxton D. Mitchell of University of Maryland School of Medicine in Baltimore said, “Specifically, our meta-analysis suggests that gene variants tied to blood types A and O represent nearly all of those genetically linked with early stroke. People with these gene variants may be more likely to develop blood clots, which can lead to stroke.”

stroke

The meta-analysis involved a review of 48 studies on genetics and ischemic stroke from North America, Europe and Asia. The studies included 16,927 people with stroke and 576,353 people who did not have a stroke. Of those with stroke, 5,825 people had early onset stroke and 9,269 people had late onset stroke. Early onset stroke was defined as an ischemic stroke occurring before age 60 and late onset stroke was older than 60.

Researchers looked across all the chromosomes to identify genetic variants associated with stroke. They found a link between early stroke and the area of the chromosome that includes the gene that determines A, AB, B or O blood type.

They then divided participants into A, AB, B and O blood types. They compared the prevalence of those blood types in people with early stroke, late stroke and people who did not have a stroke.

Researchers found that people with early stroke were more likely to have blood type A and less likely to have blood type O compared to people with late stroke and people without stroke. Both early and late stroke were also more likely to have blood type B compared to controls.

Blood types/photo: en.wikipedia.org

When looking at people of European ancestry and comparing 5,825 people with early stroke to 29,320 people who did not have a stroke, the meta-analysis found that 48% of people with early stroke had blood type A compared to 45% of people with late stroke and 44% of people without stroke. They also found 35% of people with early stroke had blood type O compared to 39% of those with late stroke and 41% of people without stroke.

After adjusting for sex and other factors, researchers found those who had blood type A had an 16% higher risk of having an early stroke than people with other blood types. Those who had blood type O had a 12% lower risk of having a stroke than people with other blood types.

 

 

 

 

 

Epileptic drugs linked to stroke in case of Alzheimer’s

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Antiepileptic drugs may increase the risk of stroke among persons with Alzheimer’s disease, said a new study from the University of Eastern Finland.

The risk remains the same whether the drugs are old or new antiepileptic drugs, said the study published in the Journal of the American Heart Association.

The study, conducted at the University of Eastern Finland and funded by the Academy of Finland, was based on the nationwide register-based MEDALZ cohort that includes all community-dwelling persons with clinically verified diagnosis of Alzheimer’s disease in Finland during 2005–2011 (70,718 people).

Data on antiepileptic drug use was compiled from the Finnish Prescription Register to assess the risk of stroke associated with antiepileptic drug use, and each antiepileptic drug user was matched to a non-user.

It was found that the risk of stroke was more during the first three months of antiepileptic drug use, and remains elevated after taking into account several chronic disorders, socio-economic position and use of concomitant medications.

According to another study from the same research group, persons with Alzheimer’s disease use antiepileptic drugs more often than persons without Alzheimer’s disease. The difference, which cannot be explained by epilepsy, is evident in antiepileptic drug use around the time when Alzheimer’s disease was diagnosed.

Up to 1% of population regularly requires chronic antiepileptic treatment to control epilepsy. Other indications for antiepileptic drug use include neuropathic pain and dementia-related behavioural symptoms in persons with Alzheimer’s disease.

The present findings show that persons with Alzheimer’s disease are particularly susceptible to adverse events, hence, the use of antiepileptic drugs for other indications than epilepsy should be carefully prescribed for this vulnerable population.

 

Fish oil won’t help diabetics fight heart attack or strokes: Study

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Fish oil supplements do not prevent heart attacks or strokes in patients with diabetes, according to late breaking results from the ASCEND trial presented on Friday in a Hot Line Session at ESC Congress 2018.

In observational studies, higher consumption of fish is associated with lower risks of coronary artery disease and stroke. However, previous randomised trials have not been able to show that taking fish oil supplements containing omega-3 fatty acids reduce the risk of having cardiovascular events.

The ASCEND trial (A Study of Cardiovascular Events iN Diabetes)2 examined whether fish oil supplements reduce the risk of a cardiovascular event in patients with diabetes. Between 2005 and 2011, 15,480 patients with diabetes but no history of cardiovascular disease were randomly assigned to fish oil supplementation (1 g daily) or matching placebo.

The primary efficacy outcome was first serious vascular event, which included non-fatal heart attacks, non-fatal strokes or transient ischaemic attacks (sometimes called “mini-strokes”), or deaths from a cardiovascular cause (but excluding any intracranial haemorrhage; i.e. bleeding in the head or brain3).

During an average of 7.4 years of follow-up, a first serious vascular event occurred in 689 (8.9%) participants allocated fish oil supplements and 712 (9.2%) participants allocated placebo. There was no significant difference between the two groups: rate ratio of 0.97 (95% confidence interval 0.87-1.08, p=0.55).

Dr Louise Bowman, principal investigator, Nuffield Department of Population Health, University of Oxford, UK, said: “Our large, long-term randomised trial shows that fish oil supplements do not reduce the risk of cardiovascular events in patients with diabetes. This is a disappointing finding, but it is in line with previous randomised trials in other types of patient at increased risk of cardiovascular events which also showed no benefit of fish oil supplements. There is no justification for recommending fish oil supplements to protect against cardiovascular events.”

The findings were published in the New England Journal of Medicine.

Sauna bath daily reduces risk of heart disease by 61%, says study

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Frequent sauna bathing is good as it reduces the risk of stroke, said a new international study.

The study followed people taking a sauna for 15 years and found the frequent goers benefit more from it. Those taking saunda 4-7 times a week were 61% less likely to suffer a stroke than those taking a sauna once a week, said the study published in the journal Neurology.

A team of scientists from the Universities of Eastern Finland, Bristol, Leicester, Atlanta, Cambridge and Innsbruck, based on the population-based Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study on 1,628 men and women aged 53 to 74 years living in the eastern part of Finland, found the most accurate results.

Based on their frequency of taking traditional Finnish sauna baths with relative humidity of 10-20%, the study participants were divided into three groups: those taking a sauna once a week, those taking a sauna 2-3 times a week, and those taking a sauna 4-7 times a week.

The more frequently saunas were taken, the lower was the risk of stroke. Compared to people taking one sauna session per week, the risk was decreased by 14% among those with 2-3 sessions and 61% among those with 4-7 sessions.

The association persisted even when taking into account conventional stroke risk factors, such as age, sex, diabetes, body mass index, blood lipids, alcohol consumption, physical activity and socio-economic status. The strength of association was similar in men and women.

A previous study conducted in Finland, surveyed 1,621 middle-aged men, who had normal blood pressure. During the observation for 25 years, 251 of them developed hypertension. Men who go for a single sauna session per week are 46 percent more likely to develop hypertension than the ones who visit the sauna at least four times a week, said Jari Laukkanen, a professor of medicine at the University of Eastern Finland and the lead author of the study.

The sauna’s warmth improves blood flow by increasing the flexibility of the blood vessels. A typical Finnish sauna can help in relaxation, thereby moderating blood pressure. Additionally, the act of excessive sweating acts as a natural diuretic: a long-trusted drug to cure hypertension.

Another study on the benefits of sauna, conducted by Minna L. Hannuksela and Samer Ellahham, states that regular visits to the sauna cause cardiovascular and hormonal changes that may provide relief to patients with asthma and chronic bronchitis, besides soothening skin conditions like dermatitis and psoriasis.