Scientists have found out that non-psychoactive cannabis substances, CBD and CBG, can help to reduce liver fat significantly and improve metabolic health. The researchers have found out that these compounds act by establishing a buffer of energy in the liver and by the re-activation of the cleaning crews inside the cells to clear undesirable waste products. These results point to the existence of a novel, plant-based direction of treating the most frequent chronic liver disease of the world.
According to a study by Prof. Joseph (Yossi) Tam, Dr. Liad Hinden, a PhD student, Radka Kocvarova, and the team of researchers led by Tam, at the School of Pharmacy in the Faculty of Medicine at the Hebrew University of Jerusalem, two compounds of the cannabis plant are useful in the treatment of fatty liver disease. The study indicates that the non-psychoactive and non-high-inducing Cannabidiol (CBD) and Cannabigerol (CBG) can help people live healthier lives due to its ability to alter how the liver processes energy and purifies itself.
The prevalent chronic liver disorder in the world is currently known as Maatotic asymptomatic liver disease (MASLD) which is associated with metabolic dysfunction. It is prevalent among about 1 in 3 adults, and strongly associated with obesity, hypertension and insulin resistance. Although lifestyle change such as diet and exercise is significant, it is not always easier to sustain it and known medicines approved to treat this condition are very limited. This renders the discovery of new medicines a top priority to the scientists.
The researchers demonstrated that CBD and CBG are not only fat-reducing tools with the help of sophisticated tools. In fact, they assist the liver to work more efficiently internally in a special mechanism of metabolic remodeling. The effect on the energy stores of the liver was identified as one of the most crucial findings. The compounds cause a rise in phosphocreatine levels which serve as a backup battery to keep the liver healthy despite the stress which is posed by high-fat diet. It is a novel finding because the liver is not normally dependent on such a system of energy in a heavy way.
Reinstate functions of cathepsins
Also, the experiment revealed that CBD and CBG reinstate the functions of cathepsins. They are enzymes that serve as the cleaning crew in the recycling centers of the cell and they are called lysosomes. With the help of getting this cleaning crew back at work the liver is able to better process and eliminate the harmful fats and waste. Another finding by the researchers was that the two treatments had significant lowering effects on the harmful lipids, including triglycerides and ceramides. Ceramides are those that are especially harmful since they have been identified to cause insulin resistance and liver inflammation.
The research found out that both compounds were useful but they had a slight difference in terms of benefit to metabolic health. CBD and CBG could all normalise blood sugar levels and enhance the glucose clearance in the body. Nevertheless, CBG seemed to influence some measures more strongly. It was much more effective in fat mass reduction in the body and insulin sensitivity than CBD. The CBG was also especially useful in reducing the total cholesterol and the bad LDL cholesterol levels.
Prof. Joseph Tam ssaid, “the findings of the research point to a new mechanism through which CBD and CBG improve the hepatic energy and lysosomal activity. Such dual metabolic remodelling results in a better process of lipids in liver and singling out such compounds as likely treatment options in MASLD.”
Though these findings are highly encouraging, the staff remarks that additional studies are required in order to comprehend how these findings can be optimally applied to human patients. The research provides a novel avenue in the use of plant-derived compounds to treat metabolic diseases because it is based on the energy and waste management in cells.