Higher coffee consumption associated with lower risk of death

Higher coffee consumption is associated with a lower risk of death, according to research presented today at ESC Congress.1 The observational study in nearly 20 000 participants suggests that coffee can be part of a healthy diet in healthy people.

“Coffee is one of the most widely consumed beverages around the world,” said Dr Adela Navarro, a cardiologist at Hospital de Navarra, Pamplona, Spain. “Previous studies have suggested that drinking coffee might be inversely associated with all-cause mortality but this has not been investigated in a Mediterranean country.”

The purpose of this study was to examine the association between coffee consumption and the risk of mortality in a middle-aged Mediterranean cohort. The study was conducted within the framework of the Seguimiento Universidad de Navarra (SUN) Project, a long-term prospective cohort study in more than 22 500 Spanish university graduates which started in 1999.

This analysis included 19 896 participants of the SUN Project, whose average age at enrolment was 37.7 years old. On entering the study, participants completed a previously validated semi-quantitative food frequency questionnaire to collect information on coffee consumption, lifestyle and sociodemographic characteristics, anthropometric measurements, and previous health conditions.

Patients were followed-up for an average of ten years. Information on mortality was obtained from study participants and their families, postal authorities, and the National Death Index. Cox regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for incident mortality according to baseline total coffee consumption adjusted for potential confounders.

During the ten year period, 337 participants died. The researchers found that participants who consumed at least four cups of coffee per day had a 64% lower risk of all-cause mortality than those who never or almost never consumed coffee (adjusted HR, 0.36; 95% CI, 0.19-0.70). There was a 22% lower risk of all-cause mortality for each two additional cups of coffee per day (adjusted HR, 0.78; 95% CI, 0.66-0.92).

The researchers examined whether sex, age or adherence to the Mediterranean diet had any influence on the association between baseline coffee consumption and mortality. They observed a significant interaction between coffee consumption and age (p for interaction=0.0016). In those who were at least 45 years old, drinking two additional cups of coffee per day was associated with a 30% lower risk of mortality during follow-up (adjusted HR, 0.70; 95% CI, 0.58-0.85). The association was not significant among younger participants.

Dr Navarro said: “In the SUN project we found an inverse association between drinking coffee and the risk of all-cause mortality, particularly in people aged 45 years and above. This may be due to a stronger protective association among older participants.”

She concluded: “Our findings suggest that drinking four cups of coffee each day can be part of a healthy diet in healthy people.”

Could insufficient sleep be adding centimeters to your waistline?

Adults in the UK who have poor sleep patterns are more likely to be overweight and obese and have poorer metabolic health, according to a new study.

The findings showed that people who were sleeping an average of six hours a night had a waist measurement that was 3 cm greater than individuals who were getting nine hours of sleep a night. And shorter sleepers were heavier too.

The results strengthen the evidence that insufficient sleep could contribute to the development of metabolic diseases such as diabetes-major health challenges facing the NHS.

The study – led by Dr Laura Hardie, Reader in Molecular Epidemiology at the University of Leeds – not only looked at the links between sleep duration, diet and weight, but also other indicators of overall metabolic health such as blood pressure, blood cholesterol, blood sugar, and thyroid function.

The study involved 1,615 adults who reported how long they slept and kept records of food intake. Participants had blood samples taken and their weight, waist circumference, and blood pressure recorded. The researchers looked at the associations between how long people were sleeping and these key biological parameters.

The research team, from the Leeds Institute of Cardiovascular and Metabolic Medicine and the School of Food Science and Nutrition, reported their findings in the journal PLOS ONE.

Greg Potter, one of the Leeds researchers, said “The number of people with obesity worldwide has more than doubled since 1980. Obesity contributes to the development of many diseases, most notably type 2 diabetes. Understanding why people gain weight has crucial implications for public health.”

Shorter sleep was also linked to reduced levels of HDL cholesterol in the participants’ blood-another factor that can cause health problems. HDL cholesterol is ‘good’ cholesterol that helps remove ‘bad’ fat from the circulation. In doing so, high HDL cholesterol levels protect against conditions such as heart disease.

Interestingly, the study did not find any relationship between shortened sleep and a less healthy diet – a fact that surprised the researchers. Other studies have suggested that shortened sleep can lead to poor dietary choices.

The research was a snapshot of the associations between sleep duration and measurements of metabolic health. It was not designed to assess the impact of chronic poor sleep over time, and whether that leads to disease.

Dr Laura Hardie, the study’s senior investigator, added “Because we found that adults who reported sleeping less than their peers were more likely to be overweight or obese, our findings highlight the importance of getting enough sleep. How much sleep we need differs between people, but the current consensus is that seven to nine hours is best for most adults.”

The findings add to the growing body of evidence showing just how important a good night’s sleep is to health.