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Google DeepMind researchers Demis Hassabis and John M. Jumper, along with Professor David Baker from Washington University, have been awarded the 2024 Nobel Prize in Chemistry for groundbreaking work in protein design and structure prediction.
The Royal Swedish Academy of Sciences made the announcement on Wednesday, recognizing their contributions to solving key challenges in the field of biochemistry. One half of the prize goes to Baker “for computational protein design,” while Hassabis and Jumper share the other half “for protein structure prediction.”
Demis Hassabis, the CEO of Google DeepMind, and John M. Jumper, a senior researcher at the company, were celebrated for their development of an artificial intelligence (AI) model that cracked a 50-year-old puzzle: predicting the complex 3D structures of proteins based on their amino acid sequences. This AI model, AlphaFold2, revolutionized biology by allowing researchers to predict the structure of nearly all known proteins.
David Baker, based in the U.S., was recognized for his pioneering efforts in designing entirely new proteins. Since 2003, Baker’s research team has engineered novel proteins, which have been used in a range of applications from pharmaceuticals and vaccines to nanomaterials and biosensors.
“One of the discoveries being honored this year is about creating spectacular proteins, while the other fulfills a 50-year-old dream of predicting protein structures from amino acid sequences,” said Heiner Linke, Chair of the Nobel Committee for Chemistry. He emphasized that these advancements open up “vast possibilities” in scientific research and practical applications.
AlphaFold2, introduced by Hassabis and Jumper in 2020, is now used by millions of researchers worldwide. The AI has facilitated breakthroughs in understanding antibiotic resistance and even helped map enzymes capable of breaking down plastic. Its widespread adoption has provided insights into nearly 200 million proteins identified by researchers across the globe.
The total prize of 11 million Swedish kronor (around $1.1 million) will be split between the winners, with Baker receiving half and the remaining amount shared by Hassabis and Jumper.
These discoveries are expected to fuel future innovations in medicine, environmental science, and beyond.
